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Cited by 1,371

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Biological Action of Leptin as an Angiogenic Factor

Sierra-Honigmann, M. Rocı́o, Nath, Anjali K., Murakami, Chiaki, Garcı́a-Cardeña, Guillermo, Papapetropoulos, Andreas, Sessa, William C., Madge, Lisa A., Schechner, Jeffrey S., Schwabb, Michael B., Polverini, Peter J., Flores-Riveros, Jaime R.·1998·Science
DOI 10.1126/science.281.5383.1683
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Abstract

Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) is expressed primarily in the hypothalamus. Here, it is shown that OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial cells. In vitro and in vivo assays revealed that leptin has angiogenic activity. In vivo, leptin induced neovascularization in corneas from normal rats but not in corneas from fa/fa Zucker rats, which lack functional leptin receptors. These observations indicate that the vascular endothelium is a target for leptin and suggest a physiological mechanism whereby leptin-induced angiogenesis may facilitate increased energy expenditure.

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Crossref · 10.1126/science.281.5383.1683

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Metadata

Authors
Sierra-Honigmann, M. R., Nath, A. K., Murakami, C., Garcı́a-Cardeña, G., Papapetropoulos, A., Sessa, W. C., Madge, L. A., Schechner, J. S., Schwabb, M. B., Polverini, P. J., & Flores-Riveros, J. R.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1998-09-11
Volume
281
Issue
5383
Pages
1683-1686
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.281.5383.1683
OpenAlex
W2126426760
Cited by
1,371
References
1
FWCI
18.23
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.