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Cited by 465Pleistocene-Era Hominins and ArchaeologyForensic and Genetic ResearchArchaeology and ancient environmental studies

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Neandertal and Denisovan DNA from Pleistocene sediments

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Slon, Viviane, Hopfe, Charlotte, Weiß, Clemens L., Mafessoni, Fabrizio, de la Rasilla, Marco, Lalueza-Fox, Carles, Rosas, Antonio, Soressi, Marie, Knul, Monika V., Miller, Rebecca, Stewart, John R., Derevianko, Anatoly P., Jacobs, Zenobia, Li, Bo, Roberts, Richard G., Shunkov, Michael V., de Lumley, Henry, Perrenoud, Christian, Gušić, Ivan, Kućan, Željko, Rudan, Pavao, Aximu-Petri, Ayinuer, Essel, Elena, Nagel, Sarah, Nickel, Birgit, Schmidt, Anna, Prüfer, Kay, Kelso, Janet, Burbano, Hernán A., Pääbo, Svante, Meyer, Matthias·2017·Science
DOI 10.1126/science.aam9695
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Abstract

Tracing our ancestors in cave sediments: Analysis of DNA from archaic hominids has illuminated human evolution. However, sites where thousand-year-old bones and other remains can be found are relatively rare. Slon et al. wanted to exploit any trace remains that our ancestors left behind. They looked for ancient DNA of hominids and other mammals in cave sediments, even those lacking skeletal remains. They identified mitochondrial DNA from Neandertal and Denisovan individuals in cave sediments at multiple sites. Science , this issue p. 605

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  • Current eDNA approaches build on shotgun metagenomics and more economical techniques involving target-enrichment.

    “Current approaches build on shotgun metagenomics 48 and more economical techniques involving target-enrichment 49,326 .”

    From Ancient DNA analysis (2021) · cites this paper as [49]

    The Enrichment of mammalian mtDNA section (page not provided) describes hybridization capture with probes targeting mammalian and human mitochondrial DNA in sediment samples, supporting the target-enrichment part of the claim. The Main Text discusses limitations of shotgun sequencing, but our copy does not establish that target enrichment is more economical. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Large-scale projects can benefit from nascent automation procedures for preparation of DNA libraries and their capture.

    “Large-scale projects can benefit from nascent automation procedures both for the preparation of DNA libraries and their capture 49,126,144 .”

    From Ancient DNA analysis (2021) · cites this paper as [49]

    In “Enrichment of mammalian mtDNA” (page unavailable), the paper reports using automated liquid handling to generate 102 DNA libraries, supporting automation of library preparation. It also reports hybridization capture, but does not say that capture was automated or assess a benefit for large-scale projects. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • eDNA has provided insights into spatial and temporal distribution of animal species, including extinct hominins, and impact of global climatic change.

    “Environmental DNA has also provided insights into the spatial and temporal distribution of animal species, including extinct hominins 49 , and the impact of global climatic change 22,48,90,91,328 .”

    From Ancient DNA analysis (2021) · cites this paper as [49]

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Metadata

Authors
Slon, V., Hopfe, C., Weiß, C. L., Mafessoni, F., de la Rasilla, M., Lalueza-Fox, C., Rosas, A., Soressi, M., Knul, M. V., Miller, R., Stewart, J. R., Derevianko, A. P., Jacobs, Z., Li, B., Roberts, R. G., Shunkov, M. V., de Lumley, H., Perrenoud, C., Gušić, I., Kućan, Ž., Rudan, P., Aximu-Petri, A., Essel, E., Nagel, S., Nickel, B., Schmidt, A., Prüfer, K., Kelso, J., Burbano, H. A., Pääbo, S., & Meyer, M.
Affiliations
  • Max Planck Institute for Evolutionary Anthropology (DE)
  • Max Planck Institute for Developmental Biology (DE)
  • Área de Prehistoria, Department of History, Universidad de Oviedo, Calle Teniente Alfonso Martínez s/n, 33011 Oviedo, Spain.
  • Institute of Evolutionary Biology, Universitat Pompeu Fabra–Consejo Superior de Investigaciones Científicas (UPF-CSIC), 08003 Barcelona, Spain.
  • Consejo Superior de Investigaciones Científicas (ES)
  • Leiden University (NL)
  • Bournemouth University (GB)
  • University of Liège (BE)
  • Russian Academy of Sciences (RU)
  • Australian Research Council (AU)
  • University of Wollongong (AU)
  • Institut de Paléontologie Humaine (FR)
  • Histoire Naturelle des Humanités Préhistoriques (FR)
  • Croatian Academy of Sciences and Arts (HR)
  • Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany.
Corresponding author
  • Slon, Viviane
  • Meyer, Matthias
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2017-05-12
Volume
356
Issue
6338
Pages
605-608
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.aam9695
OpenAlex
W2608083544
Cited by
465
References
18
Citations by year
2026: 37 · 2025: 45 · 2024: 61 · 2023: 42 · 2022: 38 · 2021: 76 · 2020: 50 · 2019: 37 · 2018: 65 · 2017: 12
FWCI
125.81
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Bournemouth University Research Online (Bournemouth University) (acceptedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
  • Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
  • Research Online (University of Wollongong) (submittedVersion)
  • HAL (submittedVersion, cc-by-nc-sa)
  • ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
  • Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
  • Max Planck Digital Library (submittedVersion)
  • Figshare (submittedVersion)
  • ORBi (University of Liège) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
  • European Research Council (award306903, AMD-694707-3)
  • Australian Research Council (award301789, FL130100116, award301788, FT140100384, award301787, FT150100138)
  • Max Planck Society (award301786)
  • Russian Science Foundation (award301790, 14-50-00036)
  • Max-Planck-Förderstiftung (award306902, P.S.EVANLOMP)
Topics
  • Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
  • Social Sciences › Archeology › Archaeology and ancient environmental studies
Keywords
Denisovan DNA, cave deposits, Pleistocene, Denisova Cave, Middle Pleistocene, sedimentary DNA, Eurasia
MeSH terms
DNA, Ancient, Animals, DNA, Mitochondrial, Europe, Fossils, Hominidae, Sequence Analysis, DNA, Geologic Sediments, Caves

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