Cited by 131Alzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingAmyotrophic Lateral Sclerosis Research

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Intercellular Spread of Protein Aggregates in Neurodegenerative Disease

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Davis, Albert A., Leyns, Cheryl E.G., Holtzman, David M.·2018·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev-cellbio-100617-062636PMC PMC6350082

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Abstract

Most neurodegenerative diseases are characterized by the accumulation of protein aggregates, some of which are toxic to cells. Mounting evidence demonstrates that in several diseases, protein aggregates can pass from neuron to neuron along connected networks, although the role of this spreading phenomenon in disease pathogenesis is not completely understood. Here we briefly review the molecular and histopathological features of protein aggregation in neurodegenerative disease, we summarize the evidence for release of proteins from donor cells into the extracellular space, and we highlight some other mechanisms by which protein aggregates might be transmitted to recipient cells. We also discuss the evidence that supports a role for spreading of protein aggregates in neurodegenerative disease pathogenesis and some limitations of this model. Finally, we consider potential therapeutic strategies to target spreading of protein aggregates in the treatment of neurodegenerative diseases.

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Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains
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Effects of α-Synuclein Immunization in a Mouse Model of Parkinson’s Disease
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Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons
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A Method for the Acute and Rapid Degradation of Endogenous Proteins
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Tau prion strains dictate patterns of cell pathology, progression rate, and regional vulnerability in vivo
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Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain
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Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain
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Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes
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TDP-43 is intercellularly transmitted across axon terminals
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Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity
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Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage
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“The latter finding is in contrast to work performed in a neuroblastoma cell line demonstrating a role for macropinocytosis induced by membrane ruffling in response to exposure to multiple protein aggregates, including SOD1, TDP-43, HTT, and αSyn (Zeineddine et al. 2015).”
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Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model
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Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles
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Tau as a Biomarker of Neurodegenerative Diseases
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Misfolded SOD1 is not a primary component of sporadic ALS
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Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation
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TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion
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Authors: Davis, A. A., Leyns, C. E. G., & Holtzman, D. M.
Affiliations: Washington University in St. Louis (US)
ORCID: Davis, Albert A.
Leyns, Cheryl E.G.
Holtzman, David M.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2018-10-06
Volume: 34
Issue: 1
Pages: 545-568
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev-cellbio-100617-062636
PMC: PMC6350082
OpenAlex: W2883506729
Cited by: 131
References: 174
Citations by year: 2026: 10 · 2025: 11 · 2024: 14 · 2023: 16 · 2022: 24 · 2021: 20 · 2020: 20 · 2019: 13 · 2018: 2
FWCI: 1.80
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (K08NS101118)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: protein aggregates, neurodegenerative diseases, intercellular spread, prion-like propagation, extracellular protein release, treatment options, neurodegeneration
MeSH terms: Chronic Traumatic Encephalopathy, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Humans, Huntington Disease, Neurons, Parkinson Disease, Prion Diseases, Neurodegenerative Diseases, Frontotemporal Dementia, Protein Aggregation, Pathological, Protein Aggregates

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Intercellular Spread of Protein Aggregates in Neurodegenerative Disease

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