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The Biology of Hematopoietic Stem Cells
Abstract
Hematopoietic stem cells (HSC) are the only cells in the blood-forming tissues that can give rise to all blood cell types and that can self-renew to produce more HSC. In mouse and human, HSC represent up to 0.05% of cells in the bone marrow. HSC are almost entirely responsible for the radioprotective and short- and long-term reconstituting effects observed after bone marrow transplantation. The subsets of HSC that give rise to short-term vs long-term multilineage reconstitution can be separated by phenotype, demonstrating that the fates of HSC are intrinsically determined. Here we review the ontogeny and biology of HSC, their expression of fate-determining genes, and the clinical importance of HSC for transplantation and gene therapy.
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Metadata
- Authors
- Morrison, S. J., Uchida, N., & Weissman, I. L.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 1995-11
- Volume
- 11
- Issue
- 1
- Pages
- 35-71
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2175016040
- Cited by
- 778
- References
- 8
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- closed
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