Cited by 1,415Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesParkinson's Disease Mechanisms and Treatments

The DOI matches its Crossref record; 201 of the 201 references it cites were found in a registry or an index.

Multiple Dopamine Functions at Different Time Courses

Schultz, Wolfram·2007·Annual Review of Neuroscience

DOI 10.1146/annurev.neuro.28.061604.135722

Open this paper in CoChat — free account

Abstract

Many lesion studies report an amazing variety of deficits in behavioral functions that cannot possibly be encoded in great detail by the relatively small number of midbrain dopamine neurons. Although hoping to unravel a single dopamine function underlying these phenomena, electrophysiological and neurochemical studies still give a confusing, mutually exclusive, and partly contradictory account of dopamine's role in behavior. However, the speed of observed phasic dopamine changes varies several thousand fold, which offers a means to differentiate the behavioral relationships according to their time courses. Thus dopamine is involved in mediating the reactivity of the organism to the environment at different time scales, from fast impulse responses related to reward via slower changes with uncertainty, punishment, and possibly movement to the tonic enabling of postsynaptic motor, cognitive, and motivational systems deficient in Parkinson's disease.

Integrity signals

Registry

Crossref · 10.1146/annurev.neuro.28.061604.135722

Cites

201 of 201 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Theory of games and economic behavior
Garcia, S. R., & Miller, S. J. (2019) · American Mathematical Society eBooks · doi:10.1090/mbk/121/32 · Cited by 16,777
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
Self-citation
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
Self-citation
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Theory of Games and Economic Behavior
Hawkins, D. (1945) · Philosophy of Science · doi:10.1086/286866 · Cited by 3,970
A model for Pavlovian learning: Variations in the effectiveness of conditioned but not of unconditioned stimuli.
Pearce, J. M., & Hall, G. (1980) · Psychological Review · doi:10.1037/0033-295x.87.6.532 · Cited by 3,023
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Burns, R. S., Chiueh, C. C., Markey, S. P., Ebert, M. H., Jacobowitz, D. M., & Kopin, I. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.14.4546 · Cited by 2,149
On the relations between the direction of two-dimensional arm movements and cell discharge in primate motor cortex
Georgopoulos, A. P., Kalaska, J. F., Caminiti, R., & Massey, J. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-11-01527.1982 · Cited by 2,133
Discrete coding of reward probability and uncertainty by dopamine neurons
Fiorillo, C. D., Tobler, P. N., & Schultz, W. (2003) · Science · doi:10.1126/science.1077349 · Cited by 2,085
Self-citation

Show all 201 references

Research works printed but not linked: 5

Carlsson A, 1958, Science, 471, 127
10.1037//0033-295X.87.6.532 · DOI · Paper page
Schwab RS, 1972, Electroencephalogr. Clin. Neurophysiol. Suppl., 31, 87
10.1037//0033-295X.88.2.135 · DOI · Paper page
10.1073/pnas.031374698 · DOI

