Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

Cappello, V., Marchetti, L., Parlanti, P., Landi, S., Tonazzini, I., Cecchini, M., Piazza, V., & Gemmi, M. (2016) · Scientific Reports · doi:10.1038/s41598-016-0001-8 · Cited by 13,097

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834

The biology , function , and biomedical applications of exosomes

Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770

Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles

Santos, A. G., da Rocha, G. O., & de Andrade, J. B. (2019) · Scientific Reports · doi:10.1038/s41598-018-37186-2 · Cited by 8,495

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930

mRNA vaccines — a new era in vaccinology

Pardi, N., Hogan, M. J., Porter, F. W., & Weissman, D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.243 · Cited by 4,667

Lipid nanoparticles for mRNA delivery

Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00358-0 · Cited by 4,076

Membrane vesicles as conveyors of immune responses

Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,996

Extracellular vesicles: biology and emerging therapeutic opportunities

EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,571

Exosomes

Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., Lee, J. J., & Kalluri, R. (2017) · Nature · doi:10.1038/nature22341 · Cited by 2,639

Exosomes – vesicular carriers for intercellular communication

Simons, M., & Raposo, G. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.03.007 · Cited by 2,410

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

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Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S. K., Choo, A., Chen, T. S., Salto-Tellez, M., Timmers, L., Lee, C. N., El Oakley, R. M., et al. (2010) · Stem Cell Research · doi:10.1016/j.scr.2009.12.003 · Cited by 2,215

Identification and proteomic profiling of exosomes in human urine

Pisitkun, T., Shen, R., & Knepper, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403453101 · Cited by 2,162

Exosomes: biogenesis, biologic function and clinical potential

Zhang, Y., Liu, Y., Liu, H., & Tang, W. H. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0282-2 · Cited by 2,119

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

Vlassov, A. V., Magdaleno, S. M., Setterquist, R. A., & Conrad, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.03.017 · Cited by 1,984

Extracellular vesicles as a next-generation drug delivery platform

Herrmann, I. K., Wood, M. J. A., & Fuhrmann, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00931-2 · Cited by 1,948

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Ohno, S.-I., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.180 · Cited by 1,666

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W. E., Miller, D., & Zhang, H. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,579

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Kim, M. S., Haney, M. J., Zhao, Y., Mahajan, V., Deygen, I., Klyachko, N. L., Inskoe, E., Piroyan, A., Sokolsky, M., Okolie, O., et al. (2016) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2015.10.012 · Cited by 1,410

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Mashouri, L., Yousefi, H., Aref, A. R., Ahadi, A. M., Molaei, F., & Alahari, S. K. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0991-5 · Cited by 1,363

Exosomal-like vesicles are present in human blood plasma

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Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication

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Exosomal MicroRNA: A Diagnostic Marker for Lung Cancer

Rabinowits, G., Gerçel-Taylor, Ç., Day, J. M., Taylor, D. D., & Kloecker, G. H. (2009) · Clinical Lung Cancer · doi:10.3816/clc.2009.n.006 · Cited by 1,290

Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.

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Exosomes with Immune Modulatory Features Are Present in Human Breast Milk

Admyre, C., Johansson, S. M., Qazi, K. R., Filén, J., Lahesmaa, R., Norman, M., Neve, E. P. A., Scheynius, A., & Gabrielsson, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1969 · Cited by 1,222

Engineering exosomes as refined biological nanoplatforms for drug delivery

Luan, X., Sansanaphongpricha, K., Myers, I., Chen, H., Yuan, H., & Sun, D. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.12 · Cited by 1,196

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

Arslan, F., Lai, R. C., Smeets, M. B., Akeroyd, L., Choo, A. B. H., Aguor, E. N. E., Timmers, L., van Rijen, H. V. M., Doevendans, P. A., Pasterkamp, G., et al. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.01.002 · Cited by 1,137

Exfoliation of membrane ecto-enzymes in the form of micro-vesicles

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Malignant effusions and immunogenic tumour-derived exosomes

André, F., Schartz, N. E. C., Movassagh, M., Flament, C., Pautier, P., Morice, P., Pomel, C., Lhommé, C., Escudier, B. J., Chevalier, T. L., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09552-1 · Cited by 971

Bovine milk-derived exosomes for drug delivery

Munagala, R., Aqil, F., Jeyabalan, J., & Gupta, R. C. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.020 · Cited by 936

ExoCarta: A compendium of exosomal proteins and RNA

Mathivanan, S., & Simpson, R. J. (2009) · PROTEOMICS · doi:10.1002/pmic.200900351 · Cited by 899

In vitro and ex vivo strategies for intracellular delivery

Stewart, M. P., Sharei, A., Ding, X., Sahay, G., Langer, R., & Jensen, K. F. (2016) · Nature · doi:10.1038/nature19764 · Cited by 885

Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension

Lee, C., Mitsialis, S. A., Aslam, M., Vitali, S. H., Vergadi, E., Konstantinou, G., Sdrimas, K., Fernandez‐Gonzalez, A., & Kourembanas, S. (2012) · Circulation · doi:10.1161/circulationaha.112.114173 · Cited by 795

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

Doeppner, T. R., Herz, J., Görgens, A., Schlechter, J., Ludwig, A., Radtke, S., de Miroschedji, K., Horn, P. A., Giebel, B., & Hermann, D. M. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0078 · Cited by 789

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

Hoen, E. N. M. N., Buermans, H. P. J., Waasdorp, M., Stoorvogel, W., Wauben, M. H. M., & Hoen, P. A. C. ’. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks658 · Cited by 772

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

Kojima, R., Bojar, D., Rizzi, G., Hamri, G. C.-E., El-Baba, M. D., Saxena, P., Ausländer, S., Tan, K. R., & Fussenegger, M. (2018) · Nature Communications · doi:10.1038/s41467-018-03733-8 · Cited by 748

Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

Yeo, R. W. Y., Lai, R. C., Zhang, B., Tan, S. S., Yin, Y., Teh, B. J., & Lim, S. K. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.001 · Cited by 746

Engineering hybrid exosomes by membrane fusion with liposomes

Sato, Y. T., Umezaki, K., Sawada, S., Mukai, S.-A., Sasaki, Y., Harada, N., Shiku, H., & Akiyoshi, K. (2016) · Scientific Reports · doi:10.1038/srep21933 · Cited by 744

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

Yang, Z., Shi, J., Xie, J., Wang, Y., Sun, J., Liu, T., Zhao, Y., Zhao, X., Wang, X., Ma, Y., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0485-1 · Cited by 744

Exosomes from human saliva as a source of microRNA biomarkers

Michael, A., Bajracharya, S., Yuen, P. S. T., Zhou, H., Star, R., Illei, G. G., & Alevizos, I. (2009) · Oral Diseases · doi:10.1111/j.1601-0825.2009.01604.x · Cited by 737

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

Wahlgren, J., Karlson, T. D. L., Brisslert, M., Sani, F. V., Telemo, E., Sunnerhagen, P., & Valadi, H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks463 · Cited by 727

Production and characterization of clinical grade exosomes derived from dendritic cells

Lamparski, H., Mehta-Damani, A., Yao, J.-Y., Patel, S., Hsu, D., Ruegg, C. L., & Pecq, J. L. (2002) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00330-7 · Cited by 701

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

Katakowski, M., Buller, B., Zheng, X., Lu, Y., Rogers, T., Osobamiro, O., Shu, W., Jiang, F., & Chopp, M. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.02.019 · Cited by 681

Efficient RNA drug delivery using red blood cell extracellular vesicles

Usman, W. M., Pham, T. C., Kwok, Y. Y., Vu, L. T., Ma, V., Peng, B., Chan, Y. S., Wei, L., Chin, S. M., Azad, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04791-8 · Cited by 663

Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies

Subra, C., Laulagnier, K., Perret, B., & Record, M. (2006) · Biochimie · doi:10.1016/j.biochi.2006.10.014 · Cited by 660

Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applications

Patel, G. K., Khan, M. A., Zubair, H., Srivastava, S. K., Khushman, M. M., Singh, S., & Singh, A. P. (2019) · Scientific Reports · doi:10.1038/s41598-019-41800-2 · Cited by 657

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

Subra, C., Grand, D., Laulagnier, K., Stella, A., Lambeau, G. J., Paillasse, M. R., de Médina, P., Monsarrat, B., Perret, B., Silvente‐Poirot, S., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m003657 · Cited by 654

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

Lou, G., Song, X., Yang, F., Wu, S., Wang, J., Chen, Z., & Liu, Y. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0220-7 · Cited by 651

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

Kefas, B., Godlewski, J., Comeau, L., Li, Y., Abounader, R., Hawkinson, M., Lee, J., Fine, H., Chiocca, E. A., Lawler, S., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6639 · Cited by 647

Exosome–Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

Lin, Y., Wu, J., Gu, W., Huang, Y., Tong, Z., Huang, L., & Tan, J. (2018) · Advanced Science · doi:10.1002/advs.201700611 · Cited by 625

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases

Lou, G., Chen, Z., Zheng, M., & Liu, Y. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.63 · Cited by 615

Exosome-mediated delivery of siRNA in vitro and in vivo

Andaloussi, S. E., Lee, Y., Lakhal‐Littleton, S., Li, J., Seow, Y., Gardiner, C., Alvarez‐Erviti, L., Sargent, I. L., & Wood, M. J. A. (2012) · Nature Protocols · doi:10.1038/nprot.2012.131 · Cited by 609

Recent advancements in the use of exosomes as drug delivery systems

Bunggulawa, E. J., Wang, W., Yin, T., Wang, N., Durkan, C., Wang, Y., & Wang, G. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0403-9 · Cited by 608

Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source

Meng, W., He, C., Hao, Y., Wang, L., Li, L., & Zhu, G. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1748758 · Cited by 592

Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

Godlewski, J., Nowicki, M. O., Bronisz, A., Williams, S., Otsuki, A., Nuovo, G., RayChaudhury, A., Newton, H. B., Chiocca, E. A., & Lawler, S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2629 · Cited by 587

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

Wadhwa, A., Aljabbari, A., Lokras, A., Foged, C., & Thakur, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020102 · Cited by 584

Exosomes for targeted siRNA delivery across biological barriers

Andaloussi, S. E., Lakhal‐Littleton, S., Mäger, I., & Wood, M. J. A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.008 · Cited by 555

Milk-derived exosomes for oral delivery of paclitaxel

Agrawal, A. K., Aqil, F., Jeyabalan, J., Spencer, W. A., Beck, J., Gachuki, B. W., Alhakeem, S. S., Oben, K. Z., Munagala, R., Bondada, S., et al. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.03.001 · Cited by 544

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

Munoz, J. L., Bliss, S. A., Greco, S. J., Ramkissoon, S. H., Ligon, K. L., & Rameshwar, P. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2013.60 · Cited by 520

The Polyethyleneglycol Dilemma: Advantage and Disadvantage of PEGylation of Liposomes for Systemic Genes and Nucleic Acids Delivery to Tumors

Hatakeyama, H., Akita, H., & Harashima, H. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00059 · Cited by 500

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

Shtam, T. A., Kovalev, R. A., Varfolomeeva, E. Y., Makarov, E. M., Kil, Y. V., & Filatov, M. V. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-88 · Cited by 499

Exosomes as Potent Cell-Free Peptide-Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells

André, F., Chaput, N., Schartz, N. E. C., Flament, C., Aubert, N., Bernard, J., Lemonnier, F., Raposo, G., Escudier, B., Hsu, D.-H., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2126 · Cited by 496

Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection

Yu, B., Kim, H. W., Gong, M., Wang, J., Millard, R. W., Wang, Y., Ashraf, M., & Xu, M. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.12.043 · Cited by 477

Field-Free Isolation of Exosomes from Extracellular Vesicles by Microfluidic Viscoelastic Flows

Liu, C., Guo, J., Tian, F., Yang, N., Yan, F., Ding, Y., Wei, J., Hu, G., Nie, G., & Sun, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b02277 · Cited by 477

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

Bellingham, S. A., Coleman, B. M., & Hill, A. F. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks832 · Cited by 461

Liposomes and Extracellular Vesicles as Drug Delivery Systems: A Comparison of Composition, Pharmacokinetics, and Functionalization

van der Koog, L., Gandek, T. B., & Nagelkerke, A. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100639 · Cited by 431

Challenges in Exosome Isolation and Analysis in Health and Disease

Ludwig, N., Whiteside, T. L., & Reichert, T. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194684 · Cited by 430

Packaging of prions into exosomes is associated with a novel pathway of PrP processing

Vella, L. J., Sharples, R., Lawson, V., Masters, C. L., Cappai, R., & Hill, A. F. (2007) · The Journal of Pathology · doi:10.1002/path.2145 · Cited by 426

Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment

Zhou, W., Zhou, Y., Chen, X., Ning, T., Chen, H., Guo, Q., Zhang, Y., Liu, P., Zhang, Y., Li, C., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120546 · Cited by 425

Design strategies and application progress of therapeutic exosomes

Liu, C., & Su, C. (2019) · Theranostics · doi:10.7150/thno.30853 · Cited by 424

Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools

Li, S.-P., Lin, Z., Jiang, X., & Yu, X. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.178 · Cited by 404

Manufacturing Exosomes: A Promising Therapeutic Platform

Colao, I. L., Corteling, R., Bracewell, D., & Wall, I. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.01.006 · Cited by 396

Exosome-based tumor antigens–adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA

Morishita, M., Takahashi, Y., Matsumoto, A., Nishikawa, M., & Takakura, Y. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.031 · Cited by 370

A review of nanocarriers for the delivery of small interfering RNA

Kesharwani, P., Gajbhiye, V., & Jain, N. K. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.068 · Cited by 368

Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung

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Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury

Chen, L., Wang, Y., Pan, Y., Zhang, L., Shen, C., Qin, G., Ashraf, M., Weintraub, N. L., Ma, G., & Tang, Y. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.01.015 · Cited by 359

Tumor cell-derived exosomes: A message in a bottle

Kharaziha, P., Ceder, S., Li, Q., & Panaretakis, T. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.03.006 · Cited by 347

Transfer of extracellular vesicles during immune cell‐cell interactions

Gutiérrez‐Vázquez, C., Villarroya‐Beltri, C., Mittelbrunn, M., & Sánchez‐Madrid, F. (2012) · Immunological Reviews · doi:10.1111/imr.12013 · Cited by 324

Artificial exosomes for translational nanomedicine

Li, Y.-J., Wu, J.-Y., Liu, J., Xu, W., Qiu, X., Huang, S., Hu, X.-B., & Xiang, D.-X. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00986-2 · Cited by 303

Exosomes Increase the Therapeutic Index of Doxorubicin in Breast and Ovarian Cancer Mouse Models

Hadla, M., Palazzolo, S., Corona, G., Caligiuri, I., Canzonieri, V., Toffoli, G., & Rizzolio, F. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0154 · Cited by 289

Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

Liu, Y., Li, D., Liu, Z., Zhou, Y., Chu, D., Li, X., Jiang, X., Hou, D., Chen, X., Chen, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep17543 · Cited by 288

Cationic liposome-mediated delivery of siRNAs in adult mice

Sioud, M., & Sørensen, D. R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.057 · Cited by 287

Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia

Masyuk, A. I., Huang, B. Q., Ward, C. J., Gradilone, S. A., Bañales, J. M., Masyuk, T. V., Radtke, B. N., Splinter, P. L., & LaRusso, N. F. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00093.2010 · Cited by 286

Size Characterization and Quantification of Exosomes by Asymmetrical-Flow Field-Flow Fractionation

Sitar, S., Kejžar, A., Pahovnik, D., Kogej, K., Tušek‐Žnidarič, M., Lenassi, M., & Žagar, E. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b01636 · Cited by 283

Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats

Jiang, Z.-Z., Liu, Y., Niu, X., Yin, J., Hu, B., Guo, S., Fan, Y., Wang, Y., & Wang, N. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0287-2 · Cited by 271

Proteomic Analysis of Two Types of Exosomes in Human Whole Saliva

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Toward Exosome-Based Therapeutics: Isolation, Heterogeneity, and Fit-for-Purpose Potency

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