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Cited by 157Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and Wakefulness Research

Internal desynchronization in a model of night-work by forced activity in rats

Salgado-Delgado, R., Ángeles-Castellanos, M., Buijs, M.R., Escobar, C.·2008·Neuroscience
DOI 10.1016/j.neuroscience.2008.03.066
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Abstract

Individuals engaged in shift- or night-work show disturbed diurnal rhythms, out of phase with temporal signals associated to the light/dark (LD) cycle, resulting in internal desynchronization. The mechanisms underlying internal desynchrony have been mainly investigated in experimental animals with protocols that induce phase shifts of the LD cycle and thus modify the activity of the suprachiasmatic nucleus (SCN). In this study we developed an animal model of night-work in which the light-day cycle remained stable and rats were required to be active in a rotating wheel for 8 h daily during their sleeping phase (W-SP). This group was compared with rats that were working in the wheel during their activity phase (W-AP) and with undisturbed rats (C). We provide evidence that forced activity during the sleeping phase (W-SP group) alters not only activity, but also the temporal pattern of food intake. In consequence W-SP rats showed a loss of glucose rhythmicity and a reversed rhythm of triacylglycerols. In contrast W-AP rats did not show such changes and exhibited metabolic rhythms similar to those of the controls. The three groups exhibited the nocturnal corticosterone increase, in addition the W-SP and W-AP groups showed increase of plasma corticosterone associated with the start of the working session. Forced activity during the sleep phase did not modify SCN activity characterized by the temporal patterns of PER1 and PER2 proteins, which remained in phase with the LD cycle. These observations indicate that a working regimen during the sleeping period elicits internal desynchronization in which activity combined with feeding uncouples metabolic functions from the biological clock which remains fixed to the LD cycle. The present data suggest that in the night worker the combination of work and eating during working hours may be the cause of internal desynchronization.

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Crossref · 10.1016/j.neuroscience.2008.03.066

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  • Not all organs and tissues adapt to a new feeding time with the same speed and magnitude as the liver.

    “However, not all organs and tissues adapt to a new feeding time with the same speed and magnitude as the liver [148–150].”

    From Circadian control of glucose metabolism (2014) · cites this paper as [149]

  • Rats subjected to simulated night work gain significantly more body mass than rats undertaking simulated day work.

    “In addition, rats subjected to simulated night work (forced activity during the normal rest phase) gain significantly more body mass than rats undertaking simulated day work (forced activity during the normal active phase; Salgado-Delgado et al., 2008).”

    From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Salgado-Delgado et al., 2008

  • Total daily food intake did not differ between rats subjected to simulated night work and simulated day work.

    “Total daily food intake did not differ between the two groups, but the “night workers” were less active and this may explain the above finding.”

    From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Salgado-Delgado et al., 2008

  • The night worker rats were less active, which may explain their greater body mass gain.

    “Total daily food intake did not differ between the two groups, but the “night workers” were less active and this may explain the above finding.”

    From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Salgado-Delgado et al., 2008

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Authors
Salgado-Delgado, R., Ángeles-Castellanos, M., Buijs, M. R., & Escobar, C.
Affiliations
Universidad Nacional Autónoma de México (MX)
ORCID
Escobar, C.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2008-06
Volume
154
Issue
3
Pages
922-931
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2008.03.066
OpenAlex
W2128479698
Cited by
157
References
56
Citations by year
2025: 4 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 15 · 2016: 8 · 2015: 14 · 2014: 11 · 2013: 21 · 2012: 9
FWCI
4.76
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
internal desynchronization, night work, shift work, circadian rhythm, suprachiasmatic nucleus, Per1, Per2, corticosterone, biological clock
MeSH terms
Animals, Blood Glucose, Body Weight, Cell Count, Circadian Rhythm, Corticosterone, Eating, Hormones, Immunohistochemistry, Male, Metabolism, Motor Activity, Nuclear Proteins, Suprachiasmatic Nucleus, Rats, Wistar, Cell Cycle Proteins, Sleep Disorders, Circadian Rhythm, Rats, Period Circadian Proteins

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