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Cited by 145Bipolar Disorder and TreatmentChild and Adolescent Psychosocial and Emotional DevelopmentNeural and Behavioral Psychology Studies

Irritability in pediatric mania and other childhood psychopathology

LEIBENLUFT, ELLEN, BLAIR, R JAMES R., CHARNEY, DENNIS S., PINE, DANIEL S.·2003·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1301.022
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Abstract

Irritability is an important symptom in childhood psychopathology that has received relatively little research attention. Recent controversy concerning the diagnosis of mania in children has focused attention on how little is known about how to assess irritability in a systematic way, and about its diagnostic associations. For example, subtyping irritability according to course (chronic vs. episodic), precipitants, and family history may facilitate the identification of psychopathology and the study of pathophysiology. While normative and pathologic irritability can be differentiated reliably, the validity of the distinction is unclear. In addition, there is a need for scales designed to measure the severity of irritability in children with mood and anxiety disorders. In order to facilitate research, we propose a definition of irritability from the perspective of affective neuroscience. Because reactive aggression may be a helpful animal model for irritability, we review the neural circuitry mediating this behavior. Behavioral paradigms that evoke frustration, as well as those that assess the ability to inhibit a prepotent motor response, maintain attentional focus, execute response reversal, recognize angry faces, and regulate emotional responses, may be useful in the study of irritability. Examples of such paradigms are described, and the pharmacology of irritability is reviewed briefly.

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  • There are age-related differences in the clinical presentation of mood disorders.

    “Given agerelated differences in the clinical presentation of mood disorders (e.g., Kovacs, 1996; Leibenluft et al., 2003), ESM/EMA studies in children and adolescents with MDD and BD may provide insight in how their everyday lives, which tend to differ substantially from those of adults, may in fl uence their symptoms, or be in fl uenced by them.”

    From Mood Disorders in Everyday Life: A Systematic Review of Experience Sampling and Ecological Momentary Assessment Studies (2012) · cites this paper as Leibenluft et al., 2003

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Authors
LEIBENLUFT, E., BLAIR, R. J. R., CHARNEY, D. S., & PINE, D. S.
Affiliations
  • United States Department of Health and Human Services (US)
  • National Institutes of Health (US)
Corresponding author
LEIBENLUFT, ELLEN
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2003-12
Volume
1008
Issue
1
Pages
201-218
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1196/annals.1301.022
OpenAlex
W2077483072
Cited by
145
References
106
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 8 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 13 · 2015: 9 · 2014: 8 · 2013: 4 · 2012: 7
FWCI
3.06
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 785 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
irritability, childhood psychopathology, reactive aggression, frustration, affective neuroscience, mood disorders, anxiety disorders, emotion regulation, anger recognition, response inhibition
MeSH terms
Adolescent, Aggression, Bipolar Disorder, Child, Child Behavior Disorders, Family, Humans, Nerve Net, Phenotype, Sensitivity and Specificity, Mood Disorders, Diagnostic and Statistical Manual of Mental Disorders

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