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Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation.
Open accessAbstract
The hypothesis that sleep deprivation depresses immune function was tested in 20 adults, selected on the basis of their normal blood chemistry, monitored in a laboratory for 7 d, and kept awake for 64 h. At 2200 h each day measurements were taken of total leukocytes (WBC), monocytes, granulocytes, lymphocytes, eosinophils, erythrocytes (RBC), B and T lymphocyte subsets, activated T cells, and natural killer (NK) subpopulations (CD56/CD8 dual-positive cells, CD16-positive cells, CD57-positive cells). Functional tests included NK cytotoxicity, lymphocyte stimulation with mitogens, and DNA analysis of cell cycle. Sleep loss was associated with leukocytosis and increased NK cell activity. At the maximum sleep deprivation, increases were observed in counts of WBC, granulocytes, monocytes, NK activity, and the proportion of lymphocytes in the S phase of the cell cycle. Changes in monocyte counts correlated with changes in other immune parameters. Counts of CD4, CD16, CD56, and CD57 lymphocytes declined after one night without sleep, whereas CD56 and CD57 counts increased after two nights. No changes were observed in other lymphocyte counts, in proliferative responses to mitogens, or in plasma levels of cortisol or adrenocorticotropin hormone. The physiologic leukocytosis and NK activity increases during deprivation were eliminated by recovery sleep in a manner parallel to neurobehavioral function, suggesting that the immune alterations may be associated with biological pressure for sleep.
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“In addition to infectious and chronic inflammatory conditions that involve a clear immunopathology (e.g., HIV, RA), numerous other diseases emerged in the last decades for which mild systemic elevations of inflammatory markers are characteristic, including cardiovascular (481) and metabolic diseases (153), certain forms of chronic pain (23), certain cancers (165), and neurodegenerative diseases (9”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [153]
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“Indeed, some authors have reported no change [41, 43, 74, 75] or even a slight decrease in cortisol levels [76, 77] after one or several nights of total sleep deprivation.”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [75]
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Citations
Cites
Quantification of Sleepiness: A New Approach
Hoddes, E., Zarcone, V., Smythe, H., Phillips, R., & Dement, W. C. (1973) · Psychophysiology · doi:10.1111/j.1469-8986.1973.tb00801.x · Cited by 2,538
Dinarello, C. A. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.2.3277884 · Cited by 1,532
Psychosocial Modifiers of Immunocompetence in Medical Students
Kiecolt-Glaser, J. K., Garner, W., Speicher, C., Penn, G. M., Holliday, J., & Glaser, R. (1984) · Psychosomatic Medicine · doi:10.1097/00006842-198401000-00003 · Cited by 782
Sleep Deprivation in the Rat: X. Integration and Discussion of the Findings
Rechtschaffen, A., Bergmann, B. M., Everson, C. A., Kushida, C. A., & Gilliland, M. A. (2002) · SLEEP · doi:10.1093/sleep/25.1.68 · Cited by 490
Performing while sleepy: Effects of experimentally-induced sleepiness.
Dinges, D. F., & Kribbs, N. B. (1991) · Cited by 446
Self-citationModulation of cellular immunity in medical students
Kiecolt‐Glaser, J. K., Glaser, R., Strain, E. C., Stout, J. C., Tarr, K. L., Holliday, J. E., & Speicher, C. E. (1986) · Journal of Behavioral Medicine · doi:10.1007/bf00844640 · Cited by 412
Temporal Placement of a Nap for Alertness: Contributions of Circadian Phase and Prior Wakefulness
Dinges, D. F., Orne, M. T., Whitehouse, W. G., & Orne, E. C. (1987) · SLEEP · doi:10.1093/sleep/10.4.313 · Cited by 311
Self-citationLife events, depressive symptoms, and immune function
Irwin, M. R., Daniels, M., Bloom, E. T., Smith, T. L., & Weiner, H. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.4.437 · Cited by 276
Sustained sleep deprivation impairs host defense
Everson, C. A. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.265.5.r1148 · Cited by 251
Research works printed but not linked: 3
- Wake Up America: A National Sleep Alert. 1993. A Report ofthe National Commission on Sleep Disorders Research. Vol. 1: Executive Summary and Exec- utive Report. National Institute of Aging, Washington, DC. 76 pp.
- Home, J. 1988. Why We Sleep: The Functions of Sleep in Humans and Other Animals. Oxford University Press, Oxford. 319 pp.
- Roitt, I. 1991. Essential Immunology. Blackwell Scientific Publications, Oxford. 356 pp.
Cited by
Sorted by citations
Dinges, D. F., Pack, F. M., Williams, K., Gillen, K. A., Powell, J. W., Ott, G. E., Trasande, C. A., & Pack, A. I. (1997) · SLEEP · doi:10.1093/sleep/20.4.267 · Cited by 2,018
Self-citationBehavioral and Physiological Consequences of Sleep Restriction
Banks, S., & Dinges, D. F. (2007) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26918 · Cited by 1,505
Self-citationThe Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“Several studies in humans have found a reducing effect of sleep on total leukocyte count when compared with total sleep deprivation or sleep restriction for either only a few hours or up to several days (67, 69, 152, 178, 287, 326, 338, 480).”
BackgroundResultInfluentialWhy Sleep Is Important for Health: A Psychoneuroimmunology Perspective
Irwin, M. R. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115205 · Cited by 1,325
“However, when sleep loss is extended beyond a single night of sleep deprivation, numbers of circulating granulocytes and monocytes increase (Dinges et al. 1994, Irwin et al. 1996).”
BackgroundEffect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.050 · Cited by 1,195
Self-citationSleep deprivation: Impact on cognitive performance
Alhola, P., & Polo-Kantola, P. (2007) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.a930 · Cited by 869
Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation
Mullington, J. M., Haack, M., Toth, M., Serrador, J. M., & Meier-Ewert, H. K. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.003 · Cited by 783
How (and why) the immune system makes us sleep
Imeri, L., & Opp, M. R. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2576 · Cited by 710
Sleep disturbance in cancer patients
Davidson, J. R., MacLean, A., Brundage, M., & Schulze, K. M. (2002) · Social Science & Medicine · doi:10.1016/s0277-9536(01)00043-0 · Cited by 660
Role of sleep deprivation in immune-related disease risk and outcomes
Garbarino, S., Lanteri, P., Bragazzi, N. L., Magnavita, N., & Scoditti, E. (2021) · Communications Biology · doi:10.1038/s42003-021-02825-4 · Cited by 654
Wright, K. P., Drake, A. L., Frey, D. J., Fleshner, M., Desouza, C. A., Gronfier, C., & Czeisler, C. A. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.01.004 · Cited by 567
Sick and tired: does sleep have a vital role in the immune system?
Bryant, P. A., Trinder, J., & Curtis, N. (2004) · Nature Reviews Immunology · doi:10.1038/nri1369 · Cited by 551
Mullington, J. M., Simpson, N. S., Meier-Ewert, H. K., & Haack, M. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.08.014 · Cited by 519
van Leeuwen, W. M. A., Lehto, M., Karisola, P., Lindholm, H., Luukkonen, R., Sallinen, M., Härmä, M., Porkka-Heiskanen, T., & Alenius, H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004589 · Cited by 483
Partial night sleep deprivation reduces natural killer and celhdar immune responses in humans
Irwin, M., McClintick, J., Costlow, C., Fortner, M., White, J., & Gillin, J. C. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.5.8621064 · Cited by 480
Sleep Deprivation in Critical Illness
Kamdar, B. B., Needham, D. M., & Collop, N. A. (2011) · Journal of Intensive Care Medicine · doi:10.1177/0885066610394322 · Cited by 477
Shearer, W. T., Reuben, J. M., Mullington, J. M., Price, N. J., Lee, B.-N., Smith, E. O., Szuba, M. P., Van Dongen, H. P. A., & Dinges, D. F. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112270 · Cited by 455
Self-citationSmith, M. T., Huang, M. I., & Manber, R. (2005) · Clinical Psychology Review · doi:10.1016/j.cpr.2005.04.004 · Cited by 453
Sustained sleep restriction reduces emotional and physical well-being
Haack, M., & Mullington, J. M. (2005) · Pain · doi:10.1016/j.pain.2005.09.011 · Cited by 422
Immune, inflammatory and cardiovascular consequences of sleep restriction and recovery
Faraut, B., Boudjeltia, K. Z., Vanhamme, L., & Kerkhofs, M. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.05.001 · Cited by 418
Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity
Balbo, M., Leproult, R., & Van Cauter, E. (2010) · International Journal of Endocrinology · doi:10.1155/2010/759234 · Cited by 408
“Indeed, some authors have reported no change [41, 43, 74, 75] or even a slight decrease in cortisol levels [76, 77] after one or several nights of total sleep deprivation.”
BackgroundPsychomotor Vigilance Performance: Neurocognitive Assay Sensitive to Sleep Loss
Dorrian, J., Rogers, N. L., & Dinges, D. F. (2004) · CRC Press eBooks · doi:10.3109/9780203998007-4 · Cited by 404
Self-citationEffects of sleep and sleep loss on immunity and cytokines
Irwin, M. R. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00003-x · Cited by 368
Position statement. Part two: Maintaining immune health.
Walsh, N. P., Gleeson, M., Pyne, D. B., Nieman, D. C., Dhabhar, F. S., Shephard, R. J., Oliver, S. J., Bermon, S., & Kajėnienė, A. (2011) · PubMed · Cited by 365
Sleep in the intensive care unit
Parthasarathy, S., & Tobin, M. J. (2004) · Intensive Care Medicine · doi:10.1007/s00134-003-2030-6 · Cited by 356
Jewett, M. E., Dijk, D., Kronauer, R. E., & Dinges, D. F. (1999) · SLEEP · doi:10.1093/sleep/22.2.171 · Cited by 352
Self-citationSleep Enhances the Human Antibody Response to Hepatitis A Vaccination
Lange, T., Perras, B., Fehm, H. L., & Born, J. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000091382.61178.f1 · Cited by 351
Stress-Induced Changes in Skin Barrier Function in Healthy Women
Altemus, M. M., Rao, B. K., Dhabhar, F. S., Ding, W., & Granstein, R. D. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01373.x · Cited by 347
The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults
Frey, D. J., Fleshner, M., & Wright, K. P. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.04.003 · Cited by 330
Sleep and Cardiovascular Disease
Wolk, R. A., Gami, A. S., García‐Touchard, A., & Somers, V. K. (2005) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2005.07.002 · Cited by 340
Xie, H., Kang, J., & MILLS, G. H. (2009) · Critical Care · doi:10.1186/cc7154 · Cited by 319
Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects
Irwin, M., Clark, C., Kennedy, B., Christian Gillin, J., & Ziegler, M. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00031-x · Cited by 268
Effect of acute sleep deprivation on vascular function in healthy subjects
Sauvet, F., Leftheriotis, G., Gomez-Merino, D., Langrume, C., Drogou, C., Van Beers, P., Bourrilhon, C., Florence, G., & Chennaoui, M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00851.2009 · Cited by 268
Dinges, D. F., Mallis, M. M., Maislin, G., & Powell, J. W. (1998) · Cited by 260
Self-citationSystematic review: fatigue in inflammatory bowel disease
van Langenberg, D. R., & Gibson, P. R. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04347.x · Cited by 245
Liu, Y., Wheaton, A. G., Chapman, D. P., & Croft, J. B. (2013) · SLEEP · doi:10.5665/sleep.3028 · Cited by 244
Sleep deprivation and human immune function
Dinges, D. F., Douglas, S. D., Hamarman, S., Zaugg, L., & Kapoor, S. C. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(95)00002-j · Cited by 234
Self-citationSong, C., Lin, A., Bonaccorso, S., Heide, C., Verkerk, R., Kenis, G., Bosmans, E., Scharpe, S., Whelan, A., Cosyns, P., et al. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00025-1 · Cited by 232
Napping: a public health issue. From epidemiological to laboratory studies
Faraut, B., Andrillon, T., Vecchierini, M.-F., & Leger, D. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.09.002 · Cited by 217
Moreno, C. R. D. C., Marqueze, E. C., Sargent, C., Wright, K. P., Ferguson, S. A., & Tucker, P. (2019) · Industrial Health · doi:10.2486/indhealth.sw-1 · Cited by 246
Interactive Mathematical Models of Subjective Alertness and Cognitive Throughput in Humans
Jewett, M. E., & Kronauer, R. E. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000920 · Cited by 212
