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The Regulator of G Protein Signaling Family

De Vries, Luc, Zheng, Bin, Fischer, Thierry, Elenko, Eric, Farquhar, Marilyn G.·2000·Annual Review of Pharmacology and Toxicology
DOI 10.1146/annurev.pharmtox.40.1.235
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Abstract

Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G protein–coupled receptor signaling pathways. The major mechanism whereby RGS proteins negatively regulate G proteins is via the GTPase activating protein activity of their RGS domain. Structural and mutational analyses have characterized the RGS/Gα interaction in detail, explaining the molecular mechanisms of the GTPase activating protein activity of RGS proteins. More than 20 RGS proteins have been isolated, and there are indications that specific RGS proteins regulate specific G protein–coupled receptor pathways. This specificity is probably created by a combination of cell type–specific expression, tissue distribution, intracellular localization, posttranslational modifications, and domains other than the RGS domain that link them to other signaling pathways. In this review we discuss what has been learned so far about the role of RGS proteins in regulating G protein–coupled receptor signaling and point out areas that may be fruitful for future research.

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Metadata

Authors
De Vries, L., Zheng, B., Fischer, T., Elenko, E., & Farquhar, M. G.
Venue
Annual Review of Pharmacology and Toxicology
Publisher
Annual Reviews
Published
2000-04
Volume
40
Issue
1
Pages
235-271
ISSN
  • 0362-1642 (ISSN-L)
  • 1545-4304
DOI
10.1146/annurev.pharmtox.40.1.235
OpenAlex
W2148882351
Cited by
592
References
2
FWCI
3.42
Type
journal article
Language
en
Open access
closed

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De Vries, L., Zheng, B., Fischer, T., Elenko, E., & Farquhar, M. G. (2000). The Regulator of G Protein Signaling Family. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.40.1.235

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