Cited by 5,784Cardiovascular Health and Risk FactorsHealthcare Systems and Public HealthHealth Promotion and Cardiovascular Prevention

The DOI matches its Crossref record; 255 of the 255 references it cites were found in a registry or an index.

Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association

Open access

Virani, Salim S., Alonso, Alvaro, Aparicio, Hugo J., Benjamin, Emelia J., Bittencourt, Marcio S., Callaway, Clifton W., Carson, April P., Chamberlain, Alanna M., Cheng, Susan, Delling, Francesca N., Elkind, Mitchell S.V., Evenson, Kelly R., Ferguson, Jane F., Gupta, Deepak K., Khan, Sadiya S., Kissela, Brett M., Knutson, Kristen L., Lee, Chong D., Lewis, Tené T., Liu, Junxiu, Loop, Matthew Shane, Lutsey, Pamela L., Ma, Jun, Mackey, Jason, Martin, Seth S., Matchar, David B., Mussolino, Michael E., Navaneethan, Sankar D., Perak, Amanda Marma, Roth, Gregory A., Samad, Zainab, Satou, Gary M., Schroeder, Emily B., Shah, Svati H., Shay, Christina M., Stokes, Andrew, VanWagner, Lisa B., Wang, Nae-Yuh, Tsao, Connie W., On behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee·2021·Circulation

DOI 10.1161/cir.0000000000000950PMC PMC13036842

Open this paper in CoChat — free account Open PDF

Abstract

Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). Methods: The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2021 Statistical Update is the product of a full year’s worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year’s edition includes data on the monitoring and benefits of cardiovascular health in the population, an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, the global burden of cardiovascular disease, and further evidence-based approaches to changing behaviors related to cardiovascular disease. Results: Each of the 27 chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. Conclusions: The Statistical Update represents a critical resource for the lay public, policy makers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/cir.0000000000000950

Cites

0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

2 retracted

Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med 2013;368:1279-90.
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmc1806491 · Cited by 1,008
Retracted
RETRACTED: Relationship between Clinic and Ambulatory Blood-Pressure Measurements and Mortality
Banegas, J. R., Ruilope, L. M., de la Sierra, A., Vinyoles, E., Gorostidi, M., de la Cruz, J. J., Ruiz-Hurtado, G., Segura, J., Rodríguez-Artalejo, F., & Williams, B. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1712231 · Cited by 490
Retracted
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
Vos, T., Lim, S. S., Abbafati, C., Abbas, K. M., Abbasi, M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abdelalim, A., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30925-9 · Cited by 19,358
Self-citation
Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271
Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies
(2004) · The Lancet · doi:10.1016/s0140-6736(03)15268-3 · Cited by 12,717
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026
The Physical Activity Guidelines for Americans
Piercy, K. L., Troiano, R. P., Ballard, R. M., Carlson, S. A., Fulton, J. E., Galuska, D. A., George, S. M., & Olson, R. D. (2018) · JAMA · doi:10.1001/jama.2018.14854 · Cited by 9,755
Prevalence of Childhood and Adult Obesity in the United States, 2011-2012
Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2014) · JAMA · doi:10.1001/jama.2014.732 · Cited by 8,072
IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045
Cho, N. H., Shaw, J. E., Karuranga, S., Huang, Y., da Rocha Fernandes, J. D., Ohlrogge, A. W., & Malanda, B. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.02.023 · Cited by 7,283

Show all 0 references

Research works printed but not linked: 2713

World Health Organization. International Statistical Classification of Diseases and Related Health Problems, 10th Revision. 2008 ed. Geneva, Switzerland: World Health Organization; 2009.
Anderson, RN, Rosenberg, HM. Age standardization of death rates: implementation of the year 2000 standard. Natl Vital Stat Rep. 1998;47:1–16, 20.
10.1016/S0140-6736(20)30752-2 · DOI · Paper page
10.1016/j.pcad.2015.05.003 · DOI
10.1016/j.ahj.2016.02.008 · DOI
10.1161/CIRCHEARTFAILURE.116.003682 · DOI
10.1016/j.amjmed.2015.03.027 · DOI
10.1371/journal.pone.0052771 · DOI
10.1161/JAHA.116.005180 · DOI
10.1093/ajh/hpz057 · DOI
10.1016/j.hlc.2016.02.007 · DOI
10.1016/j.ijcard.2015.03.051 · DOI
10.1016/j.mayocp.2016.01.019 · DOI · Paper page
10.1136/jech-2017-210396 · DOI
10.1016/j.ypmed.2016.12.017 · DOI
10.1111/ene.13056 · DOI
10.1111/1744-7917.12513 · DOI
10.1161/ATVBAHA.118.311821 · DOI
10.3390/ijerph16112028 · DOI
10.1016/j.ijcard.2018.06.037 · DOI
10.1177/0003319718813448 · DOI
10.1016/j.jacc.2010.11.041 · DOI · Paper page
10.1016/j.ijcard.2016.03.210 · DOI
10.1001/jama.2012.339 · DOI · Paper page
10.1161/STROKEAHA.111.000352 · DOI
10.1001/jama.2012.14312 · DOI
10.1016/j.ahj.2014.12.017 · DOI
10.1161/CIRCIMAGING.114.001851 · DOI
10.1371/journal.pone.0089317 · DOI
10.1016/j.psym.2013.06.016 · DOI
10.1161/JAHA.114.001322 · DOI
10.1161/JAHA.116.004105 · DOI
10.1136/bmjopen-2016-012486 · DOI
10.1016/j.rmed.2017.08.001 · DOI
10.1161/JAHA.114.001494 · DOI
10.1161/JAHA.117.007234 · DOI
10.1016/j.ijcard.2018.07.107 · DOI
10.1161/JAHA.117.007658 · DOI
10.1161/JAHA.117.008424 · DOI
10.1016/j.ypmed.2019.105890 · DOI
10.1136/bmjopen-2017-019434 · DOI · Paper page
10.1519/JSC.0000000000003052 · DOI
10.1016/j.maturitas.2018.11.015 · DOI
10.1016/j.pmedr.2019.100922 · DOI
10.1016/j.ijcard.2015.05.007 · DOI
10.1016/j.healthplace.2017.01.005 · DOI
10.1016/j.amepre.2015.03.034 · DOI
10.1016/j.mayocp.2016.12.026 · DOI · Paper page
10.1001/jamanetworkopen.2019.4758 · DOI
10.1161/CIRCULATIONAHA.111.081083 · DOI · Paper page
10.1161/JAHA.116.003192 · DOI
10.1007/s00125-018-4792-y · DOI
10.1161/JAHA.116.005008 · DOI
10.1016/j.amepre.2015.07.039 · DOI
10.1161/CIRCULATIONAHA.112.001183 · DOI
10.1016/S0140-6736(20)30752-2 · DOI · Paper page
10.1016/S0140-6736(20)30925-9 · DOI · Paper page
10.1056/NEJMsa1211127 · DOI · Paper page
10.15585/mmwr.mm6806e1 · DOI
10.15585/mmwr.mm6845a2 · DOI
10.1056/NEJMp1805758 · DOI
10.15585/mmwr.ss6812a1 · DOI · Paper page
Drake, P, Driscoll, AK, Mathews, TJ. Cigarette smoking during pregnancy: United States, 2016. NCHS Data Brief. 20181–8.
10.1001/jamanetworkopen.2018.7794 · DOI
10.15585/mmwr.mm6744a2 · DOI
US Department of Health and Human Services. The Health Consequences of Smoking-50 Years of Progress: A Report of the Surgeon GeneralUS Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2014.
10.15585/mmwr.mm6544a2 · DOI
10.1016/j.amjmed.2019.12.020 · DOI
US Department of Health and Human Services. How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon GeneralUS Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2010.
10.1186/s12889-015-1617-5 · DOI
10.1093/cid/civ013 · DOI
10.1161/STR.0000000000000046 · DOI · Paper page
10.1161/STROKEAHA.113.002342 · DOI
10.1177/2047487318806658 · DOI
10.1016/j.amjcard.2019.03.015 · DOI
10.3109/08958378.2016.1171934 · DOI
10.1093/aje/kwq191 · DOI
10.1161/CIR.0000000000000107 · DOI
10.1007/s12170-016-0505-6 · DOI
10.1016/j.tcm.2019.04.006 · DOI
10.1016/j.amepre.2018.05.004 · DOI
10.1016/j.amjmed.2019.02.016 · DOI
10.1016/j.biopsych.2018.11.024 · DOI
10.1038/s41380-018-0313-0 · DOI
10.1161/CIRCULATIONAHA.116.022069 · DOI
10.1136/tobaccocontrol-2014-052207 · DOI · Paper page
10.1093/ntr/ntz123 · DOI
10.1056/NEJMp1603294 · DOI
10.15585/mmwr.mm6828a1 · DOI
10.1161/JAHA.118.011307 · DOI
10.1001/jamanetworkopen.2019.4585 · DOI
10.1016/j.ahj.2019.03.019 · DOI
10.1001/jama.2019.10298 · DOI
10.1016/j.amepre.2008.04.009 · DOI · Paper page
10.1161/CIR.0000000000000678 · DOI · Paper page
10.1161/CIRCULATIONAHA.115.019634 · DOI
10.1016/S0140-6736(16)30272-0 · DOI · Paper page
10.1001/jamainternmed.2014.8313 · DOI
Centers for Disease Control and Prevention. Quitting smoking among adults–United States, 2001-2010. MMWR Morb Mortal Wkly Rep. 2011;60:1513–1519.
10.1016/j.amepre.2014.10.011 · DOI
10.1161/JAHA.113.000740 · DOI
10.1056/NEJMoa1808779 · DOI
10.1136/tobaccocontrol-2017-054108 · DOI
10.1001/jama.2018.0158 · DOI
10.1136/bmj.h1551 · DOI
10.1007/s10654-015-0031-8 · DOI
10.1161/CIR.0000000000000669 · DOI
10.7326/M18-1826 · DOI
Arrazola, RA, Singh, T, Corey, CG, Husten, CG, Neff, LJ, Apelberg, BJ, Bunnell, RE, Choiniere, CJ, King, BA, Cox, S, et al; Centers for Disease Control and Prevention (CDC). Tobacco use among middle and high school students–United States, 2011-2014. MMWR Morb Mortal Wkly Rep. 2015;64:381–385.
10.15585/mmwr.mm6710a3 · DOI · Paper page
10.1136/tobaccocontrol-2014-051670 · DOI
10.7326/M17-3440 · DOI
10.1093/ntr/ntz021 · DOI
Eaton, DL, Kwan, LY, Stratton, K, eds. Public Health Consequences of E-CigarettesWashington, DC: National Academies Press; 2018.
10.1093/ntr/nty089 · DOI
10.7326/M16-1107 · DOI · Paper page
10.7759/cureus.7088 · DOI
10.1001/jamanetworkopen.2019.16800 · DOI
10.1186/s12890-019-0950-3 · DOI
10.1016/j.amepre.2019.10.014 · DOI
10.1161/STROKEAHA.116.014099 · DOI
10.1016/j.ijcard.2015.07.011 · DOI
10.1371/journal.pone.0147848 · DOI
10.1016/j.jacc.2019.07.060 · DOI
10.1136/hrt.2010.199026 · DOI
Centers for Disease Control and Prevention. Vital signs: disparities in nonsmokers’ exposure to secondhand smoke–United States, 1999-2012. MMWR Morb Mortal Wkly Rep. 2015;64:103–108.
10.1016/j.amepre.2014.10.012 · DOI
10.1016/S0140-6736(18)32225-6 · DOI · Paper page
10.1016/S0140-6736(20)30752-2 · DOI · Paper page
10.15585/mmwr.mm6738a7 · DOI
10.1161/CIRCULATIONAHA.109.192703 · DOI · Paper page
US Department of Health and Human Services. Physical Activity Guidelines for Americans. 2nd ed. Department of Health and Human Services; 2018.
10.15585/mmwr.ss6708a1 · DOI · Paper page
10.1161/01.cir.0000435708.67487.da · DOI · Paper page
10.1161/CIR.0000000000000678 · DOI · Paper page
2018 Physical Activity Guidelines Advisory Committee. 2018 Physical Activity Guidelines Advisory Committee Scientific ReportUS Department of Health and Human Services; 2018.
10.1161/STR.0000000000000148 · DOI · Paper page
10.1001/jamaneurol.2017.1658 · DOI · Paper page
10.1016/j.amepre.2018.07.036 · DOI
10.1161/CIR.0b013e31827ee100 · DOI
10.1161/CIR.0000000000000461 · DOI · Paper page
10.1016/j.pcad.2014.09.008 · DOI
10.2471/BLT.18.213728 · DOI
10.1371/journal.pone.0115915 · DOI
Gahche, J, Fakhouri, T, Carroll, DD, Burt, VL, Wang, CY, Fulton, JE. Cardiorespiratory fitness levels among U.S. youth aged 12-15 years: United States, 1999-2004 and 2012. NCHS Data Brief. 20141–8.
10.1016/j.ypmed.2018.10.016 · DOI
Rideout, V. The Common Sense Census: Media Use by Kids Age Zero to EightCommon Sense Media; 2017. Accessed March 9, 2020. https://www.vjrconsulting.com/featured/2018/9/16/the-common-sense-census-media-use-by-kids-age-zero-to-eight-2017.
10.1542/peds.2016-2592 · DOI · Paper page
10.1016/j.amepre.2010.12.016 · DOI · Paper page
10.5888/pcd11.140189 · DOI
10.1186/s12966-017-0642-4 · DOI
The Nielsen Total Audience Report. 2019. Accessed October 20, 2020. https://www.nielsen.com/us/en/insights/article/2020/the-nielsen-total-audience-report-hub/.
10.1136/bjsports-2018-100056 · DOI · Paper page
10.1097/AOG.0000000000001214 · DOI
10.1249/MSS.0000000000001941 · DOI
10.1136/bjsports-2018-099399 · DOI
10.1016/j.amepre.2016.05.023 · DOI
10.1016/j.amepre.2018.07.008 · DOI
10.15585/mmwr.ss6407a1 · DOI
10.1001/jama.2018.17797 · DOI
10.1001/jama.2019.3636 · DOI
10.1016/j.amepre.2018.05.027 · DOI
Shifts in Viewing: The Cross-Platform Report: September 2014Nielsen Company; 2014.
10.1016/j.ypmed.2018.02.011 · DOI
10.1038/s41366-018-0120-3 · DOI · Paper page
10.1161/CIR.0000000000000440 · DOI · Paper page
10.1249/MSS.0000000000001607 · DOI
US Department of Health and Human Services. Step It Up! The Surgeon General’s Call to Action to Promote Walking and Walkable CommunitiesUS Dept of Health and Human Services, Office of the Surgeon General; 2015.
10.1001/jama.2016.5898 · DOI
10.1289/ehp.1510425 · DOI
Centers for Disease Control and Prevention and SHAPE America–Society of Health and Physical Educators. . Strategies for Recess in SchoolsCenters for Disease Control and Prevention, US Department of Health and Human Services; 2017.
10.1016/j.amepre.2015.06.022 · DOI
10.1249/MSS.0000000000001328 · DOI
10.5888/pcd18.170354 · DOI · Paper page
10.1136/bjsports-2014-094306 · DOI · Paper page
10.1001/jamainternmed.2015.0533 · DOI · Paper page
10.1161/JAHA.117.007677 · DOI
10.1007/s40279-018-1023-0 · DOI
10.1136/bmj.j1456 · DOI
10.1136/bjsports-2017-098540 · DOI · Paper page
10.1016/S0140-6736(16)30370-1 · DOI · Paper page
10.1093/aje/kwy125 · DOI
10.1016/j.amepre.2018.12.006 · DOI
10.1249/MSS.0000000000000885 · DOI
10.1249/MSS.0000000000001932 · DOI
10.1161/CIRCOUTCOMES.113.000531 · DOI
10.1016/j.ypmed.2019.105799 · DOI
10.1093/eurheartj/ehw249 · DOI
10.1038/ijo.2016.210 · DOI
10.3945/ajcn.116.150540 · DOI
10.1249/MSS.0000000000001310 · DOI
10.1080/02640414.2016.1260150 · DOI
10.1161/JAHA.116.004413 · DOI
10.1177/2047487314562741 · DOI
10.1161/HYPERTENSIONAHA.116.08994 · DOI
10.1249/MSS.0000000000001484 · DOI
Zwald, ML, Akinbami, LJ, Fakhouri, TH, Fryar, CD. Prevalence of low high-density lipoprotein cholesterol among adults, by physical activity: United States, 2011-2014. NCHS Data Brief. 20171–8.
10.1161/CIRCULATIONAHA.115.016938 · DOI
10.1161/CIRCULATIONAHA.116.026858 · DOI
10.1111/aogs.13151 · DOI

