Cited by 5,325Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationHedgehog Signaling Pathway Studies

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE

Logan, Catriona Y., Nusse, Roel·2004·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev.cellbio.20.010403.113126

Open this paper in CoChat — free account

Abstract

▪ Abstract Tight control of cell-cell communication is essential for the generation of a normally patterned embryo. A critical mediator of key cell-cell signaling events during embryogenesis is the highly conserved Wnt family of secreted proteins. Recent biochemical and genetic analyses have greatly enriched our understanding of how Wnts signal, and the list of canonical Wnt signaling components has exploded. The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels. In addition, receptor-ligand specificity and feedback loops help to determine Wnt signaling outputs. Wnts are required for adult tissue maintenance, and perturbations in Wnt signaling promote both human degenerative diseases and cancer. The next few years are likely to see novel therapeutic reagents aimed at controlling Wnt signaling in order to alleviate these conditions.

Integrity signals

Registry

Crossref · 10.1146/annurev.cellbio.20.010403.113126

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
Self-citation
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591
Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway
Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839 · cited 2×
“Because LRP can interact with the cytosolic protein Axin (Mao et al. 2001b, Tolwinski et al. 2003) (Figures 2 and 3), Wnts are thought to induce the phosphorylation of LRP on a PPP(S/T)P motif, thus allowing the docking of Axin to the LRP cytoplasmic tail.”
Background
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
Bafico, A., Liu, G., Yaniv, A., Gazit, A., & Aaronson, S. A. (2001) · Nature Cell Biology · doi:10.1038/35083081 · Cited by 772
The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H., et al. (1999) · Nature · doi:10.1038/21674 · Cited by 621
WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra
Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C. M., von Laue, C. C., Snyder, P., Rothbächer, U., & Holstein, T. W. (2000) · Nature · doi:10.1038/35025063 · Cited by 599
Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81922-4 · Cited by 518 · cited 1×
“In general, both SFRPs and WIFs are thought to function as extracellular Wnt inhibitors (Bafico et al. 1999, Dennis et al. 1999, Hsieh et al. 1999a, Leyns et al. 1997, Salic et al. 1997, Uren et al. 2000, Wang et al. 1997).”
Background
Control of β-Catenin Stability
Salic, A., Lee, E., Mayer, L., & Kirschner, M. W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80446-3 · Cited by 335
An ancient role for nuclear β-catenin in the evolution of axial polarity and germ layer segregation
Wikramanayake, A. H., Hong, M., Lee, P. N., Pang, K., Byrum, C. A., Bince, J. M., Xu, R., & Martindale, M. Q. (2003) · Nature · doi:10.1038/nature02113 · Cited by 324
Wise, a context-dependent activator and inhibitor of Wnt signalling
Itasaki, N., Jones, C. M., Mercurio, S., Rowe, A., Domingos, P. M., Smith, J. C., & Krumlauf, R. (2003) · Development · doi:10.1242/dev.00674 · Cited by 321

Show all 15 references

Research works printed but not linked: 181

10.1093/emboj/16.13.3797 · DOI
10.1016/S0014-5793(03)01190-6 · DOI
10.1016/S0092-8674(01)00445-7 · DOI
10.1101/gad.230302 · DOI
10.1016/S1534-5807(03)00055-8 · DOI
Baeg GH, 2001, Development, 128, 87, 10.1242/dev.128.1.87 · DOI
10.1074/jbc.274.23.16180 · DOI
10.1093/emboj/20.17.4935 · DOI
10.1101/gad.1044903 · DOI
10.1038/382638a0 · DOI · Paper page
10.1038/382225a0 · DOI
Bhanot P, 1999, Development, 126, 4175, 10.1242/dev.126.18.4175 · DOI
10.1038/nrm806 · DOI
10.1126/science.1091266 · DOI
10.1101/gad.11.18.2359 · DOI
10.1101/gad.11.24.3286 · DOI · Paper page
10.1016/S0092-8674(00)81438-5 · DOI
10.1038/26982 · DOI · Paper page
10.1126/science.1064437 · DOI
Chen CM, 1999, Development, 126, 5441, 10.1242/dev.126.23.5441 · DOI
10.1101/gad.13.17.2218 · DOI
10.1126/science.1082808 · DOI · Paper page
10.1016/S0960-9822(03)00370-1 · DOI
Cox RT, 1999, Development, 126, 1327, 10.1242/dev.126.6.1327 · DOI
10.1016/S0092-8674(02)01279-5 · DOI · Paper page
10.1038/383332a0 · DOI
10.1016/S1097-2765(02)00631-7 · DOI
10.1038/35083601 · DOI
Dennis S, 1999, J. Cell Sci., 112, 3815, 10.1242/jcs.112.21.3815 · DOI
10.1101/gad.13.6.709 · DOI
Galceran J, 2000, Development, 127, 469, 10.1242/dev.127.3.469 · DOI
10.1007/978-1-4615-6823-0 · DOI
Giles RH, 2003, Biochim. Biophys. Acta, 1653, 1
10.1242/dev.00904 · DOI
10.1016/S1534-5807(02)00180-6 · DOI
10.1038/34848 · DOI · Paper page
10.1016/S0092-8674(01)00571-2 · DOI · Paper page
10.1016/S1097-2765(02)00637-8 · DOI
10.1016/S0092-8674(01)00484-6 · DOI
10.1038/35047099 · DOI
10.1083/jcb.148.3.399 · DOI
10.1073/pnas.0402802101 · DOI
10.1016/S0092-8674(00)80689-3 · DOI
10.1016/S0960-9822(98)70226-X · DOI
10.1126/science.281.5382.1509 · DOI · Paper page
10.1093/emboj/19.8.1839 · DOI
10.1128/MCB.19.10.7147 · DOI
10.1210/en.2002-220275 · DOI
10.1074/jbc.271.42.26131 · DOI
10.1016/S0968-0004(99)01539-X · DOI · Paper page
10.1038/88264 · DOI
10.1038/18899 · DOI · Paper page
10.1073/pnas.96.7.3546 · DOI
10.1074/jbc.274.6.3439 · DOI
10.1038/40146 · DOI
Ishikawa T, 2001, Development, 128, 25, 10.1242/dev.128.1.25 · DOI
10.1128/MCB.20.6.2228-2238.2000 · DOI
10.1038/nature01458 · DOI
10.1128/MCB.22.4.1172-1183.2002 · DOI
10.1093/emboj/16.3.441 · DOI
10.1101/gad.10.24.3116 · DOI
10.1016/S0092-8674(00)81725-0 · DOI
10.1038/35038097 · DOI
10.1126/science.1651562 · DOI
10.1016/S0092-8674(02)01084-X · DOI
10.1074/jbc.273.18.10823 · DOI
Kispert A, 1998, Development, 125, 4225, 10.1242/dev.125.21.4225 · DOI
10.1038/1270 · DOI
10.1016/S0092-8674(02)00679-7 · DOI
10.1016/S0378-1119(99)00365-0 · DOI
10.1073/pnas.2536800100 · DOI
10.1086/386293 · DOI
10.1038/sj.onc.1202653 · DOI
10.1371/journal.pbio.0000010 · DOI · Paper page
10.1074/jbc.274.30.21464 · DOI
Lee SM, 2000, Development, 127, 457, 10.1242/dev.127.3.457 · DOI
10.1016/S1535-6108(03)00334-9 · DOI
10.1016/S0092-8674(00)81921-2 · DOI
10.1006/dbio.2002.0729 · DOI
10.1093/emboj/18.15.4233 · DOI
10.1016/S1535-6108(03)00268-X · DOI
10.1038/22343 · DOI
10.1016/S0945-053X(00)00073-1 · DOI
10.1086/338450 · DOI · Paper page
10.1073/pnas.96.11.6273 · DOI
10.1016/S0092-8674(02)00685-2 · DOI
10.1038/11932 · DOI
10.1126/science.1060100 · DOI
10.1073/pnas.96.25.14383 · DOI
10.1126/science.1081403 · DOI
10.1126/science.1089610 · DOI
10.1242/dev.00520 · DOI
10.1016/S0378-1119(02)01106-X · DOI · Paper page
10.1038/nature756 · DOI · Paper page
10.1038/35077108 · DOI
Megason SG, 2002, Development, 129, 2087, 10.1242/dev.129.9.2087 · DOI
10.1016/j.chembiol.2003.11.010 · DOI
10.1038/21666 · DOI · Paper page
10.1242/dev.00935 · DOI
10.1083/jcb.139.1.229 · DOI
10.1016/S0092-8674(00)80112-9 · DOI · Paper page
10.1016/S0925-4773(99)00138-0 · DOI
Muller H, 1999, Development, 126, 577, 10.1242/dev.126.3.577 · DOI
10.1002/1521-4141(200204)32:4<967::AID-IMMU967>3.3.CO;2-Y · DOI
10.1128/MCB.16.8.4088 · DOI
10.1126/science.1094291 · DOI
10.1086/382196 · DOI
10.1126/science.1651563 · DOI
10.1016/0925-4773(95)00348-7 · DOI
10.1038/367080a0 · DOI
10.1016/S0168-9525(01)02349-6 · DOI
10.1016/S0092-8674(02)01047-4 · DOI
Parker DS, 2002, Development, 129, 2565, 10.1242/dev.129.11.2565 · DOI
10.1006/dbio.2001.0373 · DOI
10.1038/27221 · DOI
10.1038/35035124 · DOI
10.1101/gad.267103 · DOI · Paper page
Plyte SE, 1999, Development, 126, 325, 10.1242/dev.126.2.325 · DOI
10.1016/S0960-9822(02)01068-0 · DOI
10.1016/S0092-8674(00)80771-0 · DOI
10.1073/pnas.94.7.2859 · DOI
10.1016/S1074-7613(00)00004-2 · DOI · Paper page
10.1038/ng957 · DOI
10.1016/S0092-8674(00)80531-0 · DOI · Paper page
10.1126/science.285.5435.1923 · DOI
10.1101/gad.869201 · DOI
10.1016/S1097-2765(00)00013-7 · DOI
10.1074/jbc.274.20.14090 · DOI
Salic AN, 1997, Development, 124, 4739, 10.1242/dev.124.23.4739 · DOI
10.1146/annurev.cellbio.20.010403.092805 · DOI
Sato A, 1999, Development, 126, 4421, 10.1242/dev.126.20.4421 · DOI
10.1038/73448 · DOI
10.1016/S0960-9822(01)00290-1 · DOI · Paper page
Shimizu H, 1997, Cell Growth Differ., 8, 1349
10.1073/pnas.96.10.5522 · DOI · Paper page
Shu W, 2002, Development, 129, 4831, 10.1242/dev.129.20.4831 · DOI
10.1016/S1097-2765(00)80327-5 · DOI
10.1093/emboj/19.10.2270 · DOI
10.1016/S0960-9822(00)00378-X · DOI
10.1242/dev.00695 · DOI
10.1038/35083016 · DOI
Tago K, 2000, Genes Dev., 14, 1741, 10.1101/gad.14.14.1741 · DOI
10.1038/35077219 · DOI
10.1038/nature01570 · DOI
10.1083/jcb.149.2.249 · DOI
10.1038/35035117 · DOI · Paper page
10.1016/S1097-2765(03)00484-2 · DOI · Paper page
10.1038/18884 · DOI · Paper page
10.1038/ncb786 · DOI
10.1371/journal.pbio.0020095 · DOI
10.1083/jcb.133.5.1123 · DOI
10.1086/383202 · DOI
10.1038/22336 · DOI
10.1093/emboj/19.18.4944 · DOI
10.1074/jbc.275.6.4374 · DOI
10.1038/17068 · DOI
10.1016/S0092-8674(00)81925-X · DOI
10.1101/gad.8.22.2691 · DOI
10.1016/S1534-5807(03)00266-1 · DOI · Paper page
10.1038/374070a0 · DOI
10.1038/26785 · DOI
10.1523/JNEUROSCI.21-13-04761.2001 · DOI
10.1523/JNEUROSCI.22-19-08563.2002 · DOI
10.1038/35035110 · DOI
10.1006/dbio.2001.0238 · DOI
10.1186/1471-213X-2-8 · DOI
10.1016/S1097-2765(03)00427-1 · DOI
10.1074/jbc.M207850200 · DOI
10.1016/S0092-8674(04)00216-8 · DOI · Paper page
Yamaguchi TP, 1999, Development, 126, 1211, 10.1242/dev.126.6.1211 · DOI
10.1093/emboj/21.7.1733 · DOI
10.1101/gad.9.9.1087 · DOI
10.1242/dev.00762 · DOI
10.1242/dev.00324 · DOI
10.1523/JNEUROSCI.21-01-j0002.2001 · DOI
10.1038/nature01522 · DOI
10.1006/dbio.1997.8502 · DOI
10.1016/S0092-8674(00)81208-8 · DOI
10.1101/gad.10.12.1443 · DOI
10.1016/S0092-8674(00)81991-1 · DOI
Zhai L, 2004, J. Biol. Cell., 279, 33220

Sorted by citations

Adipocyte differentiation from the inside out
Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607
Development, maintenance and disruption of the blood-brain barrier
Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452
Normal Bone Anatomy and Physiology
Clarke, B. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04151206 · Cited by 2,192
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis
Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.016 · Cited by 1,616
Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation.
Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.017 · Cited by 1,558
Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528
Regulation of bone mass by Wnt signaling
Krishnan, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28551 · Cited by 1,407
Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors
Gordon, M. D., & Nusse, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600015200 · Cited by 1,333
Self-citation
Histone Deacetylase Inhibitors as Anticancer Drugs
Eckschlager, T., Plch, J., Stiborova, M., & Hrabeta, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071414 · Cited by 1,206
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500608200 · Cited by 1,170
Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
Li, V. S. W., Ng, S. S., Boersema, P. J., Low, T. Y., Karthaus, W. R., Gerlach, J. P., Mohammed, S., Heck, A. J. R., Maurice, M. M., Mahmoudi, T., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.002 · Cited by 889
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
Akhmetshina, A., Palumbo, K., Dees, C., Bergmann, C., Venalis, P., Zerr, P., Horn, A., Kireva, T., Beyer, C., Zwerina, J., et al. (2012) · Nature Communications · doi:10.1038/ncomms1734 · Cited by 843
Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells
Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764
Osteoclast–osteoblast communication
Matsuo, K., & Irie, N. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.027 · Cited by 780
Genetic Control of Bone Formation
Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667
Neuronal polarity: from extracellular signals to intracellular mechanisms.
Arimura, N., & Kaibuchi, K. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2056 · Cited by 655
β-Catenin destruction complex: insights and questions from a structural perspective
Kimelman, D., & Xu, W. (2006) · Oncogene · doi:10.1038/sj.onc.1210055 · Cited by 628
The cell biology of bone metabolism
Datta, H. K., Ng, W. F., Walker, J. A., Tuck, S. P., & Varanasi, S. S. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.048868 · Cited by 614
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R., & Alessi, D. R. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600633 · Cited by 594
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
Firestein, R., Blander, G., Michan, S., Oberdoerffer, P., Ogino, S., Campbell, J., Bhimavarapu, A., Luikenhuis, S., de Cabo, R., Fuchs, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002020 · Cited by 588
Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein
Bartscherer, K., Pelte, N., Ingelfinger, D., & Boutros, M. (2006) · Cell · doi:10.1016/j.cell.2006.04.009 · Cited by 580
Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis
Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., et al. (2012) · Nature Medicine · doi:10.1038/nm.2653 · Cited by 542
WNT1-inducible signaling protein–1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
Königshoff, M., Kramer, M., Balsara, N., Wilhelm, J., Amarie, O. V., Jahn, A., Rose, F., Fink, L., Seeger, W., Schaefer, L., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci33950 · Cited by 558
Metabolic zonation of the liver: The oxygen gradient revisited
Kietzmann, T. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.012 · Cited by 499
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
Seifert, J. R. K., & Mlodzik, M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2042 · Cited by 513
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions
Zeng, X., Huang, H., Tamai, K., Zhang, X., Harada, Y., Yokota, C., Almeida, K., Wang, J., Doble, B., Woodgett, J., et al. (2008) · Development · doi:10.1242/dev.013540 · Cited by 492
Wnt signaling: complexity at the surface
Cadigan, K. M., & Liu, Y. I. (2006) · Journal of Cell Science · doi:10.1242/jcs.02826 · Cited by 486
Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2
Wayman, G. A., Impey, S., Marks, D., Saneyoshi, T., Grant, W. F., Derkach, V., & Soderling, T. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.008 · Cited by 466
β-Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis
Gurley, K. A., Rink, J. C., & Alvarado, A. S. (2008) · Science · doi:10.1126/science.1150029 · Cited by 469
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response
Gerdes, J. M., Liu, Y., Zaghloul, N. A., Leitch, C. C., Lawson, S. S., Kato, M., Beachy, P. A., Beales, P. L., DeMartino, G. N., Fisher, S., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.12 · Cited by 399
Smed- β catenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration
Petersen, C. P., & Reddien, P. W. (2008) · Science · doi:10.1126/science.1149943 · Cited by 364
TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway
Zheng, H., Jia, L., Liu, C.-C., Rong, Z., Zhong, L., Yang, L., Chen, X.-F., Fryer, J. D., Wang, X., Zhang, Y.-W., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2459-16.2017 · Cited by 317
Wnt signaling in the nervous system and in Alzheimer's disease
Inestrosa, N. C., & Varela-Nallar, L. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt051 · Cited by 324
Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes
Naito, A. T., Sumida, T., Nomura, S., Liu, M.-L., Higo, T., Nakagawa, A., Okada, K., Sakai, T., Hashimoto, A., Hara, Y., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.047 · Cited by 320
Wnt/β-catenin-driven EMT regulation in human cancers
Xue, W., Yang, L., Chen, C., Ashrafizadeh, M., Tian, Y., & Sun, R. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05099-7 · Cited by 321
Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets
Dewanjee, S., Das, S., Das, A. K., Bhattacharjee, N., Dihingia, A., Dua, T. K., Kalita, J., & Manna, P. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.034 · Cited by 300
Epigenetic changes during aging and their reprogramming potential
Kane, A. E., & Sinclair, D. A. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1570075 · Cited by 283
Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation
Chen, J., Park, C. S., & Tang, S.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511920200 · Cited by 298
Wnt signaling and cellular metabolism in osteoblasts
Karner, C. M., & Long, F. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2425-5 · Cited by 295
Wnt Signaling Regulates Neuronal Differentiation of Cortical Intermediate Progenitors
Munji, R. N., Choe, Y., Li, G., Siegenthaler, J. A., & Pleasure, S. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5404-10.2011 · Cited by 275
Cellular and epigenetic drivers of stem cell ageing
Ermolaeva, M., Neri, F., Ori, A., & Rudolph, K. L. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0020-3 · Cited by 272
Wnt signaling in neural circuit assembly
Salinas, P. C., & Zou, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125649 · Cited by 274
WNT signaling in neuronal maturation and synaptogenesis
Rosso, S. B., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00103 · Cited by 272
A wound-induced Wnt expression program controls planarian regeneration polarity
Petersen, C. P., & Reddien, P. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906823106 · Cited by 251
WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes
Bohring, A., Stamm, T., Spaich, C., Haase, C., Spree, K., Hehr, U., Hoffmann, M., Ledig, S., Sel, S., Wieacker, P., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.06.001 · Cited by 232
Dishevelled promotes axon differentiation by regulating atypical protein kinase C
Zhang, X., Zhu, J., Yang, G.-Y., Wang, Q.-J., Qian, L., Chen, Y.-M., Chen, F., Tao, Y., Hu, H.-S., Wang, T., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1603 · Cited by 220
The c‐myc Promoter: Still MysterY and Challenge
(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211
Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response
Gurley, K. A., Elliott, S. A., Simakov, O., Schmidt, H. A., Holstein, T. W., & Alvarado, A. S. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.08.007 · Cited by 212
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation
Devgan, V., Mammucari, C., Millar, S. E., Brisken, C., & Dotto, G. P. (2005) · Genes & Development · doi:10.1101/gad.341405 · Cited by 209
Targeted disruption of β-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex
Kim, A. C., Reuter, A. L., Zubair, M., Else, T., Serecky, K., Bingham, N. C., Lavery, G. G., Parker, K. L., & Hammer, G. D. (2008) · Development · doi:10.1242/dev.021493 · Cited by 202
Signals and switches in mammalian neural crest cell differentiation
Bhatt, S., Diaz, R., & Trainor, P. A. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008326 · Cited by 200
A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis
Fang, L., Zhu, Q., Neuenschwander, M., Specker, E., Wulf-Goldenberg, A., Weis, W. I., von Kries, J. P., & Birchmeier, W. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1519 · Cited by 190
Promising molecular mechanisms responsible for gemcitabine resistance in cancer
Jia, Y., & Xie, J. (2015) · Genes & Diseases · doi:10.1016/j.gendis.2015.07.003 · Cited by 170
Roles and regulation of Wnt signaling and β-catenin in prostate cancer
Verras, M., & Sun, Z. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.06.004 · Cited by 180
Wnt3a Induces Myofibroblast Differentiation by Upregulating TGF-β Signaling Through SMAD2 in a β-Catenin-Dependent Manner
Carthy, J. M., Garmaroudi, F. S., Luo, Z., & McManus, B. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019809 · Cited by 172
The Wnt code: cnidarians signal the way
Guder, C., Philipp, I., Lengfeld, T., Watanabe, H., Hobmayer, B., & Holstein, T. W. (2006) · Oncogene · doi:10.1038/sj.onc.1210052 · Cited by 177
The FoxO transcription factors and metabolic regulation
Nakae, J., Oki, M., & Cao, Y. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.11.025 · Cited by 176
Wnts in adult brain: from synaptic plasticity to cognitive deficiencies
Oliva, C. A., Vargas, J. Y., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00224 · Cited by 162
Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders
Vlashi, R., Zhang, X., Wu, M., & Chen, G. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.07.011 · Cited by 165
Inositol Pyrophosphates as Mammalian Cell Signals
Chakraborty, A., Kim, S., & Snyder, S. H. (2011) · Science Signaling · doi:10.1126/scisignal.2001958 · Cited by 160
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo
Miao, Y., Ha, A., de Lau, W., Yuki, K., Santos, A. J. M., You, C., Geurts, M. H., Puschhof, J., Pleguezuelos-Manzano, C., Peng, W. C., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.07.020 · Cited by 151
Self-citation
Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling
Sheng, R., Kim, H., Lee, H., Xin, Y., Chen, Y., Tian, W., Cui, Y., Choi, J.-C., Doh, J., Han, J.-K., et al. (2014) · Nature Communications · doi:10.1038/ncomms5393 · Cited by 157
Helping Wingless take flight: how WNT proteins are secreted
Hausmann, G., Bänziger, C., & Basler, K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2141 · Cited by 147
The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis
Tencerova, M., & Kassem, M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00127 · Cited by 149
Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica
Adamska, M., Larroux, C., Adamski, M., Green, K., Lovas, E., Koop, D., Richards, G. S., Zwafink, C., & Degnan, B. M. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00435.x · Cited by 139
Mesenchymal stem cells produce Wnt isoforms and TGF-β1 that mediate proliferation and procollagen expression by lung fibroblasts
Salazar, K. D., Lankford, S. M., & Brody, A. R. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90347.2008 · Cited by 134
DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune cell activation
Xiao, Q., Wu, J., Wang, W.-J., Chen, S., Zheng, Y., Yu, X., Meeth, K., Sahraei, M., Bothwell, A. L. M., Chen, L., et al. (2018) · Nature Medicine · doi:10.1038/nm.4496 · Cited by 130
NARF, an Nemo-like Kinase (NLK)-associated Ring Finger Protein Regulates the Ubiquitylation and Degradation of T Cell Factor/Lymphoid Enhancer Factor (TCF/LEF)
Yamada, M., Ohnishi, J., Ohkawara, B., Iemura, S., Satoh, K., Hyodo-Miura, J., Kawachi, K., Natsume, T., & Shibuya, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602089200 · Cited by 132
Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation
Khalturin, K., Anton-Erxleben, F., Milde, S., Plötz, C., Wittlieb, J., Hemmrich, G., & Bosch, T. C. G. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.06.013 · Cited by 125
Impaired Wnt Signaling in the Prefrontal Cortex of Alzheimer’s Disease
Folke, J., Pakkenberg, B., & Brudek, T. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1103-z · Cited by 123
Genomic insights into Wnt signaling in an early diverging metazoan, the ctenophore Mnemiopsis leidyi
Pang, K., Ryan, J. F., Program, N. C. S., Mullikin, J. C., Baxevanis, A. D., & Martindale, M. Q. (2010) · EvoDevo · doi:10.1186/2041-9139-1-10 · Cited by 115
The Metabolic Microenvironment Steers Bone Tissue Regeneration
Loeffler, J., Duda, G. N., Sass, F. A., & Dienelt, A. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.11.008 · Cited by 113
Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis
Zhu, C., Tabas, I., Schwabe, R. F., & Pajvani, U. B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00365-6 · Cited by 112
Versican in inflammation and tissue remodeling: The impact on lung disorders
Andersson-Sjoland, A., Hallgren, O., Rolandsson, S., Weitoft, M., Tykesson, E., Larsson-Callerfelt, A.-K., Rydell-Tormanen, K., Bjermer, L., Malmstrom, A., Karlsson, J. C., et al. (2015) · Glycobiology · doi:10.1093/glycob/cwu120 · Cited by 98
WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway
Binet, R., Ythier, D., Robles, A. I., Collado, M., Larrieu, D., Fonti, C., Brambilla, E., Brambilla, C., Serrano, M., Harris, C. C., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1016 · Cited by 101
Wnt Signaling in Renal Cell Carcinoma
Xu, Q., Krause, M., Samoylenko, A., & Vainio, S. (2016) · Cancers · doi:10.3390/cancers8060057 · Cited by 99
Modulation of the microtubule cytoskeleton: a role for a divergent canonical Wnt pathway
Salinas, P. C. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.003 · Cited by 100
Wnt/β-Catenin Signaling in Alzheimer’s Disease
Ferrari, G., Avila, M., Medina, M., Perez-Palma, E., Bustos, B., & Alarcon, M. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527312666131223113900 · Cited by 95
Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
Varela-Nallar, L., Grabowski, C. P., Alfaro, I. E., Alvarez, A. R., & Inestrosa, N. C. (2009) · Neural Development · doi:10.1186/1749-8104-4-41 · Cited by 97
HIC1 attenuates Wnt signaling by recruitment of TCF‐4 and β‐catenin to the nuclear bodies
Valenta, T., Lukas, J., Doubravska, L., Fafilek, B., & Korinek, V. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601147 · Cited by 91
Heme Oxygenase Gene Targeting to Adipocytes Attenuates Adiposity and Vascular Dysfunction in Mice Fed a High-Fat Diet
Cao, J., Peterson, S. J., Sodhi, K., Vanella, L., Barbagallo, I., Rodella, L. F., Schwartzman, M. L., Abraham, N. G., & Kappas, A. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.193805 · Cited by 94
The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation
Ji, L., Jiang, B., Jiang, X., Charlat, O., Chen, A., Mickanin, C., Bauer, A., Xu, W., Yan, X., & Cong, F. (2017) · Genes & Development · doi:10.1101/gad.300053.117 · Cited by 89
A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism
Seldin, M. M., Koplev, S., Rajbhandari, P., Vergnes, L., Rosenberg, G. M., Meng, Y., Pan, C., Phuong, T. M. N., Gharakhanian, R., Che, N., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.015 · Cited by 84
Extracellular Matrix-Mediated Differentiation of Human Embryonic Stem Cells: Differentiation to Insulin-Secreting Beta Cells
Narayanan, K., Lim, V. Y., Shen, J., Tan, Z. W., Rajendran, D., Luo, S.-C., Gao, S., Wan, A. C. A., & Ying, J. Y. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0257 · Cited by 83
Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition
Shi, X., Miller, J. S., Harper, L. J., Poole, R. L., Gould, T. J., & Unterwald, E. M. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3491-8 · Cited by 79
Proteomic Plasma Membrane Profiling Reveals an Essential Role for gp96 in the Cell Surface Expression of LDLR Family Members, Including the LDL Receptor and LRP6
Weekes, M. P., Antrobus, R., Talbot, S., Hör, S., Simecek, N., Smith, D. L., Bloor, S., Randow, F., & Lehner, P. J. (2012) · Journal of Proteome Research · doi:10.1021/pr201135e · Cited by 82
Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation
Barchetta, I., Cimini, F. A., Ciccarelli, G., Baroni, M. G., & Cavallo, M. G. (2019) · Journal of Endocrinological Investigation · doi:10.1007/s40618-019-01052-3 · Cited by 77
Dysregulated Wnt Signalling in the Alzheimer’s Brain
Aghaizu, N. D., Jin, H., & Whiting, P. J. (2020) · Brain Sciences · doi:10.3390/brainsci10120902 · Cited by 70
A Wnt-CKIɛ-Rap1 Pathway Regulates Gastrulation by Modulating SIPA1L1, a Rap GTPase Activating Protein
Tsai, I.-C., Amack, J. D., Gao, Z.-H., Band, V., Yost, H. J., & Virshup, D. M. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.02.009 · Cited by 67
Spatio-temporal Model of Endogenous ROS and Raft-Dependent WNT/Beta-Catenin Signaling Driving Cell Fate Commitment in Human Neural Progenitor Cells
Haack, F., Lemcke, H., Ewald, R., Rharass, T., & Uhrmacher, A. M. (2015) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004106 · Cited by 66
Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci
Kennedy, A. L., McBryan, T., Enders, G. H., Johnson, F. B., Zhang, R., & Adams, P. D. (2010) · Cell Division · doi:10.1186/1747-1028-5-16 · Cited by 61
Common Genetic Variants and Gene-Expression Changes Associated with Bipolar Disorder Are Over-Represented in Brain Signaling Pathway Genes
Pedroso, I., Lourdusamy, A., Rietschel, M., Nöthen, M. M., Cichon, S., McGuffin, P., Al-Chalabi, A., Barnes, M. R., & Breen, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.031 · Cited by 59
Neuron activity–induced Wnt signaling up-regulates expression of brain-derived neurotrophic factor in the pain neural circuit
Zhang, W., Shi, Y., Peng, Y., Zhong, L., Zhu, S., Zhang, W., & Tang, S.-J. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002840 · Cited by 59
Critical Scaffolding Regions of the Tumor Suppressor Axin1 Are Natively Unfolded
Noutsou, M., Duarte, A. M. S., Anvarian, Z., Didenko, T., Minde, D. P., Kuper, I., de Ridder, I., Oikonomou, C., Friedler, A., Boelens, R., et al. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.11.013 · Cited by 58
Genome-Wide Analysis of a Wnt1-Regulated Transcriptional Network Implicates Neurodegenerative Pathways
Wexler, E. M., Rosen, E., Lu, D., Osborn, G. E., Martin, E., Raybould, H., & Geschwind, D. H. (2011) · Science Signaling · doi:10.1126/scisignal.2002282 · Cited by 56
Developmental Lead Exposure Alters Synaptogenesis through Inhibiting Canonical Wnt Pathway In Vivo and In Vitro
Hu, F., Xu, L., Liu, Z.-H., Ge, M.-M., Ruan, D.-Y., & Wang, H.-L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101894 · Cited by 54
Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a
Kobayashi, Y., Thirukonda, G. J., Nakamura, Y., Koide, M., Yamashita, T., Uehara, S., Kato, H., Udagawa, N., & Takahashi, N. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.06.102 · Cited by 47
Lrp6 Dynamic Expression in Tooth Development and Mutations in Oligodontia
Yu, M., Fan, Z., Wong, S. W., Sun, K., Zhang, L., Liu, H., Feng, H., Liu, Y., & Han, D. (2021) · Journal of Dental Research · doi:10.1177/0022034520970459 · Cited by 41

Authors: Logan, C. Y., & Nusse, R.
Affiliations: Howard Hughes Medical Institute (US)
Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University, Stanford, California 94305;,
ORCID: Logan, Catriona Y.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2004-11-01
Volume: 20
Issue: 1
Pages: 781-810
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.20.010403.113126
OpenAlex: W2119284420
Cited by: 5,325
References: 15
Citations by year: 2026: 84 · 2025: 121 · 2024: 133 · 2023: 186 · 2022: 185 · 2021: 257 · 2020: 267 · 2019: 211 · 2018: 253 · 2017: 267 · 2016: 264 · 2015: 321 · 2014: 308 · 2013: 346 · 2012: 354
FWCI: 14.87
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords: Wnt signaling, Wnt proteins, cell-to-cell communication, embryonic development, canonical Wnt pathway, receptor ligand specificity, feedback loops, tissue maintenance, degenerative diseases, cancer
MeSH terms: Animals, Cell Nucleus, Cytoplasm, Disease, Gene Expression Regulation, Glycoproteins, Humans, Neoplasms, Proto-Oncogene Proteins, Signal Transduction, Protein Transport, Intercellular Signaling Peptides and Proteins, Embryonic Development, Wnt Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks