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Notch Signaling
Abstract
The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans . Studies on the expression, mutant phenotypes, and developmental consequences of unregulated receptor activation have implicated these proteins in a general mechanism of local cell signaling, which includes interactions between equivalent cells and between different cell types. Genetic approaches in flies and worms have identified putative components of the signaling cascade, including a conserved family of extracellular ligands and two cellular factors that may associate with the Notch Intracellular domain. One factor, the Drosophila Suppressor of Hairless protein, is a DNA-binding protein, which suggests that Notch signaling may involve relatively direct signal transmission from the cell surface to the nucleus. Several vertebrate Notch receptors have also been discovered recently and play important roles in normal development and tumorigenesis.
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Citations
Cited by
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
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Joutel, A., Corpechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenga, V., Cécillion, M., Maréchal, E., et al. (1996) · Nature · doi:10.1038/383707a0 · Cited by 2,068
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828
Gene Regulatory Networks and the Evolution of Animal Body Plans
Davidson, E. H., & Erwin, D. H. (2006) · Science · doi:10.1126/science.1113832 · Cited by 1,207
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Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science · doi:10.1126/science.1087573 · Cited by 1,121
Skeletal and CNS Defects in Presenilin-1-Deficient Mice
Shen, J., Bronson, R. T., Chen, D. F., Xia, W., Selkoe, D. J., & Tonegawa, S. (1997) · Cell · doi:10.1016/s0092-8674(00)80244-5 · Cited by 959
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
Ohtsuka, T., Ishibashi, M., Gradwohl, G., Nakanishi, S., Guillemot, F., & Kageyama, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.8.2196 · Cited by 852
Chenn, A., & McConnell, S. K. (1995) · Cell · doi:10.1016/0092-8674(95)90035-7 · Cited by 766
Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients
Joutel, A., Vahedi, K., Corpechot, C., Troesch, A., Chabriat, H., Vayssière, C., Cruaud, C., Maciazek, J., Weissenbach, J., Bousser, M.-G., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(97)08083-5 · Cited by 682
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells
Tanigaki, K., Han, H., Yamamoto, N., Tashiro, K., Ikegawa, M., Kuroda, K., Suzuki, A., Nakano, T., & Honjo, T. (2002) · Nature Immunology · doi:10.1038/ni793 · Cited by 478
Constructing the cerebral cortex: Neurogenesis and fate determination
McConnell, S. K. (1995) · Neuron · doi:10.1016/0896-6273(95)90168-x · Cited by 416
ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models
Price, D. L., Tanzi, R. E., Borchelt, D. R., & Sisodia, S. S. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.461 · Cited by 406
Song, W., Nadeau, P., Yuan, M., Yang, X., Shen, J., & Yankner, B. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6959 · Cited by 362
Patel, N. S., Li, J.-L., Generali, D., Poulsom, R., Cranston, D. W., & Harris, A. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1208 · Cited by 349
Santolini, E., Puri, C., Salcini, A. E., Gagliani, M. C., Pelicci, P. G., Tacchetti, C., & Di Fiore, P. P. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.6.1345 · Cited by 331
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Nakamura, Y., Sakakibara, S.-I., Miyata, T., Ogawa, M., Shimazaki, T., Weiss, S., Kageyama, R., & Okano, H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00283.2000 · Cited by 316
Dishevelled: at the crossroads of divergent intracellular signaling pathways
Boutros, M., & Mlodzik, M. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00046-5 · Cited by 275
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Guan, Y., Xu, D., Garfin, P. M., Ehmer, U., Hurwitz, M., Enns, G., Michie, S., Wu, M., Zheng, M., Nishimura, T., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.94954 · Cited by 243
Baladrón, V., Ruiz-Hidalgo, M. J., Nueda, M. L., Díaz-Guerra, M. J. M., García-Ramírez, J. J., Bonvini, E., Gubina, E., & Laborda, J. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.10.001 · Cited by 226
Notch1 control of oligodendrocyte differentiation in the spinal cord
Genoud, S., Lappe-Siefke, C., Goebbels, S., Radtke, F., Aguet, M., Scherer, S. S., Suter, U., Nave, K.-A., & Mantei, N. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202002 · Cited by 211
Bondjers, C., He, L., Takemoto, M., Norlin, J., Asker, N., Hellström, M., Lindahl, P., Betsholtz, C., Bondjers, C., He, L., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-4944fje · Cited by 193
Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis
Kawaguchi, A., Ikawa, T., Kasukawa, T., Ueda, H. R., Kurimoto, K., Saitou, M., & Matsuzaki, F. (2008) · Development · doi:10.1242/dev.022616 · Cited by 193
Possible roles of DLK1 in the Notch pathway during development and disease
Falix, F. A., Aronson, D. C., Lamers, W. H., & Gaemers, I. C. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.02.003 · Cited by 191
Li, J., Xu, M., Zhou, H., Ma, J., & Potter, H. (1997) · Cell · doi:10.1016/s0092-8674(00)80356-6 · Cited by 172
The physiology of the β‐amyloid precursor protein intracellular domain AICD
Pardossi‐Piquard, R., & Checler, F. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07475.x · Cited by 159
msh may play a conserved role in dorsoventral patterning of the neuroectoderm and mesoderm
D'Alessio, M., & Frasch, M. (1996) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00583-7 · Cited by 126
Liao, Y.-C., Hsiao, C.-T., Fuh, J.-L., Chern, C.-M., Lee, W.-J., Guo, Y.-C., Wang, S.-J., Lee, I.-H., Liu, Y.-T., Wang, Y.-F., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0136501 · Cited by 123
Santolini, E., Salcini, A. E., Kay, B. K., Yamabhai, M., & Di Fiore, P. P. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4694 · Cited by 111
Kinoshita, A., Whelan, C. M., Berezovska, O., & Hyman, B. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203372200 · Cited by 109
Mechanisms of asymmetric cell division during animal development
Knoblich, J. A. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80085-3 · Cited by 87
The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons
Berezovska, O., Frosch, M., McLean, P., Knowles, R., Koo, E., Kang, D., Shen, J., Lu, F. M., Lux, S. E., Tonegawa, S., et al. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00119-9 · Cited by 68
Abramycheva, N., Stepanova, M., Kalashnikova, L., Zakharova, M., Maximova, M., Tanashyan, M., Lagoda, O., Fedotova, E., Klyushnikov, S., Konovalov, R., et al. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.01.018 · Cited by 28
Michellod, M., Forquignon, F., Santamaria, P., & Randsholt, N. B. (2003) · genesis · doi:10.1002/gene.10233 · Cited by 17
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Metadata
- Authors
- Artavanis-Tsakonas, S., Matsuno, K., & Fortini, M. E.
- Venue
- Science
- Published
- 1995-04-14
- Volume
- 268
- Issue
- 5208
- Pages
- 225-232
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4210958860
- Cited by
- 1,303
- References
- 0
- FWCI
- 43.46
- Type
- journal article
- Language
- en
- Open access
- closed
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