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Cited by 1,699

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids

Scheinman, Robert I., Cogswell, Patricia C., Lofquist, Alan K., Baldwin, Albert S.·1995·Science
DOI 10.1126/science.270.5234.283
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Abstract

Glucocorticoids are potent immunosuppressive drugs, but their mechanism is poorly understood. Nuclear factor kappa B (NF-κB), a regulator of immune system and inflammation genes, may be a target for glucocorticoid-mediated immunosuppression. The activation of NF-κB involves the targeted degradation of its cytoplasmic inhibitor, IκBα, and the translocation of NF-κB to the nucleus. Here it is shown that the synthetic glucocorticoid dexamethasone induces the transcription of the IκBα gene, which results in an increased rate of IκBα protein synthesis. Stimulation by tumor necrosis factor causes the release of NF-κB from IκBα. However, in the presence of dexamethasone this newly released NF-κB quickly reassociates with newly synthesized IκBα, thus markedly reducing the amount of NF-κB that translocates to the nucleus. This decrease in nuclear NF-κB is predicted to markedly decrease cytokine secretion and thus effectively block the activation of the immune system.

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Metadata

Authors
Scheinman, R. I., Cogswell, P. C., Lofquist, A. K., & Baldwin, A. S.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1995-10-13
Volume
270
Issue
5234
Pages
283-286
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.270.5234.283
OpenAlex
W1717444875
Cited by
1,699
References
3
FWCI
56.78
Type
journal article
Language
en
Open access
closed

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