Mechanisms and functions of coupling between sleep and temperature rhythms
Van Someren, E. J. W. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53018-3 · Cited by 209
Miller, M. A., Kandala, N.-B., Mika Kivimaki, B., Meena Kumari, B., Brunner, E. J., Lowe, G. D. O., Marmot, M. G., & Cappuccio, F. P. (2009) · SLEEP · doi:10.1093/sleep/32.7.857 · Cited by 206
A prospective study of sleep duration and pneumonia risk in women
Patel, S. R., Malhotra, A., Gao, X., Hu, F. B., Neuman, M. I., & Fawzi, W. W. (2012) · Sleep · doi:10.5665/sleep.1594 · Cited by 195
Benz, R. L., Pressman, M. R., Hovick, E. T., & Peterson, D. D. (1999) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(99)70015-6 · Cited by 199
Changes in brain gene expression after long‐term sleep deprivation
Cirelli, C., Faraguna, U., & Tononi, G. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04058.x · Cited by 197
The relevance of sleep abnormalities to chronic inflammatory conditions
Ranjbaran, Z., Keefer, L., Stepanski, E. J., Farhadi, A., & Keshavarzian, A. (2007) · Inflammation Research · doi:10.1007/s00011-006-6067-1 · Cited by 191
Chronic Insomnia and Immune Functioning
Savard, J., Laroche, L., Simard, S., Ivers, H., & Morin, C. M. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000033126.22740.f3 · Cited by 190
Chennaoui, M., Sauvet, F., Drogou, C., Van Beers, P., Langrume, C., Guillard, M., Gourby, B., Bourrilhon, C., Florence, G., & Gomez-Merino, D. (2011) · Cytokine · doi:10.1016/j.cyto.2011.06.002 · Cited by 186
Nocturnal Care Interactions with Patients in Critical Care Units
Tamburri, L. M., DiBrienza, R., Zozula, R., & Redeker, N. S. (2004) · American Journal of Critical Care · doi:10.4037/ajcc2004.13.2.102 · Cited by 184
Walder, B., Francioli, D., Meyer, J.-J., Lançon, M., & Romand, J.-A. (2000) · Critical Care Medicine · doi:10.1097/00003246-200007000-00010 · Cited by 170
Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis
Nilsonne, G., Lekander, M., Åkerstedt, T., Axelsson, J., & Ingre, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165799 · Cited by 171
Sleep-dependent activity of T cells and regulatory T cells
Bollinger, T., Bollinger, A., Skrum, L., Dimitrov, S., Lange, T., & Solbach, W. (2009) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2008.03822.x · Cited by 167
Sleep in the intensive care unit
Drouot, X., Cabello, B., d’Ortho, M., & Brochard, L. J. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.11.004 · Cited by 167
Number and Function of Circulating Human Antigen Presenting Cells Regulated by Sleep
Dimitrov, S., Lange, T., Nohroudi, K., & Born, J. (2007) · Sleep · doi:10.1093/sleep/30.4.401 · Cited by 164
Physiological Roles of the Leptin Endocrine System: Differences between Mice and Humans
Himms‐Hagen, J. (1999) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408369991239259 · Cited by 168
Immune Correlates of Depression
Irwin, M. R. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_1 · Cited by 162
Haack, M., Lee, E., Cohen, D. A., & Mullington, J. M. (2009) · Pain · doi:10.1016/j.pain.2009.05.029 · Cited by 158
Dongen, H. P. A. V., Maislin, G., & Dinges, D. F. (2004) · PubMed · Cited by 156
Self-citationSavard, J., Simard, S., Ivers, H., & Morin, C. M. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.12.513 · Cited by 154
Faraut, B., Boudjeltia, K. Z., Dyzma, M., Rousseau, A., David, E., Stenuit, P., Franck, T. J., Antwerpen, P. V., Vanhaeverbeek, M., & Kerkhofs, M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.08.001 · Cited by 158
