Cited by 5,784Cardiovascular Health and Risk FactorsHealthcare Systems and Public HealthHealth Promotion and Cardiovascular Prevention

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Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association

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Virani, Salim S., Alonso, Alvaro, Aparicio, Hugo J., Benjamin, Emelia J., Bittencourt, Marcio S., Callaway, Clifton W., Carson, April P., Chamberlain, Alanna M., Cheng, Susan, Delling, Francesca N., Elkind, Mitchell S.V., Evenson, Kelly R., Ferguson, Jane F., Gupta, Deepak K., Khan, Sadiya S., Kissela, Brett M., Knutson, Kristen L., Lee, Chong D., Lewis, Tené T., Liu, Junxiu, Loop, Matthew Shane, Lutsey, Pamela L., Ma, Jun, Mackey, Jason, Martin, Seth S., Matchar, David B., Mussolino, Michael E., Navaneethan, Sankar D., Perak, Amanda Marma, Roth, Gregory A., Samad, Zainab, Satou, Gary M., Schroeder, Emily B., Shah, Svati H., Shay, Christina M., Stokes, Andrew, VanWagner, Lisa B., Wang, Nae-Yuh, Tsao, Connie W., On behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee·2021·Circulation

DOI 10.1161/cir.0000000000000950PMC PMC13036842

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Abstract

Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). Methods: The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2021 Statistical Update is the product of a full year’s worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year’s edition includes data on the monitoring and benefits of cardiovascular health in the population, an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, the global burden of cardiovascular disease, and further evidence-based approaches to changing behaviors related to cardiovascular disease. Results: Each of the 27 chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. Conclusions: The Statistical Update represents a critical resource for the lay public, policy makers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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Clinical trials and advanced MRI techniques with stem cell therapy for ischemic stroke: present and future perspectives
Liu, J.-H., Cheng, L., Ma, C., Wang, X.-L., Ji, X.-F., Li, Y., & Liu, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07054-5 · Cited by 5
“Stroke is the principal cause of death and long-term disability worldwide [1].”
Self-citation
Prevalence of physical activity and its association with atherosclerotic cardiovascular risk factors in young women in the middle east: a sub-analysis of the ANCHORS study
Alkouri, O., Alrida, N., Alabkal, R. M., Khader, Y., Albikawi, Z., Ababneh, A., Alobaidly, A., Qaladi, O., Alharbi, A., Jarrah, M., et al. (2025) · BMC Public Health · doi:10.1186/s12889-025-24595-y · Cited by 5
Out-of-Hospital Cardiac Arrest Patients: Different Donor Pathways for an Existing Donor Pool Still Underestimated—Perspective
Lazzeri, C., Grippo, A., Feltrin, G., Peris, A., & Quatrale, R. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14196946 · Cited by 5
S100A11/ANXA2 axis mediates electrotransduction to promote electrically-induced contraction in engineered myocardial tissues
Li, X., Zhang, Q., Wang, Y., Wang, Z., Cui, M., Peng, N., Jiang, Z., Xiao, Z., & Zhang, X. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123712 · Cited by 5
Unleashing Vision Foundation Models for Coronary Artery Segmentation: Parallel ViT-CNN Encoding and Variational Fusion
Dong, C., Dai, D.-W., Han, X.-Y., Liu, F., Yang, X., Li, Z., & Xu, S.-Y. (2025) · International Conference on Medical Image Computing and Computer-Assisted Intervention · doi:10.48550/arxiv.2507.12938 · Cited by 5
“Coronary artery disease (CAD) is the most common type of heart disease and a leading cause of global mortality [20].”
The association between insulin resistance-related markers and ASCVD with hyperuricemia: results from the 2005 to 2018 National Health and Nutrition Examination Survey
Shi, Y., Zhang, Z., Yang, J., & Cui, S. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1583944 · Cited by 5
Diabetic ketoacidosis and hyperosmolar hyperglycemic state in diabetes patients with heart failure: insight from the National inpatient sample
Alroobi, H., Dargham, S., Mahfoud, Z., Jayyousi, A., Suwaidi, J. A., & Khalil, C. A. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-04832-3 · Cited by 5
“For example, in the United States, HF is a leading cause of hospitalization among older adults, with annual costs projected to exceed $70 billion by 2030 [3].”
