Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Cites (623)

Items 401–600 of 609

1. Long-term effects of ruxolitinib versus best available therapy on bone marrow fibrosis in patients with myelofibrosis
   Hans Michael Kvasnicka, Jürgen Thiele, Carlos Bueso-Ramos, William Y. Sun, Jörge E. Cortes, Hagop M. Kantarjian, Srđan Verstovšek · 2018 · Journal of Hematology & Oncology
2. β‐carotene attenuates lipopolysaccharide‐induced inflammation via inhibition of the NF‐κB, JAK2/STAT3 and JNK/p38 MAPK signaling pathways in macrophages
   Ruonan Li, Hong Pan, Xin Zheng · 2018 · Animal Science Journal
3. Aberrant LPL expression, driven by STAT3, mediates free fatty acid metabolism in CLL cells
   Rozovski, Uri, Grgurevic, Srdana, Bueso-Ramos, Carlos, Harris, David M., Li, Ping, Liu, Zhiming, Wu, Ji Yuan, Jain, Preetesh, Wierda, William, Burger, Jan et al. · 2015 · Molecular Cancer Research
4. Mitochondrial STAT3 plays a major role in IgE-antigen–mediated mast cell exocytosis
   Tal Hadad Erlich, Zohar Yagil, Gillian Kay, Alona Peretz, Helena Migalovich-Sheikhet, Sagi Tshori, Hovav Nechushtan, Francesca Levi‐Schaffer, Ann Saada, Ehud Razin · 2014 · Journal of Allergy and Clinical Immunology
5. Bcl‐X L and STAT3 mediate malignant actions of γ‐irradiation in lung cancer cells
   Jin‐Nyoung Ho, Ga Young Kang, Seung‐Sook Lee, Jongdoo Kim, In Hwa Bae, Sang‐Gu Hwang, Hong‐Duck Um · 2010 · Cancer Science
6. Stat3 signaling activation crosslinking of TGF-β1 in hepatic stellate cell exacerbates liver injury and fibrosis
   Mingyi Xu, Junjie Hu, Jie Shen, Meiling Wang, Qingqing Zhang, Ying Qu, Lungen Lu · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
7. Disruption of Protein Arginine N -Methyltransferase 2 Regulates Leptin Signaling and Produces Leanness In Vivo Through Loss of STAT3 Methylation
   Hiroaki Iwasaki, Jason Ciril Kovacic, Michelle Olive, Jeanette K. Beers, Takanobu Yoshimoto, Martin F. Crook, Leonardo H. Tonelli, Elizabeth G. Nabel · 2010 · Circulation Research
8. Pivotal importance of STAT3 in protecting the heart from acute and chronic stress: new advancement and unresolved issues
   Zouein, Fouad A., Altara, Raffaele, Chen, Qun, Lesnefsky, Edward J., Kurdi, Mazen, Booz, George W. · 2015 · Frontiers in Cardiovascular Medicine
9. S-Glutathionylation at Cys328 and Cys542 impairs STAT3 phosphorylation
   Butturini, Elena, Darra, Elena, Chiavegato, Giulia, Cellini, Barbara, Cozzolino, Flora, Monti, Maria, Pucci, Piero, Dell’Orco, Daniele, Mariotto, Sofia · 2014 · ACS Chemical Biology
10. STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFβ-activated kinase 1 for STAT3 Ser-727 phosphorylation
    Kojima, Hirotada, Sasaki, Takanori, Ishitani, Tohru, Iemura, Shun-ichiro, Zhao, Hong, Kaneko, Shuhei, Kunimoto, Hiroyuki, Natsume, Tohru, Matsumoto, Kunihiro, Nakajima, Koichi · 2005 · Proceedings of the National Academy of Sciences
11. The role of leptin-->STAT3 signaling in neuroendocrine function: an integrative perspective
    Bates, Sarah H., Myers, Martin G. · 2004 · Journal of Molecular Medicine
12. MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells
    Zhang, Yiguo, Liu, Guangming, Dong, Zigang · 2001 · Journal of Biological Chemistry
13. Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro
    Weidong Li, Shakir M. Saud, Matthew R. Young, Nancy H. Colburn, Baojin Hua · 2015 · Molecular and Cellular Biochemistry
14. Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN
    Sun, Xiaoxia, Zhang, Jian, Wang, Lihua, Tian, Zhigang · 2008 · Cancer Letters
15. Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride-induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production
    Hua Wang, Fouad Lafdil, Lei Wang, Shi Yin, Dechun Feng, Bin Gao · 2011 · Cell & Bioscience
16. The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3
    Vogt, Michael, Domoszlai, Tamas, Kleshchanok, Dzina, Lehmann, Swen, Schmitt, Anne, Poli, Valeria, Richtering, Walter, Müller-Newen, Gerhard · 2011 · Journal of Cell Science
17. Can the Protective Actions of JAK-STAT in the Heart be Exploited Therapeutically? Parsing the Regulation of Interleukin-6-Type Cytokine Signaling
    Mazen Kurdi, George W. Booz · 2007 · Journal of Cardiovascular Pharmacology
18. A STAT3 dimer formed by inter-chain disulphide bridging during oxidative stress
    Li, Li, Shaw, Peter E. · 2004 · Biochemical and Biophysical Research Communications
19. Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition
    Su, Tung-Hung, Shiau, Chung-Wai, Jao, Ping, Liu, Chen-Hua, Liu, Chun-Jen, Tai, Wei-Tien, Jeng, Yung-Ming, Yang, Hung-Chih, Tseng, Tai-Chung, Huang, Hsiang-Po et al. · 2015 · Proceedings of the National Academy of Sciences
20. IL-6/STAT3/TWIST inhibition reverses ionizing radiation-induced EMT and radioresistance in esophageal squamous carcinoma
    Chunbao Zang, Xujie Liu, Bing Li, Yanqiong He, Shen Jing, Yujia He, Wenli Wu, Bingqian Zhang, Shuhong Ma, Weiwei Dai et al. · 2017 · Oncotarget
21. Prevention and Treatment of Experimental Estrogen Receptor–Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268
    Karen T. Liby, Renee Risingsong, Darlene B. Royce, Charlotte R. Williams, Mark M. Yore, Tadashi Honda, Gordon W. Gribble, William W. Lamph, Nicola Vannini, Ilaria Sogno et al. · 2008 · Clinical Cancer Research
22. Thrombopoietin
    Kenneth Kaushansky · 1997 · Trends in Endocrinology and Metabolism
23. Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice
    Kroy, Daniela C., Beraza, Naiara, Tschaharganeh, Darjus F., Sander, Leif E., Erschfeld, Stephanie, Giebeler, Arne, Liedtke, Christian, Wasmuth, Hermann E., Trautwein, Christian, Streetz, Konrad L. · 2010 · Hepatology
