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Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut
Open accessAbstract
Tuft cells help contain parasites: Trillions of microbes inhabit our guts, including worms and other parasites. Epithelial cells that line the gut orchestrate parasite-targeted immune responses. Howitt et al. now identify a key cellular player in immunity to parasites: tuft cells (see the Perspective by Harris). Tuft cells make up a small fraction of gut epithelial cells but expand when parasites colonize or infect the gut. Parasites cause tuft cells to secrete large amounts of interleukin-25, a key cytokine for parasite clearance that also indirectly feeds back on tuft cells to expand their numbers. Tuft cells express chemosensory signaling machinery: disrupting this blocked parasite-triggered tuft cell expansion and weakened the ability of mice to control a parasitic infection. Science , this issue p. 1329 ; see also p. 1264
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Metadata
- Authors
- Howitt, M. R., Lavoie, S., Michaud, M., Blum, A. M., Tran, S. V., Weinstock, J. V., Gallini, C. A., Redding, K., Margolskee, R. F., Osborne, L. C., Artis, D., & Garrett, W. S.
- Venue
- Science
- Published
- 2016-03-18
- Volume
- 351
- Issue
- 6279
- Pages
- 1329-1333
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2278768857
- Cited by
- 928
- References
- 6
- FWCI
- 50.64
- Type
- journal article
- Language
- en
- Open access
- green
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