Identification and analysis of diagnostic markers related to lactate metabolism in myocardial infarction.
Yu, H., Gu, L., Ma, H., & Yu, L. (2025) · Pathology, Research and Practice · doi:10.1016/j.prp.2025.156010 · Cited by 5
A minimally invasive thrombotic model to study stroke in awake mice
Marks, K., Ahn, S. J., Rai, N., Anfray, A., Iadecola, C., & Anrather, J. (2025) · Nature Communications · doi:10.1038/s41467-025-59617-1 · Cited by 11
“Of these, roughly 87% are ischemic, in that brain damage occurs from a clot blocking a major cerebral artery, most commonly the middle cerebral artery (MCA) 2,3 .”
Incidence and outcomes of out-of-hospital cardiac arrest from initial asystole: a systematic review and meta-analysis.
Dwivedi, D., Ball, J., Smith, K., & Nehme, Z. (2025) · Resuscitation · doi:10.1016/j.resuscitation.2025.110629 · Cited by 5
Implementation and effectiveness of advance care planning in hospitalized older adults with chronic heart failure: a mixed-methods systematic review and meta-analysis
Chen, L., Cheng, Y.-Q., Qu, J., & Wang, Z.-Y. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1566977 · Cited by 5
Amplitude of low-frequency fluctuation (ALFF) alterations in heart transplant patients with cognitive impairment: a resting-state fMRI study
Qin, Q., Liu, J., Fan, W., Zhang, X., Lu, J., Guo, X., Lei, Z., & Wang, J. (2025) · Clinical Autonomic Research · doi:10.1007/s10286-025-01124-w · Cited by 4
“Currently, approximately 65 million adults worldwide have heart failure, and the incidence of heart failure is expected to continue to rise over the next decade as the population ages [1].”
Self-citation
Effect of 1-Kestose on Lipid Metabolism in a High-Fat-Diet Rat Model
Kuramitsu, K., Kubo, M., Cindy, F., Shibata, T., Kadota, Y., & Kitaura, Y. (2025) · Nutrients · doi:10.3390/nu17081362 · Cited by 5
Spontaneous Coronary Artery Dissection: A Narrative Review of Epidemiology and Public Health Implications
Pender, P., Zaheen, M., Dang, Q., Dang, V., Xu, J., Hollings, M., Lo, S. T., Negishi, K., & Zaman, S. J. (2025) · Medicina · doi:10.3390/medicina61040650 · Cited by 13
“Given the high burden of ACS (e.g., an estimated 805,000 ACS cases annually in the United States alone [20]), SCAD represents a significant global burden.”
Trajectories of activities of daily living/ instrumental activities of daily living and the risk of cardiovascular diseases.
Han, W.-Y., Mao, K., Li, Y.-Q., Jiang, M.-L., Ren, X., Zheng, X., & Zhang, K.-X. (2025) · NMCD. Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2025.103969 · Cited by 5
Stroke in Heart Failure With Reduced Ejection Fraction: Systematic Review and Meta-Analysis of Randomized Trials.
Gallone, G., Savoca, F., Miccoli, D., Böhm, M., de Ferrari, G. D., Gottlieb, S. S., Lancellotti, P., Lindenfeld, J., Saldarriaga, C., Samad, Z., et al. (2025) · JACC. Heart failure · doi:10.1016/j.jchf.2024.12.008 · Cited by 5
Self-citation
Mission and One-Year Experience of a Kidney–Heart Outpatient Service: A Patient-Centered Management Model
Carollo, C., Evola, S., Sorce, A., Cirafici, E., Bennici, M., Mulè, G., & Geraci, G. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14062102 · Cited by 5
“every two years. reducing frequency and improving outcomes associated with heart failure hospitalizations is a public health priority [22,23]. associated with poor clinical outcomes and higher resources utilization [24].”
