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Late-Night Salivary Cortisol as a Screening Test for Cushing's Syndrome
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“Various methods have been used to measure cortisol in the saliva, resulting in different reference ranges and yielding differences in sensitivity and specificity (59 -67).”
From The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. (2008) · cites this paper as [64]
In the citing paper
“Using a variety of assays and diagnostic criteria, investigators from different countries have reported that late-night salivary cortisol levels yield a 92-100% sensitivity and a 93-100% specificity for the diagnosis of Cushing's syndrome (59 -67).”
From The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. (2008) · cites this paper as [64]
In the citing paper
“Finally, stress immediately before the collection also may increase salivary cortisol physiologically; therefore, ideally, samples should be collected on a quiet evening at home (64).”
From The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. (2008) · cites this paper as [64]
In the citing paper
“LNSC is well-established as a first-line screening test for patients with CS (7–10).”
From The diagnostic value of salivary cortisol and salivary cortisone in patients with suspected hypercortisolism (2022) · cites this paper as [7]
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“Finally, stress immediately before the collection also may increase salivary cortisol physiologically; therefore, ideally, samples should be collected on a quiet evening at home (64).”
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Late-night Salivary Cortisol as A Screening Test for the Diagnosis of Cushing's Syndrome in Japan
Doi, M., Sekizawa, N., Tani, Y., Tsuchiya, K., Kouyama, R., Tateno, T., Izumiyama, H., Yoshimoto, T., & Hirata, Y. (2008) · Endocrine Journal · doi:10.1507/endocrj.k07e-023 · Cited by 40
Variability of late-night salivary cortisol in Cushing disease: a prospective study
Sandouk, Z., Johnston, P., Bunch, D., Wang, S., Bena, J., Hamrahian, A., & Kennedy, L. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02020 · Cited by 39
Diagnostic value of salivary cortisol in Cushing's syndrome (CS)
Cardoso, E. M. L., Arregger, A. L., Tumilasci, O. R., & Contreras, L. N. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03381.x · Cited by 37
Yaneva, M., Кirilov, G., & Zacharieva, S. (2009) · Open Medicine · doi:10.2478/s11536-009-0004-y · Cited by 38
Valassi, E., Crespo, I., Keevil, B. G., Aulinas, A., Urgell, E., Vives, A. S., Trainer, P. J., & Webb, S. M. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0779 · Cited by 39
Metadata
- Authors
- Raff, H.
- Corresponding author
- Raff, H.
- ORCID
- Raff, H.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1998-08-01
- Volume
- 83
- Issue
- 8
- Pages
- 2681-2686
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W4248166725
- Cited by
- 194
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 14
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Keywords
- Cushing's syndrome, salivary cortisol, screening test, hypercortisolism
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