Cited by 109Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsNuclear Structure and Function

The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.

Telomeres and immunological diseases of aging.

Open access

Andrews, Nicolas P., Fujii, Hiroshi, Goronzy, Jörg J., Weyand, Cornelia M.·2010·Gerontology

DOI 10.1159/000268620PMC PMC2917738

Open this paper in CoChat — free account

Abstract

A defining feature of the eukaryotic genome is the presence of linear chromosomes. This arrangement, however, poses several challenges with regard to chromosomal replication and maintenance. To prevent the loss of coding sequences and to suppress gross chromosomal rearrangements, linear chromosomes are capped by repetitive nucleoprotein structures, called telomeres. Each cell division results in a progressive shortening of telomeres that, below a certain threshold, promotes genome instability, senescence, and apoptosis. Telomeric erosion, maintenance, and repair take center stage in determining cell fate. Cells of the immune system are under enormous proliferative demand, stressing telomeric intactness. Lymphocytes are capable of upregulating telomerase, an enzyme that can elongate telomeric sequences and, thus, prolong cellular lifespan. Therefore, telomere dynamics are critical in preserving immune function and have become a focus for studies of immunosenescence and autoimmunity. In this review, we describe the role of telomeric nucleoproteins in shaping telomere architecture and in suppressing DNA damage responses. We summarize new insights into the regulation of telomerase activity, hereditary disorders associated with telomere dysfunction, the role of telomere loss in immune aging, and the impact of telomere dysfunction in chronic inflammatory disease.