Dual-targeted microbubbles for atherosclerosis therapy: Inducing M1 macrophage apoptosis by inhibiting telomerase activity
Xue, W., Huang, Z., Huang, Y., Xiong, K., Sheng, Y., Lin, X., Zhong, X., Ye, J., Guo, Y., Arkin, G., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101675 · Cited by 4
“The growth of AS lesions or rupture of ‘vulnerable ’ plaques can lead to acute myocardial infarction, stroke, and sudden cardiac death [3,4].”
Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020
Naveed, M., Neppala, S., Chigurupati, H., Ali, A., Rehan, M., Fath, A., Azeem, B., Iqbal, R., Mubeen, M., Naveed, H., et al. (2025) · International Journal of Cardiology Cardiovascular Risk and Prevention · doi:10.1016/j.ijcrp.2025.200392 · Cited by 5
“Elderly individuals, precisely those aged 65 and older, are at the highest risk for both malignancy and AMI due to age-related physiological changes and the rising prevalence of chronic conditions within this group [8,9].”
Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin
Gao, Y., Qin, G., Liang, S.-C., Yin, J., Wang, B., Jiang, H., Liu, M., Luo, F., & Li, X. (2025) · Drug Design, Development and Therapy · doi:10.2147/dddt.s504884 · Cited by 5
RiboTag RNA Sequencing Identifies Local Translation of HSP70 in Astrocyte Endfeet After Cerebral Ischemia
Shim, B., Ciryam, P., Tosun, Ç., Serra, R., Tsymbalyuk, N., Keledjian, K., Gerzanich, V., & Simard, J. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26010309 · Cited by 5
Sex hormone-dependent host-microbiome interactions and cardiovascular risk (XCVD): design of a longitudinal multi-omics cohort study
Franz, K., Markó, L., Mähler, A., Chakaroun, R., Heinitz, S., Schlögl, H., Sacher, J., Steckhan, N., Dechend, R., Adams, N., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-087982 · Cited by 5
Exposure to Perchlorate and Cardiovascular Disease in China: A Community-Based Cross-Sectional Study and Benchmark Dose Estimation.
Lei, K., Xia, L.-L., Chen, J., Li, W., Wang, Q., Huang, Y., Wang, P., Liang, X.-L., Li, Y., Chen, L.-K., et al. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.125429 · Cited by 5
Association of depressive symptoms and engagement in physical activity with event-free survival in patients with heart failure
Cha, G., Chung, M. L., Kang, J., Lin, C., Biddle, M., Wu, J. R., Lennie, T. A., Thapa, A., & Moser, D. K. (2024) · Heart & Lung · doi:10.1016/j.hrtlng.2024.10.003 · Cited by 5
Stroke recurrence prediction using machine learning and segmented neural network risk factor aggregation
Ding, X., Meng, Y., Xiang, L., & Boden-Albala, B. M. (2024) · Discover Public Health · doi:10.1186/s12982-024-00199-6 · Cited by 5
“Stroke has remained the fifth leading cause of mortality in the United States for years [2–5], and it has been a major cause of long-term disabilities [6, 7].”
Bio Inspired Technological Performance in Color Doppler Ultrasonography and Echocardiography for Enhanced Diagnostic Precision in Fetal Congenital Heart Disease.
Zhang, K., & Zhong, J. (2024) · SLAS technology · doi:10.1016/j.slast.2024.100207 · Cited by 5
Immunometabolic effects of β-carotene and vitamin A in atherogenesis
Blanco, A., & Amengual, J. (2024) · Immunometabolism · doi:10.1097/in9.0000000000000051 · Cited by 5
Evaluation of a nomogram model for predicting in-hospital mortality risk in patients with acute ST-elevation myocardial infarction and acute heart failure post-PCI
Yu, F., Xu, Y.-C., & Peng, J.-C. (2024) · Scandinavian Cardiovascular Journal · doi:10.1080/14017431.2024.2387001 · Cited by 5
“Studies have shown that women are more likely to develop ischemic cardiomyopathy and have a higher mortality rate from cardiovascular disease compared to men [32, 33].”
