Cited by 1,260Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietPomegranate: compositions and health benefits

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I NHIBITION OF C ARCINOGENESIS BY D IETARY P OLYPHENOLIC C OMPOUNDS

Yang, Chung S, Landau, Janelle M, Huang, Mou-Tuan, Newmark, Harold L·2001·Annual Review of Nutrition

DOI 10.1146/annurev.nutr.21.1.381

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Abstract

Plants consumed by humans contain thousands of phenolic compounds. The effects of dietary polyphenols are of great current interest due to their antioxidative and possible anticarcinogenic activities. A popular belief is that dietary polyphenols are anticarcinogens because they are antioxidants, but direct evidence for this supposition is lacking. This chapter reviews the inhibition of tumorigenesis by phenolic acids and derivatives, tea and catechins, isoflavones and soy preparations, quercetin and other flavonoids, resveratrol, and lignans as well as the mechanisms involved based on studies in vivo and in vitro. Polyphenols may inhibit carcinogenesis by affecting the molecular events in the initiation, promotion, and progression stages. Isoflavones and lignans may influence tumor formation by affecting estrogen-related activities. The bioavailability of the dietary polyphenols is discussed extensively, because the tissue levels of the effective compounds determine the biological activity. Understanding the bioavailability and blood and tissue levels of polyphenols is also important in extrapolating results from studies in cell lines to animal models and humans. Epidemiological studies concerning polyphenol consumption and human cancer risk suggest the protective effects of certain food items and polyphenols, but more studies are needed for clear-cut conclusions. Perspectives on the application of dietary polyphenols for the prevention of human cancer and possible concerns on the consumption of excessive amounts of polyphenols are discussed.

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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658
Antioxidant and Prooxidant Behavior of Flavonoids: Structure-Activity Relationships
Cao, G., Sofic, E., & Prior, R. L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00351-6 · Cited by 2,415
Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
Guido, S., Joy, D. C., Joseph, T., Majeed, M. A., Rajendran, R., & Srinivas, P. (1998) · Planta Medica · doi:10.1055/s-2006-957450 · Cited by 1,976
Soy intake and cancer risk: A review of the in vitro and in vivo data
Messina, M. J., Persky, V., Setchell, K. D. R., & Barnes, S. (1994) · Nutrition and Cancer · doi:10.1080/01635589409514310 · Cited by 1,315
Phyto-oestrogens and Western Diseases
Adlercreutz, H., & Mazur, W. (1997) · Annals of Medicine · doi:10.3109/07853899709113696 · Cited by 1,282
Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands
Hertog, M. G. L., Hollman, P. C. H., Katan, M. B., & Kromhout, D. (1993) · Nutrition and Cancer · doi:10.1080/01635589309514267 · Cited by 1,216
Tea and Cancer
Yang, C. S., & Wang, Z.-Y. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.13.1038 · Cited by 995
Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
Hollman, P. C. H., de Vries, J., van Leeuwen, S., Mengelers, M. J. B., & Katan, M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1276 · Cited by 956
Phenol Antioxidant Quantity and Quality in Foods: Vegetables
Vinson, J. A., Hao, Y., Su, X., & Zubik, L. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980295o · Cited by 948

Show all 120 references

Research works printed but not linked: 26

Chung F-L, 1998, Cancer Res., 58, 4096
Constantinou AI, 1996, Anticancer Res., 16, 3293
Dorai T, 2000, Mol. Urol., 4, 1
Ferry DR, 1996, Clin. Cancer Res., 2, 659
Hsieh TC, 2000, Anticancer Res., 20, 225
Huang M-T, 1994, Cancer Res., 54, 5841
Huang M-T, 1988, Cancer Res., 48, 5941
Huang M-T, 1997, Cancer Res., 57, 2623
Jang M, 1999, Drugs Exp. Clin. Res., 25, 65
Katiyar SK, 1996, Int. J. Oncol., 8, 221
Kawamori T, 1999, Cancer Res., 59, 597
Leth T, Justesen U. 1998. Analysis of flavonoids in fruits, vegetables and beverages by HPLC-UV and LC-MS and estimation of the total daily flavonoid intake in Denmark. InPolyphenols in Food, ed. R Amado, H Andersson, S Bardocz, F Serra, pp. 39–40. Luxembourg: Off. Off. Publ. Eur. Commun.
Lu LJ, 2000, Cancer Res., 60, 4112
Lu LJ, 2000, Cancer Res., 60, 1299
Makita H, 1996, Cancer Res., 56, 4904
Mitchell SH, 1999, Cancer Res., 59, 5892
Rao CV, 1997, Cancer Res., 57, 3717
Su LJ, 2000, Proc. Ann. Meet. Am. Assoc. Cancer Res.,
Su S-J, 2000, Clin. Cancer Res., 6, 230
Verma AK, 1988, Cancer Res., 48, 5754
Wolffram S, 1995, J. Nutr., 125, 1300
Xu Y, 1992, Cancer Res., 52, 3875
Yamane T, 1995, Cancer Res., 55, 2081
Yang CS, 1998, Cancer Epidemiol. Biomark. Prev., 7, 351
Yang G-Y, 1997, Cancer Res., 57, 1889
Zhou JR, 1998, Cancer Res., 58, 5231