Simulated Night Shift Disrupts Circadian Rhythms of Immune Functions in Humans
Cuesta, M., Boudreau, P., Dubeau‐Laramée, G., Cermakian, N., & Boivin, D. B. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502422 · Cited by 152
Simpson, N. S., & Dinges, D. F. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00371.x · Cited by 148
Self-citationStress assessment based on EEG univariate features and functional connectivity measures
Alonso, J. F., Romero, S., Ballester, M. R., Antonijoan, R. M., & Mañanas, M. Á. (2015) · Physiological Measurement · doi:10.1088/0967-3334/36/7/1351 · Cited by 155
Lorton, D., Lubahn, C. L., Estus, C., Millar, B. A., Carter, J. L., Wood, C. A., & Bellinger, D. L. (2006) · NeuroImmunoModulation · doi:10.1159/000104864 · Cited by 147
Everson, C. A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00021.2005 · Cited by 141
An Initial Report of Sleep Disturbance in Inactive Inflammatory Bowel Disease
Keefer, L., Stepanski, E. J., Ranjbaran, Z., Benson, L. M., & Keshavarzian, A. (2006) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26656 · Cited by 137
Cell Injury and Repair Resulting from Sleep Loss and Sleep Recovery in Laboratory Rats
Everson, C. A., Henchen, C. J., Szabo, A., & Hogg, N. (2014) · Sleep · doi:10.5665/sleep.4244 · Cited by 136
Circadian Influence on Metabolism and Inflammation in Atherosclerosis
McAlpine, C. S., & Świrski, F. K. (2016) · Circulation Research · doi:10.1161/circresaha.116.308034 · Cited by 141
A review of health effects of aircraft noise
Morrell, S. L., Taylor, R. J., & Lyle, D. M. (1997) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1467-842x.1997.tb01690.x · Cited by 133
Ruiz, F. S., Andersen, M. L., Martins, R. C., Zager, A., Lopes, J. D., & Tufik, S. (2012) · Innate Immunity · doi:10.1177/1753425910385962 · Cited by 132
Ackermann, K., Revell, V. L., Lao, O., Rombouts, E. J., Skene, D. J., & Kayser, M. (2012) · Sleep · doi:10.5665/sleep.1954 · Cited by 129
Delaney, L., van Haren, F. M. P., & López, V. (2015) · Annals of Intensive Care · doi:10.1186/s13613-015-0043-2 · Cited by 129
Sleep management training for cancer patients with insomnia
Simeit, R., Deck, R., & Conta-Marx, B. (2004) · Supportive Care in Cancer · doi:10.1007/s00520-004-0594-5 · Cited by 129
Sleep Disturbance in Family Caregivers of Individuals With Dementia: A Review of the Literature
Peng, H.-L., & Chang, Y.-P. (2013) · Perspectives in Psychiatric Care · doi:10.1111/ppc.12005 · Cited by 120
Rangaraj, V. R., & Knutson, K. L. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2015.02.535 · Cited by 120
Sleep and immunity: A growing field with clinical impact
Opp, M. R., & Krueger, J. M. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.03.011 · Cited by 120
Neuroendocrine, immune and oxidative stress in shift workers
Faraut, B., Bayon, V., & Léger, D. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.12.006 · Cited by 114
Dinges, D. (2003) · Sleep Medicine · doi:10.1016/s1389-9457(03)00108-4 · Cited by 132
Self-citationMediators of Inflammation and Their Interaction with Sleep
Mullington, J. M., Hinze‐Selch, D., & Pollmächer, T. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05825.x · Cited by 108
Prather, A. A., Marsland, A. L., Hall, M., Neumann, S. A., Muldoon, M. F., & Manuck, S. B. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.04.008 · Cited by 106
White blood cells and cortisol after sleep deprivation and recovery sleep in humans
Heiser, P., Dickhaus, B., Schreiber, W., Clement, H. W., Hasse, C., Hennig, J., Remschmidt, H., Krieg, J. C., Wesemann, W., & Opper, C. (2000) · European Archives of Psychiatry and Clinical Neurosciences · doi:10.1007/pl00007534 · Cited by 105
Brain-Immune interactions in sleep
Marshall, L., & Born, J. (2002) · International Review of Neurobiology · doi:10.1016/s0074-7742(02)52007-9 · Cited by 102
Whitehouse, W. G., Dinges, D. F., Orne, E. C., Keller, S. E., Bates, B. L., Bauer, N. K., Morahan, P. S., Haupt, B. A., Carlin, M. M., Bloom, P. B., et al. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199605000-00009 · Cited by 100
Self-citationLiu, H., Huang, X., Li, Y., Xi, K., Han, Y., Mao, H., Ren, K., Wang, W., & Wu, Z. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.12.006 · Cited by 99
Sleep quality in renal transplant patients: a never investigated problem
Sabbatini, M., Crispo, A., Pisani, A., Gallo, R., Cianciaruso, B., Fuíano, G., Federico, S., & Andreucci, V. E. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh604 · Cited by 98
Self-reported Sleep Duration and Prediction of Proteinuria: A Retrospective Cohort Study
Yamamoto, R., Nagasawa, Y., Iwatani, H., Shinzawa, M., Obi, Y., Teranishi, J., Ishigami, T., Yamauchi‐Takihara, K., Nishida, M., Rakugi, H., et al. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.08.032 · Cited by 93
Sleep, sleep deprivation and infectious disease: Studies in animals
Toth, L. A. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(94)00045-p · Cited by 93
Neural-immune interactions in the regulation of sleep
Opp, M. R. (2003) · Frontiers in Bioscience · doi:10.2741/1061 · Cited by 92
Duration of sleep and breast cancer risk in a large population‐based case–control study
McElroy, J. A., Newcomb, P. A., Titus-Ernstoff, L. T., Trentham‐Dietz, A., Hampton, J. M., & Egan, K. M. (2006) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2006.00523.x · Cited by 92
Circadian effects in cancer-relevant psychoneuroendocrine and immune pathways
Eismann, E. A., Cash, E. D., & Sephton, S. E. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.12.011 · Cited by 96
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Metadata
- Authors
- Dinges, D. F., Douglas, S. D., Zaugg, L., Campbell, D. E., McMann, J. M., Whitehouse, W. G., Orne, E. C., Kapoor, S. C., Icaza, E., & Orne, M. T.
- Affiliations
- Pennsylvania Hospital (US)
- Children's Hospital of Philadelphia (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1994-05-01
- Volume
- 93
- Issue
- 5
- Pages
- 1930-1939
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC294300
- OpenAlex
- W2027223222
- Cited by
- 361
- References
- 43
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 14 · 2020: 13 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 13 · 2015: 19 · 2014: 18 · 2013: 15 · 2012: 13
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Aeronautics and Space Administration
- National Institutes of Health (5p01mh044193-05)
- Ames Research Center
- National Institute of Mental Health (MH44193)
- National Center for Research Resources (CRC RR 00040)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, leukocytosis, natural killer cells, immune function, monocytes, lymphocyte subsets, NK cell cytotoxicity, cell cycle, CD56, CD57, CD16, CD4, recovery sleep, cortisol, ACTH
- MeSH terms
- Adult, Arousal, Body Temperature, Mental Fatigue, Female, Glucocorticoids, Humans, Killer Cells, Natural, Leukocytosis, Lymphocytes, Male, Movement, Sleep Deprivation, Biomarkers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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