Cited by 101Posttraumatic Stress Disorder ResearchMemory and Neural MechanismsStress Responses and Cortisol

The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.

Establishing an Agenda for Translational Research on PTSD

MILLER, MELINDA M., McEWEN, BRUCE S.·2006·Annals of the New York Academy of Sciences

Open this paper in CoChat — free account

Abstract

Abstract: Animal research on brain mechanisms involved in psychiatric disorders presents an enormous challenge because it is impossible to precisely model symptoms of a human disorder in a rat or mouse. Nevertheless, there are uses for animal models as long as the limitations are recognized. Animal research related to posttraumatic stress disorder (PTSD) points to acute and chronic stressors, such as restraint or immobilization as being the most relevant stimuli to study how neural and endocrine systems are affected, both immediately and long term. Of particular relevance are the onset and duration of effects of stressors on brain areas subserving emotional memories, such as the amygdala, prefrontal cortex, and hippocampus. The hippocampus plays a role in memory and in vegetative functions of the body. The hippocampus receives input from the amygdala and its function in spatial memory is altered by amygdala activity. Repeated stress in the rat suppresses dentate gyrus neurogenesis and causes dendrites of hippocampal and medial prefrontal cortical neurons to shrink. Conversely, it causes basolateral amygdala neurons to increase in dendritic complexity and sprout new synapses. Repeated stress also increases fear and aggression, reduces spatial memory, and alters contextual fear conditioning. Antidepressants and mood stabilizers have diverse effects on these processes. New data indicate that a single stress episode can cause a delayed alteration in synapse formation in the basolateral amygdala without changing dendritic length and branching. Further studies are examining the structural changes in prefrontal cortex and hippocampus as a result of single traumatic stressors, which may reflect the functional interactions with the amygdala. Together with mechanistic studies of the role of adrenal glucocorticoids and catecholamines, these results may tell us how the brain is shaped by acute and repeated uncontrollable stress in ways that then can be investigated in human anxiety disorders.

