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A common precursor for hematopoietic and endothelial cells
Abstract
Embryonic stem cell-derived embryoid bodies contain a unique precursor population which, in response to vascular endothelial growth factor, gives rise to blast colonies in semi-solid medium. Upon transfer to liquid culture with appropriate cytokines, these blast colonies generate both hematopoietic and adherent, stromal-type cells. Cells within the adherent population display characteristics of endothelial lineage including the expression of CD31, flk-1, flt-1, tie-2, the capacity to take up acetylated LDL and the presence of cytoplasmic Weibel-Palade bodies. Mixing studies demonstrated that the hematopoietic and endothelial precursors within the blast colonies develop from the same cell, the blast colony-forming cell. Kinetic analysis showed that the blast colony-forming cell represents a transient cell population that develops early and is lost quickly during embryoid body development. These findings provide strong evidence that the blast colony-forming cell represents the long-hypothesized hemangioblast, the common precursor of the hematopoietic and endothelial lineages.
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Metadata
- Authors
- Choi, K., Kennedy, M., Kazarov, A., Papadimitriou, J. C., & Keller, G.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-02-15
- Volume
- 125
- Issue
- 4
- Pages
- 725-732
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2127432537
- Cited by
- 1,427
- References
- 4
- FWCI
- 18.46
- Type
- journal article
- Language
- en
- Open access
- closed
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