Hemispheric asymmetry in human lateral prefrontal cortex during cognitive set shifting
Open accessAbstract
Functional organization of human cerebral hemispheres is asymmetrically specialized, most typically along a verbal/nonverbal axis. In this event-related functional MRI study, we report another example of the asymmetrical specialization. Set-shifting paradigms derived from the Wisconsin card sorting test were used, where subjects update one behavior to another on the basis of environmental feedback. The cognitive requirements constituting the paradigms were decomposed into two components according to temporal stages of task events. Double dissociation of the component brain activity was found in the three bilateral pairs of regions in the lateral frontal cortex, the right regions being activated during exposure to negative feedback and the corresponding left regions being activated during updating of behavior, to suggest that both hemispheres contribute to cognitive set shifting but in different ways. The asymmetrical hemispheric specialization within the same paradigms further implies an interhemispheric interaction of these task components that achieve a common goal.
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Regions in the right hemisphere are active when subjects receive negative feedback indicating that their hypothesis is no longer correct.
“Regions in the right hemisphere are also active when subjects receive negative feedback indicating that their hypothesis is no longer correct”
From Divergent hemispheric reasoning strategies: reducing uncertainty versus resolving inconsistency (2014) · cites this paper as Konishi et al., 2002
The brain regions commonly activated by WCST, ID/ED, and TMT involve fronto-parietal and fronto-striatal areas.
“As shown in Table 1 (in the main text), regions commonly activated during these tasks are related to fronto-parietal and fronto-striatal brain regions [59–65].”
From The paradox of cognitive flexibility in autism (2009) · cites this paper as [59]
The left inferior frontal gyrus may mediate cognitive shift.
“mediate the cognitive shift,42,43”
From Cognitive inflexibility and frontal–cortical activation in pediatric obsessive–compulsive disorder (2010) · cites this paper as [43]
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- Authors
- Konishi, S., Hayashi, T., Uchida, I., Kikyo, H., Takahashi, E., & Miyashita, Y.
- Affiliations
- National Institute for Physiological Sciences (JP)
- Corresponding author
- Konishi, Seiki
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-05-21
- Volume
- 99
- Issue
- 11
- Pages
- 7803-7808
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC124358
- OpenAlex
- W2014245638
- Cited by
- 161
- References
- 61
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 10 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 5 · 2012: 6
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- hemispheric lateralization, lateral prefrontal cortex, Wisconsin Card Sorting Test, interhemispheric interaction, negative feedback, event-related brain activity
- MeSH terms
- Adult, Analysis of Variance, Cognition, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Organ Specificity, Set, Psychology, Prefrontal Cortex
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