Recall of emotional states in posttraumatic stress disorder: an fMRI investigation
Abstract
Background The goal of this study was to examine the neuronal circuitry underlying different emotional states (neutral, sad, anxious, and traumatic) in posttraumatic stress disorder (PTSD) in traumatized subjects versus traumatized subjects without PTSD. Methods Traumatized subjects with (n = 10) and without (n = 10) PTSD were studied using the script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging (fMRI) at a 4 Tesla field strength. Results Compared to the trauma-exposed comparison group, PTSD subjects showed significantly less activation of the thalamus and the anterior cingulate gyrus (area 32) in all three emotional states (sad, anxious, and traumatic). Conclusion These findings suggest thalamic and anterior cingulate dysfunction in the recollection of traumatic as well as other negative events. Thalamic and anterior cingulate dysfunction may underlie emotion dysregulation often observed clinically in PTSD.
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The VLPAG receives signals from deep somatic (muscle, joint) or visceral tissues via the dorsal horn of the spinal cord, from the parabrachial nucleus, and from the vagal sensory nucleus (the solitary track nucleus).
“The VLPAG receives signals from deep somatic (muscle, joint) or visceral tissues via the dorsal horn of the spinal cord, from the parabrachial nucleus,25,94,95 and from the vagal sensory nucleus (the solitary track nucleus).28,96”
From Fear and the Defense Cascade (2015) · cites this paper as [96]
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- Authors
- Lanius, R. A., Williamson, P. C., Hopper, J., Densmore, M., Boksman, K., Gupta, M. A., Neufeld, R. W. J., Gati, J. S., & Menon, R. S.
- Affiliations
- Western University (CA)
- Boston University (US)
- Corresponding author
- Lanius, Ruth A
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 53
- Issue
- 3
- Pages
- 204-210
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2008286604
- Cited by
- 311
- References
- 8
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 12 · 2019: 15 · 2018: 13 · 2017: 10 · 2016: 12 · 2015: 19 · 2014: 12 · 2013: 20 · 2012: 13
- FWCI
- 15.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- post-traumatic stress disorder, thalamus, anterior cingulate cortex, emotional dysregulation, traumatic memory, negative emotions, anxiety, sadness, neural circuits
- MeSH terms
- Adult, Arousal, Brain, Brain Mapping, Cerebral Cortex, Dominance, Cerebral, Emotions, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Mental Recall, Stress Disorders, Post-Traumatic, Thalamus
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