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Enzymatic Synthesis of Novel Phloretin Glucosides
Pandey, R. P., Li, T. F., Kim, E., Yamaguchi, T., Park, Y. I., Kim, J. S., & Sohng, J. K. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.00409-13 · Cited by 95
The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin
Siegelin, M. D., Reuß, D., Habel, A., Herold‐Mende, C. C., & von Deimling, A. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0236 · Cited by 95
Epigenetics: A New Link Between Nutrition and Cancer
Šupić, G., Jagodic, M., & Magić, Z. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.805794 · Cited by 95
Plants of the genus Vitis: Phenolic compounds, anticancer properties and clinical relevance
Salehi, B., Vlaisavljević, S., Adetunji, C. O., Adetunji, J. B., Kręgiel, D., Antolak, H., Pawlikowska, E., Uprety, Y., Mileski, K. S., Devkota, H. P., et al. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.07.042 · Cited by 102
Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin
Girish, C., & Pradhan, S. C. (2008) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2008.00618.x · Cited by 94
Disposition of Naringenin via Glucuronidation Pathway Is Affected by Compensating Efflux Transporters of Hydrophilic Glucuronides
Xu, H., Kulkarni, K. H., Singh, R., Yang, Z., Wang, S. W. J., Tam, V. H., & Hu, M. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900013d · Cited by 93
Nutritional, functional, and bioactive properties of african underutilized legumes
Popoola, J. O., Ojuederie, O. B., Aworunse, O. S., Adelekan, A. O., Oyelakin, A. S., Oyesola, O. L., Akinduti, P. A., Dahunsi, S. O., Adegboyega, T. T., Oranusi, S. U., et al. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1105364 · Cited by 92
Selection of elderberry (Sambucus nigra L.) genotypes best suited for the preparation of elderflower extracts rich in flavonoids and phenolic acids
Christensen, L. P., Kaack, K., & Fretté, X. C. (2007) · European Food Research and Technology · doi:10.1007/s00217-007-0723-8 · Cited by 92
Protection against hepatic ischemia-reperfusion injury in rats by oral pretreatment with quercetin.
Su, J., Guo, C., Wei, J., Yang, J.-J., Jiang, Y., & Li, Y.-F. (2003) · PubMed · Cited by 92
Phenolic Antioxidants from the Heartwood of Acacia confusa
Wu, J., Tung, Y., Wang, S., Shyur, L., Kuo, Y., & Chang, S. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050550m · Cited by 90
Resveratrol inhibits oral squamous cell carcinoma through induction of apoptosis and G2/M phase cell cycle arrest
Xiao-dong, Y., Yang, J.-L., Zhang, W., & Liu, D. (2015) · Tumor Biology · doi:10.1007/s13277-015-3793-4 · Cited by 89
DNA Adducts with Antioxidant Flavonoids: Morin, Apigenin, and Naringin
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Effects of surfactant micelles on solubilization and DPPH radical scavenging activity of Rutin
Chat, O. A., Najar, M. H., Mir, M. A., Rather, G. M., & Dar, A. A. (2010) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2010.11.044 · Cited by 88
Effect of polyphenols-membrane interactions on the performance of membrane-based processes. A review
Cassano, A., Luca, G. D., Conidi, C., & Drioli, E. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.06.013 · Cited by 88
Plant polyphenols associated with vitamin E can reduce plasma lipoperoxidation in dairy cows given n-3 polyunsaturated fatty acids
Gobert, M., Martin, B., Ferlay, A., Chilliard, Y., Graulet, B., Pradel, P., Bauchart, D., & Durand, D. (2009) · Journal of Dairy Science · doi:10.3168/jds.2009-2087 · Cited by 87
Drying kinetics and thermal degradation of phenolic compounds and anthocyanins in pomegranate arils dried under vacuum conditions
Karaaslan, M., Yılmaz, F. M., Cesur, Ö., Vardın, H., İkinci, A., & Dalgıç, A. Ç. (2013) · International Journal of Food Science & Technology · doi:10.1111/ijfs.12342 · Cited by 87
Hibiscus sabdariffa leaf induces apoptosis of human prostate cancer cells in vitro and in vivo
Lin, H., Chan, K., Sheu, J.-Y., Hsuan, S., Wang, C., & Chen, J. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.11.057 · Cited by 87
Apigenin inhibits renal cell carcinoma cell proliferation
Meng, S., Zhu, Y., Li, J., Wang, X., Liang, Z. C., Li, S., Xu, X., Chen, H., Liu, B., Zheng, X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15771 · Cited by 89
Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells
Vrhovac, I., Madunić, J., Antunović, M., Paradžik, M., Garaj‐Vrhovac, V., Breljak, D., Marijanović, I., & Gajski, G. (2018) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-018-1486-4 · Cited by 87
A review of plant metabolites with metal interaction capacity: a green approach for industrial applications
Nobahar, A., Carlier, J., Miguel, M. G., & Costa, M. C. (2021) · BioMetals · doi:10.1007/s10534-021-00315-y · Cited by 93
Inhibition of Rat Mammary Tumorigenesis by Concord Grape Juice Constituents
Singletary, K. W., Stansbury, M. J., Giusti, M. M., van Breemen, R. B., Wallig, M. A., & Rimando, A. M. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030278l · Cited by 86
Resveratrol Antagonizes EGFR-Dependent Erk1/2 Activation in Human Androgen-Independent Prostate Cancer Cells with Associated Isozyme-Selective PKCα Inhibition
Stewart, J. R., & O’Brian, C. A. (2004) · Investigational New Drugs · doi:10.1023/b:drug.0000011787.75522.ec · Cited by 86
Dietary antioxidants in the prevention of hepatocarcinogenesis: A review
Glauert, H. P., Calfee-Mason, K. G., Stemm, D. N., Tharappel, J. C., & Spear, B. T. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900482 · Cited by 90
Effect of genistein on the pharmacokinetics of paclitaxel administered orally or intravenously in rats
Li, X., & Choi, J. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.01.002 · Cited by 85
Flavonols in fresh and processed Brazilian fruits
Ribani, R. H., Huber, L. S., & Rodriguez–Amaya, D. B. (2009) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2008.12.004 · Cited by 85
Cytotoxic polyphenols against breast tumor cell in Smilax china L.
Wu, L., Wang, X., Wang, H., Yang, H.-W., Jia, A., & Ding, Q. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.05.032 · Cited by 85
Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells
Wenzel, U., Herzog, A., Kuntz, S., & Daniel, H. (2004) · PROTEOMICS · doi:10.1002/pmic.200300726 · Cited by 85
Lignans: Quantitative Analysis of the Research Literature
Yeung, A. W. K., Tzvetkov, N. T., Balacheva, A. A., Georgieva, M. G., Gan, R., Jóźwik, A., Pyzel, B., Horbańczuk, J. O., Novellino, E., Durazzo, A., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00037 · Cited by 87

Authors: Yang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L.
Affiliations: Rutgers, The State University of New Jersey (US)
ORCID: Yang, Chung S
Venue: Annual Review of Nutrition
Publisher: Annual Reviews
Published: 2001-07
Volume: 21
Issue: 1
Pages: 381-406
ISSN: 0199-9885 (ISSN-L)
1545-4312
DOI: 10.1146/annurev.nutr.21.1.381
OpenAlex: W2158944838
Cited by: 1,260
References: 120
Citations by year: 2026: 14 · 2025: 18 · 2024: 23 · 2023: 39 · 2022: 45 · 2021: 55 · 2020: 43 · 2019: 50 · 2018: 52 · 2017: 59 · 2016: 56 · 2015: 61 · 2014: 71 · 2013: 65 · 2012: 69
FWCI: 4.54
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA056673, CA56673)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: dietary polyphenols, anticarcinogenic activity, carcinogenesis inhibition, antioxidants, phenolic acids, tea catechins, isoflavones, soybean, quercetin, flavonoids, resveratrol, lignans, bioavailability, cancer prevention, cancer risk
MeSH terms: Absorption, Antioxidants, Biological Availability, Biotransformation, Catechin, Diet, Flavonoids, Humans, Isoflavones, Phenols, Polymers, Tea, Anticarcinogenic Agents

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