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A Stem Cell Molecular Signature

Ivanova, Natalia B., Dimos, John T., Schaniel, Christoph, Hackney, Jason A., Moore, Kateri A., Lemischka, Ihor R.·2002·Science

DOI 10.1126/science.1073823

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Abstract

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.

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Authors: Ivanova, N. B., Dimos, J. T., Schaniel, C., Hackney, J. A., Moore, K. A., & Lemischka, I. R.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2002-10-18
Volume: 298
Issue: 5593
Pages: 601-604
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1073823
OpenAlex: W2119739306
Cited by: 1,542
References: 1
FWCI: 55.34
Type: journal article
Language: en
Open access: closed

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A Stem Cell Molecular Signature

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