Integrity signals

Registry

Crossref · 10.1159/000268620

Cites

148 of 148 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.
Akiyama, M., Hideshima, T., Hayashi, T., Tai, Y., Mitsiades, C. S., Mitsiades, N., Chauhan, D., Richardson, P. G. G., Munshi, N. C., & Anderson, K. C. (2003) · PubMed · Cited by 212
Retracted
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 1×
“Regulation of Telomerase ActivityIn the process of carcinogenesis, cells escape senescence through the mutation of tumor suppressor genes and survive crisis through telomerase upregulation. Thus, approximately 90p of tumor cells are positive for telomerase activity [”
Background
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
Oxidative stress shortens telomeres
von Zglinicki, T. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02110-2 · Cited by 2,524
Mammalian Telomeres End in a Large Duplex Loop
Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., & de Lange, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80760-6 · Cited by 2,447
How Shelterin Protects Mammalian Telomeres
Palm, W., & de Lange, T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130350 · Cited by 1,802
ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex
Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424
Obesity, cigarette smoking, and telomere length in women
Valdes, A., Andrew, T., Gardner, J., Kimura, M., Oelsner, E., Cherkas, L., Aviv, A., & Spector, T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66630-5 · Cited by 1,363
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
Armanios, M. Y., Chen, J. J.-L., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066157 · Cited by 1,357
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
Hemann, M. T., Strong, M. A., Hao, L.-Y., & Greider, C. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00504-9 · Cited by 1,219
Homeostasis of Naive and Memory T Cells
Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193
p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086
Requirement of the MRN complex for ATM activation by DNA damage
Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075
The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder
Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053
Ageing and infection
Gavazzi, G., & Krause, K.-H. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00437-1 · Cited by 990
X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions
Heiss, N. S., Knight, S. W., Vulliamy, T. J., Klauck, S. M., Wiemann, S., Mason, P. J., Poustka, A., & Dokal, I. (1998) · Nature Genetics · doi:10.1038/ng0598-32 · Cited by 976
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P. J., & Dokal, I. (2001) · Nature · doi:10.1038/35096585 · Cited by 960
DNA Repair, Genome Stability, and Aging
Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
Lavin, M. F. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2514 · Cited by 901
Human Telomerase and Its Regulation
Cong, Y.-S., Wright, W. E., & Shay, J. W. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.407-425.2002 · Cited by 898
Direct activation of TERT transcription by c-MYC
Wu, K.-J., Grandori, C., Amacker, M., Simon-Vermot, N., Polack, A., Lingner, J., & Dalla-Favera, R. (1999) · Nature Genetics · doi:10.1038/6010 · Cited by 893
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Denchi, E. L., & de Lange, T. (2007) · Nature · doi:10.1038/nature06065 · Cited by 880
Activation of telomerase in human lymphocytes and hematopoietic progenitor cells
Hiyama, K., Hirai, Y., Kyoizumi, S., Akiyama, M., Hiyama, E., Piatyszek, M. A., Shay, J. W., Ishioka, S., & Yamakido, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.8.3711 · Cited by 853 · cited 1×
“Lymphocytes have a unique requirement for clonal expansion that necessitates robust proliferative capacity. To circumvent growth arrest due to replication-associated telomere loss, immune cells maintain their chromosome ends via telomerase induction during entry into the cell cycle. Early studies described very low to…”
Background
Senescence and immortalization: role of telomeres and telomerase
Shay, J. W., & Wright, W. E. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh296 · Cited by 747
Telomerase maintains telomere structure in normal human cells
Kenichi, M., Yu, E. Y., Shilagardi, K., Ben‐Porath, I., Currier, J. L., Metz, G. B., Brooks, M. W., Kaneko, S., Seishi, M., DeCaprio, J. A., et al. (2006) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 738
Genetic determination of telomere size in humans: a twin study of three age groups.
Slagboom, P. E., Droog, S., & Boomsma, D. I. (1994) · PubMed Central · Cited by 734
Mutations in TERT, the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia
Yamaguchi, H., Calado, R. T., Ly, H., Kajigaya, S., Baerlocher, G. M., Chanock, S. J., Lansdorp, P. M., & Young, N. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042980 · Cited by 723
Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
Rufer, N., Brümmendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., & Lansdorp, P. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.157 · Cited by 709
The rate of telomere sequence loss in human leukocytes varies with age
Frenck, R. W., Blackburn, E. H., & Shannon, K. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5607 · Cited by 675
HIF-1α induces cell cycle arrest by functionally counteracting Myc
Koshiji, M., Kageyama, Y., Pete, E. A., Horikawa, I., Barrett, J. C., & Huang, L. E. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600196 · Cited by 652
Telomere Length as an Indicator of Biological Aging
Bénétos, A., Okuda, K., Lajemi, M., Kimura, M., Thomas, F., Skurnick, J., Labat, C., Bean, K., & Aviv, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.381 · Cited by 627
DNA methylation: past, present and future directions
Robertson, K. D., & Jones, P. A. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.461 · Cited by 613
Dyskeratosis congenita in all its forms
Dokal, I. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02109.x · Cited by 575
T‐loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang
Stansel, R. M., de Lange, T., & Griffith, J. D. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5532 · Cited by 562
Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes.
Liuzzo, G., Goronzy, J. J., Yang, H., Kopecky, S. L., Holmes, D. R., Frye, R. L., & Weyand, C. M. (2000) · Circulation · doi:10.1161/01.cir.101.25.2883 · Cited by 552
Self-citation
Genomic 5-methyldeoxycytidine decreases with age.
Wilson, V. L., Smith, R. A., Ma, S., & Cutler, R. G. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61057-9 · Cited by 521
Telomere Length in the Newborn
Okuda, K., Bardeguez, A., Gardner, J. P., Rodriguez, P., Ganesh, V., Kimura, M., Skurnick, J., Awad, G., & Aviv, A. (2002) · Pediatric Research · doi:10.1203/00006450-200209000-00012 · Cited by 507
Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT)
Kyo, S. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.3.669 · Cited by 499
Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit
Kang, S. S., Kwon, T., Kwon, D. Y., & Do, S.-I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13085 · Cited by 489
CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.
Schmidt, D., Goronzy, J. J., & Weyand, C. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118638 · Cited by 482
Self-citation
T cell homeostasis in patients with rheumatoid arthritis
Koetz, K., Bryl, E., Spickschen, K., O’Fallon, W. M., Goronzy, J. J., & Weyand, C. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9203 · Cited by 465
Self-citation
Replication and protection of telomeres
Verdun, R. E., & Karlseder, J. (2007) · Nature · doi:10.1038/nature05976 · Cited by 463
Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC
Vulliamy, T., Marrone, A., Szydlo, R., Walne, A., Mason, P. J., & Dokal, I. (2004) · Nature Genetics · doi:10.1038/ng1346 · Cited by 461
Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis
Effros, R. B., Allsopp, R., Chiu, C.-P., Hausner, M. A., Hirji, K., Wang, L., Harley, C. B., Villeponteau, B., West, M. D., & Giorgi, J. V. (1996) · AIDS · doi:10.1097/00002030-199607000-00001 · Cited by 457
The molecular inflammatory process in aging
Chung, H. Y., Sung, B., Jung, K. J., Zou, Y., & Yu, B. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.572 · Cited by 437
Site‐specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening
Oikawa, S., & Kawanishi, S. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00748-6 · Cited by 435
Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts
Petersen, S., Saretzki, G., & Zglinicki, T. V. (1998) · Experimental Cell Research · doi:10.1006/excr.1997.3893 · Cited by 427
TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita
Savage, S. A., Giri, N., Baerlocher, G. M., Orr, N., Lansdorp, P. M., & Alter, B. P. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.10.004 · Cited by 414
Accelerated Telomere Erosion Is Associated with a Declining Immune Function of Caregivers of Alzheimer’s Disease Patients
Damjanovic, A. K., Yang, Y., Glaser, R., Kiecolt‐Glaser, J. K., Nguyen, H., Laskowski, B. F., Zou, Y., Beversdorf, D. Q., & Weng, N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4249 · Cited by 413
Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.
Horikawa, I., Cable, P. L., Afshari, C. A., & Barrett, J. C. (1999) · PubMed · Cited by 393
Molecular mechanisms of aging-associated inflammation.
Sarkar, D., & Fisher, P. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.04.009 · Cited by 379
Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence
Effros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90073-6 · Cited by 377 · cited 1×
“which provides indirect evidence that telomere erosion negatively affects the maintenance of a functional memory T-cell pool in elderly individuals. T-Lymphocyte Senescence Is Associated with Low Telomerase Activity Loss of the co-stimulatory molecule CD28 on T cells is considered the best marker of T-lymphocyte aging…”
Background
Reduced telomerase activity in human T lymphocytes exposed to cortisol
Choi, J., Fauce, S. R., & Effros, R. B. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.12.004 · Cited by 352
Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentation
Vulliamy, T., Marrone, A., Knight, S. W., Walne, A. J., Mason, P. J., & Dokal, I. S. (2005) · Blood · doi:10.1182/blood-2005-07-2622 · Cited by 347
Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells
Xu, D., Popov, N., Hou, M., Wang, Q., Björkholm, M., Gruber, A., Menkel, A. R., & Arsenian‐Henriksson, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071043198 · Cited by 324
