Candida parapsilosis: from Genes to the Bedside

RNA-Seq: a revolutionary tool for transcriptomics

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Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America

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International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

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Evolution of pathogenicity and sexual reproduction in eight Candida genomes

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Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

Conti, H. R., Shen, F., Nayyar, N., Stocum, E., Sun, J. N., Lindemann, M. J., Ho, A. W., Hai, J. H., Yu, J. J., Jung, J. W., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081463 · Cited by 1,024

Candidalysin is a fungal peptide toxin critical for mucosal infection

Moyes, D. L., Wilson, D., Richardson, J. P., Mogavero, S., Tang, S. X., Wernecke, J., Hoefs, S., Gratacap, R. L., Robbins, J., Runglall, M., et al. (2016) · Nature · doi:10.1038/nature17625 · Cited by 928

Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species

Whaley, S. G., Berkow, E. L., Rybak, J. M., Nishimoto, A. T., Barker, K. S., & Rogers, P. D. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02173 · Cited by 900

Potential Role of Phospholipases in Virulence and Fungal Pathogenesis

Ghannoum, M. A. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.1.122-143.2000 · Cited by 823

Amphotericin B formulations: a comparative review of efficacy and toxicity

Hamill, R. J. (2013) · Drugs · doi:10.1007/s40265-013-0069-4 · Cited by 807

Antifungal Susceptibility of Candida Biofilms: Unique Efficacy of Amphotericin B Lipid Formulations and Echinocandins

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Genome-wide measurement of RNA secondary structure in yeast

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Rapid Hypothesis Testing with Candida albicans through Gene Disruption with Short Homology Regions

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RNA ‐Seq methods for transcriptome analysis

Hrdličková, R., Toloue, M., & Tian, B. (2016) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1364 · Cited by 746

The SAT1 flipper, an optimized tool for gene disruption in Candida albicans

Reuß, O., Vik, Å., Kolter, R., & Morschhäuser, J. (2004) · Gene · doi:10.1016/j.gene.2004.06.021 · Cited by 744

Mechanism of NLRP3 inflammasome activation

Sutterwala, F. S., Haasken, S., & Cassel, S. L. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12458 · Cited by 736

A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans

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Candida Biofilms: Threats, Challenges, and Promising Strategies

Cavalheiro, M., & Teixeira, M. C. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00028 · Cited by 690

Global trends in the distribution of Candida species causing candidemia

Guinea, J. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12539 · Cited by 680

Candida orthopsilosis and Candida metapsilosis spp. nov. To Replace Candida parapsilosis Groups II and III

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Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans

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Strains and Strategies for Large-Scale Gene Deletion Studies of the Diploid Human Fungal Pathogen Candida albicans

Noble, S. M., & Johnson, A. D. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.2.298-309.2005 · Cited by 592

Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: A multicenter, prospective, observational study in France (2005–2006)

Leroy, O., Gangneux, J., Montravers, P., Mira, J. P., Gouin, F., Sollet, J.-P., Carlet, J. M., Reynes, J., Rosenheim, M., Regnier, B., et al. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e31819efac0 · Cited by 551

Liposomal Amphotericin B (AmBisome®): A Review of the Pharmacokinetics, Pharmacodynamics, Clinical Experience and Future Directions

Stone, N. R. H., Bicanic, T., Salim, R., & Hope, W. (2016) · Drugs · doi:10.1007/s40265-016-0538-7 · Cited by 537

Large‐scale essential gene identification in Candida albicans and applications to antifungal drug discovery

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Mechanism of Fluconazole Resistance in Candida albicans Biofilms: Phase-Specific Role of Efflux Pumps and Membrane Sterols

Mukherjee, P. K., Chandra, J., Kuhn, D. M., & Ghannoum, M. A. (2003) · Infection and Immunity · doi:10.1128/iai.71.8.4333-4340.2003 · Cited by 511

Antifungal Susceptibility Survey of 2,000 Bloodstream Candida Isolates in the United States

Ostrosky‐Zeichner, L., Rex, J. H., Pappas, P. G., Hamill, R. J., Larsen, R. A., Horowitz, H. W., Powderly, W. G., Hyslop, N. E., Kauffman, C. A., Cleary, J. D., et al. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.10.3149-3154.2003 · Cited by 494

