Cited by 2,017

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

Wodarz, Andreas, Nusse, Roel·1998·Annual Review of Cell and Developmental Biology

Open this paper in CoChat — free account

Abstract

▪ Abstract Wnt genes encode a large family of secreted, cysteine-rich proteins that play key roles as intercellular signaling molecules in development. Genetic studies in Drosophila and Caenorhabditis elegans, ectopic gene expression in Xenopus, and gene knockouts in the mouse have demonstrated the involvement of Wnts in processes as diverse as segmentation, CNS patterning, and control of asymmetric cell divisions. The transduction of Wnt signals between cells proceeds in a complex series of events including post-translational modification and secretion of Wnts, binding to transmembrane receptors, activation of cytoplasmic effectors, and, finally, transcriptional regulation of target genes. Over the past two years our understanding of Wnt signaling has been substantially improved by the identification of Frizzled proteins as cell surface receptors for Wnts and by the finding that β-catenin, a component downstream of the receptor, can translocate to the nucleus and function as a transcriptional activator. Here we review recent data that have started to unravel the mechanisms of Wnt signaling.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1146/annurev.cellbio.14.1.59

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M., & Cantley, L. C. (1997) · Science · doi:10.1126/science.275.5296.73 · Cited by 1,385
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
Stambolic, V., Ruel, L., & Woodgett, J. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70790-2 · Cited by 1,321
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
Thomas, K. R., & Capecchi, M. R. (1990) · Nature · doi:10.1038/346847a0 · Cited by 896
Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling
Slusarski, D. C., Corces, V. G., & Moon, R. T. (1997) · Nature · doi:10.1038/37138 · Cited by 680 · cited 6×
“IN DROSOPHILAAND CAENORHABDITIS ELEGANS”
BackgroundMethodInfluential
Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81922-4 · Cited by 518 · cited 2×
“…of Xwnt-5A to induce a secondary axis can be overcome by coinjection of human Frizzled 5, suggesting that the availability of a specific receptor rather than a fundamental difference in its signal transduction P1: APR/ary P2: ARS/dat QC: ARS/APM T1: ARS August 29, 1998 9:42 Annual Reviews AR066-03”
Background
Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1
Lijam, N., Paylor, R., McDonald, M. P., Crawley, J. N., Deng, C.-X., Herrup, K., Stevens, K. E., Maccaferri, G., McBain, C. J., Sussman, D. J., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80354-2 · Cited by 470
Modulation of Embryonic Intracellular Ca2+Signaling byWnt-5A
Slusarski, D. C., Yang-Snyder, J., Busa, W. B., & Moon, R. T. (1997) · Developmental Biology · doi:10.1006/dbio.1996.8463 · Cited by 404
Wnt family proteins are secreted and associated with the cell surface.
Smolich, B. D., McMahon, J. A., McMahon, A. P., & Papkoff, J. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.12.1267 · Cited by 172

Research works printed but not linked: 133

10.1093/emboj/16.13.3797 · DOI · Paper page
10.1002/bies.950141103 · DOI
10.1016/S0960-9822(06)00413-1 · DOI
10.1016/S0092-8674(00)80094-X · DOI · Paper page
10.1126/science.271.5257.1826 · DOI · Paper page
10.1016/S0955-0674(97)80122-6 · DOI · Paper page
Baylies MK, 1995, Development, 121, 3829, 10.1242/dev.121.11.3829 · DOI
Bejsovec A, 1995, Genetics, 139, 309, 10.1093/genetics/139.1.309 · DOI
10.1038/382225a0 · DOI · Paper page
Binari RC, 1997, Development, 124, 2623, 10.1242/dev.124.13.2623 · DOI · Paper page
10.1002/j.1460-2075.1990.tb08276.x · DOI
10.1101/gad.11.18.2359 · DOI · Paper page
10.1038/385829a0 · DOI · Paper page
10.1016/0092-8674(87)90039-0 · DOI · Paper page
Cadigan KM, 1996, Development, 122, 2801, 10.1242/dev.122.9.2801 · DOI
10.1016/S0092-8674(00)81438-5 · DOI · Paper page
10.1101/gad.11.24.3286 · DOI · Paper page
10.1016/S0959-437X(97)80071-8 · DOI
10.1016/S0092-8674(00)81374-4 · DOI · Paper page
10.1101/gad.7.1.13 · DOI · Paper page
10.1002/j.1460-2075.1996.tb00830.x · DOI · Paper page
Couso JP, 1994, Development, 120, 621, 10.1242/dev.120.3.621 · DOI · Paper page
10.1016/0092-8674(94)90195-3 · DOI
10.1073/pnas.92.18.8498 · DOI · Paper page
10.1016/S0092-8674(00)81307-0 · DOI · Paper page
10.1128/MCB.15.5.2625 · DOI · Paper page
10.1073/pnas.94.13.6770 · DOI · Paper page
10.1083/jcb.128.5.959 · DOI
Goode N, 1992, J. Biol. Chem., 267, 16878, 10.1016/S0021-9258(18)41866-2 · DOI · Paper page
10.1006/dbio.1995.0009 · DOI
Häcker U, 1997, Development, 124, 3565, 10.1242/dev.124.18.3565 · DOI · Paper page
Haerry TE, 1997, Development, 124, 3055, 10.1242/dev.124.16.3055 · DOI
10.1016/S0092-8674(00)80517-6 · DOI
10.1073/pnas.94.1.242 · DOI
Hays R, 1997, Development, 124, 3727, 10.1242/dev.124.19.3727 · DOI
10.1126/science.275.5306.1652 · DOI · Paper page
10.1038/374617a0 · DOI · Paper page
10.1016/0092-8674(94)90069-8 · DOI · Paper page
10.1016/0092-8674(95)90238-4 · DOI · Paper page
10.1083/jcb.124.5.729 · DOI · Paper page
10.1016/0925-4773(94)90044-2 · DOI
10.1074/jbc.271.42.26131 · DOI
10.1101/gad.10.21.2805 · DOI · Paper page
10.1016/0925-4773(96)00597-7 · DOI · Paper page
10.1093/emboj/17.5.1371 · DOI · Paper page
Itoh K, 1994, Development, 120, 2703, 10.1242/dev.120.9.2703 · DOI
10.1038/35154 · DOI · Paper page
Jones KH, 1996, Genetics, 142, 205, 10.1093/genetics/142.1.205 · DOI
10.1128/MCB.12.1.321 · DOI
10.1101/gad.10.24.3116 · DOI · Paper page
10.1128/MCB.12.2.784 · DOI
10.1006/dbio.1994.1325 · DOI
10.1101/gad.8.1.118 · DOI · Paper page
10.1126/science.275.5307.1784 · DOI · Paper page
Krasnow RE, 1995, Development, 121, 4095, 10.1242/dev.121.12.4095 · DOI
10.1083/jcb.136.5.1123 · DOI · Paper page
10.1016/S0092-8674(00)81921-2 · DOI · Paper page
10.1073/pnas.94.21.11196 · DOI
10.1016/0092-8674(95)90100-0 · DOI · Paper page
10.1038/384176a0 · DOI · Paper page
10.1016/S0925-4773(97)00035-X · DOI
10.1016/0092-8674(90)90385-R · DOI · Paper page
10.1016/0092-8674(89)90506-0 · DOI · Paper page
10.1083/jcb.139.1.229 · DOI
10.1016/S0092-8674(00)80112-9 · DOI · Paper page
10.1016/S0168-9525(97)01093-7 · DOI · Paper page
10.1016/S0092-8674(00)81915-7 · DOI
Moon RT, 1993, Development, 119, 97, 10.1242/dev.119.1.97 · DOI · Paper page
10.1126/science.275.5307.1787 · DOI · Paper page
10.1128/MCB.16.8.4088 · DOI
10.1073/pnas.92.7.3046 · DOI · Paper page
Neumann CJ, 1997, Development, 124, 871, 10.1242/dev.124.4.871 · DOI · Paper page
Noordermeer J, 1992, Development, 116, 711, 10.1242/dev.116.3.711 · DOI
10.1038/367080a0 · DOI · Paper page
10.1016/S0092-8674(00)80210-X · DOI
Nusse R, 1997, Cold Spring Harbor Symp. Quant. Biol., 185
10.1016/0092-8674(82)90409-3 · DOI · Paper page
10.1016/0092-8674(92)90630-U · DOI · Paper page
10.1038/287795a0 · DOI · Paper page
10.1083/jcb.134.5.1283 · DOI · Paper page
Pai LM, 1997, Development, 124, 2255, 10.1242/dev.124.11.2255 · DOI · Paper page
10.1128/MCB.16.5.2128 · DOI · Paper page
10.1016/0959-437X(94)90067-D · DOI
Peifer M, 1994, Development, 120, 369, 10.1242/dev.120.2.369 · DOI · Paper page
10.1016/0092-8674(94)90351-4 · DOI
10.1016/0968-0004(96)30027-3 · DOI
10.1073/pnas.94.7.2859 · DOI · Paper page
10.1083/jcb.135.3.819 · DOI · Paper page
10.1016/S0092-8674(00)81924-8 · DOI · Paper page
10.1016/0092-8674(90)90451-J · DOI · Paper page
10.1016/0092-8674(87)90038-9 · DOI · Paper page
10.1016/S0092-8674(00)80531-0 · DOI · Paper page
10.1126/science.272.5264.1023 · DOI · Paper page
10.1126/science.275.5307.1790 · DOI · Paper page
10.1126/science.8259518 · DOI · Paper page
Rulifson EJ, 1995, Development, 121, 2813, 10.1242/dev.121.9.2813 · DOI
10.1073/pnas.95.6.3020 · DOI · Paper page
Sampedro J, 1993, Development, 117, 677, 10.1242/dev.117.2.677 · DOI
10.1038/383627a0 · DOI · Paper page
10.1101/gad.10.17.2189 · DOI
10.1016/0925-4773(96)00546-1 · DOI · Paper page
10.1016/S0092-8674(05)80065-0 · DOI · Paper page
10.1038/367076a0 · DOI · Paper page
10.1016/S0960-9822(96)00750-6 · DOI · Paper page
Sokol SY, 1995, Development, 121, 1637, 10.1242/dev.121.6.1637 · DOI
10.1038/384129a0 · DOI · Paper page
10.1038/387292a0 · DOI · Paper page
10.1126/science.8259519 · DOI · Paper page
Theisen H, 1994, Development, 120, 347, 10.1242/dev.120.2.347 · DOI · Paper page
10.1016/S0092-8674(00)80530-9 · DOI
Tomlinson A, 1997, Development, 124, 4515, 10.1242/dev.124.22.4515 · DOI
10.1083/jcb.133.5.1123 · DOI · Paper page
10.1002/j.1460-2075.1993.tb06225.x · DOI · Paper page
10.1038/382547a0 · DOI · Paper page
10.1016/0092-8674(89)90020-2 · DOI · Paper page
10.1016/S0092-8674(00)81925-X · DOI · Paper page
10.1038/368342a0 · DOI
10.1038/329549a0 · DOI · Paper page
10.1038/338263a0 · DOI · Paper page
10.1083/jcb.136.2.411 · DOI
10.1074/jbc.271.8.4468 · DOI · Paper page
10.1093/hmg/6.3.465 · DOI
10.1093/emboj/16.11.3089 · DOI · Paper page
10.1016/S0959-437X(98)80068-3 · DOI · Paper page
10.1128/MCB.14.9.6278 · DOI · Paper page
10.1083/jcb.123.1.209 · DOI · Paper page
10.1101/gad.9.9.1087 · DOI · Paper page
10.1074/jbc.272.40.25243 · DOI
10.1016/S0960-9822(02)70716-1 · DOI · Paper page
10.1101/gad.10.12.1443 · DOI · Paper page
10.1016/S0092-8674(00)81991-1 · DOI · Paper page
10.1016/S0092-8674(00)80324-4 · DOI · Paper page
Zheng L, 1995, Development, 121, 3045, 10.1242/dev.121.9.3045 · DOI

Wnt signaling and cancer
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763
Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.055 · Cited by 1,377
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366

See all 2,017

Authors: Wodarz, A., & Nusse, R.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 1998-11
Volume: 14
Issue: 1
Pages: 59-88
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.14.1.59
OpenAlex: W2165061154
Cited by: 2,017
References: 9
FWCI: 4.86
Type: journal article
Language: en
Open access: closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks

Data sources