Sorted by citations

Items 101–200 of 1,000

Reward and aversion
Hu, H. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014106 · Cited by 253
Identifying Neurobiological Phenotypes Associated with Alcohol Use Disorder Severity
Claus, E. D., Ewing, S. W. F., Filbey, F. M., Sabbineni, A., & Hutchison, K. E. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.99 · Cited by 251
Reward functions of the basal ganglia
Schultz, W. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1510-0 · Cited by 264
Self-citation
Control of synaptic plasticity in deep cortical networks
Roelfsema, P. R., & Holtmaat, A. J. D. G. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.6 · Cited by 254
Brain plasticity-based therapeutics
Merzenich, M. M., Vleet, T. V., & Nahum, M. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00385 · Cited by 261
Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine
Gan, J. O., Walton, M. E., & Phillips, P. E. M. (2009) · Nature Neuroscience · doi:10.1038/nn.2460 · Cited by 244
Age-related changes in midbrain dopaminergic regulation of the human reward system
Dreher, J.-C., Meyer-Lindenberg, A., Kohn, P., & Berman, K. F. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802127105 · Cited by 230
The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats
Choi, D. L., Davis, J. F., Fitzgerald, M. E., & Benoit, S. C. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.002 · Cited by 239
Neuromodulation of reward‐based learning and decision making in human aging
Eppinger, B., Hämmerer, D., & Li, S. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06230.x · Cited by 236
Gain in sensitivity and loss in temporal contrast of STDP by dopaminergic modulation at hippocampal synapses
Zhang, J.-C., Lau, P.-M., & Bi, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900546106 · Cited by 241
Aversive Stimuli Differentially Modulate Real-Time Dopamine Transmission Dynamics within the Nucleus Accumbens Core and Shell
Badrinarayan, A., Wescott, S. A., Vander Weele, C. M., Saunders, B. T., Couturier, B. E., Maren, S., & Aragona, B. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3557-12.2012 · Cited by 225
Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?
Ranjbar‐Slamloo, Y., & Fazlali, Z. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00334 · Cited by 241
Potential Vulnerabilities of Neuronal Reward, Risk, and Decision Mechanisms to Addictive Drugs
Schultz, W. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.014 · Cited by 224
Self-citation
Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia
Barch, D. M., Pagliaccio, D., & Luking, K. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_376 · Cited by 218
Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons
Kim, J.-I., Ganesan, S., Luo, S. X., Wu, Y.-W., Park, E., Huang, E. J., Chen, L., & Ding, J. B. (2015) · Science · doi:10.1126/science.aac4690 · Cited by 217
Subsecond dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual reward
Kishida, K. T., Sáez, I., Lohrenz, T. M., Witcher, M. R., Laxton, A. W., Tatter, S. B., White, J. P., Ellis, T. L., Phillips, P. E. M., & Montague, P. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513619112 · Cited by 224
K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration
Schiemann, J. M., Schlaudraff, F., Klose, V., Bingmer, M., Seino, S., Magill, P. J., Zaghloul, K. A., Schneider, G., Liss, B., & Roeper, J. (2012) · Nature Neuroscience · doi:10.1038/nn.3185 · Cited by 215
Synaptic Activity Unmasks Dopamine D2 Receptor Modulation of a Specific Class of Layer V Pyramidal Neurons in Prefrontal Cortex
Gee, S., Ellwood, I., Patel, T., Luongo, F., Deisseroth, K., & Sohal, V. S. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5835-11.2012 · Cited by 214
The Feedback-Related Negativity Signals Salience Prediction Errors, Not Reward Prediction Errors
Talmi, D., Atkinson, R., & El‐Deredy, W. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5695-12.2013 · Cited by 231
Instructional control of reinforcement learning: A behavioral and neurocomputational investigation
Doll, B. B., Jacobs, W. J., Sanfey, A. G., & Frank, M. J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.007 · Cited by 218
Minireview: New Roles for Peripheral Dopamine on Metabolic Control and Tumor Growth: Let’s Seek the Balance
Rubí, B., & Maechler, P. (2010) · Endocrinology · doi:10.1210/en.2010-0745 · Cited by 219
Prediction error associated with the perceptual segmentation of naturalistic events
Zacks, J. M., Kurby, C. A., Eisenberg, M. L., & Haroutunian, N. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00078 · Cited by 202
Brain Circuits Encoding Reward from Pain Relief
Navratilova, E., Atcherley, C. W., & Porreca, F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.09.003 · Cited by 208
Updating memories—The role of prediction errors in memory reconsolidation
Exton-McGuinness, M. T. J., Lee, J. L. C., & Reichelt, A. C. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.011 · Cited by 220
Role of attention in the generation and modulation of tinnitus
Roberts, L. E., Husain, F. T., & Eggermont, J. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.007 · Cited by 202
The temporal paradox of Hebbian learning and homeostatic plasticity
Zenke, F., Gerstner, W., & Ganguli, S. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.015 · Cited by 201
Motivation and its Relationship to Neurocognition, Social Cognition, and Functional Outcome in Schizophrenia
Gard, D. E., Fisher, M., Garrett, C. T., Genevsky, A., & Vinogradov, S. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.08.015 · Cited by 217
Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications
Kohls, G., Chevallier, C., Troiani, V., & Schultz, R. T. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-10 · Cited by 197
Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis
Tritsch, N. X., Oh, W., Gu, C., & Sabatini, B. L. (2014) · eLife · doi:10.7554/elife.01936 · Cited by 213
Disconnecting force from money: effects of basal ganglia damage on incentive motivation
Schmidt, L., d’Arc, B. F., Lafargue, G., Galanaud, D., Czernecki, V., Grabli, D., Schüpbach, M. W. M., Hartmann, A., Lévy, R., Dubois, B., et al. (2008) · Brain · doi:10.1093/brain/awn045 · Cited by 197
Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse
Willuhn, I., Wanat, M. J., Clark, J. J., & Phillips, P. E. M. (2010) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2009_27 · Cited by 193
A Triadic Neurocognitive Approach to Addiction for Clinical Interventions
Noël, X., Brevers, D., & Bechara, A. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00179 · Cited by 210
Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0556-3 · Cited by 192
The evolutionary origin of the vertebrate basal ganglia and its role in action selection
Grillner, S., Robertson, B., & Stephenson‐Jones, M. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.246660 · Cited by 184
Anhedonia and Emotional Experience in Schizophrenia: Neural and Behavioral Indicators
Dowd, E. C., & Barch, D. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.020 · Cited by 184
Midbrain dopamine neurons bidirectionally regulate CA3-CA1 synaptic drive
Rosen, Z. B., Cheung, S., & Siegelbaum, S. A. (2015) · Nature Neuroscience · doi:10.1038/nn.4152 · Cited by 183
Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection
Surmeier, D. J., Plotkin, J. L., & Shen, W. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.10.003 · Cited by 183
Local control of striatal dopamine release
Cachope, R., & Cheer, J. F. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00188 · Cited by 191
Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds
Puig, M. V., Rose, J., Schmidt, R., & Freund, N. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00093 · Cited by 207
Neurobehavioral foundation of environmental reactivity.
Moore, S. R., & Depue, R. A. (2015) · Psychological Bulletin · doi:10.1037/bul0000028 · Cited by 183
Risk-dependent reward value signal in human prefrontal cortex
Tobler, P. N., Christopoulos, G. I., O’Doherty, J. P., Dolan, R. J., & Schultz, W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809599106 · Cited by 185
Self-citation
Phasic dopamine release in appetitive behaviors and drug addiction
Wanat, M., Willuhn, I., Clark, J., & Phillips, P. (2009) · Current Drug Abuse Reviewse · doi:10.2174/1874473710902020195 · Cited by 177
Transient Firing of Dorsal Raphe Neurons Encodes Diverse and Specific Sensory, Motor, and Reward Events
Ranade, S., & Mainen, Z. F. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00507.2009 · Cited by 174
Influence of reward motivation on human declarative memory
Lombard, E., Bavelier, D., & Schwartz, S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.015 · Cited by 191
Tonic Dopamine Modulates Exploitation of Reward Learning
