The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Towards an integrated view of Wnt signaling in development
Abstract
Wnt signaling is crucial for embryonic development in all animal species studied to date. The interaction between Wnt proteins and cell surface receptors can result in a variety of intracellular responses. A key remaining question is how these specific responses take shape in the context of a complex, multicellular organism. Recent studies suggest that we have to revise some of our most basic ideas about Wnt signal transduction. Rather than thinking about Wnt signaling in terms of distinct, linear, cellular signaling pathways, we propose a novel view that considers the integration of multiple,often simultaneous, inputs at the level of both Wnt-receptor binding and the downstream, intracellular response.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
Self-citationA role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159
Self-citationWNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763
Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528 · cited 1×
“Over the years, we have come to view the different responses downstream of Wnt-receptor binding as distinct, linear pathways (for reviews, see James et al., 2008; Komiya and Habas, 2008) (Box 1).”
BackgroundKremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B. M., Delius, H., Hoppe, D., Stannek, P., Walter, C., et al. (2002) · Nature · doi:10.1038/nature756 · Cited by 1,038
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
Heisenberg, C.-P., Tada, M., Rauch, G.-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C., & Wilson, S. W. (2000) · Nature · doi:10.1038/35011068 · Cited by 1,013
Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Krönig, C., Schermer, B., Benzing, T., Cabello, O. A., Jenny, A., et al. (2005) · Nature Genetics · doi:10.1038/ng1552 · Cited by 767
Unexpected complexity of the Wnt gene family in a sea anemone
Kusserow, A., Pang, K., Sturm, C., Hrouda, M., Lentfer, J., Schmidt, H. A., Technau, U., von Haeseler, A., Hobmayer, B., Martindale, M. Q., et al. (2005) · Nature · doi:10.1038/nature03158 · Cited by 599
Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D., Asashima, M., Wylie, C. C., Lin, X., & Heasman, J. (2005) · Cell · doi:10.1016/j.cell.2005.01.013 · Cited by 510
Zeng, X., Huang, H., Tamai, K., Zhang, X., Harada, Y., Yokota, C., Almeida, K., Wang, J., Doble, B., Woodgett, J., et al. (2008) · Development · doi:10.1242/dev.013540 · Cited by 492
Cited by
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Nishita, M., Park, S.-Y., Nishio, T., Kamizaki, K., Wang, Z., Tamada, K., Takumi, T., Hashimoto, R., Otani, H., Pazour, G. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-016-0028-x · Cited by 15,947
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
Nusse, R., & Clevers, H. (2017) · Cell · doi:10.1016/j.cell.2017.05.016 · Cited by 4,342
Self-citationWNT signaling in bone homeostasis and disease: From human mutations to treatments
Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093
The Juvenile Hormone Signaling Pathway in Insect Development
Jindra, M., Palli, S. R., & Riddiford, L. M. (2013) · Annual Review of Entomology · doi:10.1146/annurev-ento-120811-153700 · Cited by 874
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
Akhmetshina, A., Palumbo, K., Dees, C., Bergmann, C., Venalis, P., Zerr, P., Horn, A., Kireva, T., Beyer, C., Zwerina, J., et al. (2012) · Nature Communications · doi:10.1038/ncomms1734 · Cited by 843
Understanding multicellular function and disease with human tissue-specific networks
Greene, C. S., Krishnan, A., Wong, A. K., Ricciotti, E., Zelaya, R. A., Himmelstein, D. S., Zhang, R., Hartmann, B. M., Zaslavsky, E., Sealfon, S. C., et al. (2015) · Nature Genetics · doi:10.1038/ng.3259 · Cited by 832
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells
Farin, H. F., Van Es, J. H., & Clevers, H. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.08.031 · Cited by 655
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Diez-Roux, G., Banfi, S., Sultan, M., Geffers, L., Anand, S., Rozado, D., Magen, A., Canidio, E., Pagani, M., Peluso, I., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000582 · Cited by 638
Gurney, A., Axelrod, F., Bond, C. J., Cain, J., Chartier, C., Donigan, L., Fischer, M., Chaudhari, A., Ji, M., Kapoun, A. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120068109 · Cited by 614
Physiological and molecular determinants of embryo implantation
Zhang, S., Lin, H., Kong, S., Wang, S., Wang, H., Wang, H., & Armant, D. R. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.011 · Cited by 587
Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation
Ma, B., & Hottiger, M. O. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00378 · Cited by 563
Esen, E., Chen, J., Karner, C. M., Okunade, A. L., Patterson, B. W., & Long, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.017 · Cited by 367
The Role of Wnt Signaling in Physiological and Pathological Angiogenesis
Dejana, E. (2010) · Circulation Research · doi:10.1161/circresaha.110.223750 · Cited by 347
Jang, G.-B., Kim, J.-Y., Cho, S.-D., Park, K.-S., Jung, J.-Y., Lee, H.-Y., Hong, I.-S., & Nam, J.-S. (2015) · Scientific Reports · doi:10.1038/srep12465 · Cited by 328
Mitotic and mitogenic Wnt signalling
Niehrs, C., & Acebron, S. P. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.124 · Cited by 305
WNT signaling in neuronal maturation and synaptogenesis
Rosso, S. B., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00103 · Cited by 272
Chen, D., Jarrell, A., Guo, C., Lang, R., & Atit, R. (2012) · Development · doi:10.1242/dev.076463 · Cited by 260
Maintaining embryonic stem cell pluripotency with Wnt signaling
Sokol, S. Y. (2011) · Development · doi:10.1242/dev.066209 · Cited by 257
The WNT system: background and its role in bone
Lerner, U. H., & Ohlsson, C. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12368 · Cited by 228
Jeong, W.-J., Ro, E. J., & Choi, K.-Y. (2018) · npj Precision Oncology · doi:10.1038/s41698-018-0049-y · Cited by 220
Wei, J., Melichian, D., Komura, K., Hinchcliff, M., Lam, A. P., Lafyatis, R., Gottardi, C. J., MacDougald, O. A., & Varga, J. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30312 · Cited by 214
Gurley, K. A., Elliott, S. A., Simakov, O., Schmidt, H. A., Holstein, T. W., & Alvarado, A. S. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.08.007 · Cited by 212
β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis
Beyer, C., Schramm, A., Akhmetshina, A., Dees, C., Kireva, T., Gelse, K., Sonnylal, S., de Crombrugghe, B., Taketo, M. M., Distler, O., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200568 · Cited by 203
Connecting Vascular and Nervous System Development: Angiogenesis and the Blood-Brain Barrier
Tam, S. J., & Watts, R. J. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-152829 · Cited by 197
The endocrinology of the menstrual cycle
Barbieri, R. L. (2014) · Methods in Molecular Biology · doi:10.1007/978-1-4939-0659-8_7 · Cited by 196
Wnts in adult brain: from synaptic plasticity to cognitive deficiencies
Oliva, C. A., Vargas, J. Y., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00224 · Cited by 162
Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling
Sheng, R., Kim, H., Lee, H., Xin, Y., Chen, Y., Tian, W., Cui, Y., Choi, J.-C., Doh, J., Han, J.-K., et al. (2014) · Nature Communications · doi:10.1038/ncomms5393 · Cited by 157
The Wnt/beta-catenin pathway in adrenocortical development and cancer
El Wakil, A., & Lalli, E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.014 · Cited by 134
Tanaka, S., Terada, K., & Nohno, T. (2011) · Journal of Molecular Signaling · doi:10.1186/1750-2187-6-12 · Cited by 124
“Wnt signaling plays key roles in stem cell maintenance and adult tissue homeostasis [1,2].”
BackgroundVersican in inflammation and tissue remodeling: The impact on lung disorders
Andersson-Sjoland, A., Hallgren, O., Rolandsson, S., Weitoft, M., Tykesson, E., Larsson-Callerfelt, A.-K., Rydell-Tormanen, K., Bjermer, L., Malmstrom, A., Karlsson, J. C., et al. (2015) · Glycobiology · doi:10.1093/glycob/cwu120 · Cited by 98
McGough, I. J., de Groot, R. E. A., Jellett, A. P., Betist, M. C., Varandas, K. C., Danson, C. M., Heesom, K. J., Korswagen, H. C., & Cullen, P. J. (2018) · Nature Communications · doi:10.1038/s41467-018-06114-3 · Cited by 87
Wnt Signaling Regulates Multipolar-to-Bipolar Transition of Migrating Neurons in the Cerebral Cortex
Boitard, M., Bocchi, R., Egervari, K., Petrenko, V., Viale, B., Gremaud, S., Zgraggen, E., Salmon, P., & Kiss, J. Z. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.061 · Cited by 83
Cai, X., Zhang, W., Hu, J., Zhang, L., Sultana, N., Wu, B., Cai, W., Zhou, B., & Cai, C.-L. (2013) · Development · doi:10.1242/dev.092502 · Cited by 75
Context-Dependent Regulation of Wnt Signaling through the Primary Cilium
Oh, E. C., & Katsanis, N. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012050526 · Cited by 73
Structural basis of coactivation of liver receptor homolog-1 by β-catenin
Yumoto, F., Nguyen, P., Sablin, E. P., Baxter, J. D., Webb, P., & Fletterick, R. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117036108 · Cited by 63
(2018) · doi:10.1158/2326-6066.cir-17-0712 · Cited by 40
Posterior Wnts have distinct roles in specification and patterning of the planarian posterior region
Sureda-Gómez, M., Pascual-Carreras, E., & Adell, T. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125970 · Cited by 32
Silverman, S. L. (2010) · Journal of Osteoporosis · doi:10.4061/2010/941419 · Cited by 30
ULK1 negatively regulates Wnt signaling by phosphorylating Dishevelled
Hwang, S.-H., Bang, S., Kang, K. S., Kang, D., & Chung, J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.11.139 · Cited by 13
(2015) · International Journal of Kinesiology and Sports Science · doi:10.7575/aiac.ijkss.v.3n.4p.40 · Cited by 5
Sardar, S., Kanne, K., & Andersson, Å. (2018) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-018-0516-8 · Cited by 3
Metadata
- Authors
- van Amerongen, R., & Nusse, R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2009-10-01
- Volume
- 136
- Issue
- 19
- Pages
- 3205-3214
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2113263838
- Cited by
- 1,175
- References
- 14
- FWCI
- 37.93
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