Integrity signals

Registry

Crossref · 10.1196/annals.1364.023

Cites

107 of 107 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Self-citation
Extinction Learning in Humans
Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753
Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons
Vyas, A., Mitra, R., Shankaranarayana Rao, B. S., & Chattarji, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06810.2002 · Cited by 1,662
Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders
MCEWEN, B. S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.001 · Cited by 1,638
Self-citation
Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580
Differential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428
Lesions of the human amygdala impair enhanced perception of emotionally salient events
Anderson, A. K., & Phelps, E. A. (2001) · Nature · doi:10.1038/35077083 · Cited by 1,379
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310
Stress and glucocorticoids impair retrieval of long-term spatial memory
de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L. (1998) · Nature · doi:10.1038/29542 · Cited by 1,182
The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress
Diorio, D., Viau, V, & Meaney, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03839.1993 · Cited by 1,151
The human amygdala in social judgment
Adolphs, R., Tranel, D., & Damasio, A. R. (1998) · Nature · doi:10.1038/30982 · Cited by 1,125
Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons
Woolley, C. S., Gould, E., & McEwen, B. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90778-a · Cited by 1,020
Self-citation
Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala
Pitkänen, A., Savander, V., & LeDoux, J. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01125-9 · Cited by 980
Memory Formation: The Sequence of Biochemical Events in the Hippocampus and Its Connection to Activity in Other Brain Structures
Izquierdo, I., & Medina, J. H. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1997.3799 · Cited by 959
Why We Think Plasticity Underlying Pavlovian Fear Conditioning Occurs in the Basolateral Amygdala
Fanselow, M. S., & LeDoux, J. E. (1999) · Neuron · doi:10.1016/s0896-6273(00)80775-8 · Cited by 933
Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons
Quirk, G. J., Likhtik, E., Pelletier, J. G., & Paré, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08800.2003 · Cited by 927
Extinction of emotional learning: contribution of medial prefrontal cortex
Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90241-c · Cited by 897
The Human Amygdala in Social Judgment
Adolphs, R., Tranel, D., & Damásio, A. R. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0027 · Cited by 881
Stress doses of hydrocortisone reverse hyperdynamic septic shock
Briegel, J., Forst, H., Haller, M., Schelling, G., Kilger, E., Kuprat, G., Hemmer, B., Hummel, T., Lenhart, A., Heyduck, M., et al. (1999) · Critical Care Medicine · doi:10.1097/00003246-199904000-00025 · Cited by 876
Chronic Psychosocial Stress Causes Apical Dendritic Atrophy of Hippocampal CA3 Pyramidal Neurons in Subordinate Tree Shrews
Magariños, A. M., McEwen, B. S., Flügge, G., & Fuchs, E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03534.1996 · Cited by 864
Self-citation
Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of glucocorticoid secretion and excitatory amino acid receptors
Magarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00259-l · Cited by 863
Self-citation
Behavioral changes associated with ablation of the amygdaloid complex in monkeys.
Weiskrantz, L. (1956) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0088009 · Cited by 837
Repeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex
Radley, J. J., Rocher, A. B., Miller, M., Janssen, W. G. M., Liston, C., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi104 · Cited by 820
Self-citation
Chronic stress alters dendritic morphology in rat medial prefrontal cortex
Cook, S. C., & Wellman, C. L. (2004) · Journal of Neurobiology · doi:10.1002/neu.20025 · Cited by 785
Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex
Radley, J. J., Sisti, H. M., Hao, J., Rocher, A. B., McCall, T., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.006 · Cited by 769
Self-citation
Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement
Sousa, N., Lukoyanov, N. V., Madeira, M. D., Almeida, O. F. X., & Paula-Barbosa, M. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00050-6 · Cited by 758
Acute cortisone administration impairs retrieval of long-term declarative memory in humans
de Quervain, D. J.-F., Roozendaal, B., Nitsch, R. M., McGaugh, J. L., & Hock, C. (2000) · Nature Neuroscience · doi:10.1038/73873 · Cited by 745
Interaction between the Amygdala and the Medial Temporal Lobe Memory System Predicts Better Memory for Emotional Events
Dolcos, F., LaBar, K. S., & Cabeza, R. (2004) · Neuron · doi:10.1016/s0896-6273(04)00289-2 · Cited by 714
Glucocorticoids, depression, and mood disorders: Structural remodeling in the brain
McEwen, B. S. (2005) · Metabolism · doi:10.1016/j.metabol.2005.01.008 · Cited by 687
Self-citation
Glucocorticoids and the regulation of memory consolidation
Roozendaal, B. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00058-x · Cited by 665
Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala
Mitra, R., Jadhav, S., McEwen, B. S., Vyas, A., & Chattarji, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504011102 · Cited by 663
Self-citation
Repeated restraint stress suppresses neurogenesis and induces biphasic PSA‐NCAM expression in the adult rat dentate gyrus
Pham, K., Nacher, J., Hof, P. R., & McEwen, B. S. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02513.x · Cited by 657
Self-citation
Impaired fear conditioning following unilateral temporal lobectomy in humans
LaBar, K., LeDoux, J., Spencer, D., & Phelps, E. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06846.1995 · Cited by 631
Corticosteroids in relation to fear, anxiety and psychopathology
Korte, S. M. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00002-1 · Cited by 607
Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala
Dębiec, J., & Ledoux, J. E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.018 · Cited by 602
Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration
Wellman, C. L. (2001) · Journal of Neurobiology · doi:10.1002/neu.1079 · Cited by 594
Memory consolidation and the amygdala: a systems perspective
McGaugh, J. L. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02211-7 · Cited by 572
Amygdala is critical for stress-induced modulation of hippocampal long-term potentiation and learning
Kim, J. J., Lee, H. J., Han, J.-S., & Packard, M. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05222.2001 · Cited by 537
Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo
Maren, S., & Fanselow (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07548.1995 · Cited by 499
Sex Differences and Opposite Effects of Stress on Dendritic Spine Density in the Male Versus Female Hippocampus
Shors, T. J., Chua, C., & Falduto, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06292.2001 · Cited by 496
Predicting the development of posttraumatic stress disorder from the acute response to a traumatic event
Yehuda, R., McFarlane, A. C., & Shalev, A. Y. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00276-5 · Cited by 478
Regulation of adult neurogenesis by antidepressant treatment
Duman, R. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00358-x · Cited by 463
Recovery after chronic stress fails to reverse amygdaloid neuronal hypertrophy and enhanced anxiety-like behavior
Vyas, A., Pillai, A. G., & Chattarji, S. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.013 · Cited by 445
Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli.
Muller, J., Corodimas, K. P., Fridel, Z., & LeDoux, J. E. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.4.683 · Cited by 401
Glucocorticoid enhancement of memory storage involves noradrenergic activation in the basolateral amygdala
Quirarte, G. L., Roozendaal, B., & McGaugh, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14048 · Cited by 386
Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli.
Muller, J., Corodimas, K. P., Fridel, Z., & LeDoux, J. E. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.4.683 · Cited by 382
The epidemiology of posttraumatic stress disorder: what is the extent of the problem?
Breslau, N. (2001) · PubMed · Cited by 370
Stress facilitates classical conditioning in males, but impairs classical conditioning in females through activational effects of ovarian hormones
Wood, G. E., & Shors, T. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.4066 · Cited by 359
Phenytoin prevents stress‐ and corticosterone‐induced atrophy of CA3 pyramidal neurons
Watanabe, Y., Gould, E., Cameron, H. A., Daniels, D. C., & McEwen, B. S. (1992) · Hippocampus · doi:10.1002/hipo.450020410 · Cited by 350
Self-citation
Low-Dose Cortisol for Symptoms of Posttraumatic Stress Disorder
Aerni, A., Traber, R., Höck, C., Roozendaal, B., Schelling, G., Papassotiropoulos, A., Nitsch, R. M., Schnyder, U., & de Quervain, D. J. ‐. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.8.1488 · Cited by 342
The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors
Schelling, G., Briegel, J., Roozendaal, B., Stoll, C., Rothenhäusler, H., & Kapfhammer, H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01270-7 · Cited by 341
Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress
Magariños, A. M., Deslandes, A., & McEwen, B. S. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00163-6 · Cited by 330
Self-citation
Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress
RADLEY, J., ROCHER, A., JANSSEN, W., HOF, P., MCEWEN, B., & MORRISON, J. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.07.008 · Cited by 323
Self-citation
Prefrontal Cortex Long-Term Potentiation, But Not Long-Term Depression, Is Associated with the Maintenance of Extinction of Learned Fear in Mice
Herry, C., & Garcia, R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00577.2002 · Cited by 323
Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: Absence of a temporal gradient.
Maren, S., Aharonov, G., & Fanselow, M. S. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.4.718 · Cited by 320
Inhibition of the Amygdala: Key to Pathological States?
Quirk, G. J., & Gehlert, D. R. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07087.x · Cited by 314
Neural activity associated with episodic memory for emotional context
Maratos, E. J., Dolan, R. J., Morris, J. S., Henson, R. N. A., & Rugg, M. D. (2001) · Neuropsychologia · doi:10.1016/s0028-3932(01)00025-2 · Cited by 306
Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects
Protopopescu, X., Pan, H., Tüscher, O., Cloître, M., Goldstein, M., Engelien, W., Epstein, J., Yang, Y., Gorman, J. M., LeDoux, J. E., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.026 · Cited by 296
Effects of chronic stress on dendritic arborization in the central and extended amygdala
Vyas, A., Bernal, S., & Chattarji, S. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04162-8 · Cited by 291
Damage to the Lateral and Central, but Not Other, Amygdaloid Nuclei Prevents the Acquisition of Auditory Fear ConditioningPreprint
Nader, K., Majidishad, P., Amorapanth, P., & LeDoux, J. E. (2001) · Learning & Memory · doi:10.1101/lm.38101 · Cited by 287
Amygdala Modulation of Multiple Memory Systems: Hippocampus and Caudate-Putamen
Packard, M. G., & Teather, L. A. (1998) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1997.3815 · Cited by 287
Independence of memory functions and emotional behavior: Separate contributions of the hippocampal formation and the amygdala
Zola‐Morgan, S., Squire, L. R., Clower, R. P., & Alvarez‐Royo, P. (1991) · Hippocampus · doi:10.1002/hipo.450010208 · Cited by 265
Conceptually Driven Pharmacologic Approaches to Acute Trauma
Pitman, R. K., & Delahanty, D. L. (2005) · CNS Spectrums · doi:10.1017/s109285290001943x · Cited by 252
Sex Differences in Chronic Stress Effects on Memory in Rats
Luine, V. (2002) · Stress · doi:10.1080/1025389021000010549 · Cited by 250
Restraint stress reversibly enhances spatial memory performance
Luine, V. N., Martinez, C., Villegas, M., Magariños, A. M., & McEwen, B. S. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02016-0 · Cited by 249
Self-citation
Auditory Thalamus, Dorsal Hippocampus, Basolateral Amygdala, and Perirhinal Cortex Role in the Consolidation of Conditioned Freezing to Context and to Acoustic Conditioned Stimulus in the Rat
Sacchetti, B., Lorenzini, C. A., Baldi, E., Tassoni, G., & Bucherelli, C. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09570.1999 · Cited by 246
The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine
Burghardt, N. S., Sullivan, G. M., McEwen, B. S., Gorman, J. M., & LeDoux, J. E. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.029 · Cited by 246
Self-citation
Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala
Johnson, L. R., Farb, C., Morrison, J. H., McEwen, B. S., & Ledoux, J. E. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.050 · Cited by 205
Self-citation
The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder and health-related quality of life in survivors
Schelling, G., Stoll, C., Kapfhammer, H., Rothenhäusler, H., Krauseneck, T., Durst, K., Haller, M., & Briegel, J. (1999) · Critical Care Medicine · doi:10.1097/00003246-199912000-00012 · Cited by 203
Amygdalar Inactivation Blocks Stress-Induced Impairments in Hippocampal Long-Term Potentiation and Spatial Memory
Kim, J. J., Koo, J. W., Lee, H. J., & Han, J.-S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4623-04.2005 · Cited by 184
Acute Stress Rapidly and Persistently Enhances Memory Formation in the Male Rat
Shors, T. J. (2001) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1999.3956 · Cited by 183
The Amygdala, the Hippocampus, and Emotional Modulation of Memory
Richter‐Levin, G. (2004) · The Neuroscientist · doi:10.1177/1073858403259955 · Cited by 182
Effects of aspiration versus neurotoxic lesions of the amygdala on emotional responses in monkeys
Meunier, M., Bachevalier, J., Murray, E. A., Málková, L., & Mishkin, M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00854.x · Cited by 179
Memory for Emotional Words Following Unilateral Temporal Lobectomy
Phelps, E. A., LaBar, K. S., & Spencer, D. D. (1997) · Brain and Cognition · doi:10.1006/brcg.1997.0929 · Cited by 178
Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine
McEwen, B. S., & Chattarji, S. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.09.008 · Cited by 174
Self-citation
Overcoming the effects of stress on synaptic plasticity in the intact hippocampus: rapid actions of serotonergic and antidepressant agents
Shakesby, A. C., Anwyl, R., & Rowan, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03638.2002 · Cited by 173
Morphological changes in the hippocampal CA3 region induced by non-invasive glucocorticoid administration: a paradox
Magariños, A. M., Orchinik, M., & McEwen, B. S. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00882-8 · Cited by 163
Self-citation
Neural plasticity, neuropeptides and anxiety in animals — implications for understanding and treating affective disorder following traumatic stress in humans
Adamec, R., Kent, P., Anisman, H., Shallow, T., & Merali, Z. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00032-3 · Cited by 154
Effect of chronic restraint stress on dendritic spines and excrescences of hippocampal CA3 pyramidal neurons—a quantitative study
Sunanda, Rao, M. S. R., & Raju, T. R. (1995) · Brain Research · doi:10.1016/0006-8993(95)00822-8 · Cited by 143
Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine
McEwen, B. S., & Olié, J. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001648 · Cited by 136
Self-citation
A systemically administered β-adrenoceptor antagonist blocks corticosterone-induced impairment of contextual memory retrieval in rats
Roozendaal, B., de Quervain, D. J. ‐., Schelling, G., & McGaugh, J. L. (2003) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2003.10.001 · Cited by 129
Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy
Bonne, O. B., Grillon, C., Vythilingam, M., Neumeister, A., & Charney, D. S. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.12.001 · Cited by 128
Evidence that a single exposure to aversive stimuli triggers long-lasting effects in the hypothalamus-pituitary-adrenal axis that consolidate with time
Martı́, O., García, A., Vellès, A., Harbuz, M. S., & Armario, A. (2001) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2001.01355.x · Cited by 114
Effects of the beta-blocker propranolol on cued and contextual fear conditioning in humans
Grillon, C., Cordova, J., Morgan, C. A., Charney, D. S., & Davis, M. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1819-5 · Cited by 104
Stress and the Individual: Mechanisms Leading to Disease
McEwen, B. S. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410180039004 · Cited by 103
Self-citation
Amygdala β-noradrenergic influence on hippocampal longterm potentiation in vivo
Ikegaya, Y., Nakanishi, K., Saito, H., & Abe, K. (1997) · NeuroReport · doi:10.1097/00001756-199709290-00027 · Cited by 98
Bidirectional shift in the cornu ammonis 3 pyramidal dendritic organization following brief stress
Kole, M. H. P., Costoli, T., Koolhaas, J. M., & Fuchs, E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.02.014 · Cited by 96
Acknowledging the Psychiatric Cost of War
Friedman, M. J. (2004) · New England Journal of Medicine · doi:10.1056/nejme048129 · Cited by 94
Deficit in long‐term contextual fear memory induced by blockade of β‐adrenoceptors in hippocampal CA1 region
Ji, J., Wang, X., & Li, B. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02620.x · Cited by 92
Psychobiology of the acute stress response and its relationship to the psychobiology of post-traumatic stress disorder
Marshall, R. D., & Garakani, A. (2002) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(01)00005-3 · Cited by 87
Requirement of basolateral amygdala neuron activity for the induction of long-term potentiation in the dentate gyrus in vivo
Ikegaya, Y., Saitō, H., & Abe, K. (1995) · Brain Research · doi:10.1016/0006-8993(94)01403-5 · Cited by 84
Effects of bilateral adrenalectomy on the induction of learned helplessness behavior.
Edwards, E., Harkins, K., Wright, G. P., & Henn, F. A. (1990) · PubMed · Cited by 68
Medial prefrontal cortical integration of psychological stress in rats
McDougall, S. J., Widdop, R. E., & Lawrence, A. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03707.x · Cited by 65
Genetic predisposition and the development of posttraumatic stress disorder in an animal model
King, J. A., Abend, S., & Edwards, E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01071-x · Cited by 65
Post-training injections of catecholaminergic drugs do not modulate fear conditioning in rats and mice
Lee, H. J., Berger, S. Y., Stiedl, O., Spiess, J., & Kim, J. J. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01733-5 · Cited by 57
A comparative study of fluoxetine, moclobemide, and tianeptine in the treatment of posttraumatic stress disorder following an earthquake
Önder, E., Tural, Ü., & Aker, T. (2005) · European Psychiatry · doi:10.1016/j.eurpsy.2005.03.007 · Cited by 47
Predator Exposure Produces Retrograde Amnesia and Blocks Synaptic Plasticity: Progress toward Understanding How the Hippocampus Is Affected by Stress
DIAMOND, D. M., & PARK, C. R. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06743.x · Cited by 37
The temporal dynamics of retention of a context memory: Something is missingPreprint
Rudy, J. W., & Wright-Hardesty, K. J. (2005) · Learning & Memory · doi:10.1101/lm.84005 · Cited by 35
Biphasic Effects of Adrenal Steroids on Learned Helplessness Behavior Induced by Inescapable Shock
Kademian, S., Bignante, A. E., Lardone, P. J., McEwen, B. S., & Volosin, M. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300577 · Cited by 34
Self-citation
Socioemotional Behavior in Adult Rhesus Monkeys after Early versus Late Lesions of the Medial Temporal Lobe
Málková, L., Mishkin, M., Suomi, S. J., & Bachevalier, J. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51961.x · Cited by 31
The basolateral complex of the amygdala mediates the modulation of intracranial self‐stimulation threshold by drug‐associated cues
Hayes, R. J., & Gardner, E. L. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03463.x · Cited by 23
Behavioral, neuroendocrine, and immunological outcomes of escapable or inescapable shocks
Sandi, C., Borrell, J. I., & Guaza, C. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90192-5 · Cited by 22
The Applicability of Inescapable Shock as a Source of Animal Depression
Wagner, H. R., Hall, T. L., & Cote, I. (1977) · The Journal of General Psychology · doi:10.1080/00221309.1977.9920828 · Cited by 22
Evaluation of cognitive function of fluoxetine, sertraline and tianeptine in isolation and chronic unpredictable mild stress-induced depressive Wistar rats.
Ramanathan, M., Kumar, S., & Suresh, B. (2003) · PubMed · Cited by 22
A nonextinction procedure for long-term studies of classically conditioned enhancement of acoustic startle in the rat
WINSTON, C., Leavell, B. J., Ardayfio, P. A., BEARD, C., & Commissaris, R. L. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00443-7 · Cited by 13

Research works printed but not linked: 2

10.1037/0735-7044.110.4.718 · DOI
10.1111/j.1460-9568.2001.01355.x · DOI

Sorted by citations

IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862
Response Variation following Trauma: A Translational Neuroscience Approach to Understanding PTSD
Yehuda, R., & LeDoux, J. E. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.006 · Cited by 841
Water associated zero maze: a novel rat test for long term traumatic re-experiencing
Ritov, G., & Richter‐Levin, G. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00001 · Cited by 580
Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response
Hunter, R. G., Murakami, G., Dewell, S. B., Seligsohn, M., Baker, M. E. R., Datson, N. A., McEwen, B. S., & Pfaff, D. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215810109 · Cited by 178
Self-citation
A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear
Meyer, R. M., Burgos-Robles, A., Liu, E., Correia, S. S., & Goosens, K. A. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.135 · Cited by 169

See all 101

Authors: MILLER, M. M., & McEWEN, B. S.
Affiliations: Rockefeller University (US)
Corresponding author: McEWEN, BRUCE S.
ORCID: MILLER, MELINDA M.
McEWEN, BRUCE S.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2006-07
Volume: 1071
Issue: 1
Pages: 294-312
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1196/annals.1364.023
OpenAlex: W2108172799
Cited by: 101
References: 107
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 5 · 2013: 11 · 2012: 5
FWCI: 1.53
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 25 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH-41256, MH-58911, P50MH058911)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: post-traumatic stress disorder, animal model of PTSD, restraint stress, repeated stress, hippocampus, dentate gyrus neurogenesis, basolateral amygdala, prefrontal cortex, dendritic changes, contextual fear conditioning, spatial memory, antidepressants, mood stabilizers, glucocorticoids, catecholamines, anxiety disorders, translational research
MeSH terms: Amygdala, Hippocampus, Hormones, Humans, Neurosciences, Research, Stress Disorders, Post-Traumatic, Stress, Psychological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Establishing an Agenda for Translational Research on PTSD

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks