The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The RNA Polymerase II Core Promoter
Abstract
▪ Abstract The events leading to transcription of eukaryotic protein-coding genes culminate in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which can extend ∼35 bp upstream and/or downstream of this site, plays a central role in regulating initiation. Specific DNA elements within the core promoter bind the factors that nucleate the assembly of a functional preinitiation complex and integrate stimulatory and repressive signals from factors bound at distal sites. Although core promoter structure was originally thought to be invariant, a remarkable degree of diversity has become apparent. This article reviews the structural and functional diversity of the RNA polymerase II core promoter.
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Citations
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Metadata
- Authors
- Smale, S. T., & Kadonaga, J. T.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2003-06
- Volume
- 72
- Issue
- 1
- Pages
- 449-479
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2170698318
- Cited by
- 1,133
- References
- 6
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- closed
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