Cited by 391Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Extensive migration of young neurons into the infant human frontal lobe

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Paredes, Mercedes F., James, David, Gil-Perotin, Sara, Kim, Hosung, Cotter, Jennifer A., Ng, Carissa, Sandoval, Kadellyn, Rowitch, David H. +5 more·2016·Science

Abstract

Building the human brain: As the brain develops, neurons migrate from zones of proliferation to their final locations, where they begin to build circuits. Paredes et al. have discovered that shortly after birth, a group of neurons that proliferates near the ventricles migrates in chains alongside circulatory vessels into the frontal lobes (see the Perspective by McKenzie and Fishell). Young neurons that migrate postnatally into the anterior cingulate cortex then develop features of inhibitory interneurons. The number of migratory cells decreases over the first 7 months of life, and by 2 years of age, migratory cells are not evident. Any damage during migration, such as hypoxia, may affect the child's subsequent physical and behavioral development. Science , this issue p. 81 ; see also p. 38

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  • Pyramidal excitatory neurons born in the ventricular and subventricular zones of prefrontal subdomains migrate radially toward the cortical plate under the influence of Fgfs.

    “The pyramidal excitatory neurons born in the VZ and SVZ of the prefrontal subdomains, similar to other cortical areas, start to migrate radially toward the proper position in the CP under the influence of Fgfs [50, 59, 60].”

    From Development of prefrontal cortex (2022) · cites this paper as [60]

    The Abstract and Discussion describe young neurons migrating tangentially into the infant frontal lobe and contributing to inhibitory circuits, rather than pyramidal excitatory neurons migrating radially. The section “Postnatally migrating neurons differentiate into interneurons” reports that these cells lack markers of excitatory neurons. Our copy does not identify Fgfs as an influence on their migration. (LLM, conf=0.90)

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  • Widespread migration of new neurons, mainly inhibitory interneurons, to the cingulate cortex and superior frontal gyrus occurs in the first five months after birth.

    “Another study found widespread migration of new neurons, mainly inhibitory interneurons, to the cingulate cortex and superior frontal gyrus in the first 5 months after birth206.”

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Authors
Paredes, M. F., James, D., Gil-Perotin, S., Kim, H., Cotter, J. A., Ng, C., Sandoval, K., Rowitch, D. H., Xu, D., McQuillen, P. S., Garcia-Verdugo, J.-M., Huang, E. J., & Alvarez-Buylla, A.
Affiliations
  • University of California, San Francisco (US)
  • Laboratory of Comparative Neurobiology, Instituto Cavanilles, Universidad de Valencia, CIBERNED, Valencia, Spain.
  • Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA.
Corresponding author
Huang, Eric J.
Venue
Science
Published
2016-10-07
Volume
354
Issue
6308
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2529762510
Cited by
391
References
46
Citations by year
2026: 27 · 2025: 33 · 2024: 27 · 2023: 41 · 2022: 41 · 2021: 40 · 2020: 79 · 2019: 40 · 2018: 32 · 2017: 26 · 2016: 4 · 2012: 1
FWCI
17.36
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion, cc-by)
  • Europe PMC (PubMed Central) (acceptedVersion, cc-by)
  • eScholarship (California Digital Library) (submittedVersion)
  • Apollo (University of Cambridge) (submittedVersion)
  • Apollo
Funders
  • California Institute of Regenerative Medicine (TG-01153)
  • NIH (RO1 HD032116-21, PO1 NS083513-02, R01EB009756, TB1-01194)
  • Spanish Institute of Health Carlos III (ISCIII2012-RD19-016)
  • Rio Hortega fellowship (CM12/00014)
  • Banting and FRS Canadian fellowships
  • Economics and Competitivity Ministry of Spain (BFU2015-64207-P)
  • Generalitat Valenciana (PrometeoII 2014-075)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neuronal migration, postnatal brain development, interneurons, inhibitory circuits, tangential migration, lateral ventricle, blood vessels, developmental plasticity, neurodevelopmental disorders, human brain evolution
MeSH terms
Doublecortin Domain Proteins, Cell Movement, Frontal Lobe, Gyrus Cinguli, Humans, Infant, Interneurons, Microtubule-Associated Proteins, Neuronal Plasticity, Neurons, Neuropeptides, Lateral Ventricles, Neurogenesis

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