Cited by 109Muscle metabolism and nutritionMuscle Physiology and DisordersNutrition and Health in Aging

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Dose-dependent responses of myofibrillar protein synthesis with beef ingestion are enhanced with resistance exercise in middle-aged men

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Robinson, Meghann J., Burd, Nicholas A., Breen, Leigh, Rerecich, Tracy, Yang, Yifan, Hector, Amy J., Baker, Steven K., Phillips, Stuart M.·2013·Applied Physiology, Nutrition, and Metabolism

DOI 10.1139/apnm-2012-0092

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Abstract

Aging impairs the sensitivity of skeletal muscle to anabolic stimuli, such as amino acids and resistance exercise. Beef is a nutrient-rich source of dietary protein capable of stimulating muscle protein synthesis (MPS) rates in older men at rest. To date, the dose–response of myofibrillar protein synthesis to graded ingestion of protein-rich foods, such as beef, has not been determined. We aimed to determine the dose–response of MPS with and without resistance exercise to graded doses of beef ingestion. Thirty-five middle-aged men (59 ± 2 years) ingested 0 g, 57 g (2 oz; 12 g protein), 113 g (4 oz; 24 g protein), or 170 g (6 oz; 36 g protein) of (15% fat) ground beef (n = 7 per group). Subjects performed a bout of unilateral resistance exercise to allow measurement of the fed state and the fed plus resistance exercise state within each dose. A primed constant infusion of l-[1-13 C]leucine was initiated to measure leucine oxidation and of l-[ring-13 C 6]phenylalanine was initiated to measure myofibrillar MPS. Myofibrillar MPS was increased with ingestion of 170 g of beef to a greater extent than all other doses at rest and after resistance exercise. There was more leucine oxidation with ingestion of 113 g of beef than with 0 g and 57 g, and it increased further after ingestion of 170 g of beef (all p < 0.05). Ingestion of 170 g of beef protein is required to stimulate a rise in myofibrillar MPS over and above that seen with lower doses. An isolated bout of resistance exercise was potent in stimulating myofibrillar MPS, and acted additively with feeding.

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Authors: Robinson, M. J., Burd, N. A., Breen, L., Rerecich, T., Yang, Y., Hector, A. J., Baker, S. K., & Phillips, S. M.
Affiliations: McMaster University (CA)
ORCID: Burd, Nicholas A.
Breen, Leigh
Yang, Yifan
Baker, Steven K.
Phillips, Stuart M.
Venue: Applied Physiology, Nutrition, and Metabolism
Publisher: Canadian Science Publishing
Published: 2013-02
Volume: 38
Issue: 2
Pages: 120-125
ISSN: 1715-5312 (ISSN-L)
1715-5320
DOI: 10.1139/apnm-2012-0092
OpenAlex: W2071076747
Cited by: 109
References: 47
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 12 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 17 · 2015: 10 · 2014: 8 · 2013: 7
FWCI: 3.79
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations: Applied Physiology Nutrition and Metabolism (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: National Cattlemen's Beef Association
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: myofibrillar protein synthesis, resistance training, dose-response relationship, dietary protein, leucine oxidation, skeletal muscle anabolism, middle-aged men, aging, fed state
MeSH terms: Amino Acids, Animals, Cattle, Gene Expression Regulation, Humans, Male, Meat, Middle Aged, Muscle Proteins, Exercise

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Dose-dependent responses of myofibrillar protein synthesis with beef ingestion are enhanced with resistance exercise in middle-aged men

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