The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease
Engel, P., Eck, M. J., & Terhorst, C. (2003) · Nature reviews. Immunology · doi:10.1038/nri1202 · Cited by 323
Telomeres in T and B cells
Hodes, R. J., Hathcock, K. S., & Weng, N. (2002) · Nature reviews. Immunology · doi:10.1038/nri890 · Cited by 317
Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10
Walne, A. J., Vulliamy, T., Marrone, A., Beswick, R., Kirwan, M., Masunari, Y., Al-Qurashi, F.-H., Aljurf, M., & Dokal, I. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm111 · Cited by 316
Leukocyte Telomere Dynamics: Longitudinal Findings Among Young Adults in the Bogalusa Heart Study
Aviv, A., Chen, W., Gardner, J. P., Kimura, M., Brimacombe, M. B., Cao, X., Srinivasan, S. R., & Berenson, G. S. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn338 · Cited by 293
Expansion of unusual CD4+ T cells in severe rheumatoid arthritis
Martens, P. B., Goronzy, J. J., Schaid, D. J., & Weyand, C. M. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400615 · Cited by 290
Self-citation
Telomere Length of Circulating Leukocytes Is Decreased in Patients With Chronic Heart Failure
van der Harst, P., van der Steege, G., de Boer, R. A., Voors, A. A., Hall, A. S., Mulder, M. J., van Gilst, W. H., & van Veldhuisen, D. J. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.01.027 · Cited by 285
The many facets of H/ACA ribonucleoproteins
Meier, U. T. (2005) · Chromosoma · doi:10.1007/s00412-005-0333-9 · Cited by 281
Perturbation of the T cell repertoire in rheumatoid arthritis
Wagner, U. G., Koetz, K., Weyand, C. M., & Goronzy, J. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14447 · Cited by 278
Self-citation
Why females live longer than males? Importance of the upregulation of longevity‐associated genes by oestrogenic compounds
Viña, J., Borrás, C., Gambini, J., Sastre, J., & Pallardó, F. V. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.090 · Cited by 271
Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks
Digweed, M., & Sperling, K. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.004 · Cited by 255
Divergent Telomerase and CD28 Expression Patterns in Human CD4 and CD8 T Cells Following Repeated Encounters with the Same Antigenic Stimulus
Valenzuela, H. (2002) · Clinical Immunology · doi:10.1006/clim.2002.5271 · Cited by 254
Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis
Melchiorri, C., Melicòni, R., Frizziero, L., Silvestri, T., Pulsatelli, L., Mazzetti, I., Borzı̀, R. M., Uguccioni, M., & Facchini, A. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199812)41:12 · Cited by 254
Self-citation
Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes
Liu, K., Schoonmaker, M. M., Levine, B. L., June, C. H., Hodes, R. J., & Weng, N.-P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5147 · Cited by 233
T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection
Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.01.002 · Cited by 223
Self-citation
The loss of telomerase activity in highly differentiated CD8+CD28−CD27− T cells is associated with decreased Akt (Ser473) phosphorylation
Plunkett, F. J., Franzese, O., Finney, H. M., Fletcher, J. M., Belaramani, L. L., Salmon, M., Dokal, I., Webster, D., Lawson, A. D. G., & Akbar, A. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.7710 · Cited by 222
Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.
Kanaya, T., Kyo, S., Hamada, K., Takakura, M., Kitagawa, Y., Harada, H., & Inoue, M. (2000) · PubMed · Cited by 222
Hypoxia-Inducible Factor 1 Mediates Upregulation of Telomerase (hTERT)
Nishi, H., Nakada, T., Kyo, S., Inoue, M., Shay, J. W., & Isaka, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.6076-6083.2004 · Cited by 219
Shortened telomere length in white blood cells of patients with IDDM.
Jeanclos, E., Krolewski, A., Skurnick, J., Kimura, M., Aviv, H., Warram, J. H., & Aviv, A. (1998) · Diabetes · doi:10.2337/diabetes.47.3.482 · Cited by 217
Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages
Schönland, S. O., Lopez, C., Widmann, T., Zimmer, J., Bryl, E., Goronzy, J. J., & Weyand, C. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233561100 · Cited by 216
Self-citation
IL-7-Dependent Extrathymic Expansion of CD45RA+ T Cells Enables Preservation of a Naive Repertoire
Soares, M. V. D., Soares, D., Borthwick, N., Maini, M. K., Janossy, G., Salmon, M., & Akbar, A. N. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.5909 · Cited by 216
Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene
Renaud, S., Loukinov, D. I., Abdullaev, Z., Guilleret, I., Bosman, F. T., Lobanenkov, V. V., & Benhattar, J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1125 · Cited by 211
Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenitaPreprint
Wong, J. M. Y., & Collins, K. (2006) · Genes & Development · doi:10.1101/gad.1476206 · Cited by 208
Telomere length and heredity: Indications of paternal inheritance
Nordfjäll, K., Larefalk, Å., Lindgren, P., Holmberg, D., & Roos, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501724102 · Cited by 205
Protein Phosphatase 2A Inhibits Nuclear Telomerase Activity in Human Breast Cancer Cells
Li, H., Zhao, L., Funder, J. W., & Liu, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.16729 · Cited by 201
Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with Age
Son, N. H., Murray, S., Yanovski, J., Hodes, R. J., & Weng, N.-P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1191 · Cited by 200
Sp1 and Sp3 Recruit Histone Deacetylase to Repress Transcription of Human Telomerase Reverse Transcriptase (hTERT) Promoter in Normal Human Somatic Cells
Won, J., Yim, J., & Kim, T. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206064200 · Cited by 184
DNA damage response at functional and dysfunctional telomeresPreprint
Longhese, M. P. (2008) · Genes & Development · doi:10.1101/gad.1626908 · Cited by 184
Transfer of the human telomerase reverse transcriptase(TERT) gene into T lymphocytes results in extension of replicative potential
Rufer, N., Migliaccio, M., Antonchuk, J., Humphries, R. K., Roosnek, E. E., & Lansdorp, P. M. (2001) · Blood · doi:10.1182/blood.v98.3.597 · Cited by 180
Paternal age at birth is an important determinant of offspring telomere length
Meyer, T. D., Rietzschel, E. R., Buyzere, M. D., Bacquer, D. D., Criekinge, W. V., Backer, G. D., Gillebert, T. C., Oostveldt, P. V., Bekaert, S., & on behalf of the Asklepios investigators (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm271 · Cited by 179
Loss of CD28 expression on T lymphocytes: A marker of replicative senescence
Effros, R. B. (1997) · Developmental & Comparative Immunology · doi:10.1016/s0145-305x(97)00027-x · Cited by 175
Telomerase insufficiency in rheumatoid arthritis
Fujii, H., Shao, L., Colmegna, I., Goronzy, J. J., & Weyand, C. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811332106 · Cited by 172
Self-citation
Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes
Fauce, S. R., Jamieson, B. D., Chin, A. C., Mitsuyasu, R. T., Parish, S. T., Ng, H. L., Ramirez, C. M., Yang, O. O., Harley, C. B., & Effros, R. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7400 · Cited by 171
Identification of Mad as a repressor of the human telomerase (hTERT) gene
Oh, S., Song, Y., Yim, J., & Kim, T. K. (2000) · Oncogene · doi:10.1038/sj.onc.1203439 · Cited by 161
Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis.
Goronzy, J. J., Bartz‐Bazzanella, P., Hu, W. T., Jendro, M. C., Walser-Kuntz, D. R., & Weyand, C. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117561 · Cited by 156
Self-citation
Untitled work
(2003) · doi:10.1186/ar974 · Cited by 156
Self-citation
Histone Deacetylation Is Involved in the Transcriptional Repression of hTERT in Normal Human Cells
Cong, Y., & Bacchetti, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000637200 · Cited by 150
The Wilms' Tumor 1 Tumor Suppressor Gene Represses Transcription of the Human Telomerase Reverse Transcriptase Gene
Oh, S., Song, Y., Yim, J., & Kim, T. K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37473 · Cited by 148
CTCF binds the proximal exonic region of hTERT and inhibits its transcription
Renaud, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki989 · Cited by 142
Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study
Andriollo-Sanchez, M., Hininger‐Favier, I., Meunier, N., Venneria, E., O’Connor, J. M., Maiani, G., Coudray, C., & Roussel, A. M. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602300 · Cited by 140
Costimulatory molecules in Wegener's granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells
Moosig, F., Csernok, E., Wang, G., & Gross, W. L. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00695.x · Cited by 138
Will telomere erosion lead to a loss of T-cell memory?
Akbar, A. N., Beverley, P. C. L., & Salmon, M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1440 · Cited by 135
Telomerase levels control the lifespan of human T lymphocytes
Röth, A., Yssel, H., Pène, J., Chavez, E. A., Schertzer, M., Lansdorp, P. M., Spits, H., & Luiten, R. M. (2003) · Blood · doi:10.1182/blood-2002-07-2015 · Cited by 133
HIF-1-mediated activation of telomerase in cervical cancer cells
Yatabe, N., Kyo, S., Maida, Y., Nishi, H., Nakamura, M., Kanaya, T., Tanaka, M., Isaka, K., Ogawa, S., & Inoue, M. (2004) · Oncogene · doi:10.1038/sj.onc.1207460 · Cited by 132
Dyskeratosis congenita: The diverse clinical presentation of mutations in the telomerase complex
Vulliamy, T., & Dokal, I. S. (2007) · Biochimie · doi:10.1016/j.biochi.2007.07.017 · Cited by 131
Transforming Growth Factor β Suppresses Human Telomerase Reverse Transcriptase (hTERT) by Smad3 Interactions with c-Myc and the hTERT Gene
Li, H., Xu, D., Li, J., Berndt, M. C., & Liu, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602381200 · Cited by 126
Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT
Fujimoto, K., Kyo, S., Takakura, M., Kanaya, T., Kitagawa, Y., Itoh, H., Takahashi, M., & Inoue, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.13.2557 · Cited by 116
Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT
Lv, J., Liu, H., Wang, Q., Tang, Z., Hou, L., & Zhang, B. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.235 · Cited by 115
Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor
Goueli, B. S., & Janknecht, R. (2003) · Oncogene · doi:10.1038/sj.onc.1206847 · Cited by 115
Effect of Long-Term Hormone Therapy on Telomere Length in Postmenopausal Women
Lee, D., Im, J., Kim, J., Lee, H.-R., & Shim, J. (2005) · Yonsei Medical Journal · doi:10.3349/ymj.2005.46.4.471 · Cited by 114