200 of 2713 shown

Sorted by citations

Items 601–700 of 1,044

Sex Associated Differences in the Clinical Outcomes of Left Ventricular Assist Device Recipients: Insights from INTERMACS
Shetty, N., Parcha, V., Abdelmessih, P., Patel, N., Hasnie, A., Kalra, R., Pandey, A., Breathett, K. K., Morris, A., Arora, G., et al. (2023) · Circulation: Heart Failure · doi:10.1161/circheartfailure.122.010189 · Cited by 9
Anti-inflammatory Therapy Progress in Major Adverse Cardiac Events after PCI: Chinese and Western Medicine
Ren, X., Li, Y.-F., Liu, H.-Q., Lin, H., Lin, Q., Wu, Y., Wan, J., Lu, J.-J., Liu, J., & Cui, X.-Y. (2023) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-023-3638-8 · Cited by 9
Self-citation
Anti-inflammation nanomedicine shots through atherosclerotic plaques for targeted treatment and precise diagnosis
Zhu, L., Xu, W., Chatterjee, E., Li, G., Wang, X., Xiao, J., Chen, X., & Yang, L. M. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.112005 · Cited by 8
Efficacy and Safety Profile of Berberine Treatment in Improving Risk Factors for Cardiovascular Disease: A Systematic Review and Meta-analysis of Randomized, Double-blind Trials
Lei, L., Li, J.-K., & Wang, B. (2023) · Cardiology Discovery · doi:10.1097/cd9.0000000000000087 · Cited by 9
Sex and hypertensive organ damage: stroke
Dawson, J., & MacDonald, A. S. (2023) · Journal of Human Hypertension · doi:10.1038/s41371-023-00830-0 · Cited by 10
“INCIDENCE OF STROKE IN MEN AND WOMEN AND PRESENTING FEATURES Age specific incidence of stroke is higher in men but more strokes, and more than half of stroke related deaths, occur in women [1].”
Background
Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest
Rutledge, C. A., Lagranha, C. J., Chiba, T., Redding, K., Stolz, D. B., Goetzman, E. S., Sims‐Lucas, S., & Kaufman, B. A. (2023) · Journal of Molecular and Cellular Cardiology Plus · doi:10.1016/j.jmccpl.2023.100034 · Cited by 9
“Cardiac arrest (CA) refers to the abrupt cessation of cardiac function and affects over 600,000 patients annually in the United States [1,2].”
Background
Defibrillation in the Cardiac Arrest Patient.
Dreyfuss, A., & Carlson, G. K. (2023) · Emergency medicine clinics of North America · doi:10.1016/j.emc.2023.03.006 · Cited by 9
FPGA-Based Real-Time ECG Classification System Using Quantized Inception-ResNeXt Neural Network and CWT Approximation
Cao, T., Ng, W. S., Goh, W. L., Gao, Y., & Huang, H. (2025) · IEEE Transactions on Very Large Scale Integration (VLSI) Systems · doi:10.1109/tvlsi.2025.3617535 · Cited by 11
“…performance in a wide range of classiﬁcation tasks in the areas of image recognition [1], [2] and natural language processing [3], and recently shown great potential in biomedical signal processing, particularly in electrocardiogram (ECG) analysis for cardiovascular disease (CVD) monitoring [4].”
A shikonin/Cu2+ coordination complex-encapsulated hydrogel drug depot alleviates myocardial ischemia-reperfusion injury by disrupting energy metabolism-mediated intercellular crosstalk.
Tang, J., Li, T., He, X., Liu, Y.-L., Zhou, M.-L., Wu, M., Li, Y., Lan, Y., Tan, X., Tian, J., et al. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.139580 · Cited by 8
New advances in small molecule drugs targeting NMDA receptors
Zeng, Y., Qu, Z.-Y., Zhu, Q., Wang, H., Zhou, Y., & Gao, Z.-B. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01675-8 · Cited by 8
“Current treatments remain largely limited to thrombolysis and supportive care, underscoring the urgent need for effective neuroprotective strategies [307 – 309].”
Iron Deficiency in Heart Failure: Cellular Mechanisms and Therapeutic Implications
Tsarouchas, A., Vassilikos, V. P., Mouselimis, D., Papadopoulos, C. E., Tachmatzidis, D., Vassilikou, A., & Bakogiannis, C. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12110415 · Cited by 9
“With an aging population and improved survival from acute cardiovascular events, the prevalence of HF is projected to increase by 46% by 2030, resulting in more than 8 million cases in the United States alone [2,3].”
Bayesian Network Modeling of Environmental, Social, and Behavioral Determinants of Cardiovascular Disease Risk
Nyavor, H., & Obeng-Gyasi, E. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22101551 · Cited by 8
“Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide, responsible for approximately one-third of global deaths annually [1].”
Apolipoprotein B in the Risk Assessment, Diagnosis, and Treatment of Cardiometabolic Diseases
Patel, S., Patel, H., Mukadam, S., & Agrawal, D. K. (2025) · Cardiology and Cardiovascular Medicine · doi:10.26502/fccm.92920466 · Cited by 8
“Individuals with inactivating mutations in angiopoietin-like protein 3 (ANGPTL3), an endogenous inhibitor of lipoprotein lipase, exhibit lifelong reductions in LDL and VLDL concentrations [49].”
Deep learning for cardiovascular management: optimizing pathways and cost control under diagnosis-related group models
Chen, H., Zeng, Y., & Cai, D. (2025) · Frontiers in Artificial Intelligence · doi:10.3389/frai.2025.1580445 · Cited by 10
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy
Wang, Y., Liao, Q., Mei, X., Han, X., Luo, L., Huang, R., Tang, Y., & Zhou, C. (2025) · PLoS ONE · doi:10.1371/journal.pone.0326687 · Cited by 6
“Atherosclerosis(AS) is one of the leading causes of cardiovascular diseases and related mortality globally, including conditions such as myocardial infarction and stroke [1,2].”
Mortality trends related to cardiogenic shock in heart failure patients aged 25 and older across the United States: A study utilizing the CDC WONDER database from 1999 to 2023
Muhammad, A. N., Neppala, S., Chigurupati, H., Rehan, M., Naveed, H., Iqbal, R., Azeem, B., Ali, A., Ahmed, M., Upreti, P., et al. (2025) · International Journal of Cardiology: Heart & Vasculature · doi:10.1016/j.ijcha.2025.101732 · Cited by 8
“Currently, more than 6.7 million adults in the United States are affected by heart failure, and this figure is projected to increase due to an aging population and higher survival rates from acute cardiovascular events [11].”
Influential
iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025
Chopra, V., Khan, M. S., Abdelhamid, M., Abraham, W. T., Amir, O., Anker, S. D., Atherton, J. J., Bacal, F., von Bardeleben, R. S., Brito, D. A., et al. (2025) · Heart Lung and Circulation · doi:10.1016/j.hlc.2025.05.094 · Cited by 19
The biology of exosomes and exosomal non-coding RNAs in cardiovascular diseases
Gan, L., Guo, X., Dong, S., & Sun, C. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1529375 · Cited by 9
Trends and disparities in ischemic stroke mortality and location of death in the United States: A comprehensive analysis from 1999–2020
Lim, J. K., Pagnotta, J., Lee, R., Lim, D. H., Breton, J. M., Abecassis, Z., Meyer, R. M., Mai, J. C., & Levitt, M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0319867 · Cited by 8
Explainable artificial intelligence for stroke risk stratification in atrial fibrillation
Zimmerman, R., Hernandez, E., Tristani-Firouzi, M., Yandell, M., & Steinberg, B. A. (2025) · European Heart Journal - Digital Health · doi:10.1093/ehjdh/ztaf019 · Cited by 8
Deep learning on electrocardiogram waveforms to stratify risk of obstructive stable coronary artery disease
Trivedi, R., Chiu, I.-M., Hughes, J., Rogers, A. J., & Ouyang, D. (2025) · European Heart Journal - Digital Health · doi:10.1093/ehjdh/ztaf020 · Cited by 8
“…were developed for ECG waveforms alone (DL-ECG), clinical features from standard risk scores (DL-Clinical), and the combination of ECG waveforms and clinical features (DL-MM); a commonly used pre-test probability estimation tool from the CAD Consortium study was used for comparison (CAD2) [3].”
Empagliflozin Inhibits Neuronal Ferroptosis Induced by Oxygen–Glucose Deprivation/Reoxygenation by Activating the Nrf2/HO-1 Pathway
Ma, J., Wang, H., Jia, J., Tao, T., Shan, L., Sun, S., & Wang, M.-X. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04800-0 · Cited by 8
“Ischemic stroke, accounting for approximately 87% of all stroke events [1], occurs when cerebral blood vessels are obstructed, leading to an interruption of cerebral blood perfusion and oxygen supply.”
Self-citation
Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair
Ren, J., Chen, X., Wang, T., Liu, C.-Y., & Wang, K. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1533105 · Cited by 8
How Much Will a Pig Organ Transplant Cost? A Preliminary Estimate of the Cost of Xenotransplantation Versus Allotransplantation in the USA
Vasudev, K., & Cooper, D. (2025) · Xenotransplantation · doi:10.1111/xen.70018 · Cited by 8
“Heart failure affects 6.2 million adults in the United States, with advanced cases requiring heart transplantation or mechanical support [32].”
Influential
Curcumin Regulates Microglia Polarization to Alleviate Ischemic Stroke by Targeting microRNA‐205‐5p/Kruppel‐Like Factor 2 (KLF2)/Activating Transcription Factor 2 (ATF2) Axis
Cao, X., & Pu, Y. (2025) · Chemical Biology and Drug Design · doi:10.1111/cbdd.70050 · Cited by 8
Feature importance and model performance for prediabetes prediction: A comparative study
Al-Qahtani, S. A. M., Alobaid, H. M., Alshammari, J., Alqarzae, S. A., Aloyouni, S., Aleidan, A., Alhamad, S., Almiman, A. A., Alkhulaifi, F., & Alomar, S. (2024) · Journal of King Saud University: Science · doi:10.1016/j.jksus.2024.103583 · Cited by 8
MrSeNet: Electrocardiogram signal denoising based on multi-resolution residual attention network.
Wang, Z., Xie, H., Liu, Y., Zhu, H., Zhang, H., Wang, Z., & Pan, Y. (2024) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2024.153858 · Cited by 8
Functional Foods and Nutraceuticals for the Management of Cardiovascular Disease Risk in Postmenopausal Women
Meegaswatte, H., Speer, K., McKune, A. J., & Naumovski, N. (2024) · Reviews in cardiovascular medicine · doi:10.31083/j.rcm2512460 · Cited by 8
“More-over, CVD is the leading cause of death in women [1,2].”
Qingre Huoxue Decoction Alleviates Atherosclerosis by Regulating Macrophage Polarization Through Exosomal miR-26a-5p
He, W., Zhao, H.-Y., Xue, W., Luo, Y., Yan, M., Li, J.-L., Qing, L.-J., Wu, W., & Jin, Z. (2024) · Drug Design, Development and Therapy · doi:10.2147/dddt.s487476 · Cited by 8
“62 Statins are commonly prescribed as first-line medications for the prevention and treatment of AS.”
Phase I/II trial of intracerebral transplantation of autologous bone marrow stem cells combined with recombinant peptide scaffold for patients with chronic intracerebral haemorrhage: a study protocol
Kawabori, M., Shichinohe, H., Kahata, K., Miura, A., Maeda, K., Ito, Y. M., Mukaino, M., Kogawa, R., Nakamura, K., Gotoh, S., et al. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-083959 · Cited by 8
Real-world evidence study on the impact of SPECT MPI, PET MPI, cCTA and stress echocardiography on downstream healthcare utilisation in patients with coronary artery disease in the US
Pelletier-Galarneau, M., Cabra, A., Szabo, E., & Angadageri, S. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-04225-y · Cited by 8
“In the US, CAD affects 16.8 million people and was associated with direct and indirect costs of $363 billion in 2016– 2017 [6, 7].”
BackgroundInfluential
Plasma Proteomic Biomarkers in Alzheimer’s Disease and Cardiovascular Disease: A Longitudinal Study
Theeke, L. A., Liu, Y., Wang, S., Luο, X., Navia, R. O., Xiao, D., Xu, C. D., Wang, K., & Initiative, T. A. A. D. N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910751 · Cited by 10
“CVDs impact 126.9 million adults in the United States (U.S.), a number that increases with age [4].”
BackgroundInfluential
Risk factors for deep vein thrombosis of the lower extremity after total hip arthroplasty
Hang, L., Haibier, A., Kayierhan, A., & Abudurexiti, T. (2024) · BMC Surgery · doi:10.1186/s12893-024-02561-6 · Cited by 8
“Globally, there are nearly 10 million cases of DVT each year in patients with post-THA [6], and approximately 300,000 deaths in the United States are attributed to DVT each year [7].”
Background
Cardiac troponin I directly binds and inhibits mitochondrial ATP synthase with a noncanonical role in the post-ischemic heart
Elezaby, A., Lin, A. J., Vijayan, V., Pokhrel, S., Kraemer, B. R., Bechara, L. R. G., Larus, I., Sun, J., Baena, V., Syed, Z. A., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00512-1 · Cited by 12
“A search for a short homology stretch Myocardial infarction, the leading cause of cardiovascular death 16 , causes impaired mitochondrial function, bioenergetics and redox balance in cardiomyocytes, which ultimately results in cell death, tissue remodeling and the development of heart failure 17–19…”
Management and outcomes of heart failure hospitalization among older adults in the United States and Japan
Bates, B. A., Enzan, N., Tohyama, T., Gandhi, P., Matsushima, S., Tsutsui, H., Setoguchi, S., & Ide, T. (2024) · ESC Heart Failure · doi:10.1002/ehf2.14873 · Cited by 8
Characterization of an algorithm for autonomous, closed-loop neuromodulation during motor rehabilitation
Epperson, J. D., Meyers, E. C., Pruitt, D. T., Wright, J. M., Hudson, R. A., Adehunoluwa, E. A., Nguyen-Duong, Y.-N., Rennaker, R., Hays, S., & Kilgard, M. (2024) · Neurorehabilitation and Neural Repair · doi:10.1177/15459683241252599 · Cited by 8
Greater weekly physical activity linked to left resting frontal alpha asymmetry in women: A study on gender differences in highly active young adults
Wilhelm, R. A., Lacey, M. F., Masters, S. L., Breeden, C. J., Mann, E., MacDonald, H. V., Gable, P. A., White, E. J., & Stewart, J. L. (2024) · Psychology of sport and exercise · doi:10.1016/j.psychsport.2024.102679 · Cited by 8
Systemic immune inflammation index and system inflammation response index on the third postoperative day predict poor prognosis of aneurysmal subarachnoid hemorrhage patients
Wang, X., Tian, W., Zhao, Y.-F., Yang, Y., & Deng, L. (2024) · Medicine · doi:10.1097/md.0000000000037818 · Cited by 8
Spectrum of Ischemic Heart Disease Throughout a Woman’s Life Cycle
Gowda, S. N., Garapati, S. S., & Kurrelmeyer, K. M. (2024) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcvj.1331 · Cited by 9
Design of 6-DoF Holonomic Drive-based Upper and Lower-Limb Stroke Rehabilitation System
Jonna, P., Madurwar, A., Bk, A., & Rao, M. (2024) · International Conference on Automation, Robotics and Applications · doi:10.1109/icara60736.2024.10552936 · Cited by 8