HDL cholesterol efflux capacity and cholesterol loading capacity in long-term fasting: Evidence from a prospective, single-arm interventional study in healthy individuals.
Grundler, F., Palumbo, M., Adorni, M., Zimetti, F., Papotti, B., Plonné, D., Holley, A., Mesnage, R., Ruscica, M., & de Toledo, F. W. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.118548 · Cited by 5
Characteristics associated with 30-day post-stroke readmission within an academic urban hospital network.
Spiegler, K., Irvine, H., Torres, J., Cardiel, M., Ishida, K., Lewis, A., Galetta, S., & Melmed, K. R. (2024) · Journal of Stroke & Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2024.107984 · Cited by 5
Stationary Prospective Cardiac Gated Computed Tomography—Dynamic Study in Phantoms and In Vivo
Billingsley, A., Inscoe, C., Attia, M. F., Lu, J., Zhou, O., & Lee, Y. Z. (2024) · Physics in Medicine and Biology · doi:10.1088/1361-6560/ad62d1 · Cited by 5
“659 000 people die each year, contributing to 1 in every 4 deaths (Virani et al 2021).”
Remote Monitoring of Cardiac Implantable Electronic Devices in Very Elderly Patients: Advantages and Specific Problems
Scacciavillani, R., Koliastasis, L., Doundoulakis, I., Chiotis, S., Kordalis, A., Narducci, M., Kotoulas, S., Pinnacchio, G., Bencardino, G., Perna, F., et al. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11070209 · Cited by 5
“Stroke risk increases with age, and the medical treatment itself may lead to more complications in the elderly [18,19].”
Background
Predicting mortality amongst Jordanian men with heart attacks using the chi-square automatic interaction detection model
Hani, S. H. B., & Ahmad, M. M. (2024) · Health Informatics Journal · doi:10.1177/14604582241270830 · Cited by 5
Differentiation, Metabolism, and Cardioprotective Secretory Functions of Human Cardiac Stromal Cells from Ischemic and Endocarditis Patients
Nguyen, H. H., Hsu, C.-C., Meeson, A. P., Oldershaw, R. A., Richardson, G. D., Czosseck, A., & Lundy, D. J. (2024) · Stem Cells and Development · doi:10.1089/scd.2024.0103 · Cited by 5
The Puerto Rico Young Adults’ Stress, Contextual, Behavioral, and Cardiometabolic Risk (PR-OUTLOOK) Study: design and methods
Pérez, C. M., Kiefe, C., Person, S. D., Tucker, K. L., Torres, P., Sandoval, E., Boneu, C., Ramírez, Z., Mattei, J., Rodriguez-Orengo, J. F., et al. (2024) · American Journal of Epidemiology · doi:10.1093/aje/kwae163 · Cited by 5
Identification and correction for collider bias in a genome-wide association study of diabetes-related heart failure
Sun, Y. V., Liu, C., Hui, Q., Zhou, J. J., Gaziano, J. M., Wilson, P. W. F., Program, T. M. V., Phillips, L. S., & Phillips, L. S. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.05.018 · Cited by 7
Long Term Systemic Use of Calcium Channel Blockers and Incidence of Primary Open Angle Glaucoma.
Tavakoli, K., Sidhu, S., Saseendrakumar, B. R., Weinreb, R. N., & Baxter, S. (2024) · Ophthalmology Glaucoma · doi:10.1016/j.ogla.2024.06.003 · Cited by 5
T-Wave Peak-to-End Changes Quantified by Time-Warping Predicts Ventricular Fibrillation in a Porcine Myocardial Infarction Model
Gómez, N., Ramírez, J., Martín-Yebra, A., Demidova, M., Platonov, P., Martínez, J., & Laguna, P. (2024) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2024.3404254 · Cited by 5
“T HE development of life-threatening arrhythmias, such as ventricular ﬁbrillation (VF), is the main cause of sudden cardiac death (SCD), in both myocardial infarction settings and the general population, remaining the leading cause of death worldwide [1], [2].”
Trends in Cardiovascular Health Among US Adolescents Aged 12-19 Years Using the New "Life's Essential 8" Metrics, 2007-2018.
Yang, H., Wang, J.-X., Li, Y.-Z., Zhao, M., Magnussen, C., & Xi, B. (2024) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2024.03.004 · Cited by 5
Plasma Metabolites and Life’s Simple 7 in REGARDS
Kijpaisalratana, N., Ament, Z., Patki, A., Bhave, V. M., Jones, A. C., Couch, C. A., Guarniz, A.-L. G., Cushman, M., Long, D., Judd, S. E., et al. (2024) · Stroke · doi:10.1161/strokeaha.123.044714 · Cited by 5
New approach to heart failure: Integrated traditional Chinese with Western medicine
Wang, Q., Cao, H.-S., Li, P., Li, C., Shi, Z.-X., & Ren, J. (2024) · Advanced Chinese Medicine · doi:10.1002/acm4.10 · Cited by 5
Contemporary evaluation and treatment of tricuspid regurgitation
Minciunescu, A., & Emaminia, A. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1350536 · Cited by 5
Female-specific risk variables: From innocent bystanders to key players in cardiovascular risk prediction
Maas, A. H. E. M. (2024) · Maturitas · doi:10.1016/j.maturitas.2024.107970 · Cited by 6
Correlation between systolic blood pressure and mortality in heart failure patients with hypertension
Lang, X., Peng, C. Y., Zhang, Y., Gao, R., Zhao, B., Li, Y., & Zhang, Y. (2024) · Journal of Hypertension · doi:10.1097/hjh.0000000000003693 · Cited by 5
Sex Disparities in Left Ventricular Assist Device Implantation: Delayed Presentation and Worse Right Heart Failure
Lamba, H., Kherallah, R., Nair, A., Shafii, A., Loor, G., Kassi, M., Chatterjee, S., Rogers, J. G., Civitello, A., & Liao, K. K. (2024) · ASAIO journal (1992) · doi:10.1097/mat.0000000000002134 · Cited by 5
Cardiovascular Disease in the Caribbean: Risk Factor Trends, Care and Outcomes Still Far From Expectations
Bahall, M. U. (2024) · Cureus · doi:10.7759/cureus.52581 · Cited by 4
“The mean age is at least a decade earlier (58.6 ± 13.43 years in 2019) compared to Japan (70 ± 13 years in 2011) [61] and USA (65.6 years for men and 72.0 years for women) [63].”
BackgroundInfluential
Women Veterans’ Barriers to Care-Seeking for Cardiovascular Disease Prevention
Orshak, J., Ondoma, C., Johnson, H. M., & Lauver, D. (2024) · Nursing Research · doi:10.1097/nnr.0000000000000684 · Cited by 5
“Nurse researchers generated a survey guided by current CVD literature (e.g., Virani et al., 2021), women veteran literature, and prior TCSB research (Backonja et al., 2014).”
BackgroundMethod
Hypertensive Disorders of Pregnancy and Pre-Pregnancy Hypertension with Subsequent Incident Venous Thromboembolic Events
Malek, A., Wilson, D., Turan, T. N., Mateus, J., Lackland, D. T., & Hunt, K. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21010089 · Cited by 5
“NHB women are a critical group to study because of their high risk of cardiovascular disease risk factors as well as HDP and related outcomes in general [44,45].”
Background
Mediation of metabolic syndrome in the association between long-term exposure to particulate matter and incident cardiovascular disease: Evidence from a population-based cohort in Chengdu.
Zhou, H., Liang, X., Tan, K., Guo, Y., Zhao, X., Chen, G.-B., Guo, B., Li, S.-S., Feng, S., Pan, Q., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115827 · Cited by 5
Plateauing atrial fibrillation burden in acute ischemic stroke admissions in the United States from 2010 to 2020
Otite, F., Patel, S. D., Aneni, E., Lamikanra, O., Wee, C., Albright, K. C., Burke, D., Latorre, J., Morris, N. A., Anikpezie, N., et al. (2023) · International Journal of Stroke · doi:10.1177/17474930231222163 · Cited by 5
Case report: C-reactive protein apheresis in cardiogenic shock: case series from the C-reactive protein apheresis in acute myocardial infarction-registry
Torzewski, J., Mattecka, S., Ries, W., Garlichs, C. D., Heigl, F., Fiedler, J., & Sheriff, A. (2023) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2023.1286710 · Cited by 5
Herbal formulas for detoxification and dredging collaterals in treating carotid atherosclerosis: a systematic review and meta-analysis
Zhang, L., Huang, X., Gao, Y.-H., Li, X.-Y., Kong, Q., Chen, Y., Chang, J.-L., Zhang, G.-M., & Ma, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1147964 · Cited by 5
Numerical simulation analysis of multi-scale computational fluid dynamics on hemodynamic parameters modulated by pulsatile working modes for the centrifugal and axial left ventricular assist devices
Huo, M., Giridharan, G., Sethu, P., Qu, P., Qin, K., & Wang, Y. (2023) · Comput. Biol. Medicine · doi:10.1016/j.compbiomed.2023.107788 · Cited by 5
Endovascular treatment of acute ischemic stroke patients with tandem lesions: antegrade versus retrograde approach
Galecio-Castillo, M., Abraham, M., Farooqui, M., Hassan, A., Divani, A., Jumaa, M., Ribó, M., Petersen, N., Fifi, J., Guerrero, W. R., et al. (2023) · Journal of Neurosurgery · doi:10.3171/2023.10.jns231702 · Cited by 5
Bioprinted in vitro tissue models: an emerging platform for developing therapeutic interventions and disease modelling
Bhardwaj, N., Dey, S., Bhar, B., & Mandal, B. B. (2023) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ad10b4 · Cited by 9
“The mortality rate associated with CVD is approximately 17.5 million deaths every year, which are expected to rise to 70% by 2030 [173].”
BackgroundInfluential
Pumping for Two: Pregnancy in Patients Supported With a Left Ventricular Assist Device.
Oren, D., Moeller, C., Haythe, J., Rubinstein, G., Valledor, A. F., Lotan, D., Rosenblum, H., Colombo, P., Yuzefpolskaya, M., Topkara, V., et al. (2023) · ASAIO journal (1992) · doi:10.1097/mat.0000000000002082 · Cited by 5
Investigating the role of NPR1 in dilated cardiomyopathy and its potential as a therapeutic target for glucocorticoid therapy
Huang, Y., Li, T., Gao, S.-C., Li, S., Zhu, X., Li, Y., Liu, D., Li, W., Yang, L.-Q., Liu, K.-S., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1290253 · Cited by 5
Identification of an association between coronary heart disease and ITGB2 methylation in peripheral blood by a case-control study.
Zhu, L., Zhu, C., Jin, J., Wang, J.-X., Zhao, X.-J., & Yang, R.-X. (2023) · Clinica chimica acta; international journal of clinical chemistry · doi:10.1016/j.cca.2023.117627 · Cited by 5
The Impact of Age on the Physiological Assessment of Borderline Coronary Stenoses
Zasada, W., Zdzierak, B., Rakowski, T., Bobrowska, B., Krawczyk-Ożóg, A., Surowiec, S., Bartuś, S., Surdacki, A., & Dziewierz, A. (2023) · Medicina · doi:10.3390/medicina59101863 · Cited by 5
“Coronary artery disease (CAD) is one of the most prevalent heart diseases among adult patients [1].”
Background
Sex and Gender Differences in Ventricular Arrhythmias
Warnock, R. K., Modi, R. D., & Westerman, S. B. (2023) · US Cardiology Review · doi:10.15420/usc.2022.38 · Cited by 5
“2 In one registry study, women had higher rates of VT recurrence within 1 year following ablation compared with men despite being younger, having fewer medical comorbidities, and having a higher average left ventricular ejection fraction.”
Background
Are Physical and Depressive Symptoms Different Between Women and Men With Heart Failure? An Exploration Using Two Analytic Techniques
Davis, M. C. R., Dieckmann, N., Hansen, L., Gupta, N., Hiatt, S., Lee, C. S., & Denfeld, Q. (2023) · Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000001036 · Cited by 5
Self-citation
Improving multidisciplinary hospital care for acute cerebral circulation disorders in Kazakhstan
Adenova, G., Kausova, G., & Tazhiyeva, A. Y. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18435 · Cited by 6
Broadening Heart Failure Care Beyond Cardiology: Challenges and Successes Within the Landscape of Multidisciplinary Heart Failure Care
Olson, M., Thompson, Z., Xie, L. X., & Nair, A. P. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01907-5 · Cited by 7
Application of Human Induced Pluripotent Stem Cells for Tissue Engineered Cardiomyocyte Modelling
Katili, P. A., Karima, A. P., Azwani, W., Antarianto, R. D., & Djer, M. M. (2023) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-023-00294-1 · Cited by 6
“Heart failure remains a massive burden in cardiovascular diseases, contributing 6.5 million cases in the USA in 2015–2018 [1].”
Influential
Delayed Muscle Activity in Stroke Survivors with Upper-Limb Hemiparesis
Lopez, D. R., Thomson, C. J., Mino, F. R., Edgely, S. R., Maitre, P. P., Iversen, M., & George, J. A. (2023) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society · doi:10.1109/embc40787.2023.10340726 · Cited by 5
“Over 795,000 people in the United States suffer from a stroke each year, and upper-limb hemiparesis comprises 80% of motor deficits in stroke survivors [1].”
Background
Percutaneous Left Atrial Appendage Occlusion Therapy: Evolution and Growing Evidence
Han, X.-Q., & Benditt, D. (2023) · Reviews in cardiovascular medicine · doi:10.31083/j.rcm2407211 · Cited by 5
“Thromboembolic complications, particularly stroke, are among the most important adverse events associated with atrial fibrillation (AF) [1–3], and the left atrial appendage (LAA), with its muscular trabeculations and often complex multilobular structure has long been considered the principal site…”
Background
The effect of sedation and time after cardiac arrest on coma outcome prognostication based on EEG power spectra
Pelentritou, A., Nguissi, N. A. N., Iten, M., Haenggi, M., Zubler, F., Rossetti, A., & Lucia, M. D. (2023) · Brain Communications · doi:10.1093/braincomms/fcad190 · Cited by 5
“Advances in resuscitation and post-CA care have allowed for improvement of survival rate and functional outcome.(2) From those patients admitted to the intensive care unit after CA, many remain unconscious and suffer from post-CA syndromes, known to affect cerebral and cardiac function.”
Background
A bibliometric analysis of acute myocardial infarction in women from 2000 to 2022
Xu, M., Yang, F., Shen, B., Wang, J., Niu, W., Chen, H., Li, N., Chen, W., Wang, Q., He, Z.-Q., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1090220 · Cited by 5
Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study
Laupsa‐Borge, J., Grytten, E., Bohov, P., Bjørndal, B., Strand, E., Skorve, J., Nordrehaug, J. E., Berge, R. K., Rostrup, E., Mellgren, G., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1020678 · Cited by 5
Care delivery team composition effect on hospitalization risk in African Americans with congestive heart failure
Williams, T., Crump, A., Garza, M. Y., Parker, N., Simmons, S., Lipschitz, R., & Sexton, K. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286363 · Cited by 5
Marital status impact on the outcomes of patients admitted for acute decompensation of heart failure: A retrospective, single‐center, analysis
Marcus, G., Kofman, N., Maymon, S. L., Asher, E., Loberman, D., Pereg, D., Fuchs, S., & Minha, S. (2023) · Clinical Cardiology · doi:10.1002/clc.24053 · Cited by 5
“It is estimated that >6 million adult Americans were diagnosed with HF between 2015 and 2018, and similar trends are seen in Europe.(1,2) Socioeconomic status (SES) impacts both the incidence and the outcome of HF.”
Impact of Baseline Heart Failure on Acute Pulmonary Embolism Risk Stratification and Clinical Outcomes.
Katterle, K., Niedoba, M. J., Pasadyn, V., Mann, A., Brewster, P., Dasa, O., Ruzieh, M., Ammari, Z., & Gupta, R. (2023) · American Journal of Cardiology · doi:10.1016/j.amjcard.2023.05.008 · Cited by 5
Advancing Equity in Diabetes Prevention, Treatment, and Outcomes
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Self-citation
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Authors: Virani, S. S., Alonso, A., Aparicio, H. J., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Cheng, S., Delling, F. N., Elkind, M. S. V., Evenson, K. R., Ferguson, J. F., Gupta, D. K., Khan, S. S., Kissela, B. M., Knutson, K. L., Lee, C. D., Lewis, T. T., Liu, J., Loop, M. S., Lutsey, P. L., Ma, J., Mackey, J., Martin, S. S., Matchar, D. B., Mussolino, M. E., Navaneethan, S. D., Perak, A. M., Roth, G. A., Samad, Z., Satou, G. M., Schroeder, E. B., Shah, S. H., Shay, C. M., Stokes, A., VanWagner, L. B., Wang, N.-Y., Tsao, C. W., & On behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
ORCID: Virani, Salim S.
Aparicio, Hugo J.
Benjamin, Emelia J.
Callaway, Clifton W.
Carson, April P.
Chamberlain, Alanna M.
Cheng, Susan
Delling, Francesca N.
Elkind, Mitchell S.V.
Evenson, Kelly R.
Ferguson, Jane F.
Gupta, Deepak K.
Khan, Sadiya S.
Knutson, Kristen L.
Lee, Chong D.
Lewis, Tené T.
Liu, Junxiu
Loop, Matthew Shane
Lutsey, Pamela L.
Ma, Jun
Mackey, Jason
Martin, Seth S.
Matchar, David B.
Navaneethan, Sankar D.
Perak, Amanda Marma
Roth, Gregory A.
Samad, Zainab
Satou, Gary M.
Schroeder, Emily B.
Shah, Svati H.
Shay, Christina M.
Stokes, Andrew
VanWagner, Lisa B.
Wang, Nae-Yuh
Tsao, Connie W.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2021-02-23
Volume: 143
Issue: 8
Pages: e254-e743
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/cir.0000000000000950
PMC: PMC13036842
OpenAlex: W3122226502
Cited by: 5,784
References: 0
Citations by year: 2026: 503 · 2025: 658 · 2024: 915 · 2023: 1282 · 2022: 1694 · 2021: 646
FWCI: 764.95
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-nd)
eCommons - AKU (Aga Khan University) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (R03HL145195, R01HL155717)
National Institute of Neurological Disorders and Stroke (L30 NS093634, R01NS017950)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
Keywords: heart disease, stroke, cardiovascular disease statistics, cardiovascular risk factors, cardiovascular health behaviors, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary artery disease, heart failure, valvular heart disease, venous disease, peripheral arterial disease, quality of care, health care costs, social determinants of health, adverse pregnancy outcomes, cardiovascular disease prevention
MeSH terms: Global Burden of Disease, Diet, Healthy, American Heart Association, Blood Pressure, Cholesterol, Diabetes Mellitus, Heart Diseases, Hospitalization, Humans, Obesity, Risk Factors, Smoking, United States, Health Behavior, Exercise, Prevalence, Stroke

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