24. The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition
    Courapied, Sandy, Sellier, Hélène, de Carné Trécesson, Sophie, Vigneron, Arnaud, Bernard, Anne-Charlotte, Gamelin, Erick, Barré, Benjamin, Coqueret, Olivier · 2010 · Journal of Biological Chemistry
25. Transcriptional Stimulation of the Surfactant Protein B Gene by STAT3 in Respiratory Epithelial Cells
    Cong Yan, Angela Naltner, Michelle R. Martin, Michael Naltner, Jessica M. Fangman, Okyanus Gurel · 2002 · Journal of Biological Chemistry
26. STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13
    Huiyuan Zhang, Hongbo Hu, Nathaniel R. Greeley, Jin Jin, Allison J. Matthews, Erika Ohashi, Mauricio S. Caetano, Haiyan S. Li, Xuefeng Wu, Pijus Kumar Mandal et al. · 2014 · Nature Communications
27. Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3
    Moammir Hasan Aziz, Herbert T. Manoharan, Ajit Kumar Verma · 2007 · Cancer Research
28. Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanism
    Grant, Louise, Shearer, Kirsty D., Czopek, Alicja, Lees, Emma K., Owen, Carl, Agouni, Abdelali, Workman, James, Martin-Granados, Cristina, Forrester, John V., Wilson, Heather M. et al. · 2014 · Diabetes
29. Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCα/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells
    Soo‐Jin Kim, Thu‐Huyen Pham, Yesol Bak · 2018 · Phytomedicine
30. Heterogeneity in fibroblast proliferation and survival in idiopathic pulmonary fibrosis
    David M. Habiel, Cory M. Hogaboam · 2014 · Frontiers in Pharmacology
31. Activation of JAK2 by the oxidative stress generated with oxidized low-density lipoprotein
    Mazière, Cécile, Conte, Marie-Alix, Mazière, Jean-Claude · 2001 · Free Radical Biology and Medicine
32. A Distal Enhancer in Il12b Is the Target of Transcriptional Repression by the STAT3 Pathway and Requires the Basic Leucine Zipper (B-ZIP) Protein NFIL3
    Amber M. Smith, Joseph E. Qualls, Kevin O’Brien, Liza Balouzian, Peter Frederick Johnson, Stacey Schultz‐Cherry, Stephen T. Smale, Peter J. Murray · 2011 · Journal of Biological Chemistry
33. Signal transducer and activator of transcription 3 (STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity
    Zhou, Zhou, Gushiken, Francisca C., Bolgiano, Doug, Salsbery, Breia J., Aghakasiri, Niloufar, Jing, Naijie, Wu, Xiaoping, Vijayan, K. Vinod, Rumbaut, Rolando E., Adachi, Roberto et al. · 2013 · Circulation
34. Overexpression of Stat3C in pulmonary epithelium protects against hyperoxic lung injury
    Lian, Xuemei, Qin, Yulin, Hossain, Shaikh Abu, Yang, Li, White, Amanda, Xu, Huan, Shipley, J Michael, Li, Tingyu, Senior, Robert M, Du, Hong et al. · 2005 · The Journal of Immunology
35. Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: The ENTRANCE study
    Klaus Robert Herrlinger, Mircea Diculescu, Klaus Fellermann, H Hartmann, Stefanie M. Howaldt, Rosen K. Nikolov, Andrej Petrov, Wolfgang Reindl, J.‐M. Otte, Simeon G Stoynov et al. · 2012 · Journal of Crohn s and Colitis
36. Bone marrow fibrosis in primary myelofibrosis: pathogenic mechanisms and the role of TGF-β.
    Archana M. Agarwal, Kerry A. Morrone, Matthias Bartenstein, Zhizhuang Joe Zhao, Amit K. Verma, Swati Goel · 2016 · Europe PMC (PubMed Central)
37. Targeting oncogenic transcription factors: therapeutic implications of endogenous STAT inhibitors
    Heppler, Lisa N., Frank, David A. · 2017 · Trends in Cancer
38. Nucleus, mitochondrion, or reticulum? STAT3 à La Carte
    Avalle, Lidia, Poli, Valeria · 2018 · International Journal of Molecular Sciences
39. Are STATS Arginine-methylated?
    Waraporn Komyod, Uta‐Maria Bauer, Peter Claus Heinrich · 2005 · Journal of Biological Chemistry
40. Mesenchymal stem cells protect against obstruction-induced renal fibrosis by decreasing STAT3 activation and STAT3-dependent MMP-9 production
    Futoshi Matsui, Stephen A. Babitz, Audrey C. Rhee, Karen L. Hile, Hongji Zhang, Kirstan K. Meldrum · 2016 · American Journal of Physiology-Renal Physiology
41. Role of STAT3 in skin fibrosis and transforming growth factor beta signalling
    Mesias Pedroza, Sarah To, Shervin Assassi, Minghua Wu, David John Tweardy, Sandeep Krishna Agarwal · 2017 · Rheumatology
42. The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis
    Zhuo Wang, Jia’an Li, Wen'ang Xiao, Jiafu Long, Hongmin Zhang · 2018 · Laboratory Investigation
43. Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway
    Albertus T.J. Wierenga, Irma Vogelzang, Bart J. L. Eggen · 2003 · Experimental Hematology
44. DNA damage induces the IL-6/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors
    Yun, Un Jung, Park, Sang Eun, Jo, Yong Sam, Kim, Jungbin, Shin, Deug Y. · 2012 · Cancer Letters
45. Current hypotheses for the biochemical basis of diabetic retinopathy
    Mandarino, Lawrence J · 1992 · Diabetes Care
46. JAK-STAT in Lipid Metabolism of Adipocytes
    Xu, Dong, Yin, Chunyan, Wang, Sisi, Xiao, Yanfeng · 2013 · JAK-STAT
47. Lysine methylation of promoter-bound transcription factors and relevance to cancer
    George Robert Stark, Yuxin Wang, Tao Lu · 2010 · Cell Research
48. Cutting Edge: IL-10–Mediated Tristetraprolin Induction Is Part of a Feedback Loop That Controls Macrophage STAT3 Activation and Cytokine Production
    Anthony Gaba, Sergei I. Grivennikov, Mahn Vu, Deborah J. Stumpo, Perry J. Blackshear, Michael Karin · 2012 · The Journal of Immunology
49. Critical roles of STAT3 in β-adrenergic functions in the heart
    Zhang, Wenjun, Qu, Xiuxia, Chen, Biyi, Snyder, Marylynn, Wang, Meijing, Li, Baiyan, Tang, Yue, Chen, Hanying, Zhu, Wuqiang, Zhan, Li et al. · 2016 · Circulation
50. Human hyper-IgE syndrome: singular or plural?
    Zhang, Qian, Boisson, Bertrand, Béziat, Vivien, Puel, Anne, Casanova, Jean-Laurent · 2018 · Mammalian Genome
51. Gut‐derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin‐6/signal transducer and activator of transcription 3 activity
    J. Lunz, S. Specht, N. Murase, K. Isse, A. Demetris · 2007 · Hepatology
52. Novel mechanisms of platelet clearance and thrombopoietin regulation
    Grozovsky, Renata, Giannini, Silvia, Falet, Hervé, Hoffmeister, Karin M. · 2015 · Current Opinion in Hematology
53. Siltuximab (CNTO 328): a promising option for human malignancies
    Chen, Bao-An, Chen, Runzhe · 2015 · Drug Design, Development and Therapy
54. Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 - protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells
    Mandal, Tapashi, Bhowmik, Arijit, Chatterjee, Anirban, Chatterjee, Uttara, Chatterjee, Sandip, Ghosh, Mrinal Kanti · 2014 · Cellular Signalling
55. The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway
    Abe, Koji, Hirai, Manabu, Mizuno, Katsunori, Higashi, Natsuko, Sekimoto, Toshihiro, Miki, Tokuhiko, Hirano, Toshio, Nakajima, Koichi · 2001 · Oncogene
56. Physical and functional interactions between STAT3 and ZIP kinase
    Noriko Sato, Taro Kawai, Kenji Sugiyama, Ryuta Muromoto, Seiyu Imoto, Yuichi Sekine, Masato Ishida, Shizuo Akira, Tadashi Matsuda · 2005 · International Immunology
57. Angiotensinogen Gene Expression Is Dependent on Signal Transducer and Activator of Transcription 3-Mediated p300/cAMP Response Element Binding Protein-Binding Protein Coactivator Recruitment and Histone Acetyltransferase Activity
    Sutapa Ray, Christopher T. Sherman, Muping Lu, Allan R. Brasier · 2002 · Molecular Endocrinology
58. Unphosphorylated STAT and heterochromatin protect genome stability
    Shian‐Jang Yan, Su Jun Lim, Song Shi, Pranabananda Dutta, Willis X. Li · 2010 · The FASEB Journal
59. Critical Role for Lysine 685 in Gene Expression Mediated by Transcription Factor Unphosphorylated STAT3
    Dasgupta, Maupali, Unal, Hamiyet, Willard, Belinda, Yang, Jinbo, Karnik, Sadashiva S., Stark, George R. · 2014 · Journal of Biological Chemistry
60. Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis
    Zhang, Yun, Dees, Clara, Beyer, Christian, Lin, Neng-Yu, Distler, Alfiya, Zerr, Pawel, Palumbo, Katrin, Susok, Laura, Kreuter, Alexander, Distler, Oliver et al. · 2015 · Annals of the Rheumatic Diseases
61. The EGFR-STAT3 Oncogenic Pathway Up-regulates the Eme1 Endonuclease to Reduce DNA Damage after Topoisomerase I Inhibition
    Arnaud M. Vigneron, Erick C. Gamelin, Olivier Coqueret · 2008 · Cancer Research
62. Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis
    Hox, Valerie, O'Connell, Michael P., Lyons, Jonathan J., Sackstein, Paul, Dimaggio, Thomas, Jones, Nina, Nelson, Celeste, Boehm, Manfred, Holland, Steven M., Freeman, Alexandra F. et al. · 2016 · Journal of Allergy and Clinical Immunology
63. Mitochondrial STAT3: Powering up a potent factor
    Daniel J. Garama, Christine L. White, Jesse J. Balic, Daniel J. Gough · 2016 · Cytokine
64. STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis posttranscriptionally, and is essential for lung myofibroblast differentiation
    Papaioannou, Ioannis, Xu, Shiwen, Denton, Christopher P., Abraham, David J., Ponticos, Markella · 2018 · Molecular Biology of the Cell
65. STAT3: The art of multi-tasking of metabolic and immune functions in obesity
    Wei Hu, Jianjun Lv, Mengzhen Han, Zhi Ping Yang, Tian Xiang Li, Shuai Jiang, Yang Yang · 2018 · Progress in Lipid Research
66. Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer
    Lewis, Katherine M., Bharadwaj, Uddalak, Eckols, T. Kris, Kolosov, Mikhail, Kasembeli, Moses M., Fridley, Colleen, Siller, Ricardo, Tweardy, David J. · 2015 · Lung Cancer
67. High glucose and endothelial cell growth: novel effects independent of autocrine TGF-β1 and hyperosmolarity
    McGinn, S., Poronnik, P., King, M., Gallery, E. D. M., Pollock, C. A. · 2003 · American Journal of Physiology-Cell Physiology
68. Role of a Janus kinase 2-dependent signaling pathway in platelet activation
    Wan‐Jung Lu, Kao‐Chang Lin, Shih‐Yi Huang, Philip Aloysius Thomas, Yu-Hua Wu, Hsu-Chu Wu, Kuan‐Hung Lin, Joen‐Rong Sheu · 2014 · Thrombosis Research
69. Stat3 inhibits Beclin 1 expression through recruitment of HDAC3 in nonsmall cell lung cancer cells
    Miao, Li-Jun, Huang, Feng-Xiang, Sun, Zhen-Tao, Zhang, Rui-Xia, Huang, Shi-Fu, Wang, Jing · 2014 · Tumor Biology
70. JNK-Dependent Stat3 Phosphorylation Contributes to Akt Activation in Response to Arsenic Exposure
    Jing Liu, B. Chen, Yi-Ming Lu, Youfei Guan, Fei Chen · 2012 · Toxicological Sciences
71. Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing
    Shi, Sally Yu, Luk, Cynthia T., Brunt, Jara J., Sivasubramaniyam, Tharini, Lu, Shun-Yan, Schroer, Stephanie A., Woo, Minna · 2014 · Diabetologia
72. Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation
    Jiaying Sun, Miaomiao Yu, Yongju Lu, Chitra Thakur, Bailing Chen, Ping Qiu, Hongwen Zhao, Fei Chen · 2014 · Cancer Letters
73. Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity
    TANAKA, Y, ALEKSUNES, L, GOEDKEN, M, CHEN, C, REISMAN, S, MANAUTOU, J, KLAASSEN, C · 2008 · Toxicology and Applied Pharmacology
74. NEAT1 paraspeckle promotes human hepatocellular carcinoma progression by strengthening IL-6/STAT3 signaling
    Shuai Wang, Qian Zhang, Qinlan Wang, Qicong Shen, Xiang Chen, Zhenyang Li, Ye Zhou, Jin Hou, Bowen Xu, Nan Li et al. · 2018 · OncoImmunology
75. Distinct effects of systemic infusion of G-CSF vs. IL-6 on lung and liver inflammation and injury in hemorrhagic shock
    Meng, Zhi Hong, Dyer, Kevin, Billiar, Timothy R., Tweardy, David J. · 2000 · Shock
76. Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity
    Mertens, Claudia, Haripal, Bhagwattie, Klinge, Sebastian, Darnell, James E. · 2015 · Proceedings of the National Academy of Sciences
77. Control of Myeloid-specific Integrin αMβ2 (CD11b/CD18) Expression by Cytokines Is Regulated by Stat3-dependent Activation of PU.1
    Panopoulos, Athanasia D., Bartos, David, Zhang, Ling, Watowich, Stephanie S. · 2002 · Journal of Biological Chemistry
78. A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis
    Samudio, Ismael, Konopleva, Marina, Pelicano, Helene, Huang, Peng, Frolova, Olga, Bornmann, William, Ying, Yunming, Evans, Randall, Contractor, Rooha, Andreeff, Michael · 2006 · Molecular Pharmacology
79. A first-in-human phase I study of OPB-111077, a small-molecule STAT3 and oxidative phosphorylation inhibitor, in patients with advanced cancers
    Tolcher, Anthony, Flaherty, Keith, Shapiro, Geoffrey I., Berlin, Jordan, Witzig, Thomas, Habermann, Thomas, Bullock, Andrea, Rock, Edwin, Elekes, Agnes, Lin, Chester et al. · 2018 · The Oncologist
80. Angiotensinogen Gene Expression Is Dependent on Signal Transducer and Activator of Transcription 3-Mediated p300/cAMP Response Element Binding Protein-Binding Protein Coactivator Recruitment and Histone Acetyltransferase Activity
    Sutapa Ray, Christopher T. Sherman, Muping Lu · 2002 · Molecular Endocrinology
81. Stat Acetylation--A Key Facet of Cytokine Signaling?
    John J. O’Shea, Yuka Kanno, Xiaomin Chen · 2005 · Science
82. Protein kinase Cε interacts with Stat3 and regulates its activation that is essential for the development of skin cancer
    Moammir Hasan Aziz, Herbert T. Manoharan, Jordan M. Sand, Ajit Kumar Verma · 2007 · Molecular Carcinogenesis
83. STAT3-mediated activation of microRNA cluster 17 92 promotes proliferation and survival of ALK-positive anaplastic large cell lymphoma
    Elisa Spaccarotella, Elisa Pellegrino, Manuela Ferracin et al. · 2013 · Haematologica
84. A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3
    Daniel J. Garama, Tiffany J. Harris, Christine L. White, Fernando Jaime Rossello, Maher Abdul‐Hay, Daniel J. Gough, David E. Levy · 2015 · Molecular and Cellular Biology
85. Evidence of a Role for SHP-1 in Platelet Activation by the Collagen Receptor Glycoprotein VI
    Jean‐Max Pasquet, Lynn Swun Quek, Sophie Pasquet · 2000 · Journal of Biological Chemistry
86. Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease
    Silvia C. Sookoian, Gustavo Osvaldo Castaño, Tomas Fernández Gianotti, Carolina Gemma, María Soledad Rosselli, Carlos Jose Pirola · 2008 · Cytokine
87. Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10
    Hongwei Wang, Fengdong Cheng, Karrune V. Woan, Eva Sahakian, Oscar Merino, Jennifer A. Rock-Klotz, Ildefonso Vicente-Suarez, Javier A. Pinilla-Ibarz, Kenneth L. Wright, Edward Seto et al. · 2011 · The Journal of Immunology
88. The use of structural biology in Janus kinase targeted drug discovery
    L. Alicea-Velazquez, Nilda, J. Boggon, Titus · 2011 · Current Drug Targets
89. Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif
    Shao, Huang, Xu, Xuejun, Mastrangelo, Mary-Ann A., Jing, Naijie, Cook, Richard G., Legge, Glen B., Tweardy, David J. · 2004 · Journal of Biological Chemistry
90. Phosphorylation of JAK2 in thrombin-stimulated human platelets
    Rodríguez-Liñares, Belén, Watson, Steve P. · 1994 · FEBS Letters
91. Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis
    Babaei, Rohollah, Schuster, Maximilian, Meln, Irina, Lerch, Sarah, Ghandour, Rayane A., Pisani, Didier F., Bayindir-Buchhalter, Irem, Marx, Julia, Wu, Shuang, Schoiswohl, Gabriele et al. · 2018 · Science Signaling
92. Interleukin-10 Inhibits Lipopolysaccharide-induced Tumor Necrosis Factor-α Translation through a SHIP1-dependent Pathway
    Chan, Catherine S., Ming-Lum, Andrew, Golds, Gary B., Lee, Shaina J., Anderson, Raymond J., Mui, Alice L.-F. · 2012 · Journal of Biological Chemistry
93. Syk and Fyn Are Required by Mouse Megakaryocytes for the Rise in Intracellular Calcium Induced by a Collagen-related Peptide
    Steven K. Melford, Martin Turner, Stephen J. Briddon · 1997 · Journal of Biological Chemistry
94. Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry
    Heidelberger, Sibylle, Zinzalla, Giovanna, Antonow, Dyeison, Essex, Samantha, Piku Basu, B., Palmer, Jonathan, Husby, Jarmila, Jackson, Paul J.M., Rahman, Khondaker M., Wilderspin, Andrew F. et al. · 2013 · Bioorganic & Medicinal Chemistry Letters
95. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation
    Tibbles, Heather E., Vassilev, Alexei, Wendorf, Heather, Schonhoff, Dawn, Zhu, Dan, Lorenz, David, Waurzyniak, Barbara, Liu, Xing-Ping, Uckun, Fatih M. · 2001 · Journal of Biological Chemistry
96. A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function
    Mercedes Rincón, Felipe Pereira · 2018 · International Journal of Molecular Sciences
97. Targeting Stat3 Induces Senescence in Tumor Cells and Elicits Prophylactic and Therapeutic Immune Responses against Breast Cancer Growth Mediated by NK Cells and CD4+ T Cells
    Mercedes Tkach, Lorena M. Coria, Cinthia Rosemblit, Martín A. Rivas, Cecilia Jazmín Proietti, María C. Díaz Flaqué, Wendy Béguelin, Isabel Frahm, Eduardo H. Charreau, Juliana Cassataro et al. · 2012 · The Journal of Immunology
98. Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent
    Ball, Daniel P., Lewis, Andrew M., Williams, Declan, Resetca, Diana, Wilson, Derek J., Gunning, Patrick T. · 2016 · Oncotarget
99. Dimethylfumarate Suppresses Adipogenic Differentiation in 3T3-L1 Preadipocytes through Inhibition of STAT3 Activity
    Kang, Hyeon-Ji, Seo, Hyun-Ae, Go, Younghoon, Oh, Chang Joo, Jeoung, Nam Ho, Park, Keun-Gyu, Lee, In-Kyu · 2013 · PLoS ONE
100. Doubles game: Src-Stat3 versus p53-PTEN in cellular migration and invasion
     Mukhopadhyay, Utpal K., Mooney, Patrick, Jia, Lilly, Eves, Robert, Raptis, Leda, Mak, Alan S. · 2010 · Molecular and Cellular Biology
101. STAT3 Protein Up-regulates Gα-interacting Vesicle-associated Protein (GIV)/Girdin Expression, and GIV Enhances STAT3 Activation in a Positive Feedback Loop during Wound Healing and Tumor Invasion/Metastasis
     Ying Dunkel, Andrew Ong, Dimple Notani, Yash Mittal, Michael T. Y. Lam, Xiaoyi Mi, Pradipta Ghosh · 2012 · Journal of Biological Chemistry
102. Stat3 Cleavage by Caspases
     James W. Darnowski, Frederick A. Goulette, Yingjie A. Guan, Devasis Chatterjee, Zhongfa Yang, Leslie P. Cousens, Yue Eugene Chin · 2006 · Journal of Biological Chemistry
103. Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization
     Resetca, Diana, Haftchenary, Sina, Gunning, Patrick T., Wilson, Derek J. · 2014 · Journal of Biological Chemistry