“The Upper limb and Lower limb exercises under the supervision of a physiotherapist or occupational therapist is the only solution for patients in hemiparesis condition to regain control [6].”
Background
Impact of angiotensin receptor-neprilysin inhibition (ARNI) in improving ejection fraction and left and right ventricular remodeling in heart failure.
Sandeep, B., Huang, X., Jiang, F., & Xiao, Z.-W. (2024) · Current problems in cardiology · doi:10.1016/j.cpcardiol.2024.102464 · Cited by 8
Misconceptions and do-not-resuscitate preferences of healthcare professionals commonly involved in cardiopulmonary resuscitations: A national survey
Amacher, S., Gross, S., Becker, C., Arpagaus, A., Urben, T., Gaab, J., Emsden, C., Tisljar, K., Sutter, R., Pargger, H., et al. (2024) · Resuscitation Plus · doi:10.1016/j.resplu.2024.100575 · Cited by 8
Thrombin as target for prevention of recurrent events after acute coronary syndromes
Bahit, M. C., & Gibson, C. M. (2024) · Thrombosis Research · doi:10.1016/j.thromres.2024.02.003 · Cited by 10
Alcohol Consumption, High-Density Lipoprotein Particles and Subspecies, and Risk of Cardiovascular Disease: Findings from the PREVEND Prospective Study
Kunutsor, S., Bhattacharjee, A., Connelly, M., Bakker, S. J., & Dullaart, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042290 · Cited by 8
“Established risk factors for CVD include hypertension, diabetes, smoking, obesity, and dyslipidemia [2].”
Background
Prevalence and trend of multiple coronary artery disease risk factors and their 5-year incidence rate among adult population of Kerman: results from KERCADR study
Nezhad, N. Z., Najafipour, H., Shadkam, M., & Pourhamidi, R. (2024) · BMC Public Health · doi:10.1186/s12889-023-17504-8 · Cited by 8
Empagliflozin and other SGLT2 inhibitors in patients with heart failure and preserved ejection fraction: a systematic review and meta-analysis
Hamid, A. K., Tayem, A. A., Al-Aish, S. T., Sakini, A. S. A., Hadi, D. D., & Al-Aish, R. T. (2024) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/17539447241289067 · Cited by 12
“5,6 There are several ways that HF can be categorized; however, classification based on the left ventricle ejection fraction (EF) measurement is considered the basis for diagnosis and treatment strategy.”
Background
Sex and race differences in the performance of the European Society of Cardiology 0/1‐h algorithm with high‐sensitivity troponin T
Supples, M., Snavely, A., O'Neill, J., Ashburn, N., Allen, B. R., Christenson, R., Nowak, R., Wilkerson, R. G., Mumma, B., Madsen, T., et al. (2023) · Clinical Cardiology · doi:10.1002/clc.24199 · Cited by 8
Heart Disease Prediction based on Physiological Parameters Using Ensemble Classifier and Parameter Optimization
Muliawan, A., Rizal, A., & Hadiyoso, S. (2023) · Journal of Applied Engineering and Technological Science (JAETS) · doi:10.37385/jaets.v5i1.2169 · Cited by 8
“Based on data from 2018, 405 people die from a stroke daily (Virani et al., 2021).”
Method
Resistance valves in circulatory loops have a significant impact on in vitro evaluation of blood damage caused by blood pumps: a computational study
Wu, P., Bai, Y., Du, G., Zhang, L., & Zhao, X.-Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1287207 · Cited by 8
From Ultraviolet to Near-Infrared: Label-Free Reflection-Mode Hyperspectral Photoacoustic Microscopy for Single-Cell Biochemical Mapping
Rong, Q.-Z., Taboada, C., Águila, Á. D., Merutka, I., Jayasundara, N., Zeng, Y.-S., Yang, W., Zhou, Q.-F., & Yao, J.-J. (2023) · GEN Biotechnology · doi:10.1089/genbio.2023.0035 · Cited by 8
Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome: A Systematic Review and Meta-Analysis.
Shah, R., Shafiq, A., Hamza, M., Maniya, M. T., Duhan, S., Keisham, B., Patel, B., Alamzaib, S. M., Yashi, K., Uppal, D., et al. (2023) · American Journal of Cardiology · doi:10.1016/j.amjcard.2023.08.117 · Cited by 8
Enhancing the Accuracy and Explainability of Heart Disease Prediction Models through Interpretable Machine Learning Techniques
Moushi, O. M., Ara, N., Uddin, M. H., & Mondal, H. S. (2023) · 2023 International Conference on Information and Communication Technology for Sustainable Development (ICICT4SD) · doi:10.1109/icict4sd59951.2023.10303572 · Cited by 8
“Nowadays, the increasing rate of heart disease is the main reason for high mortality rate in USA [1].”
Background
Menstrual Cycle Irregularity in Adolescence Is Associated With Cardiometabolic Health in Early Adulthood
Keenan, K. E., Hipwell, A., & Polonsky, T. S. (2023) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.123.029372 · Cited by 8
A systematic review of randomised controlled trials with adaptive and traditional group sequential designs – applications in cardiovascular clinical trials
Zhang, J.-F., & Saju, C. (2023) · BMC Medical Research Methodology · doi:10.1186/s12874-023-02024-1 · Cited by 8
“1 per 100,000 in the US [2] and 266 per 100,000 in the UK in 2018 (Statista).”
The Impact of COVID-19 on Hypertension and Hypertension Medication Adherence Among Underrepresented Racial and Ethnic Groups: A Scoping Review
Foster, M. V., Etchin, A. G., Pope, C., Hartmann, C., Emidio, O., & Bosworth, H. (2023) · Current Hypertension Reports · doi:10.1007/s11906-023-01262-4 · Cited by 8
“Medications for HTN can substantially reduce morbidity and mortality, leading to better health outcomes and lower costs of medical care [6].”
Background
Energy Efficient Software-hardware Co-design of Quantized Recurrent Convolutional Neural Network for Continuous Cardiac Monitoring
Hu, J., Leow, C. S., Goh, W. L., & Gao, Y. (2023) · IEEE International Conference on Artificial Intelligence Circuits and Systems (AICAS) · doi:10.1109/aicas57966.2023.10168601 · Cited by 12
“However, some cardiovascular events such as heart rate variability (HRV) and atrial fibrillation are rare and not predictable, which cannot be detected by regular health checks [3].”
Background
The need for a personalized, core digital resource to facilitate health self-management.
Abraham, C., Borland, R., & McNeill, I. (2023) · Preventive Medicine · doi:10.1016/j.ypmed.2023.107569 · Cited by 8
Cost-Effectiveness of Dapagliflozin vs Empagliflozin for Treating Heart Failure With Reduced Ejection Fraction in the United States.
Nechi, R., Rane, A., Karaye, R. M., Ndikumukiza, C., Alsahali, S., Jatau, A., Zoni, C., Alanzi, A., Karaye, I. M., & Yunusa, I. (2023) · Clinical Therapeutics · doi:10.1016/j.clinthera.2023.05.002 · Cited by 8
The Association Between Blood Lead Levels and Coronary Artery Calcium Score Determined by Using Coronary Computed Tomography Angiography
Park, E.-J., Kim, S., Cho, S., Kim, H., Jung, I.-H., Moon, J., & Park, W.-J. (2023) · Journal of Korean medical science · doi:10.3346/jkms.2023.38.e203 · Cited by 8
Heterozygosity for ADP-ribosylation factor 6 suppresses the burden and severity of atherosclerosis
Gogulamudi, V., Islam, M. T., Durrant, J., Adeyemo, A. O., Trott, D. W., Hyuhn, M. H., Zhu, W.-Q., Donato, A. J., Walker, A. E., & Lesniewski, L. (2023) · PLoS ONE · doi:10.1371/journal.pone.0285253 · Cited by 8
Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke
Rakkar, K., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10544-y · Cited by 8
“Furthermore ageing represents the strongest risk factor for IS and is associated with greater mortality and poorer quality of life in people ≥ 65 years of age [1, 16].”
Background
Mechanism of new optimized Sheng-Mai-San Formula to regulate cardiomyocyte apoptosis through NMDAR pathway
Hou, Y., He, Z., Han, Y., Zhang, T., Wang, S., Wang, X., & Mao, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16631 · Cited by 8
pyHeart4Fish: Chamber-specific heart phenotype quantification of zebrafish in high-content screens
Vedder, V. L., Reinberger, T., Haider, S. I., Eichelmann, L., Odenthal, N., Abdelilah-Seyfried, S., Aherrahrou, Z., Breuer, M., & Erdmann, J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1143852 · Cited by 8
“Among CVDs, congenital heart diseases (CHDs) are the most common human congenital defect (van der Linde et al., 2011; Virani et al., 2021).”
Background
Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management
Zhang, M., Hou, J., Kuang, J. C., Hao, L., & Yang, Z. (2026) · MedComm · doi:10.1002/mco2.70704 · Cited by 8
Associations between dynapenic abdominal obesity and diabetes in middle aged and older Chinese
Hao, J., Tang, C., Yang, Q.-Q., Gu, Y.-Y., Wang, S., & Zeng, B.-Q. (2025) · Scientific Reports · doi:10.1038/s41598-025-16735-6 · Cited by 7
“CVD included self-reported heart problems and stroke 21 .”
Association of lipoprotein(a) and LPA gene with calcific aortic valve disease
Yu, X.-Y., Fu, Z.-A., Yu, M., & Shi, Y.-B. (2025) · European Journal of Medical Research · doi:10.1186/s40001-025-03071-8 · Cited by 7
“The incidence of CAVD is increasing in the elderly population, and it is the second most common cardiovascular disease after coronary artery disease and hypertension and a common cause of aortic valve stenosis [1].”
Potential impacts of acupuncture on motor function recovery after ischemic stroke: insights from basic and clinical studies
He, J., Ma, L., Wen, J.-S., Zhuang, Y.-X., Qian, X., Ma, L.-H., Xiu, J., Wang, X., & Chen, M. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1623535 · Cited by 6
Cardiometabolic and anxiogenic consequences of chronic social defeat stress in male mice
Scott, K. A., Eikenberry, S. A., Elsaafien, K., Baumer-Harrison, C., Johnson, D. N., Sá, J. M., Bartolomucci, A., Sumners, C., Krause, E. G., & de Kloet, A. D. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100752 · Cited by 7
PYRCR alleviates myocardial ischemia/reperfusion injury in mice via inhibiting DRG2-mediated cardiomyocyte pyroptosis
Chen, X., Xu, H., Zhao, X., Li, F., Ren, J.-H., Zhou, L., Liu, C.-Y., Wang, Y., Yang, S., Liu, F., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01604-9 · Cited by 7
“…disorder, represents a widespread and life-threatening condition that frequently culminates in acute myocardial infarction, and ischemia ‒ reperfusion injury further compromises patient outcomes, as evidenced by the mere 10.6% survival rate following out-of-hospital cardiac arrest [3, 4].”
Influential
Association between hemoglobin, albumin, lymphocyte, and platelet scores and all-cause and cardiovascular mortality among adults with atherosclerotic cardiovascular disease in the United States: An analysis of NHANES
Zou, Y., Cong, J., Fu, J.-X., & Yang, X. (2025) · Medicine · doi:10.1097/md.0000000000042386 · Cited by 7
Autologous umbilical cord blood mononuclear cell therapy for hypoplastic left heart syndrome: a nonrandomized control trial of the efficacy and safety of intramyocardial injections
Gallego-Navarro, C., Jaggers, J. J., Burkhart, H. M., Carlo, W. F., Morales, D. L. S., Qureshi, M., Rossano, J. W., Hagen, C., Seisler, D., Peral, S. C., et al. (2025) · Stem cell research & therapeutics · doi:10.1186/s13287-025-04316-3 · Cited by 7
The Elderly Patient with Atrial Fibrillation: Optimal Treatment Strategies
Lucà, F., & Parrini, I. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14051753 · Cited by 7
CQD-based electrochemical immunosensor for sensitive D-dimer detection in thrombosis and COVID-19
Gamboa, J., Linares, C., Cebrián, V., Enshaei, H., Ahumada, Ó., Estrany, F., & Torras, J. (2025) · Sensing and Bio-Sensing Research · doi:10.1016/j.sbsr.2024.100726 · Cited by 7
iPSC-Derived Biological Pacemaker—From Bench to Bedside
Vo, Q. D., Nakamura, K., Saito, Y., Iida, T., Yoshida, M., Amioka, N., Akagi, S., Miyoshi, T., & Yuasa, S. (2024) · Cells · doi:10.3390/cells13242045 · Cited by 7
“In the United States alone, over 350,000 pacemaker procedures are conducted every year, with sinus node dysfunction accounting for more than half of these implantations [3].”
LncRNA LUCAT1 offers protection against human coronary artery endothelial cellular oxidative stress injury through modulating hsa-miR-6776-5p/LRRC25 axis and activating autophagy flux
Wang, Y., Zhang, X., Ren, M.-M., He, S., Bie, H., Duan, M.-Y., Chen, Z.-Y., Jia, Q., Chi, B.-Y., Gan, X.-K., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05966-2 · Cited by 7
“CAD is the primary cause of morbidity and mortality globally, typically marked by the gradual, irreversible progression of coronary atherosclerosis [21, 22].”
Unveiling a novel signalling pathway involving NRF2 and PGAM5 in regulating the mitochondrial unfolded protein response in stressed cardiomyocytes.
Safakli, R., Gray, S., Bernardi, N., & Smyrnias, I. (2024) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2024.106704 · Cited by 7
Trends in Gaps of Care for Patients With Congenital Heart Disease: Implications for Social Determinants of Health and Child Opportunity Index
Zaidi, A., Alberts, A., Chowdhury, D., Beaty, C., Brewer, B., Chen, M.-H., & de Ferranti, S. (2024) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.124.034796 · Cited by 7
Oxygen–ozone therapy for myocardial ischemic stroke and cardiovascular disorders
Pandolfi, S., Chirumbolo, S., Franzini, M., Tirelli, U., & Valdenassi, L. (2024) · Medical Gas Research · doi:10.4103/mgr.medgasres-d-23-00013 · Cited by 7
“25,26 The risk of developing AMI increases with increasing age and in the presence of predisposing factors to atherosclerosis.”
Background
Social Determinants of Health Phenotypes and Cardiometabolic Condition Prevalence Among Patients in a Large Academic Health System: Latent Class Analysis
Howell, C. R., Zhang, L., Clay, O. J., Dutton, G. R., Horton, T. V., Mugavero, M. J., & Cherrington, A. (2024) · JMIR Public Health and Surveillance · doi:10.2196/53371 · Cited by 10
“The population prevalence of cardiometabolic disease continues to rise [1], increasing patient burden and societal costs.”
Clinician perceptions of a novel wearable robotic hand orthosis for post-stroke hemiparesis
Winterbottom, L., Chen, A., Mendonca, R. J., Nilsen, D. M., Ciocarlie, M., & Stein, J. (2024) · Disability and Rehabilitation · doi:10.1080/09638288.2024.2375056 · Cited by 7
“Stroke affects over 795,000 individuals each year in the United States and is a common cause of long-term disability [1].”
Impact of Diabetes Mellitus on Outcomes in Patients with Left Ventricular Assist Devices
Crugnola, W., Cinquina, A., Mattimore, D., Bitzas, S., Schwartz, J. A., Zaidi, S., & Bergese, S. D. (2024) · Biomedicines · doi:10.3390/biomedicines12071604 · Cited by 7
“The prevalence of heart failure (HF) in the United States has been estimated at 6 million people between 2015 and 2018 [1].”
Hemodynamic coupling between a primary atherosclerotic plaque and subsequent secondary lesions
Nooraeen, A., Taghizadeh, H., & Ghalichi, F. (2024) · The Physics of Fluids · doi:10.1063/5.0202978 · Cited by 7
Voxel level dense prediction of acute stroke territory in DWI using deep learning segmentation models and image enhancement strategies
Koska, I. Ö., Selver, M., Gelal, F., Uluç, M. E., Çetinoğlu, Y., Yurttutan, N., Serindere, M., & Dicle, O. (2024) · Japanese Journal of Radiology · doi:10.1007/s11604-024-01582-8 · Cited by 7
Designing and validating of a questionnaire measuring perceived self-care ability (PSCA) in chronic stroke patients at home
Jafari-golestan, N., Dalvandi, A., Hosseini, M., Fallahi-khoshknab, M., Ebadi, A., Rahgozar, M., & Souraya, S. (2024) · BMC Neurology · doi:10.1186/s12883-024-03612-4 · Cited by 7
“…for stroke patients after discharge and continued rehabilitation increases satisfaction with rehabilitation and independence in performing self-care such as mobility, dressing, and personal hygiene, as well lessen the consequences of the illness such as speech impairment and depression [4].”
Impact of Insurance Status and Region on Angiotensin Receptor-Neprilysin Inhibitor Prescription During Heart Failure Hospitalizations.
Davogustto, G. E., Wells, Q., Harrell, F., Greene, S., Roden, D., & Stevenson, L. W. (2024) · JACC. Heart failure · doi:10.1016/j.jchf.2024.02.003 · Cited by 7
Associations between hypertension with reproductive and menopausal factors: An integrated women’s health programme (IWHP) study
Wang, L. Y., Thu, W. P., Chan, Y. H., Logan, S., Kramer, M., Cauley, J., & Yong, E. (2024) · PLoS ONE · doi:10.1371/journal.pone.0299840 · Cited by 7
Primary Prevention of Cardiovascular Disease in Women
Shahid, I., Avenatti, E., Titus, A., Al-Kindi, S. G., & Nasir, K. (2024) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcvj.1313 · Cited by 7
Developmental Prediction of Poststroke Patients in Activities of Daily Living by Using Tree-Structured Parzen Estimator–Optimized Stacking Ensemble Approaches
Lin, P.-H., Kuo, P., & Chen, K.-L. (2024) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2024.3372649 · Cited by 10
“Stroke is a major cause of long-term illnesses as shown by S. S. Virani et al. [5].”
Hyperpolarization‐activated cyclic nucleotide‐gated channel inhibitor in myocardial infarction: Potential benefits beyond heart rate modulation
Sripusanapan, A., Yanpiset, P., Sriwichaiin, S., Siri-Angkul, N., Chattipakorn, S., & Chattipakorn, N. (2024) · Acta Physiologica · doi:10.1111/apha.14085 · Cited by 7
ANMCO (Italian Association of Hospital Cardiologists) scientific statement: obesity in adults—an approach for cardiologists
Fusco, S. A. D., Mocini, E., Gulizia, M. M., Gabrielli, D., Grimaldi, M., Oliva, F. G., & Colivicchi, F. (2024) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-023-01630-8 · Cited by 10
“In high-income countries, such as the United States, nearly, 40% of adults met the BMI criteria for obesity in 2015–2016, with approximately 8% meeting criteria for grade 3 obesity (6.2% in males and 10.5 in females) [24].”
Influential
Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1
He, F., Chen, C., Wang, Y., Wang, S.-T., Lyu, S., Jiao, J., Huang, G.-Y., & Yang, J.-S. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12358 · Cited by 7
p38γ/δ activation alters cardiac electrical activity and predisposes to ventricular arrhythmia
Romero-Becerra, R., Cruz, F., Mora, A., López, J. A., Ponce-Balbuena, D., Allan, A., Ramos-Mondragón, R., González-Terán, B., León, M., Rodriguez, M. E., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00368-x · Cited by 7
“Most deaths that meet the definition of sudden cardiac death are caused by cardiac arrhythmias 2,3 .”
Needs of multimorbid heart failure patients and their carers: a qualitative interview study and the creation of personas as a basis for a blended collaborative care intervention
Engelmann, P., Eilerskov, N., Thilsing, T., Bernardini, F., Rasmussen, S., Löwe, B., Herrmann-Lingen, C., Gostoli, S., Andréasson, F., Rafanelli, C., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1186390 · Cited by 7
Mortality trends, disparities, and social vulnerability in cardiac arrest mortality in the young: A cross‐sectional analysis
Ibrahim, R., Shahid, M., Srivathsan, K., Sorajja, D., Deshmukh, A. J., & Lee, J. Z. (2023) · Cardiovascular Electrophysiology · doi:10.1111/jce.16112 · Cited by 7
PAKistan Study of prEmature coronary atHerosclerosis in young AdulTs (PAK-SEHAT): a prospective longitudinal study protocol investigating the prevalence, severity and determinants of atherosclerotic cardiovascular disease in the young adult Pakistani population
Hanif, B., Sheikh, S., Peerwani, G., Caínzos-Achirica, M., Javed, W., Baqar, J. B., Samad, Z., Bashir, F., Virani, S. S., Nasir, K., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-076045 · Cited by 7
“Atherosclerotic cardiovascular disease (ASCVD) remains one of the leading causes of morbidity, mortality and health expenditures worldwide, 1 and is now a major public health issue in many densely populated low-income and middle-income countries undergoing rapid urbanisation.”
BackgroundSelf-citation
Left Ventricle Contouring in Cardiac Images in the Internet of Medical Things via Deep Reinforcement Learning
Yin, S., Wang, K., Han, Y., Pan, J., Wang, Y., Li, S., & Yu, F. R. (2023) · IEEE Internet of Things Journal · doi:10.1109/jiot.2023.3280743 · Cited by 9
“A CCORDING to recent statistics from American Heart Association (AHA), cardiovascular diseases have been the top leading cause of death globally [1].”
Method
Factors shaping return to work: a qualitative study among heart failure patients in Denmark
Jørgensen, S. M. B., Johnsen, N., Maribo, T., Brøndum, S., Gislason, G., & Kristiansen, M. (2023) · Disability and Rehabilitation · doi:10.1080/09638288.2023.2266998 · Cited by 7
“…with considerable morbidity and mortality, as well as diminished functional capacity, lower quality of life, and high health care costs [1–4]. currently, the prevalence of heart failure in developed countries appears to be 1–2% of the adult population, increasing from 1% among those aged…”
Zebrafish Model Insights into Mediterranean Diet Liquids: Olive Oil and Wine
Silva, P., Rodríguez-Pérez, M., & Burgos‐Ramos, E. (2023) · Antioxidants · doi:10.3390/antiox12101843 · Cited by 7
“CVD is a life-threatening condition and a leading cause of death worldwide [31].”
Background
Protocol of the Berlin Long-term Observation of Vascular Events (BeLOVE): a prospective cohort study with deep phenotyping and long-term follow up of cardiovascular high-risk patients
Weber, J. E., Ahmadi, M., Boldt, L., Eckardt, K., Edelmann, F., Gerhardt, H., Grittner, U., Haubold, K., Hübner, N., Kollmus-Heege, J., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-076415 · Cited by 7
Association of Neighborhood Recreation Centers and Poststroke Outcomes in a Population-Based Cohort
Delhey, L. M., Shi, X., Morgenstern, L., Brown, D. L., Smith, M. A., Case, E., Springer, M. V., & Lisabeth, L. (2023) · Stroke · doi:10.1161/strokeaha.122.041852 · Cited by 7

Authors: Virani, S. S., Alonso, A., Aparicio, H. J., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Cheng, S., Delling, F. N., Elkind, M. S. V., Evenson, K. R., Ferguson, J. F., Gupta, D. K., Khan, S. S., Kissela, B. M., Knutson, K. L., Lee, C. D., Lewis, T. T., Liu, J., Loop, M. S., Lutsey, P. L., Ma, J., Mackey, J., Martin, S. S., Matchar, D. B., Mussolino, M. E., Navaneethan, S. D., Perak, A. M., Roth, G. A., Samad, Z., Satou, G. M., Schroeder, E. B., Shah, S. H., Shay, C. M., Stokes, A., VanWagner, L. B., Wang, N.-Y., Tsao, C. W., & On behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
ORCID: Virani, Salim S.
Aparicio, Hugo J.
Benjamin, Emelia J.
Callaway, Clifton W.
Carson, April P.
Chamberlain, Alanna M.
Cheng, Susan
Delling, Francesca N.
Elkind, Mitchell S.V.
Evenson, Kelly R.
Ferguson, Jane F.
Gupta, Deepak K.
Khan, Sadiya S.
Knutson, Kristen L.
Lee, Chong D.
Lewis, Tené T.
Liu, Junxiu
Loop, Matthew Shane
Lutsey, Pamela L.
Ma, Jun
Mackey, Jason
Martin, Seth S.
Matchar, David B.
Navaneethan, Sankar D.
Perak, Amanda Marma
Roth, Gregory A.
Samad, Zainab
Satou, Gary M.
Schroeder, Emily B.
Shah, Svati H.
Shay, Christina M.
Stokes, Andrew
VanWagner, Lisa B.
Wang, Nae-Yuh
Tsao, Connie W.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2021-02-23
Volume: 143
Issue: 8
Pages: e254-e743
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/cir.0000000000000950
PMC: PMC13036842
OpenAlex: W3122226502
Cited by: 5,784
References: 0
Citations by year: 2026: 503 · 2025: 658 · 2024: 915 · 2023: 1282 · 2022: 1694 · 2021: 646
FWCI: 764.95
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-nd)
eCommons - AKU (Aga Khan University) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (R03HL145195, R01HL155717)
National Institute of Neurological Disorders and Stroke (L30 NS093634, R01NS017950)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
Keywords: heart disease, stroke, cardiovascular disease statistics, cardiovascular risk factors, cardiovascular health behaviors, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary artery disease, heart failure, valvular heart disease, venous disease, peripheral arterial disease, quality of care, health care costs, social determinants of health, adverse pregnancy outcomes, cardiovascular disease prevention
MeSH terms: Global Burden of Disease, Diet, Healthy, American Heart Association, Blood Pressure, Cholesterol, Diabetes Mellitus, Heart Diseases, Hospitalization, Humans, Obesity, Risk Factors, Smoking, United States, Health Behavior, Exercise, Prevalence, Stroke

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks