The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE
Abstract
▪ Abstract Tight control of cell-cell communication is essential for the generation of a normally patterned embryo. A critical mediator of key cell-cell signaling events during embryogenesis is the highly conserved Wnt family of secreted proteins. Recent biochemical and genetic analyses have greatly enriched our understanding of how Wnts signal, and the list of canonical Wnt signaling components has exploded. The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels. In addition, receptor-ligand specificity and feedback loops help to determine Wnt signaling outputs. Wnts are required for adult tissue maintenance, and perturbations in Wnt signaling promote both human degenerative diseases and cancer. The next few years are likely to see novel therapeutic reagents aimed at controlling Wnt signaling in order to alleviate these conditions.
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“In deregulated forms, it is involved in human cancers and developmental disorders [26, 27].”
From Relating simulation studies by provenance—Developing a family of Wnt signaling models (2021) · cites this paper as [27]
In the citing paper
“the Wnt signaling protein lipoprotein receptor-related protein-6 (LRP6) which participates with Frizzled proteins as coreceptors in Wnt signaling,15”
Citations
Cites
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Self-citationHigh Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
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“Because LRP can interact with the cytosolic protein Axin (Mao et al. 2001b, Tolwinski et al. 2003) (Figures 2 and 3), Wnts are thought to induce the phosphorylation of LRP on a PPP(S/T)P motif, thus allowing the docking of Axin to the LRP cytoplasmic tail.”
BackgroundNovel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
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WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra
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Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
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BackgroundControl of β-Catenin Stability
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Metadata
- Authors
- Logan, C. Y., & Nusse, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University, Stanford, California 94305;,
- ORCID
- Logan, Catriona Y.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2004-11-01
- Volume
- 20
- Issue
- 1
- Pages
- 781-810
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2119284420
- Cited by
- 5,325
- References
- 15
- Citations by year
- 2026: 84 · 2025: 121 · 2024: 133 · 2023: 186 · 2022: 185 · 2021: 257 · 2020: 267 · 2019: 211 · 2018: 253 · 2017: 267 · 2016: 264 · 2015: 321 · 2014: 308 · 2013: 346 · 2012: 354
- FWCI
- 14.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Wnt signaling, Wnt proteins, cell-to-cell communication, embryonic development, canonical Wnt pathway, receptor ligand specificity, feedback loops, tissue maintenance, degenerative diseases, cancer
- MeSH terms
- Animals, Cell Nucleus, Cytoplasm, Disease, Gene Expression Regulation, Glycoproteins, Humans, Neoplasms, Proto-Oncogene Proteins, Signal Transduction, Protein Transport, Intercellular Signaling Peptides and Proteins, Embryonic Development, Wnt Proteins
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