Beeler, J. A., Daw, N. D., Frazier, C. R. M., & Zhuang, X. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00170 · Cited by 183
Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System
Peters, K. Z., Cheer, J. F., & Tonini, R. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.02.001 · Cited by 180
A top-down perspective on dopamine, motivation and memory
Phillips, A. G., Vacca, G., & Ahn, S. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.10.014 · Cited by 169
New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system
Volman, S. F., Lammel, S., Margolis, E. B., Kim, Y., Richard, J. M., Roitman, M. F., & Lobo, M. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3250-13.2013 · Cited by 168
Neuropharmacology of performance monitoring
Jocham, G., & Ullsperger, M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.011 · Cited by 177
Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors
Morel, C., Montgomery, S. E., Li, L., Cuttoli, R. D.-D., Teichman, E. M., Juarez, B., Tzavaras, N., Ku, S. M., Flanigan, M. E., Cai, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29155-1 · Cited by 178
Drug‐Target Residence Time—A Case for G Protein‐Coupled Receptors
Guo, D. M., Hillger, J. M., IJzerman, A. P., & Heitman, L. H. (2014) · Medicinal Research Reviews · doi:10.1002/med.21307 · Cited by 167
Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine
Shapiro, M. G., Westmeyer, G. G., Romero, P. A., Szablowski, J. O., Küster, B., Shah, A. T., Otey, C. R., Langer, R., Arnold, F. H., & Jasanoff, A. (2010) · Nature Biotechnology · doi:10.1038/nbt.1609 · Cited by 170
Individual variation in resisting temptation: Implications for addiction
Saunders, B. T., & Robinson, T. E. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.008 · Cited by 177
The phasic dopamine signal maturing: from reward via behavioural activation to formal economic utility
Schultz, W., Stauffer, W. R., & Lak, A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.013 · Cited by 171
Self-citation
Mechanisms and regulation of dopamine release
Liu, C., & Kaeser, P. S. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.01.001 · Cited by 175
Controls of tonic and phasic dopamine transmission in the dorsal and ventral striatum
Zhang, L., Doyon, W. M., Clark, J. J., Phillips, P. E. M., & Dani, J. A. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.056317 · Cited by 161
Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction
Jarcho, J. M., Mayer, E. A., Jiang, Z. K., Feier, N. A., & London, E. D. (2012) · Pain · doi:10.1016/j.pain.2012.01.002 · Cited by 160
A unified selection signal for attention and reward in primary visual cortex
Stănişor, L., van der Togt, C., Pennartz, C. M. A., & Roelfsema, P. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300117110 · Cited by 158
Principles of Neuroplasticity-Based Rehabilitation
Nahum, M., Lee, H., & Merzenich, M. M. (2013) · Progress in Brain Research · doi:10.1016/b978-0-444-63327-9.00009-6 · Cited by 158
Generating bursts (and pauses) in the dopamine midbrain neurons
Paladini, C. A., & Roeper, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.032 · Cited by 167
Effects of Drugs of Abuse on Putative Rostromedial Tegmental Neurons, Inhibitory Afferents to Midbrain Dopamine Cells
Lecca, S., Melis, M., Luchicchi, A., Ennas, M. G., Castelli, M. P., Muntoni, A. L., & Pistis, M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.190 · Cited by 158
A Meta-Analysis of Decision-Making and Attention in Adults With ADHD
Mowinckel, A. M., Pedersen, M. L., Eilertsen, E., & Biele, G. (2015) · Journal of Attention Disorders · doi:10.1177/1087054714558872 · Cited by 158
Development of pharmacotherapies for drug addiction: a Rosetta stone approach
Koob, G. F., Kenneth Lloyd, G., & Mason, B. J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2828 · Cited by 154
Aversive behavior induced by optogenetic inactivation of ventral tegmental area dopamine neurons is mediated by dopamine D2 receptors in the nucleus accumbens
Danjo, T., Yoshimi, K., Funabiki, K., Yawata, S., & Nakanishi, S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404323111 · Cited by 162
Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement
Tolu, S., Eddine, R., Marti, F., David, V, Graupner, M., Pons, S., Baudonnat, M., Husson, M., Besson, M., Reperant, C., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.83 · Cited by 151
THE BEHAVIORAL PHARMACOLOGY OF EFFORT‐RELATED CHOICE BEHAVIOR: DOPAMINE, ADENOSINE AND BEYOND
Salamone, J. D., Correa, M., Nunes, E. J., Randall, P. A., & Pardo, M. (2012) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.2012.97-125 · Cited by 151
‘Salience syndrome’ replaces ‘schizophrenia’ in DSM‐V and ICD‐11: psychiatry’s evidence‐based entry into the 21st century?
van Os, J. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01456.x · Cited by 156
In Vivo Electrochemical Sensors for Neurochemicals: Recent Update
Xu, C., Wu, F., Yu, P., & Mao, L. (2019) · ACS Sensors · doi:10.1021/acssensors.9b01713 · Cited by 149
Synaptically driven state transitions in distal dendrites of striatal spiny neurons
Plotkin, J. L., Day, M., & Surmeier, D. J. (2011) · Nature Neuroscience · doi:10.1038/nn.2848 · Cited by 157
Distinct Tonic and Phasic Anticipatory Activity in Lateral Habenula and Dopamine Neurons
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.016 · Cited by 164
Phasic Dopamine Release Drives Rapid Activation of Striatal D2-Receptors
Marcott, P. F., Mamaligas, A. A., & Ford, C. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.058 · Cited by 145
Ca v 1.3 Channel Voltage Dependence, Not Ca 2+ Selectivity, Drives Pacemaker Activity and Amplifies Bursts in Nigral Dopamine Neurons
Putzier, I., Kullmann, P. H. M., Horn, J. P., & Levitan, E. S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4742-09.2009 · Cited by 145
Adolescent cognitive control and reward processing: Implications for risk taking and substance use
Geier, C. F. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.02.008 · Cited by 160
Monoaminergic Neuromodulation of Sensory Processing
Jacob, S. N., & Nienborg, H. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00051 · Cited by 147
Chemistry of the Adaptive Mind: Lessons from Dopamine
Cools, R. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.035 · Cited by 150
Reward-related processing in the human brain: developmental considerations
Fareri, D. S., Martin, L. N., & Delgado, M. R. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000576 · Cited by 141
New insights on the subcortical representation of reward
Hikosaka, O., Bromberg-Martin, E. S., Hong, S., & Matsumoto, M. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.07.002 · Cited by 149
Taste and smell processing in the brain
Rolls, E. T. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63855-7.00007-1 · Cited by 150
Dopamine subsystems that track internal states
Grove, J. C. R., Gray, L. A., Medina, N. L. S., Sivakumar, N., Ahn, J. S., Corpuz, T. V., Berke, J. D., Kreitzer, A. C., & Knight, Z. A. (2022) · Nature · doi:10.1038/s41586-022-04954-0 · Cited by 148
Dopamine D 1 or D 2 receptor‐expressing neurons in the central nervous system
Wei, X., Ma, T., Cheng, Y., Huang, C. C., Wang, X., Lu, J., & Wang, J. (2017) · Addiction Biology · doi:10.1111/adb.12512 · Cited by 146
New perspectives on catecholaminergic regulation of executive circuits: evidence for independent modulation of prefrontal functions by midbrain dopaminergic and noradrenergic neurons
Chandler, D. J., Waterhouse, B. D., & Gao, W. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00053 · Cited by 143
The Origins of Oxidant Stress in Parkinson's Disease and Therapeutic Strategies
Surmeier, D. J., Guzmán, J. N., Sánchez-Padilla, J., & Goldberg, J. A. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3521 · Cited by 142
Dopamine midbrain neurons in health and Parkinson’s disease: Emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels
Dragicevic, E., Schiemann, J. M., & Liss, B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.037 · Cited by 141
Membrane Properties of Striatal Direct and Indirect Pathway Neurons in Mouse and Rat Slices and Their Modulation by Dopamine
Planert, H., Berger, T. K., & Silberberg, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057054 · Cited by 137
Dopamine’s Effects on Corticostriatal Synapses during Reward-Based Behaviors
Bamford, N. S., Wightman, R. M., & Sulzer, D. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.006 · Cited by 142
Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources
Beeler, J. A., Frazier, C. R. M., & Zhuang, X. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00049 · Cited by 136
Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety
Nguyen, C., Mondoloni, S., Le Borgne, T., Centeno, I., Come, M., Jehl, J., Solié, C., Reynolds, L. M., Durand-de Cuttoli, R., Tolu, S., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.06.013 · Cited by 136
21st century neurobehavioral theories of decision making in addiction: Review and evaluation
Bickel, W. K., Mellis, A. M., Snider, S. E., Athamneh, L. N., Stein, J. S., & Pope, D. A. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.09.009 · Cited by 134
Can’t or Won’t? Immunometabolic Constraints on Dopaminergic Drive
Treadway, M. T., Cooper, J. A., & Miller, A. H. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.03.003 · Cited by 141
Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease
Good, C. H., Hoffman, A. F., Hoffer, B. J., Chefer, V. I., Shippenberg, T. S., Bäckman, C. M., Larsson, N., Olson, L., Gellhaar, S., Galter, D., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-173625 · Cited by 134
Dopamine modulates neural networks involved in effort-based decision-making
Assadi, S. M., Yücel, M., & Pantelis, C. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.010 · Cited by 140
Creativity, brain, and art: biological and neurological considerations
Zaidel, D. W. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00389 · Cited by 140
The dopaminergic reward system underpins gender differences in social preferences
Soutschek, A., Burke, C. J., Beharelle, A. R., Schreiber, R., Weber, S. C., Karipidis, I. I., Velden, J. T., Weber, B., Haker, H., Kalenscher, T., et al. (2017) · Nature Human Behaviour · doi:10.1038/s41562-017-0226-y · Cited by 141
The why, what, where, when and how of goal-directed choice: neuronal and computational principles
Verschure, P. F. M. J., Pennartz, C. M. A., & Pezzulo, G. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0483 · Cited by 131
“…such as comparison—at least in the domain of reward and appetitive learning—is the reward-prediction-error mechanism that may be implemented by mesodiencephalic dopaminergic neurons projecting to striatum and prefrontal cortex [125], while the habenula has been implied in aversive learning [126].”
Background
A Role for Phasic Dopamine Release within the Nucleus Accumbens in Encoding Aversion: A Review of the Neurochemical Literature
Wenzel, J. M., Rauscher, N. A., Cheer, J. F., & Oleson, E. B. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn500255p · Cited by 131
Central fatigue theory and endurance exercise: Toward an interoceptive model
McMorris, T., Barwood, M. J., & Corbett, J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.024 · Cited by 143
What causes the death of dopaminergic neurons in Parkinson’s disease?
Surmeier, D. J., Guzmán, J. N., Sánchez-Padilla, J., & Goldberg, J. A. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)83004-3 · Cited by 132
Unmasking the mysteries of the habenula in pain and analgesia
Shelton, L., Becerra, L. R., & Borsook, D. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.01.004 · Cited by 134
Cholinergic modulation of striatal microcircuits
Abudukeyoumu, N., Hernández-Flores, T., Garcia-Munoz, M., & Arbuthnott, G. W. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13949 · Cited by 144
Neural Basis of Motivational and Cognitive Control
Mars, R., Sallet, J., Mfs., R., & Yeung, N. (2011) · The MIT Press eBooks · doi:10.7551/mitpress/9780262016438.001.0001 · Cited by 128

Authors: Schultz, W.
Affiliations: University of Cambridge (GB)
Corresponding author: Schultz, Wolfram
ORCID: Schultz, Wolfram
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2007-07-01
Volume: 30
Issue: 1
Pages: 259-288
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev.neuro.28.061604.135722
OpenAlex: W2096193724
Cited by: 1,415
References: 201
Citations by year: 2026: 47 · 2025: 58 · 2024: 73 · 2023: 73 · 2022: 75 · 2021: 68 · 2020: 66 · 2019: 63 · 2018: 66 · 2017: 74 · 2016: 79 · 2015: 100 · 2014: 99 · 2013: 87 · 2012: 85
FWCI: 5.96
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (095495)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: dopamine, midbrain dopaminergic neurons, reward, uncertainty, punishment, motor control, cognitive function, motivation, Parkinson's disease, behavioral deficits, lesion studies
MeSH terms: Animals, Behavior, Animal, Brain, Decision Making, Dopamine, Humans, Movement, Movement Disorders, Neural Pathways, Synaptic Transmission, Reward

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Multiple Dopamine Functions at Different Time Courses

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks