Cited by 362Sleep and Work-Related FatigueSleep and Wakefulness ResearchCircadian rhythm and melatonin

The DOI matches its Crossref record; 40 of the 43 references it cites were found in a registry or an index.

Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation.

Open access

Dinges, D F, Douglas, S D, Zaugg, L, Campbell, D E, McMann, J M, Whitehouse, W G, Orne, E C, Kapoor, S C, Icaza, E, Orne, M T·1994·Journal of Clinical Investigation

DOI 10.1172/jci117184PMC PMC294300

Open this paper in CoChat — free account Open PDF

Abstract

The hypothesis that sleep deprivation depresses immune function was tested in 20 adults, selected on the basis of their normal blood chemistry, monitored in a laboratory for 7 d, and kept awake for 64 h. At 2200 h each day measurements were taken of total leukocytes (WBC), monocytes, granulocytes, lymphocytes, eosinophils, erythrocytes (RBC), B and T lymphocyte subsets, activated T cells, and natural killer (NK) subpopulations (CD56/CD8 dual-positive cells, CD16-positive cells, CD57-positive cells). Functional tests included NK cytotoxicity, lymphocyte stimulation with mitogens, and DNA analysis of cell cycle. Sleep loss was associated with leukocytosis and increased NK cell activity. At the maximum sleep deprivation, increases were observed in counts of WBC, granulocytes, monocytes, NK activity, and the proportion of lymphocytes in the S phase of the cell cycle. Changes in monocyte counts correlated with changes in other immune parameters. Counts of CD4, CD16, CD56, and CD57 lymphocytes declined after one night without sleep, whereas CD56 and CD57 counts increased after two nights. No changes were observed in other lymphocyte counts, in proliferative responses to mitogens, or in plasma levels of cortisol or adrenocorticotropin hormone. The physiologic leukocytosis and NK activity increases during deprivation were eliminated by recovery sleep in a manner parallel to neurobehavioral function, suggesting that the immune alterations may be associated with biological pressure for sleep.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci117184

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.
Bøyum, A. (1968) · PubMed · Cited by 5,263
Quantification of Sleepiness: A New Approach
Hoddes, E., Zarcone, V., Smythe, H., Phillips, R., & Dement, W. C. (1973) · Psychophysiology · doi:10.1111/j.1469-8986.1973.tb00801.x · Cited by 2,538
Biology of interleukin 1
Dinarello, C. A. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.2.3277884 · Cited by 1,532
Psychosocial Modifiers of Immunocompetence in Medical Students
Kiecolt-Glaser, J. K., Garner, W., Speicher, C., Penn, G. M., Holliday, J., & Glaser, R. (1984) · Psychosomatic Medicine · doi:10.1097/00006842-198401000-00003 · Cited by 782
Sleep Deprivation in the Rat: X. Integration and Discussion of the Findings
Rechtschaffen, A., Bergmann, B. M., Everson, C. A., Kushida, C. A., & Gilliland, M. A. (2002) · SLEEP · doi:10.1093/sleep/25.1.68 · Cited by 490
Performing while sleepy: Effects of experimentally-induced sleepiness.
Dinges, D. F., & Kribbs, N. B. (1991) · Cited by 446
Self-citation
Modulation of cellular immunity in medical students
Kiecolt‐Glaser, J. K., Glaser, R., Strain, E. C., Stout, J. C., Tarr, K. L., Holliday, J. E., & Speicher, C. E. (1986) · Journal of Behavioral Medicine · doi:10.1007/bf00844640 · Cited by 412
Temporal Placement of a Nap for Alertness: Contributions of Circadian Phase and Prior Wakefulness
Dinges, D. F., Orne, M. T., Whitehouse, W. G., & Orne, E. C. (1987) · SLEEP · doi:10.1093/sleep/10.4.313 · Cited by 311
Self-citation
Life events, depressive symptoms, and immune function
Irwin, M. R., Daniels, M., Bloom, E. T., Smith, T. L., & Weiner, H. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.4.437 · Cited by 276
Sustained sleep deprivation impairs host defense
Everson, C. A. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.265.5.r1148 · Cited by 251

Flagged first, then by citations

Show all 43 references

3 of the 43 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

Wake Up America: A National Sleep Alert. 1993. A Report ofthe National Commission on Sleep Disorders Research. Vol. 1: Executive Summary and Exec- utive Report. National Institute of Aging, Washington, DC. 76 pp.
Home, J. 1988. Why We Sleep: The Functions of Sleep in Humans and Other Animals. Oxford University Press, Oxford. 319 pp.
Roitt, I. 1991. Essential Immunology. Blackwell Scientific Publications, Oxford. 356 pp.

Sorted by citations

Items 101–200 of 362

Treating the Health, Quality of Life, and Functional Impairments in Insomnia
Krystal, A. D. (2007) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26749 · Cited by 80
Sleep and COVID-19: considerations about immunity, pathophysiology, and treatment.
(2020) · PubMed Central · doi:10.5935/1984-0063.20200062 · Cited by 77
Endothelial Dysfunction in Adults with Obstructive Sleep Apnea
(2011) · Advances in cardiology · doi:10.1159/000325108 · Cited by 76
Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus
Palma, B. D., Gabriel, A., Colugnati, F. A. B., & Tufik, S. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00186.2006 · Cited by 74
Sleep, immunity and shift workers: A review
de Almeida, C. M. O., & Malheiro, A. (2016) · Sleep Science · doi:10.1016/j.slsci.2016.10.007 · Cited by 81
Hypothalamo-Pituitary-Adrenal Axis Activity Is Related to the Level of Central Arousal: Effect of Sleep Deprivation on the Association of High-Frequency Waking Electroencephalogram with Cortisol Release
Chapotot, F., Buguet, A., Gronfier, C., & Brandenberger, G. (2001) · Neuroendocrinology · doi:10.1159/000054648 · Cited by 72
Repeated Exposure to Severely Limited Sleep Results in Distinctive and Persistent Physiological Imbalances in Rats
Everson, C. A., & Szabó, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022987 · Cited by 73
Sleep Deprivation and Gut Microbiota Dysbiosis: Current Understandings and Implications
Sun, J., Fang, D., Wang, Z., & Liu, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119603 · Cited by 82
Coemergence of Insomnia and a Shift in the Th1/Th2 Balance toward Th2 Dominance
Sakami, S., Ishikawa, T., Kawakami, N., Haratani, T., Fukui, A., Kobayashi, F., Fujita, O., Araki, S., & Kawamura, N. (2002) · NeuroImmunoModulation · doi:10.1159/000071474 · Cited by 70
Effects of Fatigue on Immune Function in Nurses Performing Shift Work
Nagai, M., Morikawa, Y., Kitaoka‐Higashiguchi, K., Nakamura, K., Sakurai, M., Nishijo, M., Hamazaki, Y., Maruzeni, S., & Nakagawa, H. (2011) · Journal of Occupational Health · doi:10.1539/joh.10-0072-oa · Cited by 74
Alterations in the number of circulating leucocytes, phenotype of monocyte and cytokine production in patients undergoing cardiothoracic surgery
Hiesmayr, M., Spittler, A., Lassnigg, A. M., BERGER, R., Laufer, G., Kocher, A. A., Artemiou, O., Boltz‐Nitulescu, G., & Roth, E. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.00801.x · Cited by 70
Short Duration of Sleep Is Associated with Elevated High-Sensitivity C-Reactive Protein Level in Taiwanese Adults: A Cross-Sectional Study
Chiang, J. (2014) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.3862 · Cited by 69
Sleep Disturbance Symptoms in Patients With Heart Failure
Erickson, V., Westlake, C. A., Dracup, K., Woo, M. A., & Hage, A. (2003) · AACN Clinical Issues Advanced Practice in Acute & Critical Care · doi:10.1097/00044067-200311000-00009 · Cited by 69
Sleep Deprivation Inhibits Expression of NADPH-d and NOS while Activating Microglia and Astroglia in the Rat Hippocampus
Hsu, J., Lee, Y., Chang, C.-N., Chuang, H.-L., Ling, E., & Lan, C. (2003) · Cells Tissues Organs · doi:10.1159/000070380 · Cited by 65
Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
da Silva, F. R., Guerreiro, R. D. C., Andrade, H. D. A., Stieler, E., Silva, A., & de Mello, M. T. (2020) · Chronobiology International · doi:10.1080/07420528.2020.1756841 · Cited by 63
Acute sleep deprivation in healthy young men: Impact on population diversity and function of circulating neutrophils
Christoffersson, G., Vågesjö, E., Pettersson, U. S., Massena, S., Nilsson, E., Broman, J., Schiöth, H. B., Benedict, C., & Phillipson, M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.010 · Cited by 66
Acute Sleep Deprivation is Associated with Increased Electrocardiographic P‐Wave Dispersion in Healthy Young Men and Women
Sarı, İ., Davutoğlu, V., Ozbala, B., Özer, O., Baltacı, Y., Yavuz, S., & Aksoy, M. F. (2008) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2008.01013.x · Cited by 60
Dolphin continuous auditory vigilance for five days
Ridgway, S. H., Carder, D. A., Finneran, J. J., Keogh, M. J., Kamolnick, T., Todd, M. A., & Goldblatt, A. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02405 · Cited by 61
Sleep in host defense
Krueger, J. M., Majde, J. A., & Obál, F. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00065-x · Cited by 63
Sleep in acute care units
BaHammam, A. S. (2006) · Sleep And Breathing · doi:10.1007/s11325-005-0044-8 · Cited by 59
Status of immune mediators in fibromyalgia
Gür, A., & Oktayoğlu, P. (2008) · Current Pain and Headache Reports · doi:10.1007/s11916-008-0031-4 · Cited by 58
Pain, psychological variables, sleep quality, and natural killer cell activity in midlife women with and without fibromyalgia
Landis, C. A., Lentz, M. J., Tsuji, J. M., Buchwald, D., & Shaver, J. L. F. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.11.001 · Cited by 60
The state of sleep deprivation: From functional biology to functional consequences
Dinges, D. F. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2006.07.001 · Cited by 57
Self-citation
Sleep Disturbances and Inflammatory Bowel Disease
Ali, T., & Orr, W. C. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000108 · Cited by 56
Sleep, cytokines and immune function
Dickstein, J. B. (1999) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(99)90003-5 · Cited by 57
Chronic Sleep Restriction Impairs the Antitumor Immune Response in Mice
Lorenzo, B. H. P. D., Brito, R. R. N. E., Leal, T. P., Garcia, N. P., dos Santos, R. M. M., Alvares-Saraiva, A. M., Hurtado, E. C. P., dos Reis, T. C. B., & Palma, B. D. (2018) · NeuroImmunoModulation · doi:10.1159/000490352 · Cited by 58
Effect of Sleep Extension on the Subsequent Testosterone, Cortisol and Prolactin Responses to Total Sleep Deprivation and Recovery
Arnal, P. J., Drogou, C., Sauvet, F., Regnauld, J., Dispersyn, G., Faraut, B., Millet, G. Y., Leger, D., Gomez‐Merino, D., & Chennaoui, M. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12346 · Cited by 55
Sleep deprivation alters neutrophil functions and levels of Th1-related chemokines and CD4+ T cells in the blood
Said, E. A., Al-Abri, M., Al-Saidi, I., Al-Balushi, M. S., Al-Busaidi, J. Z., Al‐Reesi, I., Koh, C. Y., Idris, M. A., Al-Jabri, A. A., & Habbal, O. (2019) · Sleep And Breathing · doi:10.1007/s11325-019-01851-1 · Cited by 55
The association of hemocyte profile and obstructive sleep apnea
Fan, Z., Lü, X., Long, H., Li, T., & Zhang, Y. (2018) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22680 · Cited by 54
Sleep as a window on the developing brain
Kohyama, J. (1998) · Current Problems in Pediatrics · doi:10.1016/s0045-9380(98)80054-6 · Cited by 56
The influence of regulatory T cells and diurnal hormone rhythms on T helper cell activity
Bollinger, T., Bollinger, A., Naujoks, J., Lange, T., & Solbach, W. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03320.x · Cited by 52
Chronobiology of Bipolar Disorder: Therapeutic Implication
Dallaspezia, S., & Benedetti, F. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0606-9 · Cited by 55
Subjective Poor Sleep and White Blood Cell Count in Male Japanese Workers
Nishitani, N., & Sakakibara, H. (2007) · Industrial Health · doi:10.2486/indhealth.45.296 · Cited by 52
Sleep and Immunity: Cytokine Pathways Linking Sleep and Health Outcomes
Motivala, S. J., & Irwin, M. R. (2007) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2007.00468.x · Cited by 49
Cellular adhesion molecule expression, nocturnal sleep, and partial night sleep deprivation
Redwine, L. S., Dang, J., & Irwin, M. R. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.01.001 · Cited by 48
Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link
Bonilla‐Jaime, H., Zeleke, H., Rojas, A., & Espinosa‐García, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212531 · Cited by 53
Association between Sleep Quality and C-Reactive Protein: Results from National Health and Nutrition Examination Survey, 2005-2008
Liu, R., Liu, X., Zee, P. C., Hou, L., Zheng, Z., Wei, Y., & Du, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092607 · Cited by 47
Influence of Shift-work on Selected Immune Variables in Nurses
Copertaro, A., Bracci, M., Gesuita, R., Carle, F., Amati, M., Baldassari, M., Mocchegiani, E., & Santarelli, L. (2011) · Industrial Health · doi:10.2486/indhealth.ms1210 · Cited by 48
Antibody responses to bacteriophage φX-174 in human subjects exposed to the Antarctic winter-over model of spaceflight
Shearer, W. T., Lugg, D. J., Rosenblatt, H. M., Nickolls, P. M., Sharp, R., Reuben, J. M., & Ochs, H. D. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112269 · Cited by 47
Disturbances of Sleep in the Intensive Care Unit
Schwab, R. J. (1994) · Critical Care Clinics · doi:10.1016/s0749-0704(18)30100-3 · Cited by 47
Biological consequences of disturbed sleep: Important mediators of health?1
Okun, M. L. (2011) · Japanese Psychological Research · doi:10.1111/j.1468-5884.2011.00463.x · Cited by 50
The characteristics of recovery sleep when recovery opportunity is restricted.
Jay, S., Lamond, N., Ferguson, S., Dorrian, J., Jones, C. B., & Dawson, D. (2007) · Sleep · doi:10.1093/sleep/30.3.353 · Cited by 46
Acute Sleep Deprivation
Bonnet, M. H. (2005) · Elsevier eBooks · doi:10.1016/b0-72-160797-7/50012-4 · Cited by 48
Sleep Deprivation
Malik, S. W., & Kaplan, J. (2005) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2005.02.011 · Cited by 45
Sleep inflammation and cardiovascular disease
Meier-Ewert, H. K. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e560 · Cited by 43
Associations of Self-Reported Sleep Quality with Circulating Interferon Gamma-Inducible Protein 10, Interleukin 6, and High-Sensitivity C-Reactive Protein in Healthy Menopausal Women
Huang, W., Huang, C., Chang, C., Kor, C., Chen, T., & Wu, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169216 · Cited by 44
The effects of sleep and sleep deprivation on metabolic, endocrine and immune parameters.
Maurovich‐Horvat, E., Pollmächer, T., & Šonka, K. (2008) · PubMed · Cited by 43
Sleep Deprivation Disturbs Immune Surveillance and Promotes the Progression of Hepatocellular Carcinoma
Huang, J., Song, P., Hang, K., Chen, Z.-K., Zhu, Z., Zhang, Y., Xu, J., Qin, J., Wang, B., Qu, W., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.727959 · Cited by 43
Acute Sleep Deprivation is Associated with Increased QT Dispersion in Healthy Young Adults
Özer, O., Ozbala, B., Sarı, İ., Davutoğlu, V., Maden, E., Baltacı, Y., Yavuz, S., & Aksoy, M. F. (2008) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2008.01125.x · Cited by 40
Diurnal versus Nocturnal Exercise—Effect on the Gastrointestinal Tract
Gaskell, S. K., Rauch, C., Parr, A., & Costa, R. J. S. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002546 · Cited by 42
Insomnia Symptoms in a Multiethnic Sample of American Women
Jean‐Louis, G., Magai, C., Casimir, G. J., Zizi, F., Moise, F., McKenzie, D., & Graham, Y. J. (2008) · Journal of Women s Health · doi:10.1089/jwh.2006.0310 · Cited by 41
Sleep Loss and the Inflammatory Response in Mice Under Chronic Environmental Circadian Disruption
Brager, A. J., Ehlen, J. C., Castañón‐Cervantes, O., Natarajan, D., Delisser, P., Davidson, A. J., & Paul, K. N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063752 · Cited by 41
Dolphins maintain cognitive performance during 72 to 120 hours of continuous auditory vigilance
Ridgway, S. H., Keogh, M. J., Carder, D. A., Finneran, J. J., Kamolnick, T., Todd, M. A., & Goldblatt, A. (2009) · Journal of Experimental Biology · doi:10.1242/jeb.027896 · Cited by 41
Sleep quality and COVID-19 outcomes: the evidence-based lessons in the framework of predictive, preventive and personalised (3P) medicine
Richter, K., Kellner, S., Hillemacher, T., & Golubnitschaja, O. (2021) · The EPMA Journal · doi:10.1007/s13167-021-00245-2 · Cited by 37
Influence of chronic moderate sleep restriction and exercise on inflammation and carcinogenesis in mice
Zielinski, M. R., Davis, J. M., Fadel, J. R., & Youngstedt, S. D. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.03.002 · Cited by 39
Sleep monitoring in children during neuromuscular blockade in the pediatric intensive care unit
Carno, M., Hoffman, L. A., Henker, R., Carcillo, J. A., & SANDERS, M. H. (2004) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000124024.92280.f9 · Cited by 37
Differential increase in prevalence estimates of inadequate sleep among black and white Americans
Jean‐Louis, G., Grandner, M. A., Youngstedt, S. D., Williams, N. J., Zizi, F., Sarpong, D. F., & Ogedegbe, G. G. (2015) · BMC Public Health · doi:10.1186/s12889-015-2500-0 · Cited by 39
Effect of a Single Ethanol Exposure on HIV Replication in Human Lymphocytes
Cook, R. T., Stapleton, J. T., Ballas, Z. K., & Klinzman, D. (1997) · Journal of Investigative Medicine · doi:10.1177/108155899704500506 · Cited by 39
The Effects of Sleep Deprivation on Soccer Skills
Pallesen, S., Gundersen, H. S., Kristoffersen, M., Bjorvatn, B., Thun, E., & Harris, A. (2017) · Perceptual and Motor Skills · doi:10.1177/0031512517707412 · Cited by 39
Blunted rest-activity rhythm is associated with increased white blood-cell-based inflammatory markers in adults: an analysis from NHANES 2011-2014
Xu, Y., Su, S., McCall, W. V., & Wang, X. (2022) · Chronobiology International · doi:10.1080/07420528.2022.2048663 · Cited by 44
Natural Killer Cell Enumeration and Function in HIV-Infected and High-Risk Uninfected Adolescents
Douglas, S. D., Durako, S. J., Tustin, N. B., Houser, J., Muenz, L. R., Starr, S. E., & Wilson, C. M. (2001) · AIDS Research and Human Retroviruses · doi:10.1089/08892220151126643 · Cited by 38
Self-citation
Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise
Ingram, L. A., Simpson, R. J., Malone, E., & Florida-James, G. D. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.12.018 · Cited by 38
Association between Sleep Duration and Urinary Albumin Excretion in Patients with Type 2 Diabetes: The Fukuoka Diabetes Registry
Ohkuma, T., Fujii, H., Iwase, M., Kaizu, S., Ide, H., Kikuchi, Y., Idewaki, Y., Jodai, T., Hirakawa, Y., Nakamura, U., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078968 · Cited by 37
Health Behaviors Predict Higher Interleukin-6 Levels among Patients Newly Diagnosed with Head and Neck Squamous Cell Carcinoma
Duffy, S. A., Teknos, T. N., Taylor, J. M. G., Fowler, K. E., Islam, M., Wolf, G. T., McLean, S. A., Ghanem, T., & Terrell, J. E. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0987 · Cited by 37
Total Sleep Deprivation Induces an Acute and Transient Increase in NK Cell Activity in Healthy Young Volunteers
Matsumoto, Y., Mishima, K., Satoh, K., Tozawa, T., Mishima, Y., Shimizu, T., & Hishikawa, Y. (2001) · SLEEP · doi:10.1093/sleep/24.7.806 · Cited by 38
No effect of a 30-h period of sleep deprivation on leukocyte trafficking, neutrophil degranulation and saliva IgA responses to exercise
Ricardo, J. S. C., Cartner, L., Oliver, S. J., Laing, S. J., Walters, R. L., Bilzon, J., & Walsh, N. P. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0931-3 · Cited by 37
SLEEP DISRUPTION IN OLDER ADULTS
Cole, C. S., & Richards, K. C. (2007) · AJN American Journal of Nursing · doi:10.1097/01.naj.0000268167.48606.74 · Cited by 37
Influence of endotoxin on daytime sleep in humans
Korth, C., Mullington, J., Schreiber, W., & Pollmächer, T. (1996) · Infection and Immunity · doi:10.1128/iai.64.4.1110-1115.1996 · Cited by 35
