The biochemical basis of zinc physiology

Zinc and immune function: the biological basis of altered resistance to infection

Shankar, A. H., & Prasad, A. S. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.447s · Cited by 1,606

The Essential Toxin: Impact of Zinc on Human Health

Plum, L. M., Rink, L., & Haase, H. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041342 · Cited by 1,577

The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism

Kambe, T., Tsuji, T., Hashimoto, A., & Itsumura, N. (2015) · Physiological Reviews · doi:10.1152/physrev.00035.2014 · Cited by 1,158

Small-Molecule Two-Photon Probes for Bioimaging Applications

Kim, H. M., & Cho, B. R. (2015) · Chemical Reviews · doi:10.1021/cr5004425 · Cited by 1,047

Zinc biochemistry: From a single zinc enzyme to a key element of life

Maret, W. (2013) · Advances in Nutrition · doi:10.3945/an.112.003038 · Cited by 818

The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus

Gerber, P. A., & Rutter, G. A. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6755 · Cited by 654

Vitamin and mineral status: effects on physical performance

Lukaski, H. C. (2004) · Nutrition · doi:10.1016/j.nut.2004.04.001 · Cited by 587

Cutaneous photodamage, oxidative stress, and topical antioxidant protection

Pinnell, S. R. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.16 · Cited by 544

Preferential Zn 2+ influx through Ca 2+ -permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production

Sensi, S. L., Yin, H. Z., Carriedo, S. G., Rao, S. S., & Weiss, J. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2414 · Cited by 408

In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion

Chimienti, F., Devergnas, S., Pattou, F., Schuit, F., Garcia-Cuenca, R., Vandewalle, B., Kerr-Conte, J., Van Lommel, L., Grunwald, D., Favier, A., et al. (2006) · Journal of Cell Science · doi:10.1242/jcs.03164 · Cited by 349

The immune system and the impact of zinc during aging

Haase, H., & Rink, L. (2009) · Immunity & Ageing · doi:10.1186/1742-4933-6-9 · Cited by 334

ZIF-8-Modified multifunctional bone-adhesive hydrogels promoting angiogenesis and osteogenesis for bone regeneration

Liu, Y., Zhu, Z., Pei, X., Zhang, X., Cheng, X., Hu, S., Gao, X., Wang, J., Chen, J., & Wan, Q. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c12090 · Cited by 259

Magnesium, zinc, and chromium nutriture and physical activity

Lukaski, H. C. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.585s · Cited by 209

Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor

Choi, Y.-B., & Lipton, S. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80763-1 · Cited by 180

Daily intake of essential minerals and metallic micropollutants from foods in France

BIEGO, G., JOYEUX, M., HARTEMANN, P., & DEBRY, G. (1998) · The Science of The Total Environment · doi:10.1016/s0048-9697(98)00160-0 · Cited by 166

The Y ersinia pestis siderophore, yersiniabactin, and the ZnuABC system both contribute to zinc acquisition and the development of lethal septicaemic plague in mice

Bobrov, A. G., Kirillina, O., Fetherston, J. D., Miller, M. C., Burlison, J. A., & Perry, R. D. (2014) · Molecular Microbiology · doi:10.1111/mmi.12693 · Cited by 149

Regulation of T cell receptor signaling by activation-induced zinc influx

Yu, M., Lee, W.-W., Tomar, D., Pryshchep, S., Czesnikiewicz-Guzik, M., Lamar, D. L., Li, G., Singh, K., Tian, L., Weyand, C. M., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20100031 · Cited by 153

Blockade of Ca2+-Permeable AMPA/Kainate Channels Decreases Oxygen–Glucose Deprivation-Induced Zn2+Accumulation and Neuronal Loss in Hippocampal Pyramidal Neurons

Yin, H. Z., Sensi, S. L., Ogoshi, F., & Weiss, J. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01273.2002 · Cited by 143

Zinc uptake by Streptococcus pneumoniae depends on both AdcA and AdcAII and is essential for normal bacterial morphology and virulence: Zinc uptake of Streptococcus pneumoniae

Bayle, L., Chimalapati, S., Schoehn, G., Brown, J., Vernet, T., & Durmort, C. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07862.x · Cited by 137

Antiatherogenic properties of zinc: implications in endothelial cell metabolism

Hennig, B., Toborek, M., & McClain, C. J. (1996) · Nutrition · doi:10.1016/s0899-9007(96)00125-6 · Cited by 132

Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+Modulation of the NMDA Receptor

Choi, Y.-B., Chen, H.-S. V., & Lipton, S. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00392.2001 · Cited by 132

Zinc and skin biology

Ogawa, Y., Kawamura, T., & Shimada, S. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.06.003 · Cited by 123

AdcAII, a new pneumococcal Zn-binding protein homologous with ABC transporters: biochemical and structural analysis

Loisel, E., Jacquamet, L., Serre, L., Bauvois, C., Ferrer, J. L., Vernet, T., Di Guilmi, A. M., & Durmort, C. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.05.068 · Cited by 115

Maternal Supplemental and Dietary Zinc Intake and the Occurrence of Neural Tube Defects in California

Velie, E. M., Block, G., Shaw, G. M., Samuels, S. J., Schaffer, D. M., & Kulldorff, M. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010059 · Cited by 107

Acinetobacter baumannii Response to Host-Mediated Zinc Limitation Requires the Transcriptional Regulator Zur

Mortensen, B. L., Rathi, S., Chazin, W. J., & Skaar, E. P. (2014) · Journal of Bacteriology · doi:10.1128/jb.01650-14 · Cited by 94

Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results

Roselli, M., Finamore, A., Britti, M. S., Bosi, P., Oswald, I., & Mengheri, E. (2005) · Animal Research · doi:10.1051/animres:2005012 · Cited by 97

Zinc nutritional status in obese children and adolescents

Cozzolino, S. M. F., Marreiro, D. D. N., & Fisberg, M. (2002) · Biological Trace Element Research · doi:10.1385/bter:86:2:107 · Cited by 96

Zinc and Central Nervous System Disorders

Wang, B., Fang, T., & Chen, H. (2023) · Nutrients · doi:10.3390/nu15092140 · Cited by 93

Zinc attenuates tumor necrosis factor-mediated activation of transcription factors in endothelial cells

Connell, P., Young, V. M., Toborek, M., Cohen, D. A., Barve, S., McClain, C. J., & Hennig, B. (1997) · Journal of the American College of Nutrition · doi:10.1080/07315724.1997.10718706 · Cited by 87

A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease

Lovell, M. A. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0992 · Cited by 87

Analysis of Copper and Zinc Plasma Concentration and the Efficacy of Zinc Therapy in Individuals with Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and Autism

Russo, A. J., & deVito, R. (2011) · Biomarker Insights · doi:10.4137/bmi.s7286 · Cited by 80

Metallothionein: a Potential Link in the Regulation of Zinc in Nutritional Immunity

Rahman, M. T., & Karim, M. M. (2018) · Biological Trace Element Research · doi:10.1007/s12011-017-1061-8 · Cited by 77

Metal Binding Specificity of the MntABC Permease of Neisseria gonorrhoeae and Its Influence on Bacterial Growth and Interaction with Cervical Epithelial Cells

Lim, K. H. L., Jones, C. E., vanden Hoven, R. N., Edwards, J. L., Falsetta, M. L., Apicella, M. A., Jennings, M. P., & McEwan, A. G. (2008) · Infection and Immunity · doi:10.1128/iai.01725-07 · Cited by 72

Hair zinc levels and the efficacy of oral zinc supplementation in patients with atopic dermatitis

Kim, J., Yoo, S., Jeong, M., Ko, J., & Ro, Y. (2014) · Acta Dermato Venereologica · doi:10.2340/00015555-1772 · Cited by 71

Diabetes, metallothionein, and zinc interactions: A review

Islam, M. S., & Loots, D. T. (2007) · BioFactors · doi:10.1002/biof.5520290404 · Cited by 59

Mechanism of HIV Reverse Transcriptase Inhibition by Zinc

Fenstermacher, K. J., & DeStefano, J. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.289850 · Cited by 53

Characterization of the hsp70 response in lymphoblasts from aged and centenarian subjects and differential effects of in vitro zinc supplementation

Ambra, R., Mocchegiani, E., Giacconi, R., Canali, R., Rinna, A., Malavolta, M., & Virgili, F. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.07.009 · Cited by 49

Zinc in skin pathology and care

Bibi Nitzan, Y., & Cohen, A. D. (2006) · Journal of Dermatological Treatment · doi:10.1080/09546630600791434 · Cited by 47

Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene

Kurita, H., Ohsako, S., Hashimoto, S.-I., Yoshinaga, J., & Tohyama, C. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.05.013 · Cited by 45

Zinc improves gene transfer mediated by DNA/cationic polymer complexes

Pichon, C., Guérin, B., Réfrégiers, M., Gonçalves, C., Vigny, P., & Midoux, P. (2002) · The Journal of Gene Medicine · doi:10.1002/jgm.303 · Cited by 42

Stress Responses of Human Dermal Fibroblasts Exposed to Zinc Pyrithione

Rudolf, E., & Cervinka, M. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.04.028 · Cited by 36

ZnuD, a Potential Candidate for a Simple and Universal Neisseria meningitidis Vaccine

Hubert, K., Devos, N., Mordhorst, I., Tans, C., Baudoux, G., Feron, C., Goraj, K., Tommassen, J., Vogel, U., Poolman, J. T., et al. (2013) · Infection and Immunity · doi:10.1128/iai.01312-12 · Cited by 28

Differential natural selection of human zinc transporter genes between african and non-African populations.

Zhang, C., Li, J., Tian, L., Lu, D., Yuan, K., Yuan, Y., & Xu, S. (2015) · Scientific Reports · doi:10.1038/srep09658 · Cited by 27

Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus

Teng, B., Kaplan, J. P., Liang, Z., Chyung, K. S., Goldschen-Ohm, M. P., & Liman, E. R. (2023) · eLife · doi:10.7554/elife.85317 · Cited by 16

Low Zinc Environment Induces Stress Signaling, Senescence and Mixed Cell Death Modalities in Colon Cancer Cells

Rudolf, E., & Rudolf, K. (2015) · Apoptosis · doi:10.1007/s10495-015-1182-5 · Cited by 8

Human genetic adaptation related to cellular zinc homeostasis

Roca-Umbert, A., Garcia-Calleja, J., Vogel-González, M., Fierro-Villegas, A., Ill-Raga, G., Herrera-Fernández, V., Bosnjak, A., Muntané, G., Gutiérrez, E., Campelo, F., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010950 · Cited by 8

A review of magnesium, iron, and zinc supplementation effects on athletic performance

Lee, N. (2017) · The Korean Journal of Physical Education · doi:10.23949/kjpe.2017.01.56.1.59 · Cited by 7

Single nucleotide polymorphisms and Zn transport by ZIP11 shape functional phenotypes of HeLa cells

Kim, E. Y., Verdejo-Torres, O., Diaz-Rodriguez, K., Hasanain, F., Caromile, L., & Padilla-Benavides, T. (2024) · Metallomics · doi:10.1093/mtomcs/mfae006 · Cited by 7

Surface Functionalized Zinc Composite Coatings: A Review

Awasthi, S., Palomero, B. P., Srivastava, A., Selvaraj, S., Kumar, D., & Pandey, S. K. (2025) · Advanced Engineering Materials · doi:10.1002/adem.202401597 · Cited by 6