Comparison of Biofilms Formed byCandidaalbicansandCandidaparapsilosison Bioprosthetic Surfaces

Kuhn, D. M., Chandra, J., Mukherjee, P. K., & Ghannoum, M. A. (2002) · Infection and Immunity · doi:10.1128/iai.70.2.878-888.2002 · Cited by 485

Prevalence of Molecular Mechanisms of Resistance to Azole Antifungal Agents in Candida albicans Strains Displaying High-Level Fluconazole Resistance Isolated from Human Immunodeficiency Virus-Infected Patients

Perea, S., López-Ribot, J. L., Kirkpatrick, W. R., McAtee, R. K., Santillán, R. A., Martı́nez, M., Calabrese, D., Sanglard, D., & Patterson, T. F. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.10.2676-2684.2001 · Cited by 470

The Candida Genome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data

Skrzypek, M. S., Binkley, J., Binkley, G., Miyasato, S. R., Simison, M., & Sherlock, G. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw924 · Cited by 455

Incidence, characteristics and outcome of ICU-acquired candidemia in India

Chakrabarti, A., Sood, P., Rudramurthy, S. M., Chen, S., Kaur, H., Capoor, M., Chhina, D., Rao, R., Eshwara, V. K., Xess, I., et al. (2015) · Intensive Care Medicine · doi:10.1007/s00134-014-3603-2 · Cited by 454

Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study

Tabah, A., Koulenti, D., Laupland, K. B., Misset, B., Vallés, J., de Carvalho, F. B., Paiva, J. A., Çakar, N., Ma, X., Eggimann, P., et al. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2695-9 · Cited by 443

Putative Role of β-1,3 Glucans in Candida albicans Biofilm Resistance

Nett, J., Lincoln, L., Marchillo, K., Massey, R., Holoyda, K., Hoff, B., VanHandel, M., & Andes, D. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01056-06 · Cited by 407

TAC1 , Transcriptional Activator of CDR Genes, Is a New Transcription Factor Involved in the Regulation of Candida albicans ABC Transporters CDR1 and CDR2

Coste, A. T., Karababa, M., Ischer, F., Bille, J., & Sanglard, D. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.6.1639-1652.2004 · Cited by 407

Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors

Sanglard, D., Ischer, F., Monod, M., & Billé, J. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.10.2300 · Cited by 402

Epidemiology and Outcomes of Invasive Candidiasis Due to Non-albicans Species of Candida in 2,496 Patients: Data from the Prospective Antifungal Therapy (PATH) Registry 2004–2008

Pfaller, M. A., Andes, D. R., Diekema, D. J., Horn, D. L., Reboli, A. C., Rotstein, C., Franks, B., & Azie, N. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101510 · Cited by 396

In Vitro Susceptibility of Invasive Isolates of Candida spp. to Anidulafungin, Caspofungin, and Micafungin: Six Years of Global Surveillance

Pfaller, M. A., Boyken, L. B., Hollis, R. J., Kroeger, J. S., Messer, S. A., Tendolkar, S., & Diekema, D. J. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.01901-07 · Cited by 391

Biofilms of non-Candida albicans Candida species: quantification, structure and matrix composition

Silva, S., Henriques, M., Martins, A., Oliveira, R., Williams, D., & Azeredo, J. (2009) · Medical Mycology · doi:10.3109/13693780802549594 · Cited by 390

A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells

Moyes, D. L., Runglall, M., Murciano, C., Shen, C., Nayar, D., Thavaraj, S., Kohli, A., Islam, A., Mora-Montes, H. M., Challacombe, S., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.08.002 · Cited by 382

Neonatal Candidiasis: Epidemiology, Risk Factors, and Clinical Judgment

Benjamin, D. K., Stoll, B. J., Gantz, M. G., Walsh, M. C., Sánchez, P. J., Das, A., Shankaran, S., Higgins, R. D., Auten, K. J., Miller, N. A., et al. (2010) · PEDIATRICS · doi:10.1542/peds.2009-3412 · Cited by 380

A Candida albicans CRISPR system permits genetic engineering of essential genes and gene families

Vyas, V. K., Barrasa, M. I., & Fink, G. R. (2015) · Science Advances · doi:10.1126/sciadv.1500248 · Cited by 376

Epidemiology of candidemia in Latin America: a laboratory-based survey

Nucci, M., Queiroz-Telles, F., Alvarado-Matute, T., Tiraboschi, I. N., Cortes, J., Zurita, J., Guzman-Blanco, M., Santolaya, M. E., Thompson, L., Sifuentes-Osornio, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059373 · Cited by 374

Echinocandin resistance in Candida.

Perlin, D. S. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ791 · Cited by 374

Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: 10.5-Year Analysis of Susceptibilities of Noncandidal Yeast Species to Fluconazole and Voriconazole Determined by CLSI Standardized Disk Diffusion Testing

Pfaller, M. A., Diekema, D. J., Gibbs, D. L., Newell, V. A., Hu, B., Dzierzanowska, D., Климко, Н. Н., Letscher‐Bru, V., Lisalová, M., Muehlethaler, K., et al. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.01747-08 · Cited by 370

Th17 cells in immunity to Candida albicans

Hernández-Santos, N., & Gaffen, S. L. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.04.008 · Cited by 361

The Transcription Factor Mrr1p Controls Expression of the MDR1 Efflux Pump and Mediates Multidrug Resistance in Candida albicans

Morschhäuser, J., Barker, K. S., Liu, T. T., Blaß-Warmuth, J., Homayouni, R., & Rogers, P. D. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030164 · Cited by 355

Biofilm Production by Candida Species and Inadequate Antifungal Therapy as Predictors of Mortality for Patients with Candidemia

Tumbarello, M., Posteraro, B., Trecarichi, E. M., Fiori, B., Rossi, M., Porta, R., de Gaetano Donati, K., La Sorda, M., Spanu, T., Fadda, G., et al. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.00131-07 · Cited by 343

A Naturally Occurring Proline-to-Alanine Amino Acid Change in Fks1p in Candida parapsilosis , Candida orthopsilosis , and Candida metapsilosis Accounts for Reduced Echinocandin Susceptibility

Garcia-Effron, G., Katiyar, S. K., Park, S., Edlind, T. D., & Perlin, D. S. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00262-08 · Cited by 323

Biofilm lifestyle of Candida: a mini review

Seneviratne, C., Jin, L., & Samaranayake, L. (2008) · Oral Diseases · doi:10.1111/j.1601-0825.2007.01424.x · Cited by 317

Candida Species Biofilms’ Antifungal Resistance

Silva, S. M., Rodrigues, C. F., Araújo, D., Rodrigues, M. E., & Henriques, M. (2017) · Journal of Fungi · doi:10.3390/jof3010008 · Cited by 317

Immune Recognition of Candida albicans β‐glucan by Dectin‐1

Gow, N. A. R., Netea, M. G., Munro, C. A., Ferwerda, G., Bates, S., Mora‐Montes, H. M., Walker, L., Jansen, T., Jacobs, L., Tsoni, V., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/523110 · Cited by 314

Expulsion of Live Pathogenic Yeast by Macrophages

Ma, H., Croudace, J. E., Lammas, D. A., & May, R. C. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.032 · Cited by 310

Species identification and antifungal susceptibility testing of Candida bloodstream isolates from population-based surveillance studies in two U.S. cities from 2008 to 2011.

Lockhart, S. R., Iqbal, N., Cleveland, A. A., Farley, M. M., Harrison, L. H., Bolden, C. B., Baughman, W., Stein, B., Hollick, R., Park, B. J., et al. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.01283-12 · Cited by 299

Epidemiology and predictive factors for early and late mortality in Candida bloodstream infections: a population-based surveillance in Spain

Puig‐Asensio, M., Padilla, B., Garnacho‐Montero, J., Zaragoza, Ó., Aguado, J. M., Zaragoza, R., Montejo, M., Muñóz, P., Ruíz-Camps, I., Cuenca‐Estrella, M., et al. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12380 · Cited by 297

Predictors of Adverse Outcome in Cancer Patients with Candidemia

Anaissie, E. J., Rex, J. H., Uzun, Ö., & Vartivarian, S. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00030-8 · Cited by 295

Nosocomial bloodstream infections due to Candida spp. in the USA: species distribution, clinical features and antifungal susceptibilities

Wisplinghoff, H., Ebbers, J., Geurtz, L., Stefanik, D., Major, Y., Edmond, M. B., Wenzel, R. P., & Seifert, H. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2013.09.005 · Cited by 293

Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2005: an 8.5-Year Analysis of Susceptibilities of Candida Species and Other Yeast Species to Fluconazole and Voriconazole Determined by CLSI Standardized Disk Diffusion Testing

Pfaller, M. A., Diekema, D. J., Gibbs, D. L., Newell, V. A., Meis, J. F. G. M., Gould, I. M., Fu, W., Colombo, A. L., & Rodríguez-Noriega, E. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.00409-07 · Cited by 287

The ‘obligate diploid’ Candida albicans forms mating-competent haploids

Hickman, M. A., Zeng, G., Forche, A., Hirakawa, M. P., Abbey, D., Harrison, B. D., Wang, Y.-M., Su, C.-H., Bennett, R. J., Wang, Y., et al. (2013) · Nature · doi:10.1038/nature11865 · Cited by 284

International Surveillance of Bloodstream Infections Due to Candida Species: Frequency of Occurrence and Antifungal Susceptibilities of Isolates Collected in 1997 in the United States, Canada, and South America for the SENTRY Program

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Ectopic Expression of URA3 Can Influence the Virulence Phenotypes and Proteome of Candida albicans but Can Be Overcome by Targeted Reintegration of URA3 at the RPS10 Locus

Brand, A., MacCallum, D. M., Brown, A. J. P., Gow, N. A. R., & Odds, F. C. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.4.900-909.2004 · Cited by 277

Candidemia in patients with hematologic malignancies in the era of new antifungal agents (2001‐2007): Stable incidence but changing epidemiology of a still frequently lethal infection

Sipsas, N. V., Lewis, R. E., Tarrand, J., Hachem, R., Rolston, K. V., Raad, I. I., & Kontoyiannis, D. P. (2009) · Cancer · doi:10.1002/cncr.24507 · Cited by 269

Dimorphism and virulence in Candida albicans

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Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival

Zaragoza, Ó., Chrisman, C. J., Castelli, M. V., Frasés, S., Cuenca‐Estrella, M., Rodrı́guez-Tudela, J. L., & Casadevall, A. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01186.x · Cited by 252

Pathogenic Yeasts Cryptococcus neoformans and Candida albicans Produce Immunomodulatory Prostaglandins

Noverr, M. C., Phare, S. M., Toews, G. B., Coffey, M., & Huffnagle, G. B. (2001) · Infection and Immunity · doi:10.1128/iai.69.5.2957-2963.2001 · Cited by 250

Epidemiology, Risk Factors, and Prognosis of Candida parapsilosis Bloodstream Infections: Case-Control Population-Based Surveillance Study of Patients in Barcelona, Spain, from 2002 to 2003

Almirante, B., Rodríguez-Pardo, D., Cuenca‐Estrella, M., Almela, M., Sánchez, F., Ayats, J., Alonso-Tarrés, C., Rodrı́guez-Tudela, J. L., Pahissa, A., & the Barcelona Candidemia Project Study Group (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.44.5.1681-1685.2006 · Cited by 246

Candida albicans Gene Deletion with a Transient CRISPR-Cas9 System

Min, K., Ichikawa, Y., Woolford, C. A., & Mitchell, A. P. (2016) · mSphere · doi:10.1128/msphere.00130-16 · Cited by 246

Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

Flowers, S. A., Barker, K. S., Berkow, E. L., Toner, G., Chadwick, S. G., Gygax, S. E., Morschhäuser, J., & Rogers, P. D. (2012) · Eukaryotic Cell · doi:10.1128/ec.00215-12 · Cited by 239 · cited 1×

Candida Bloodstream Infections: Comparison of Species Distributions and Antifungal Resistance Patterns in Community-Onset and Nosocomial Isolates in the SENTRY Antimicrobial Surveillance Program, 2008-2009

Pfaller, M. A., Moet, G. J., Messer, S. A., Jones, R. N., & Castanheira, M. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01079-10 · Cited by 238

Candida albicans Zinc Cluster Protein Upc2p Confers Resistance to Antifungal Drugs and Is an Activator of Ergosterol Biosynthetic Genes

MacPherson, S., Akache, B., Weber, S., De Deken, X., Raymond, M., & Turcotte, B. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.5.1745-1752.2005 · Cited by 238

Outer Chain N-Glycans Are Required for Cell Wall Integrity and Virulence of Candida albicans

Bates, S., Hughes, H. B., Munro, C. A., Thomas, W. P. H., MacCallum, D. M., Bertram, G., Atrih, A., Ferguson, M. A. J., Brown, A. J. P., Odds, F. C., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510360200 · Cited by 238

Platelet Count and Sepsis in Very Low Birth Weight Neonates: Is There an Organism-Specific Response?

Guida, J. D., Kunig, A. M., Leef, K. H., McKenzie, S. E., & Paul, D. A. (2003) · PEDIATRICS · doi:10.1542/peds.111.6.1411 · Cited by 237

Adhesion, biofilm formation, cell surface hydrophobicity, and antifungal planktonic susceptibility: relationship among Candida spp.

Silva-Dias, A., Miranda, I. M., Branco, J., Monteiro‐Soares, M., Pina‐Vaz, C., & Rodrigues, A. G. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00205 · Cited by 232

Preclinical Assessment of the Efficacy of Mycograb, a Human Recombinant Antibody against Fungal HSP90

Matthews, R., Rigg, G. P., Hodgetts, S. J., Carter, T., Chapman, C. J., Gregory, C. A., Illidge, C., & Burnie, J. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.7.2208-2216.2003 · Cited by 232

Geographic Variations in Species Distribution and Echinocandin and Azole Antifungal Resistance Rates among Candida Bloodstream Infection Isolates: Report from the SENTRY Antimicrobial Surveillance Program (2008 to 2009)

Pfaller, M. A., Moet, G. J., Messer, S. A., Jones, R. N., & Castanheira, M. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01398-10 · Cited by 228

Results from the ARTEMIS DISK Global AntifungalSurveillance Study: a 6.5-Year Analysis of Susceptibilitiesof Candida and Other Yeast Species to Fluconazole andVoriconazole by Standardized Disk Diffusion Testing

Pfaller, M. A., Diekema, D. J., Rinaldi, M. G., Barnes, R., Hu, B., Veselov, A. V., Tiraboschi, N., Nagy, E., & Gibbs, D. L. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.12.5848-5859.2005 · Cited by 228

Epidemiology and Microbiologic Characterization of Nosocomial Candidemia from a Brazilian National Surveillance Program

Doi, A. M., Pignatari, A. C. C., Edmond, M. B., Marra, A. R., Camargo, L. F. A., Siqueira, R. A., da Mota, V. P., & Colombo, A. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146909 · Cited by 228

Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages

Wellington, M., Koselny, K., Sutterwala, F. S., & Krysan, D. J. (2014) · Eukaryotic Cell · doi:10.1128/ec.00336-13 · Cited by 227

In Vivo Comparison of the Pharmacodynamic Targets for Echinocandin Drugs against Candida Species

Andes, D., Diekema, D. J., Pfaller, M. A., Bohrmuller, J., Marchillo, K., & Lepak, A. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01584-09 · Cited by 226

National Surveillance of Fungemia in Denmark (2004 to 2009)

Arendrup, M. C., Bruun, B., Christensen, J. J., Fuursted, K., Johansen, H. K., Kjældgaard, P., Knudsen, J. D., Kristensen, L., Møller, J., Nielsen, L., et al. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.01811-10 · Cited by 223

The PATH (Prospective Antifungal Therapy) Alliance® registry and invasive fungal infections: update 2012

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The Facultative Intracellular Pathogen Candida glabrata Subverts Macrophage Cytokine Production and Phagolysosome Maturation

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