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Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8
Abstract
Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially involving necrosis and autophagy may exist, but their relation to apoptosis and mechanisms of regulation remains unclear. We define a new molecular pathway in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy. Autophagic death required the genes ATG7 and beclin 1 and was induced by caspase-8 inhibition. Clinical therapies involving caspase inhibitors may arrest apoptosis but also have the unanticipated effect of promoting autophagic cell death.
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Metadata
- Authors
- Yu, L., Alva, A., Su, H., Dutt, P., Freundt, E., Welsh, S., Baehrecke, E. H., & Lenardo, M. J.
- Venue
- Science
- Published
- 2004-06-04
- Volume
- 304
- Issue
- 5676
- Pages
- 1500-1502
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2149388384
- Cited by
- 1,220
- References
- 5
- FWCI
- 54.70
- Type
- journal article
- Language
- en
- Open access
- closed
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