Telomere Erosion in Memory T Cells Induced by Telomerase Inhibition at the Site of Antigenic Challenge In Vivo
Reed, J. R., Vukmanovic-Stejic, M., Fletcher, J. M., Soares, M. V. D., Cook, J. E., Orteu, C. H., Jackson, S. E., Birch, K. E., Foster, G. R., Salmon, M., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040178 · Cited by 111
Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis.
Colmegna, I., Diaz‐Borjon, A., Fujii, H., Schaefer, L., Goronzy, J. J., & Weyand, C. M. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23287 · Cited by 108
Self-citation
Telomerase Activity Is Induced in Human Peripheral B Lymphocytes by the Stimulation to Antigen Receptor
Igarashi, H., & Sakaguchi, N. (1997) · Blood · doi:10.1182/blood.v89.4.1299 · Cited by 108
Function of AP-1 in Transcription of the Telomerase Reverse Transcriptase Gene (TERT) in Human and Mouse Cells
Takakura, M., Kyo, S., Inoue, M., Wright, W. E., & Shay, J. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8037-8043.2005 · Cited by 107
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks
Helmink, B. A., Bredemeyer, A. L., Lee, B.-S., Huang, C., Sharma, G. G., Walker, L. M., Bednarski, J. J., Lee, W.-L., Pandita, T. K., Bassing, C. H., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081326 · Cited by 103
Telomere and adaptive immunity
Weng, N.-P. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.11.005 · Cited by 99
Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia
Callén, E. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.4.439 · Cited by 98
Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey
Starr, J. M., Shiels, P. G., Harris, S. E., Pattie, A., Pearce, M. S., Relton, C. L., & Deary, I. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.09.020 · Cited by 96
Telomerase Activity Is Increased and Telomere Length Shortened in T Cells from Blood of Patients with Atopic Dermatitis and Psoriasis
Wu, K., Higashi, N., Hansen, E. R., Lund, M., Bang, K., & Thestrup‐Pedersen, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4742 · Cited by 95
Reduced telomere length in rheumatoid arthritis is independent of disease activity and duration
Steer, S. E., Williams, F. M. K., Kato, B. S., Gardner, J. P., Norman, P. J., Hall, M. A., Kimura, M., Vaughan, R., Aviv, A., & Spector, T. D. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.059188 · Cited by 94
Unregulated inflammation shortens human functional longevity
Brod, S. A. (2000) · Inflammation Research · doi:10.1007/s000110050632 · Cited by 93
Quantitative changes in T cell DNA methylation occur during differentiation and ageing
Golbus, J., Palella, T. D., & Richardson, B. C. (1990) · European Journal of Immunology · doi:10.1002/eji.1830200836 · Cited by 91
Expression of human telomerase subunits in ovarian malignant, borderline and benign tumors
Kyo, S., Kanaya, T., Takakura, M., Tanaka, M., Yamashita, A., Inoue, H., & Inoue, M. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990315)80:6 · Cited by 90
Telomere Shortening and Decreased Replicative Potential, Contrasted by Continued Proliferation of Telomerase-Positive CD8+CD28lo T Cells in Patients with Systemic Lupus Erythematosus
Honda, M., Mengesha, E., Albano‐Aluquin, S., Nichols, W. S., Wallace, D. J., Al, M., Klinenberg, J. R., & Linker‐Israeli, M. (2001) · Clinical Immunology · doi:10.1006/clim.2001.5023 · Cited by 90
Prolonged exposure of naïve CD8+ T cells to interleukin‐7 or interleukin‐15 stimulates proliferation without differentiation or loss of telomere length
Wallace, D. L., Berard, M., Soares, M. V. D., Oldham, J. E., Cook, J. E., Akbar, A. N., Tough, D. F., & Beverley, P. C. L. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02429.x · Cited by 79
Premature aging of the immune system in children with juvenile idiopathic arthritis
Prelog, M., Schwarzenbrunner, N., Sailer‐Höck, M., Kern, H., Klein‐Franke, A., Ausserlechner, M. J., Koppelstaetter, C., Brunner, A., Duftner, C., Dejaco, C., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23599 · Cited by 76
Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT
Matsubara, Y., Murata, M., Yoshida, T., Watanabe, K., Saito, I., Miyaki, K., Omae, K., & Ikeda, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.163 · Cited by 75
The impact of telomere erosion on memory CD8+ T cells in patients with X-linked lymphoproliferative syndrome
Plunkett, F. J., Franzese, O., Belaramani, L. L., Fletcher, J. M., Gilmour, K. C., Sharifi, R., Khan, N., Hislop, A. D., Cara, A., Salmon, M., et al. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.006 · Cited by 74
Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
Williams, E. S., Klingler, R., Ponnaiya, B., Hardt, T., Schröck, E., Lees‐Miller, S. P., Meek, K., Ullrich, R. L., & Bailey, S. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2854 · Cited by 73
The many faces of telomerase: emerging extratelomeric effects
Bollmann, F. M. (2008) · BioEssays · doi:10.1002/bies.20793 · Cited by 72
TNFα induces rapid activation and nuclear translocation of telomerase in human lymphocytes
Akiyama, M., Yamada, O., Hideshima, T., Yanagisawa, T., Yokoi, K., Fujisawa, K., Eto, Y., Yamada, H., & Anderson, K. C. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.080 · Cited by 71
TELOMERE REDUCTION IN SCLERODERMA PATIENTS: A POSSIBLE CAUSE FOR CHROMOSOMAL INSTABILITY
Artlett, C. M., Black, C. M., Briggs, D., STEVENS, C. O., & Welsh, K. I. (1996) · Lara D. Veeken · doi:10.1093/rheumatology/35.8.732 · Cited by 71
Telomere Length Profiles in Humans: All Ends are Not Equal
Gilson, É., & Londoño‐Vallejo, A. (2007) · Cell Cycle · doi:10.4161/cc.6.20.4798 · Cited by 53
hTERT −1327T/C polymorphism is not associated with age-related telomere attrition in peripheral blood
Nordfjäll, K., Osterman, P., Melander, O., Nilsson, P. M., & Roos, G. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.099 · Cited by 49
Association between telomere length and heart disease in a narrow age cohort of older people
Starr, J., McGurn, B., HARRIS, S., Whalley, L. J., Deary, I. J., & Shiels, P. G. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.12.002 · Cited by 49
Shortening of telomeres: Evidence for replicative senescence of T cells derived from patients with Wegener's granulomatosis
Vogt, S., Iking‐Konert, C., Hug, F., Andrássy, K., & Hänsch, G. M. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00037.x · Cited by 48
Premature telomere shortening in polymorphonuclear neutrophils from patients with systemic lupus erythematosus is related to the lupus disease activity
Wu, C.-H., Hsieh, S., Li, K., Lu, M., & Yu, C.-L. (2007) · Lupus · doi:10.1177/0961203307077155 · Cited by 47
A major role of PKC θ and NFκB in the regulation of hTERT in human T lymphocytes
Sheng, W.-Y., Chen, Y.-R., & Wang, T. V. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.11.044 · Cited by 45
Telomerase activity and telomere length of peripheral blood mononuclear cells in SLE patients
Kurosaka, D., Yasuda, J., Yoshida, K., Yokoyama, T., Ozawa, Y., Obayashi, Y., Kingetsu, I., Saitô, S., & Yamada, A. (2003) · Lupus · doi:10.1191/0961203303lu426oa · Cited by 43
The Opposing Effect of Hypoxia-Inducible Factor-2α on Expression of Telomerase Reverse Transcriptase
Lou, F., Chen, X., Jalink, M., Zhu, Q., Ge, N., Zhao, S., Fang, X., Fan, Y., Björkholm, M., Liu, Z., et al. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0065 · Cited by 43
Stable telomere length and telomerase expression from naıve to memory B-lymphocyte differentiation
Son, N. H., Joyce, B. R., Hieatt, A., Chrest, F. J., Yanovski, J. A., & Weng, N. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00018-6 · Cited by 38
Mechanisms Regulating the Proliferative Potential of Human CD8+ T Lymphocytes Overexpressing Telomerase
Menzel, O., Migliaccio, M., Goldstein, D. R., Dahoun, S. P., Delorenzi, M., & Rufer, N. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.3657 · Cited by 38
Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells
Anno, K., Hayashi, A., Takahashi, T., Mitsui, Y., Ide, T., & Tahara, H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.112 · Cited by 37
Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes
Schreurs, M. W. J., Hermsen, M. A. J. A., Geltink, R. I. K., Scholten, K. B. J., Brink, A. A. T. P., Taanman-Kueter, E. W., Tijssen, M., Meijer, C. J. L. M., Ylstra, B., Meijer, G. A., et al. (2005) · Blood · doi:10.1182/blood-2004-09-3742 · Cited by 37
Telomerase activity in connective tissue diseases: elevated in rheumatoid arthritis, but markedly decreased in systemic sclerosis
Tarhan, E. F., Vural, F., Kosova, B., Aksu, K., Çoğulu, Ö., Keser, G., Gündüz, C., Tombuloğlu, M., Öder, G., Karaca, E., et al. (2007) · Rheumatology International · doi:10.1007/s00296-007-0472-9 · Cited by 36
Reversible Conversion of Immortal Human Cells from Telomerase-Positive to Telomerase-Negative Cells
Kumakura, S., Tsutsui, T. W., Yagisawa, J., Barrett, J. C., & Tsutsui, T. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1819 · Cited by 35
An Analysis of Telomere Length in Sarcoidosis
Guan, J. Z., Maeda, T., Sugano, M., Oyama, J.-I., Higuchi, Y., Suzuki, T., & Makino, N. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.11.1199 · Cited by 34
Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion
MacIntyre, A., Brouilette, S., Lamb, K. E., Radhakrishnan, K., McGlynn, L. M., Chee, M. M., Parkinson, E. K., Freeman, D. W., Madhok, R., & Shiels, P. G. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.086652 · Cited by 34
Telomere length analysis in monocytes and lymphocytes from patients with systemic lupus erythematosus using multi-color flow-FISH
Beier, F., Balabanov, S., Amberger, C., Hartmann, U., Manger, K., Dietz, K., Kötter, I., & Brümmendorf, T. H. (2007) · Lupus · doi:10.1177/0961203307084299 · Cited by 27
Differences in telomerase expression by the CD1a + cells in Langerhans cell histiocytosis reflect the diverse clinical presentation of the disease
da Costa, C., Egeler, R. M., Hoogeboom, M., Szuhai, K., Forsyth, R. G., Niesters, M., de Krijger, R. R., Tazi, A., Hogendoorn, P. C. W., & Annels, N. E. (2007) · The Journal of Pathology · doi:10.1002/path.2167 · Cited by 25
Telomere length shortening in Langerhans cell histiocytosis
Bechan, G. I., Meeker, A. K., Marzo, A. M. D., Racke, F. K., Jaffe, R., Sugar, E. A., & Arceci, R. J. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06904.x · Cited by 24
T Cell Activation as Starter and Motor of Rheumatic Inflammation
Skapenko, A., Lipsky, P. E., & Schulze‐Koops, H. (2006) · Springer eBooks · doi:10.1007/3-540-29714-6_10 · Cited by 23

