Cited by 306Posttraumatic Stress Disorder ResearchPsychoanalysis and Psychopathology ResearchTraumatic Brain Injury Research

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Toward a Psychobiology of Posttraumatic Self‐Dysregulation: Reexperiencing, Hyperarousal, Dissociation, and Emotional Numbing

FREWEN, PAUL A., LANIUS, RUTH A.·2006·Annals of the New York Academy of Sciences

DOI 10.1196/annals.1364.010

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Abstract

In this article we propose a psychobiological model that construes PTSD fundamentally as a disorder of affect arousal regulation. Neuroimaging studies of emotion regulation in psychologically healthy populations are initially reviewed as a framework for interpreting the results of previously published investigations of the neural correlates of PTSD reexperiencing and dissociation. We then apply the emotion regulation framework toward understanding other perturbed affective states in PTSD. We conclude by discussing the clinical significance of this framework for psychological assessment and treatment of posttrauma psychopathology.

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The emerging field of emotion regulation: an integrative review
Gross, J. J. (1998) · Review of General Psychology · doi:10.1037/1089-2680.2.3.271 · Cited by 9,916
Untitled work
(1993) · Cited by 7,136
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
The cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495
Manuscript Preparation
Editorial Office (1997) · Obesity Surgery · doi:10.1381/096089297765555359 · Cited by 3,941
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502
Rethinking feelings: an fMRI study of the cognitive regulation of emotion
Ochsner, K. N., Bunge, S. A., Gross, J. J., & Gabrieli, J. D. E. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902760807212 · Cited by 2,520
Neurobiology of emotion perception I: the neural basis of normal emotion perception
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00168-9 · Cited by 2,173
For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion
Ochsner, K. N., Ray, R. D., Cooper, J. C., Robertson, E. R., Chopra, S., Gabrieli, J. D. E., & Gross, J. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.030 · Cited by 2,113
The polyvagal theory: phylogenetic substrates of a social nervous system.
Porges, S. W. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00162-3 · Cited by 1,582

Show all 58 references

Research works printed but not linked: 3

Lanius R.A., 2005, A review of neuroimaging studies of hyperarousal and dissociation in PTSD: heterogeneity of response to symptom provocation, J. Psychiatr. Res.
Vermetten E.&R.Pitman.2005.Pain processing in disorders related to traumatic stress. Symposium presented at the annual meeting of the International Society for Traumatic Stress Studies Toronto Ontario Canada .
Cloitre M., 2000, Psychotherapy for the Interrupted Life: an Evidence‐Based Guide to Working Through the Complex Trauma of Childhood Abuse

Sorted by citations

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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Background
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Self-citation
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InfluentialSelf-citation
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Reinders, A. A. T. S., Willemsen, A. T. M., den Boer, J. A., Vos, H. P. J., Veltman, D. J., & Loewenstein, R. J. (2014) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2014.05.005 · Cited by 96
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Self-citation
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Nicholson, A. A., Densmore, M., McKinnon, M. C., Neufeld, R. W. J., Frewen, P. A., Théberge, J., Jetly, R., Richardson, J. D., & Lanius, R. A. (2019) · Psychological Medicine · doi:10.1017/s0033291718002866 · Cited by 79
Self-citation
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Self-citation
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Electrocortical processing of social signals of threat in combat-related post-traumatic stress disorder
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Authors: FREWEN, P. A., & LANIUS, R. A.
Affiliations: Western University (CA)
Corresponding author: LANIUS, RUTH A.
ORCID: FREWEN, PAUL A.
LANIUS, RUTH A.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2006-07
Volume: 1071
Issue: 1
Pages: 110-124
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1196/annals.1364.010
OpenAlex: W2104622135
Cited by: 306
References: 58
Citations by year: 2026: 13 · 2025: 18 · 2024: 12 · 2023: 13 · 2022: 14 · 2021: 15 · 2020: 25 · 2019: 15 · 2018: 14 · 2017: 16 · 2016: 15 · 2015: 28 · 2014: 15 · 2013: 14 · 2012: 13
FWCI: 1.72
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 25 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Keywords: post-traumatic stress disorder, emotion regulation, psychobiological model, re-experiencing, dissociation, neural correlates, psychological assessment, PTSD treatment
MeSH terms: Adaptation, Psychological, Arousal, Dissociative Disorders, Emotions, Humans, Magnetic Resonance Imaging, Mental Recall, Stress Disorders, Post-Traumatic, Wounds and Injuries

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Toward a Psychobiology of Posttraumatic Self‐Dysregulation: Reexperiencing, Hyperarousal, Dissociation, and Emotional Numbing

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