The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells
Open accessAbstract
Skin epithelial stem cells operate within a complex signaling milieu that orchestrates their lifetime regenerative properties. The question of whether and how immune cells impact on these stem cells within their niche is not well understood. Here we show that skin-resident macrophages decrease in number because of apoptosis before the onset of epithelial hair follicle stem cell activation during the murine hair cycle. This process is linked to distinct gene expression, including Wnt transcription. Interestingly, by mimicking this event through the selective induction of macrophage apoptosis in early telogen, we identify a novel involvement of macrophages in stem cell activation in vivo. Importantly, the macrophage-specific pharmacological inhibition of Wnt production delays hair follicle growth. Thus, perifollicular macrophages contribute to the activation of skin epithelial stem cells as a novel, additional cue that regulates their regenerative activity. This finding may have translational implications for skin repair, inflammatory skin diseases and cancer.
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Cites
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Self-citation
Cited by
Tissue Stem Cells: Architects of Their Niches
Fuchs, E., & Blau, H. M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.09.011 · Cited by 332
Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin
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Advancing insights into stem cell niche complexities with next-generation technologies
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Metadata
- Authors
- Castellana, D., Paus, R., & Perez-Moreno, M.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-12-23
- Volume
- 12
- Issue
- 12
- Pages
- e1002002
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2062622837
- Cited by
- 189
- References
- 23
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- gold
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