Research works printed but not linked: 2

10.1016%2FS0092-8674%2803%2900550-6 · DOI · Paper page
10.1203%2F01.PDR.0000022341.72856.72 · DOI

Sorted by citations

Understanding immunosenescence to improve responses to vaccines
Goronzy, J. J., & Weyand, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2588 · Cited by 827
Self-citation
Aging of the Immune System. Mechanisms and Therapeutic Targets
Weyand, C. M., & Goronzy, J. J. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201602-095aw · Cited by 586
Self-citation
The risk of infections associated with rheumatoid arthritis, with its comorbidity and treatment
Listing, J., Gerhold, K., & Zink, A. (2013) · Rheumatology · doi:10.1093/rheumatology/kes305 · Cited by 541
HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group
High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825a3668 · Cited by 522
Self-citation
Ageing and the telomere connection: An intimate relationship with inflammation
Zhang, J., Rane, G., Dai, X., Shanmugam, M. K., Arfuso, F., Samy, R. P., Lai, M. K. P., Kappei, D., Kumar, A. P., & Sethi, G. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.006 · Cited by 396

See all 109

Authors: Andrews, N. P., Fujii, H., Goronzy, J. J., & Weyand, C. M.
Affiliations: Emory University (US)
ORCID: Fujii, Hiroshi
Goronzy, Jörg J.
Weyand, Cornelia M.
Venue: Gerontology
Publisher: S. Karger AG
Published: 2009-12-17
Volume: 56
Issue: 4
Pages: 390-403
ISSN: 0304-324X (ISSN-L)
1423-0003
DOI: 10.1159/000268620
PMC: PMC2917738
OpenAlex: W1981392889
Cited by: 108
References: 148
Citations by year: 2025: 3 · 2024: 12 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 2 · 2016: 5 · 2015: 7 · 2014: 12 · 2013: 8 · 2012: 15
FWCI: 0.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Gerontology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American College of Rheumatology Research and Education Foundation
Rheumatology Research Foundation
National Institutes of Health
National Institute on Aging (R01AG015043, R01AG15043)
National Heart, Lung, and Blood Institute (R01HL117913)
National Eye Institute (R01EY011916, R01 EY 11916)
National Institute of Allergy and Infectious Diseases (R01AI044142, U19-AI57266, R01AI44142, R01AI108906, R56AI044142, U19AI057266)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR041974, R01 AR 41974, R01AR042527, R01AR42527)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: telomeres, immunosenescence, autoimmunity, telomerase, telomere dysfunction, lymphocytes, telomere maintenance, DNA damage response, chronic inflammatory diseases, genomic instability, cellular senescence, apoptosis
MeSH terms: Aging, Animals, Humans, Immune System Diseases, Inflammation, Models, Biological, T-Lymphocytes, Gene Expression Regulation, Enzymologic, Telomere, Cellular Senescence, Telomerase, Aging, Premature

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Telomeres and immunological diseases of aging.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks