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MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

Wodarz, Andreas, Nusse, Roel·1998·Annual Review of Cell and Developmental Biology

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Abstract

▪ Abstract Wnt genes encode a large family of secreted, cysteine-rich proteins that play key roles as intercellular signaling molecules in development. Genetic studies in Drosophila and Caenorhabditis elegans, ectopic gene expression in Xenopus, and gene knockouts in the mouse have demonstrated the involvement of Wnts in processes as diverse as segmentation, CNS patterning, and control of asymmetric cell divisions. The transduction of Wnt signals between cells proceeds in a complex series of events including post-translational modification and secretion of Wnts, binding to transmembrane receptors, activation of cytoplasmic effectors, and, finally, transcriptional regulation of target genes. Over the past two years our understanding of Wnt signaling has been substantially improved by the identification of Frizzled proteins as cell surface receptors for Wnts and by the finding that β-catenin, a component downstream of the receptor, can translocate to the nucleus and function as a transcriptional activator. Here we review recent data that have started to unravel the mechanisms of Wnt signaling.

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Functional interaction of β-catenin with the transcription factor LEF-1
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Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling
Slusarski, D. C., Corces, V. G., & Moon, R. T. (1997) · Nature · doi:10.1038/37138 · Cited by 680 · cited 6×
“IN DROSOPHILAAND CAENORHABDITIS ELEGANS”
BackgroundMethodInfluential
Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81922-4 · Cited by 518 · cited 2×
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Si, W., Kang, Q., Luu, H. H., Park, J. K., Luo, Q., Song, W.-X., Jiang, W., Luo, X., Li, X., Yin, H., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.2955-2964.2006 · Cited by 272
EGF-Induced ERK Activation Promotes CK2-Mediated Disassociation of α-Catenin from β-Catenin and Transactivation of β-Catenin
Ji, H., Wang, J., Nika, H., Hawke, D., Keezer, S., Ge, Q., Fang, B., Fang, X., Fang, D., Litchfield, D. W., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.034 · Cited by 270
WNT signaling in neuronal maturation and synaptogenesis
Rosso, S. B., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00103 · Cited by 272
Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad
Nejak-Bowen, K. N., & Monga, S. P. S. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.12.010 · Cited by 260
Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: The odonto-onycho-dermal dysplasia
Adaimy, L., Chouery, E., Mégarbané, H., Mroueh, S., Delague, V., Nicolas, E., Belguith, H., de Mazancourt, P., & Mégarbané, A. (2007) · The American Journal of Human Genetics · doi:10.1086/520064 · Cited by 248
Crystal structure of a β-catenin/Axin complex suggests a mechanism for the β-catenin destruction complex
Xing, Y., Clements, W. K., Kimelman, D., & Xu, W. (2003) · Genes & Development · doi:10.1101/gad.1142603 · Cited by 237
“The canonical Wnt/ -catenin pathway plays a critical role in embryonic development, and its deregulation in adult tissues is associated with various human diseases (for review, see Moon and Kimelman 1998; Wodarz and Nusse 1998; Peifer and Polakis 2000; Moon et al. 2002; Giles et al. 2003).”
Background
Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling
Itoh, K., Brott, B. K., Bae, G.-U., Ratcliffe, M. J., & Sokol, S. Y. (2005) · Journal of Biology · doi:10.1186/jbiol20 · Cited by 221
Dishevelled promotes axon differentiation by regulating atypical protein kinase C
Zhang, X., Zhu, J., Yang, G.-Y., Wang, Q.-J., Qian, L., Chen, Y.-M., Chen, F., Tao, Y., Hu, H.-S., Wang, T., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1603 · Cited by 220
Wnt signaling mediates regional specification in the vertebrate face
Brugmann, S. A., Goodnough, L. H., Gregorieff, A., Leucht, P., ten Berge, D., Fuerer, C., Clevers, H., Nusse, R., & Helms, J. A. (2007) · Development · doi:10.1242/dev.005132 · Cited by 213
Self-citation
β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target
Lam, A. P., & Gottardi, C. J. (2011) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32834b3309 · Cited by 191
Sclerostin Inhibition of Wnt-3a-induced C3H10T1/2 Cell Differentiation Is Indirect and Mediated by Bone Morphogenetic Proteins
Winkler, D. G., Sutherland, M. S. K., Ojala, E., Turcott, E., Geoghegan, J. C., Shpektor, D., Skonier, J. E., Yu, C., & Latham, J. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m400524200 · Cited by 164
Wnt signaling in axon guidance
Zou, Y. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.015 · Cited by 138
Rethinking WNT signaling
Tolwinski, N. S., & Wieschaus, E. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.02.003 · Cited by 151
The LRP5 High-Bone-Mass G171V Mutation Disrupts LRP5 Interaction with Mesd
Zhang, Y., Wang, Y., Li, X., Zhang, J., Mao, J., Li, Z., Zheng, J., Li, L., Harris, S., & Wu, D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4677-4684.2004 · Cited by 142
Low-Density Lipoprotein Receptor Family
Bu, G., Li, Y., & Cam, J. (2001) · Molecular Neurobiology · doi:10.1385/mn:23:1:53 · Cited by 137
POP-1 controls axis formation during early gonadogenesis in C. elegans
Siegfried, K. R., & Kimble, J. (2002) · Development · doi:10.1242/dev.129.2.443 · Cited by 136
Developmental Signaling in Hydra: What Does It Take to Build a “Simple” Animal?
Steele, R. E. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0744 · Cited by 129
Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways
Klingmüller, U., Bauer, A., Bohl, S., Nickel, P. J., Breitkopf, K., Dooley, S., Zellmer, S., Kern, C., Merfort, I., Sparna, T., et al. (2006) · IEE Proceedings - Systems Biology · doi:10.1049/ip-syb:20050067 · Cited by 127
β-Catenin is critical for early postnatal liver growth
Apte, U., Zeng, G., Thompson, M. D., Muller, P., Micsenyi, A., Cieply, B., Kaestner, K. H., & Monga, S. P. S. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00359.2006 · Cited by 119
C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity
Herman, M. A. (2001) · Development · doi:10.1242/dev.128.4.581 · Cited by 118
Severe Hypercholesterolemia, Impaired Fat Tolerance, and Advanced Atherosclerosis in Mice Lacking Both Low Density Lipoprotein Receptor-related Protein 5 and Apolipoprotein E
Magoori, K., Kang, M.-J., Ito, M. R., Kakuuchi, H., Ioka, R. X., Kamataki, A., Kim, D.-H., Asaba, H., Iwasaki, S., Takei, Y. A., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211987200 · Cited by 111
A Novel β-Catenin-binding Protein Inhibits β-Catenin-dependent Tcf Activation and Axis Formation
Sakamoto, I., Kishida, S., Fukui, A., Kishida, M., Yamamoto, H., Hino, S.-I., Michiue, T., Takada, S., Asashima, M., & Kikuchi, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004089200 · Cited by 106
Early Embryonic Death in Mice Lacking the β-Catenin-Binding Protein Duplin
Nishiyama, M., Nakayama, K., Tsunematsu, R., Tsukiyama, T., Kikuchi, A., & Nakayama, K. I. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8386-8394.2004 · Cited by 86
SUMO-1 Modification of the C-terminal KVEKVD of Axin Is Required for JNK Activation but Has No Effect on Wnt Signaling
Rui, H.-L., Fan, E., Zhou, H.-M., Xu, Z., Zhang, Y., & Lin, S.-C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208099200 · Cited by 83
The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia
Katsu, T., Ujike, H., Nakano, T., Tanaka, Y., Nomura, A., Nakata, K., Takaki, M., Sakai, A., Uchida, N., Imamura, T., et al. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.017 · Cited by 80
Targeted increase in shaggy activity levels blocks wingless signaling
Bourouis, M. (2002) · genesis · doi:10.1002/gene.10114 · Cited by 70
LDL Receptor‐Related Proteins in Neurodevelopment
May, P., & Herz, J. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00086_4_5.x · Cited by 60
The neural crest cell hypothesis: no unified explanation for domestication
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Untitled work
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Authors: Wodarz, A., & Nusse, R.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 1998-11
Volume: 14
Issue: 1
Pages: 59-88
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.14.1.59
OpenAlex: W2165061154
Cited by: 2,017
References: 9
FWCI: 4.86
Type: journal article
Language: en
Open access: closed

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MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

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