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Phylogenetic Perspectives in Innate Immunity

Hoffmann, Jules A., Kafatos, Fotis C., Janeway, Charles A., Ezekowitz, R. A. B.·1999·Science
DOI 10.1126/science.284.5418.1313
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Abstract

The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.

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Cited by

Metadata

Authors
Hoffmann, J. A., Kafatos, F. C., Janeway, C. A., & Ezekowitz, R. A. B.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1999-05-21
Volume
284
Issue
5418
Pages
1313-1318
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.284.5418.1313
OpenAlex
W2075787303
Cited by
2,492
References
2
FWCI
54.80
Type
journal article
Language
en
Open access
closed

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