104. Are Janus kinase inhibitors superior over classic biologic agents in RA patients?
     Kotyla, Przemyslaw J. · 2018 · BioMed Research International
105. LIF and the heart: Just Another Brick in the Wall?
     Fouad Anthony Zouein, Mazen Kurdi, George W. Booz · 2013 · European Cytokine Network
106. Activation of the GP130-STAT3 axis and its potential implications in nonalcoholic fatty liver disease
     Min, Hae-Ki, Mirshahi, Faridoddin, Verdianelli, Aurora, Pacana, Tommy, Patel, Vaishali, Park, Chun-Geon, Choi, Aejin, Lee, Jeong-Hoon, Park, Chung-Berm, Ren, Shunlin et al. · 2015 · American Journal of Physiology-Gastrointestinal and Liver Physiology
107. Signal integration and gene induction by a functionally distinct STAT3 phosphoform
     Waitkus, Matthew S., Chandrasekharan, Unni M., Willard, Belinda, Tee, Thomas L., Hsieh, Jason K., Przybycin, Christopher G., Rini, Brian I., DiCorleto, Paul E. · 2014 · Molecular and Cellular Biology
108. Regulation of ATGL expression mediated by leptin in vitro in porcine adipocyte lipolysis
     Yucheng Li, Xueli Zheng, Bingting Liu, Gong-she Yang · 2009 · Molecular and Cellular Biochemistry
109. JNK1/2 expression and modulation of STAT3 signaling in oral cancer
     Ioannis Gkouveris, Nikolaos G. Nikitakis, Maria Karanikou, George Z. Rassidakis, Alexandra Sklavounou · 2016 · Oncology Letters
110. Cardiac-specific ablation of theSTAT3gene in the subacute phase of myocardial infarction exacerbated cardiac remodeling
     Daichi Enomoto, Masanori Obana, Akimitsu Miyawaki · 2015 · American Journal of Physiology-Heart and Circulatory Physiology
111. Identification and characterization of cis elements in the STAT3 gene regulating STAT3α and STAT3β messenger RNA splicing
     Shao, Huang, Quintero, Andres J., Tweardy, David J. · 2001 · Blood
112. Ghrelin Inhibits the Differentiation of T Helper 17 Cells through mTOR/STAT3 Signaling Pathway
     Yanhui Xu, Zi-Ru Li, Yue Yin, H. Lan, Jun Wang, Jing Zhao, Juan Feng, Yin Li, Wei-Zhen Zhang · 2015 · PLoS ONE
113. A STAT-regulated, stress-induced signalling pathway inDictyostelium
     Tsuyoshi Araki, Masatsune Tsujioka, Tomoaki Abe et al. · 2003 · Journal of Cell Science
114. Therapeutic potential of Janus-activated kinase-2 inhibitors for the management of myelofibrosis
     Verstovsek, Srdan · 2010 · Clinical Cancer Research
115. Central insulin-mediated regulation of hepatic glucose production [Review]
     Inoue, Hiroshi · 2016 · Endocrine Journal
116. Activation of the B‐cell receptor successively activates NF‐κB and STAT3 in chronic lymphocytic leukemia cells
     Uri Rozovski, David Harris, Ping Li, Zhiming Liu, Preetesh Jain, Ivo Veletić, Alessandra Ferrajoli, Jan A. Burger, Philip A. Thompson, Nitin Jain et al. · 2017 · International Journal of Cancer
117. Synergy between Signal Transducer and Activator of Transcription 3 and Retinoic Acid Receptor-α in Regulation of the Surfactant Protein B Gene in the Lung
     Yang Li, Xuemei Lian, Angelynn Cowen · 2004 · Molecular Endocrinology
118. STAT3: a potential therapeutic target in dendritic cells for the induction of transplant tolerance
     Beverly E. Barton · 2006 · Expert Opinion on Therapeutic Targets
119. G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils
     Hoainam T. Nguyen-Jackson, Haiyan S. Li, Huiyuan Zhang, Erika Ohashi, Stephanie S. Watowich · 2012 · Journal of Leukocyte Biology
120. A Nitric Oxide Scavenger Protects Against Pulmonary Inflammation Following Hemorrhagic Shock
     Christian Hierholzer, John M. Menezes, Andreas Ungeheuer, Timothy R. Billiar, David John Tweardy, Brian G. Harbrecht · 2002 · Shock
121. Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer
     L Chen, Lin Na Fu, X Kong, Jing Xu, Z Wang, Xiong Ma, Yoshimitsu Akiyama, Yongjun Chen, Jing‐Yuan Fang · 2014 · British Journal of Cancer
122. IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin
     Nakata, M, Yamamoto, S, Okada, T, Gantulga, D, Okano, H, Ozawa, K, Yada, T · 2016 · International Journal of Obesity
123. At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells
     Uri Rozovski, David Harris, Ping Li, Zhiming Liu, Ji Yuan Wu, Srđana Grgurević, Stefan H Faderl, Alessandra Ferrajoli, William G. Wierda, Matthew Martinez et al. · 2016 · The Journal of Immunology
124. Thrombopoietin, the c-<i>mpl</i> ligand, is a major regulator of platelet production
     Broudy, Virginia C, Kaushansky, Kenneth · 1995 · Journal of Leukocyte Biology
125. Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation inJAK2V617Fmutated cells through PP2A/CIP2A axis
     Niccolò Bartalucci, Laura Calabresi, Manjola Balliu, Serena Martinelli, Maria Caterina Rossi, Jean‐Luc Villeval, Francesco Annunziato, Paola Guglielmelli, Alessandro Maria Vannucchi · 2017 · Oncotarget
126. Innate lymphoid cell type 3–derived interleukin-22 boosts lipocalin-2 production in intestinal epithelial cells via synergy between STAT3 and NF-κB
     Maarten Coorens, Anna Rao, Stefanie K. Gräfe, Daniel Unelius, Ulrik Lindforss, Birgitta Agerberth, Jenny Mjösberg, Peter Bergman · 2019 · Journal of Biological Chemistry
127. Ultraviolet light induces Stat3 activation in human keratinocytes and fibroblasts through reactive oxygen species and DNA damage
     Toshinori Bito, Naoko Sumita, Taro Masaki, Toshiro Shirakawa, Masato Ueda, Ryutaro Yoshiki, YOSHIKI TOKURA, Chikako Nishigori · 2010 · Experimental Dermatology
128. Systemic Administration of a Cyclic Signal Transducer and Activator of Transcription 3 (STAT3) Decoy Oligonucleotide Inhibits Tumor Growth without Inducing Toxicological Effects
     Malabika Sen, Kathleen C. Paul, Maria L. Freilino, Hua Li, Changyou Li, Daniel E. Johnson, Lin Wang, Julie L. Eiseman, Jennifer Rubin Grandis · 2013 · Molecular Medicine
129. Rhodium(II) proximity-labeling identifies a novel target site on STAT3 for inhibitors with potent anti-leukemia activity
     Minus, Matthew B., Liu, Wei, Vohidov, Farrukh, Kasembeli, Moses M., Long, Xin, Krueger, Michael J., Stevens, Alexandra, Kolosov, Mikhail I., Tweardy, David J., Sison, Edward Allan R. et al. · 2015 · Angewandte Chemie International Edition
130. Alantolactone Improves Prolonged Exposure of Interleukin-6-Induced Skeletal Muscle Inflammation Associated Glucose Intolerance and Insulin Resistance
     Minjee Kim, Kwangho Song, Yeong Shik Kim · 2017 · Frontiers in Pharmacology
131. Cucurbitacin‐B attenuates CC l4‐induced hepatic fibrosis in mice through inhibition of STAT ‐3
     Al-Aliaa M. Sallam, Ahmed Esmat, Ashraf B. Abdel‐Naim · 2017 · Chemical Biology & Drug Design
132. STAT3 and NF-κB are Simultaneously Suppressed in Dendritic Cells in Lung Cancer
     Rui Li, Fang Fang, Ming Jiang, Chenguang Wang, Jiajia Ma, Wenyao Kang, Qiuyan Zhang, Yuhui Miao, Dong Wang, Yugang Guo et al. · 2017 · Scientific Reports
133. Inhibitory effects of decoy-ODN targeting activated STAT3 on human glioma growth in vivo.
     Jie Shen, Ronghui Li, Gang Li · 2009 · PubMed
134. Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome
     Bocchini, Claire E., Nahmod, Karen, Katsonis, Panagiotis, Kim, Sang, Kasembeli, Moses M., Freeman, Alexandra, Lichtarge, Olivier, Makedonas, George, Tweardy, David J. · 2016 · Blood
135. Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation
     Shailaja Hegde, S Ni, Shihan He, Donghoon Yoon, Gen‐Sheng Feng, Stephanie S. Watowich, Robert F. Paulson, Pamela A. Hankey · 2009 · Oncogene
136. Dancing rhinos in stilettos
     Fouad Anthony Zouein, Mazen Kurdi, George W. Booz · 2013 · JAK-STAT
137. Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive
     Zgheib, Carlos, Kurdi, Mazen, Zouein, Fouad A., Gunter, Barak W., Stanley, Brian A., Zgheib, Joe, Romero, Damian G., King, S. Bruce, Paolocci, Nazareno, Booz, George W. · 2012 · PLoS ONE
138. STAT3 activation inhibits human bronchial epithelial cell apoptosis in response to cigarette smoke exposure
     Liu, Xiangde · 2007 · Biochemical and Biophysical Research Communications
139. Phosphoinositide 3‐kinase and integrin signalling are involved in activation of Bruton tyrosine kinase in thrombin‐stimulated platelets
     Muriel Laffargue, Jeannie M.F. Ragab-Thomas, Ashraf Ragab et al. · 1999 · FEBS Letters
140. <scp>STAT3</scp> Serine 727 Phosphorylation: A Relevant Target to Radiosensitize Human Glioblastoma
     Ouédraogo, Zangbéwendé Guy, Müller‐Barthélémy, Mélanie, Kemeny, Jean‐Louis, Dedieu, Véronique, Biau, Julian, Khalil, Toufic, Raoelfils, Lala Ines, Granzotto, Adeline, Pereira, Bruno, Beaudoin, Claude et al. · 2016 · Brain Pathology
141. Cyclin-dependent kinase 5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727
     Lam, Eric, Choi, Sung Hee, Pareek, Tej K., Kim, Byung-Gyu, Letterio, John J. · 2015 · Molecular Immunology
142. Allosteric communication across STAT3 domains associated with STAT3 function and disease-causing mutation
     Namanja, Andrew T., Wang, Jianghai, Buettner, Ralf, Colson, Loren, Chen, Yuan · 2016 · Journal of Molecular Biology
143. Low-dose radiation decreases tumor progression via the inhibition of the JAK1/STAT3 signaling axis in breast cancer cell lines
     Neha Kaushik, Min-Jung Kim, Rae-Kwon Kim, Nagendra Kumar Kaushik, Ki Moon Seong, Seon-Young Nam, Su‐Jae Lee · 2017 · Scientific Reports
144. Role of Stat3 Signaling in Control of EMT of Tubular Epithelial Cells During Renal Fibrosis
     Jingsong Liu, Ying Zhong, Guoyong Liu · 2017 · Cellular Physiology and Biochemistry
145. Opposing Actions of Extracellular Signal-regulated Kinase (ERK) and Signal Transducer and Activator of Transcription 3 (STAT3) in Regulating Microtubule Stabilization during Cardiac Hypertrophy
     Dominic C.H. Ng, Ivan H. W. Ng, Yvonne Y.C. Yeap · 2010 · Journal of Biological Chemistry
146. A novel STAT3 inhibitor negatively modulates platelet activation and aggregation
     Zhuan Xu, Yujia Xu, Yanan Hao, Lijie Ren, Zu-bin Zhang, Xin Xu, Biyin Cao, Kesheng Dai, Li Zhu, Qi Fang et al. · 2017 · Acta Pharmacologica Sinica
147. Inhibitory effects of STAT3 decoy oligodeoxynucleotides on human epithelial ovarian cancer cell growth in vivo
     Xiaolei Zhang, Peishu Liu, Bo Zhang, Hongluan Mao, Liang Shen, Yanhui Ma · 2013 · International Journal of Molecular Medicine
148. Radiation Induces Phosphorylation of STAT3 in a Dose- and Time-dependent Manner
     Ling Gao, Fengsheng Li, Xiaohua Chen · 2014 · Asian Pacific Journal of Cancer Prevention
149. Identification of Sites of STAT3 Action in the Female Reproductive Tract through Conditional Gene Deletion
     Rebecca L. Robker, Laura N. Watson, Sarah Anne Robertson, Kylie R. Dunning, Eileen A. McLaughlin, Darryl Lyndon Russell · 2014 · PLoS ONE
150. Signal transducer and activator of transcription 3 and the phosphatidylinositol 3‐kinase regulatory subunits p55α and p50α regulate autophagy <i>in vivo</i>
     Pensa, Sara, Lloyd‐Lewis, Bethan, Sargeant, Timothy J., Resemann, Henrike K., Kahn, C. Ronald, Watson, Christine J. · 2014 · The FEBS Journal
151. Differential Substrate Recognition Capabilities of Janus Family Protein Tyrosine Kinases Within the Interleukin 2 Receptor (I12R) System: Jak3 as a Potential Molecular Target for Treatment of Leukemias with a Hyperactive Jak-Stat Signaling Machinery
     Witthuhn, Bruce A., Williams, Mark D., Kerawalla, Hoshnuwar, Uckun, Fatih M. · 1999 · Leukemia &amp; Lymphoma
152. Constitutive Phosphorylation of STAT3 by the CK2–BLNK–CD5 Complex
     Uri Rozovski, David Harris, Ping Li, Zhiming Liu, Preetesh Jain, Ivo Veletić, Alessandra Ferrajoli, Jan A. Burger, Susan Mary O'Brien, Prithviraj Bose et al. · 2017 · Molecular Cancer Research
153. Deficient IL‐6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis
     P. Stärkel, B. Schnabl, S. Leclercq, M. Komuta, R. Bataller, J. Argemí, E. Palma, S. Chokshi, C. Hellerbrand, L. Maccioni et al. · 2019 · Hepatology Communications
154. Remission of food allergy by the Janus kinase inhibitor ruxolitinib in mice
     Yamaki, Kouya, Yoshino, Shin · 2014 · International Immunopharmacology
155. Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling
     Anantha S. Metlakunta, Maitrayee Sahu, Hideo Yasukawa, Sandeep S. Dhillon, Denise D. Belsham, Akihiko Yoshimura, Abhiram Sahu · 2011 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
156. Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response
     Dunwei Guo, Chaoyi Wang, Qiang Wang, Zhongpeng Qiao, Hua Tang · 2017 · Oncotarget
157. Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model
     Laura Belloni, Silvia Di Cocco, Francesca Guerrieri et al. · 2018 · Scientific Reports
158. Impact of siltuximab on patient-related outcomes in multicentric Castleman’s disease
     Jenna L. Sitenga, Gregory A. Aird, Aabra Ahmed, Peter T. Silberstein · 2018 · Patient Related Outcome Measures
159. IL-9 promotes the development of deep venous thrombosis by facilitating platelet function
     Feng, Yuqian, Yu, Miao, Zhu, Feng, Zhang, Shaoshao, Ding, Peiwu, Wang, Min · 2018 · Thrombosis and Haemostasis
160. STAT3 Oligonucleotide Inhibits Tumor Angiogenesis in Preclinical Models of Squamous Cell Carcinoma
     Jonah D. Klein, Daisuke Sano, Malabika Sen, Jeffrey N. Myers, Jennifer Rubin Grandis, Seungwon Kim · 2014 · PLoS ONE
161. Signal transducer and activator of transcription 2 (STAT2) metabolism coupling postmitotic outgrowth to visual and sound perception network in human left cerebrum by biocomputation
     Wang, Lin, Huang, Juxiang, Jiang, Minghu, Lin, Hong · 2012 · Journal of Molecular Neuroscience
162. STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5′ and 3′ ends
     Lewis, H. Dan, Winter, Ashley, Murphy, Thomas F., Tripathi, Snehlata, Pandey, Virendra N., Barton, Beverly E. · 2008 · Molecular Cancer Therapeutics
163. Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling
     Na Xu, Alexander V Emelyanov, Dmitry V. Fyodorov · 2014 · Epigenetics & Chromatin
164. Adipose triglyceride lipase protein abundance and translocation to the lipid droplet increase during leptin-induced lipolysis in bovine adipocytes
     Dawn A. Koltes, Michael E. Spurlock, Diane Moody Spurlock · 2017 · Domestic Animal Endocrinology
165. Bilateral activation of STAT3 by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and its nuclear translocation in primary sensory neurons following unilateral sciatic nerve injury
     Petr Dubový, Ivana Hradilová‐Svíženská, Ilona Klusáková, Viktória Kokošová, Václav Brázda, Marek Joukal · 2018 · Histochemistry and Cell Biology
166. SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction
     Kan Chen, Fan Yang, Siying Wang · 2018 · Stem Cells International
167. STAT3β controls inflammatory responses and early tumor onset in skin and colon experimental cancer models.
     2014 · Europe PMC (PubMed Central)
168. Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes
     Mazen Kurdi, Vidhya Sivakumaran, Roy J. Duhé, Miguel Antonio Aon, Nazareno Paolocci, George W. Booz · 2012 · The International Journal of Biochemistry & Cell Biology
169. STAT3 Inhibitors in Cancer: A Comprehensive Update
     Uddalak Bharadwaj, Moses M. Kasembeli, David John Tweardy · 2016 · Cancer drug discovery and develogment/Cancer drug discovery and development
170. Ghrelin induces leptin resistance by activation of suppressor of cytokine signaling 3 expression in male rats: implications in satiety regulation
     Heldsinger, Andrea, Grabauskas, Gintautas, Wu, Xiaoyin, Zhou, ShiYi, Lu, Yuanxu, Song, Il, Owyang, Chung · 2014 · Endocrinology
171. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3
     Moran, Ana, Tsimelzon, Anna I., Mastrangelo, Mary‐Ann A., Wu, Yong, Yu, Bi, Hilsenbeck, Susan G., Poli, Valeria, Tweardy, David J. · 2009 · Clinical and Translational Science
172. Serine-727 Phosphorylation Activates Hypothalamic STAT-3 Independently From Tyrosine-705 Phosphorylation
     Andreas Breit, Valeria Besik, Hans Jürgen Solinski, Susanne Muehlich, Evi Glas, Stephen J. Yarwood, Thomas W. Gudermann · 2015 · Molecular Endocrinology
173. Quantitative analysis of cellular senescence phenotypes using an imaging cytometer
     Udono, Miyako, Kadooka, Keishi, Yamashita, Shuntaro, Katakura, Yoshinori · 2012 · Methods
174. Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits
     S-S Dong, Y Guo, D-L Zhu, X-F Chen, X-M Wu, Hui Shen, X-D Chen, L-J Tan, Q Tian, H-W Deng et al. · 2016 · International Journal of Obesity
175. Therapeutic effects of zerumbone in an alkali-burned corneal wound healing model
     Jong Won Kim, Hyuneui Jeong, Myeon‐Sik Yang, Chae Woong Lim, Bumseok Kim · 2017 · International Immunopharmacology
176. Deciphering STAT3 Signaling in the Heart: Plasticity and Vascular Inflammation
     Mazen Kurdi, George W. Booz · 2010 · Congestive Heart Failure
177. IL-6, IL-10, c-Jun and STAT3 expression in B-CLL
     Halina Antosz, Katarzyna Wojciechowska, Joanna Sajewicz, Dorota Choroszyńska, Barbara Marzec‐Kotarska, Magdalena Osiak, Natalia Pająk, Waldemar Tomczak, Małgorzata Jargiełło-Baszak, Jacek Baszak · 2014 · Blood Cells Molecules and Diseases
178. The STAT3-DNMT1 connection
     N. Shaun B. Thomas · 2012 · JAK-STAT
179. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha.
     2008 · PubMed Central
180. Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock
     Thacker, Stephen A., Robinson, Prema, Abel, Adam, Tweardy, David J. · 2013 · Scientific Reports
181. Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response
     Soumyadeep Dey, Xiaoxia Li, Ruifeng Teng, Mawadda Alnaeeli, Zhiyong Chen, Heather Marie Rogers, Constance Tom Noguchi · 2015 · Journal of Molecular Endocrinology
182. A phase I extension study of BBI608, a first-in-class cancer stem cell (CSC) inhibitor, in patients with advanced solid tumors
     Jonker, Derek J., Stephenson, Joe, Edenfield, William Jeffery, Supko, Jeffrey G., Li, Youzhi, Li, Wei, Hitron, Matthew, Leggett, David, Kerstein, David, Li, Chiang · 2014 · Journal of Clinical Oncology
183. Dual role of IL-21 in megakaryopoiesis and platelet homeostasis
     Benbarche, Salima, Strassel, Catherine, Angénieux, Catherine, Mallo, Léa, Freund, Monique, Gachet, Christian, Lanza, François, de la Salle, Henri · 2017 · Haematologica
184. Activation of STAT proteins in the lung of rats following resuscitation from hemorrhagic shock
     Christian Hierholzer, Jörg C. Kalff, Timothy R. Billiar · 1998 · Archives of Orthopaedic and Trauma Surgery
185. Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†
     Heng-Jie Yuan, Katie L. L. Houck, Ye Tian, U. Bharadwaj, K. Hull, Zhou Zhou, Ming-Zhao Zhu, Xiao-Ping Wu, D. Tweardy, D. Romo et al. · 2015 · PLoS ONE
186. Interleukin-6 regulation of direct lung ischemia reperfusion injury
     Farivar, Alexander S., Merry, Heather E., Fica-Delgado, Mauricio J., McCourtie, Anton S., Mackinnon-Patterson, Brendan C., Mulligan, Michael S. · 2006 · The Annals of Thoracic Surgery
187. Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients
     R. Candida Mintz, Ben Zion Garty, Tsipi Meshel, Nufar Marcus, Christina Katanov, Efrat Cohen-Hillel, Adit Ben‐Baruch · 2009 · Immunology Letters
188. Blockage of STAT3 Signaling Pathway with a Decoy Oligodeoxynucleotide Inhibits Growth of Human Ovarian Cancer Cells
     Ming Liu, Fei Wang, Zeqing Wen, Min Shi, Hui Zhang · 2013 · Cancer Investigation
189. Dynamic mitochondrial localisation of STAT3 in the cellular adipogenesis model 3T3-L1
     Kramer, Adam H., Edkins, Adrienne L., Hoppe, Heinrich C., Prinsloo, Earl · 2015 · Journal of Cellular Biochemistry
190. Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock*
     Ayse Akcan‐Arikan, Bi Yu, Mary-Ann A. Mastrangelo · 2006 · Critical Care Medicine
191. A phase 1 dose-escalation study of BBI503, a first-in-class cancer stemness kinase inhibitor in adult patients with advanced solid tumors
     Laurie, Scott Andrew, Jonker, Derek J., Edenfield, William Jeffery, Stephenson, Joe, Keller, Deborah, Hitron, Matthew, Li, Wei, Li, Youzhi, Gada, Keyur, Gao, Yuan et al. · 2014 · Journal of Clinical Oncology
192. Valor de la proteína STAT3 como factor pronóstico en el carcinoma renal de célula clara. Revisión sistemática
     D. Lorente, Enrique Trilla, Anna Meseguer et al. · 2018 · Actas Urológicas Españolas
193. Ruxolitinib rechallenge in combination with hydroxyurea is effective in reverting cachexia and reducing blood transfusion demand and splenomegaly symptoms in a patient with primary myelofibrosis
     Cerchione, Claudio, Peluso, Ilaria, Nappi, Davide, Pareto, Anna Emanuele, Picardi, Marco, Martinelli, Vincenzo, Pane, Fabrizio · 2017 · Annals of Hematology
194. Investigational Janus kinase inhibitors in development for myelofibrosis
     Bose, Prithviraj, Abou Zahr, Abdallah, Verstovsek, Srdan · 2017 · Expert Opinion on Investigational Drugs
195. Restoration of lung surfactant protein D by IL-6 protects against secondary pneumonia following hemorrhagic shock
     Stephen A. Thacker, Ana Moran, Mihalis Lionakis, Mary-Ann A. Mastrangelo, Tripti Halder, Maria del Pilar Huby, Yong Wu, David John Tweardy · 2013 · Journal of Infection
196. Evaluation of toxicity and Stat3 activation induced by hydrogen peroxide exposure to the skin in healthy individuals
     Toshinori Bito, Kunio Izu, YOSHIKI TOKURA · 2010 · Journal of Dermatological Science
197. STAT Inhibitors in Cancer
     Alister C. Ward · 2016 · Cancer drug discovery and develogment/Cancer drug discovery and development
198. Stat3 and CCAAT enhancer-binding protein β (C/ebpβ) activate Fanconi C gene transcription during emergency granulopoiesis
     Shah, Chirag A., Broglie, Larisa, Hu, Liping, Bei, Ling, Huang, Weiqi, Dressler, Danielle B., Eklund, Elizabeth A. · 2018 · Journal of Biological Chemistry
199. PPARα-independent action against metabolic syndrome development by fibrates is mediated by inhibition of STAT3 signalling
     Huiying Hua, Julin Yang, Hante Lin, Yang Xi, Manyun Dai, Gang-Ming Xu, Fuyan Wang, Lihong Liu, Tingqi Zhao, Jing Huang et al. · 2018 · Journal of Pharmacy and Pharmacology
200. The role of STAT3 protein as a prognostic factor in the clear cell renal carcinoma. Systematic review
     D. Lorente, Enrique Trilla, Anna Meseguer et al. · 2019 · Actas Urológicas Españolas (English Edition)