Cited by 466Autophagy in Disease and TherapyUbiquitin and proteasome pathwaysCellular transport and secretion

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Biogenesis and Cargo Selectivity of Autophagosomes

Weidberg, Hilla, Shvets, Elena, Elazar, Zvulun·2011·Annual Review of Biochemistry

DOI 10.1146/annurev-biochem-052709-094552

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Abstract

Autophagy is a major catabolic pathway in eukaryotes, which is required for the lysosomal/vacuolar degradation of cytoplasmic proteins and organelles. Interest in the autophagy pathway has recently gained momentum largely owing to identification of multiple autophagy-related genes and recognition of its involvement in various physiological conditions. Here we review current knowledge of the molecular mechanisms regulating autophagy in mammals and yeast, specifically the biogenesis of autophagosomes and the selectivity of their cargo recruitment. We discuss the different steps of autophagy, from the signal transduction events that regulate it to the completion of this pathway by fusion with the lysosome/vacuole. We also review research on the origin of the autophagic membrane, the molecular mechanism of autophagosome formation, and the roles of two ubiquitin-like protein families and other structural elements that are essential for this process. Finally, we discuss the various modes of autophagy and highlight their functional relevance for selective degradation of specific cargos.

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Authors: Weidberg, H., Shvets, E., & Elazar, Z.
Affiliations: Weizmann Institute of Science (IL)
Corresponding author: Weidberg, Hilla
Shvets, Elena
ORCID: Weidberg, Hilla
Elazar, Zvulun
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 2011-07-07
Volume: 80
Issue: 1
Pages: 125-156
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev-biochem-052709-094552
OpenAlex: W2052470191
Cited by: 466
References: 227
Citations by year: 2026: 4 · 2025: 10 · 2024: 15 · 2023: 14 · 2022: 24 · 2021: 26 · 2020: 21 · 2019: 28 · 2018: 25 · 2017: 31 · 2016: 40 · 2015: 38 · 2014: 46 · 2013: 59 · 2012: 68
FWCI: 7.10
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: autophagy, autophagosome formation, selective autophagy, autophagosome-lysosome fusion, ubiquitin-like proteins, autophagy-related genes, signal transduction, yeast autophagy, cytoplasmic degradation
MeSH terms: Animals, Autophagy, Intracellular Membranes, Phagosomes, Yeasts, Organelles, Signal Transduction, Biomarkers

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Biogenesis and Cargo Selectivity of Autophagosomes

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