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Cited by 2,307

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Ichijo, Hidenori, Nishida, Eisuke, Irie, Kenji, Dijke, Peter ten, Saitoh, Masao, Moriguchi, Tetsuo, Takagi, Minoru, Matsumoto, Kunihiro, Miyazono, Kohei, Gotoh, Yukiko·1997·Science
DOI 10.1126/science.275.5296.90
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Abstract

Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including growth factors and environmental stresses. A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively. Overexpression of ASK1 induced apoptotic cell death, and ASK1 was activated in cells treated with tumor necrosis factor-α (TNF-α). Moreover, TNF-α-induced apoptosis was inhibited by a catalytically inactive form of ASK1. ASK1 may be a key element in the mechanism of stress- and cytokine-induced apoptosis.

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Metadata

Authors
Ichijo, H., Nishida, E., Irie, K., Dijke, P. T., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K., & Gotoh, Y.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1997-01-03
Volume
275
Issue
5296
Pages
90-94
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.275.5296.90
OpenAlex
W2034580062
Cited by
2,307
References
1
FWCI
36.67
Type
journal article
Language
en
Open access
closed

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