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Cited by 1,930

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Ferroptosis, a new form of cell death: opportunities and challenges in cancer

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Mou, Yanhua, Wang, Jun, Wu, Jinchun, He, Dan, Zhang, Chunfang, Duan, Chaojun, Li, Bin·2019·Journal of Hematology & Oncology
DOI 10.1186/s13045-019-0720-y
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Abstract

Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the current findings of ferroptosis regulation and especially focus on the function of ncRNAs in mediating the process of cell ferroptotic death and on how ferroptosis was in relation to other regulated cell deaths. Aberrant ferroptosis in diverse cancer types and tissues were summarized, and we elaborated recent data about the novel actors of some "conventional" drugs or natural compounds as ferroptosis inducers in cancer. Finally, we deliberate future orientation for ferroptosis in cancer cells and current unsettled issues, which may forward the speed of clinical use of ferroptosis induction in cancer treatment.

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Metadata

Authors
Mou, Y., Wang, J., Wu, J., He, D., Zhang, C., Duan, C., & Li, B.
Venue
Journal of Hematology & Oncology
Publisher
Springer Science and Business Media LLC
Published
2019-03-29
Volume
12
Issue
1
Pages
34-34
ISSN
1756-8722 (ISSN-L)
DOI
10.1186/s13045-019-0720-y
OpenAlex
W2939322913
Cited by
1,930
References
16
FWCI
104.43
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (tdm)
Funders
  • National Natural Science Foundation of China (81572281, 81171841, 81200366, 81702278)
  • Natural Science Foundation of Hunan Province (14JJ6004)

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CoChat. (2026). Citation check: Ferroptosis, a new form of cell death: opportunities and challenges in cancer. https://app.cochat.ai/papers/10.1186/s13045-019-0720-y
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Mou, Y., Wang, J., Wu, J., He, D., Zhang, C., Duan, C., & Li, B. (2019). Ferroptosis, a new form of cell death: opportunities and challenges in cancer. Journal of Hematology & Oncology. https://doi.org/10.1186/s13045-019-0720-y

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