Sleep, fatigue, and NK cell activity in healthy volunteers: Significant relationships revealed by within subject analyses
Shakhar, K., Valdimarsdottir, H. B., Guevarra, J. S., & Bovbjerg, D. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.06.002 · Cited by 35
Phagocyte migration and cellular stress induced in liver, lung, and intestine during sleep loss and sleep recovery
Everson, C. A., Thalacker, C. D., & Hogg, N. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90623.2008 · Cited by 35
Impact of Sleep Deprivation in the Neurological Intensive Care Unit: A Narrative Review
Chang, V. A., Owens, R. L., & LaBuzetta, J. N. (2019) · Neurocritical Care · doi:10.1007/s12028-019-00795-4 · Cited by 42
Seven days’ around the clock exhaustive physical exertion combined with energy depletion and sleep deprivation primes circulating leukocytes
Gundersen, Y., Opstad, P. K., Reistad, T., Thrane, I., & Vaagenes, P. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0150-8 · Cited by 34
Experimentally manipulated sleep duration in adolescents with asthma: Feasibility and preliminary findings
Meltzer, L. J., Faino, A. V., Szefler, S. J., Strand, M. J., Gelfand, E. W., & Beebe, D. W. (2015) · Pediatric Pulmonology · doi:10.1002/ppul.23179 · Cited by 33
Effects of sleep fragmentation on sleep and markers of inflammation in mice.
Trammell, R. A., Verhulst, S., & Toth, L. A. (2014) · PubMed Central · Cited by 33
The association between irritable bowel syndrome and the coexistence of depression and insomnia
Lee, S. K., Yoon, D. W., Lee, S., Kim, J., Choi, K.-M., & Shin, C. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.12.007 · Cited by 36
Effects of sleep deprivation and other stressors on the immune and inflammatory responses of influenza-infected mice
Toth, L. A., & Rehg, J. E. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00321-x · Cited by 33
The effects of two nights of sleep deprivation with or without energy restriction on immune indices at rest and in response to cold exposure
Costa, R. J. S., Smith, A. H., Oliver, S. J., Walters, R. L., Maassen, N., Bilzon, J., & Walsh, N. P. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1378-x · Cited by 33
Air Travel, Circadian Rhythms/Hormones, and Autoimmunity
Torres-Ruiz, J. J., Sulli, A., Cutolo, M., & Shoenfeld, Y. (2017) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-017-8599-2 · Cited by 33
Mood, Alertness, and Performance in Response to Sleep Deprivation and Recovery Sleep in Experienced Shiftworkers Versus Non-Shiftworkers
Wehrens, S. M. T., Hampton, S. M., Kerkhofs, M., & Skene, D. J. (2012) · Chronobiology International · doi:10.3109/07420528.2012.675258 · Cited by 35
Nocturnal sleep uniformly reduces numbers of different T-cell subsets in the blood of healthy men
Besedovsky, L., Dimitrov, S., Born, J., & Lange, T. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00149.2016 · Cited by 32
The Importance of Sleep and Circadian Rhythms for Vaccination Success and Susceptibility to Viral Infections
Schmitz, N. C. M., van der Werf, Y. D., & der Holst, H. M. L. (2022) · Clocks & Sleep · doi:10.3390/clockssleep4010008 · Cited by 31
Altered blood cytokines, CD4 T cells, NK and neutrophils in patients with obstructive sleep apnea
Said, E. A., Al-Abri, M., Al-Saidi, I., Al-Balushi, M. S., Al-Busaidi, J. Z., Al‐Reesi, I., Koh, C. Y., Hasson, S. S., Idris, M. A., Al-Jabri, A. A., et al. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.08.009 · Cited by 31
Sleep Deprivation Induces Changes in Immunity in Trichinella spiralis -Infected Rats
Ibarra-Coronado, E. G., Velazquéz-Moctezuma, J., Diaz, D., Becerril-Villanueva, L. E., Pavón, L., & Morales-Montor, J. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.11907 · Cited by 30
Bone marrow and peripheral white blood cells number is affected by sleep deprivation in a murine experimental model
Guariniello, L. D., Vicari, P., Lee, K. S., de Oliveira, A. C., & Tufik, S. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.22743 · Cited by 30
Effects of β-alanine supplementation on physical performance, cognition, endocrine function, and inflammation during a 24 h simulated military operation
Varanoske, A. N., Wells, A. J., Kozlowski, G. J., Gepner, Y., Frosti, C. L., Boffey, D., Coker, N. A., Harat, I., & Hoffman, J. R. (2018) · Physiological Reports · doi:10.14814/phy2.13938 · Cited by 32
Resilience of the Immune System in Healthy Young Students to 30-Hour Sleep Deprivation with Psychological Stress
Matzner, P., Hazut, O., Naim, R., Shaashua, L., Sorski, L., Levi, B. Z., Sadeh, A., Wald, I., Bar‐Haim, Y., & Ben‐Eliyahu, S. (2013) · NeuroImmunoModulation · doi:10.1159/000348698 · Cited by 30
Psychomotor Vigilance Performance: Neurocognitive Assay Sensitive to Sleep Loss
Dorrian, J., Rogers, N., & Dinges, D. (2004) · Lung biology in health and disease · doi:10.1201/b14100-5 · Cited by 452
Self-citation
Environmental factors, immune changes and respiratory diseases in troops during military activities
Korzeniewski, K., Nitsch-Osuch, A. S., Chciałowski, A., & Korsak, J. (2013) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2013.02.003 · Cited by 30
Sleep and the Immune System
Opp, M. R., Jan Born, A., & Irwin, M. R. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50034-4 · Cited by 29
The degree of radiation-induced DNA strand breaks is altered by acute sleep deprivation and psychological stress and is associated with cognitive performance in humans
Moreno‐Villanueva, M., von Scheven, G., Feiveson, A. H., Bürkle, A., Wu, H., & Goel, N. (2018) · SLEEP · doi:10.1093/sleep/zsy067 · Cited by 29
Sleep and Sedation in the Pediatric Intensive Care Unit
Carno, M., & Connolly, H. (2005) · Critical Care Nursing Clinics of North America · doi:10.1016/j.ccell.2005.04.005 · Cited by 26
A Meta-analysis of Sleep-promoting Interventions During Critical Illness
Poongkunran, C., John, S. G., Kannan, A., Shetty, S., Bime, C., & Parthasarathy, S. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.05.026 · Cited by 26
Self-reported sleep duration and daytime napping are associated with renal hyperfiltration and microalbuminuria in an apparently healthy Chinese population
Ye, Y., Zhang, L., Yan, W., Wang, A., Wang, W., Gao, Z., Tang, X., Yan, L., Wan, Q., Luo, Z., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214776 · Cited by 26
Immune Outcomes of Paradoxical Sleep Deprivation on Cellular Distribution in Naive and Lipopolysaccharide-Stimulated Mice
Zager, A., Ruiz, F. S., Tufik, S., & Andersen, M. L. (2012) · Neuroimmunomodulation · doi:10.1159/000329484 · Cited by 24
Exercise, But Not Acute Sleep Loss, Increases Salivary Antimicrobial Protein Secretion
Gillum, T., Kuennen, M. R., Castillo, M., Williams, N. L., & Jordan-Patterson, A. (2015) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000828 · Cited by 25
Excessive sleepiness: under-recognized and essential marker for sleep/wake disorder management
Roth, T. G., Bogan, R., Culpepper, L., Doghramji, K., Doghramji, P. P., Drake, C. L., Grauke, J. H., Knoepflmacher, P., Sateia, M. J., Silvershein, D. I., et al. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.532544 · Cited by 23
Using Stress Models to Evaluate Immuno-Modulating Effects of Nutritional Intervention in Healthy Individuals
Hamer, M., Wolvers, D. A. W., & Albers, R. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719405 · Cited by 23
Do sleep deprivation and time of day interact with mild obstructive sleep apnea to worsen performance and neurobehavioral function?
Desai, A. V., Marks, G. B., Jankelson, D., & Grunstein, R. R. (2006) · PubMed · Cited by 24
Self-reported sleep duration and daytime napping are associated with renal hyperfiltration in general population
Lin, M. Y., Su, Q., Wen, J., Wei, S., Yao, J., Huang, H., Liang, J., Li, L., Lin, W., Lin, L., et al. (2017) · Sleep And Breathing · doi:10.1007/s11325-017-1470-0 · Cited by 23
Microglia Are Necessary to Regulate Sleep after an Immune Challenge
Rowe, R. K., Green, T. R. F., Giordano, K. R., Ortiz, J. B., Murphy, S. M., & Opp, M. R. (2022) · Biology · doi:10.3390/biology11081241 · Cited by 25

Authors: Dinges, D. F., Douglas, S. D., Zaugg, L., Campbell, D. E., McMann, J. M., Whitehouse, W. G., Orne, E. C., Kapoor, S. C., Icaza, E., & Orne, M. T.
Affiliations: Pennsylvania Hospital (US)
Children's Hospital of Philadelphia (US)
ORCID: Dinges, D F
Douglas, S D
Kapoor, S C
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1994-05-01
Volume: 93
Issue: 5
Pages: 1930-1939
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci117184
PMC: PMC294300
OpenAlex: W2027223222
Cited by: 361
References: 43
Citations by year: 2026: 1 · 2025: 11 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 14 · 2020: 13 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 13 · 2015: 19 · 2014: 18 · 2013: 15 · 2012: 13
FWCI: 8.90
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Aeronautics and Space Administration
National Institutes of Health (5p01mh044193-05)
Ames Research Center
National Institute of Mental Health (MH44193)
National Center for Research Resources (CRC RR 00040)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: sleep deprivation, leukocytosis, natural killer cells, immune function, monocytes, lymphocyte subsets, NK cell cytotoxicity, cell cycle, CD56, CD57, CD16, CD4, recovery sleep, cortisol, ACTH
MeSH terms: Adult, Arousal, Body Temperature, Mental Fatigue, Female, Glucocorticoids, Humans, Killer Cells, Natural, Leukocytosis, Lymphocytes, Male, Movement, Sleep Deprivation, Biomarkers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks