Cited by 270Telomeres, Telomerase, and SenescenceChild Abuse and TraumaStress Responses and Cortisol

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Childhood Adversities Are Associated with Shorter Telomere Length at Adult Age both in Individuals with an Anxiety Disorder and Controls

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Kananen, Laura, Surakka, Ida, Pirkola, Sami, Suvisaari, Jaana, Lönnqvist, Jouko, Peltonen, Leena, Ripatti, Samuli, Hovatta, Iiris·2010·PLoS ONE

DOI 10.1371/journal.pone.0010826PMC PMC2876034

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Abstract

Accelerated leukocyte telomere shortening has been previously associated to self-perceived stress and psychiatric disorders, including schizophrenia and mood disorders. We set out to investigate whether telomere length is affected in patients with anxiety disorders in which stress is a known risk factor. We also studied the effects of childhood and recent psychological distress on telomere length. We utilized samples from the nationally representative population-based Health 2000 Survey that was carried out between 2000-2001 in Finland to assess major public health problems and their determinants. We measured the relative telomere length of the peripheral blood cells by quantitative real-time PCR from 321 individuals with DSM-IV anxiety disorder or subthreshold diagnosis and 653 matched controls aged 30-87 years, who all had undergone the Composite International Diagnostic Interview. While telomere length did not differ significantly between cases and controls in the entire cohort, the older half of the anxiety disorder patients (48-87 years) exhibited significantly shorter telomeres than healthy controls of the same age (P = 0.013). Interestingly, shorter telomere length was also associated with a greater number of reported childhood adverse life events, among both the anxiety disorder cases and controls (P = 0.005). Childhood chronic or serious illness was the most significantly associated single event affecting telomere length at the adult age (P = 0.004). Self-reported current psychological distress did not affect telomere length. Our results suggest that childhood stress might lead to accelerated telomere shortening seen at the adult age. This finding has potentially important implications supporting the view that childhood adversities might have a considerable impact on well being later in life.

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Figure 1 Telomere length as a function of age. Anxiety disorder core and subthreshold cases (N = 321) are shown with red dots and controls (N = 653) with blue dots, each dot representing one individual. Regression lines for both groups are shown with the same color coding.CC BY · PubMed Central

Figure 2 The number of childhood adverse life events affects relative telomere length at adult age. Relative telomere length is adjusted for age and sex. Each bar presents group mean (± standard error of the mean).CC BY · PubMed Central

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Diagnostic and Statistical Manual of Mental Disorders ( DSM ‐ IV ‐ TR )
Segal, D. L. (2010) · Wiley eBooks · doi:10.1002/9780470479216.corpsy0271 · Cited by 4,687
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,538
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002
Oxidative stress shortens telomeres
von Zglinicki, T. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02110-2 · Cited by 2,524
Childhood Adversities and Adult Psychiatric Disorders in the National Comorbidity Survey Replication I: Associations With First Onset of DSM-IV Disorders
Green, J. G., McLaughlin, K. A., Berglund, P. A., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.186 · Cited by 2,323
Telomeres and human disease: ageing, cancer and beyond
Blasco, M. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1656 · Cited by 1,434
Obesity, cigarette smoking, and telomere length in women
Valdes, A., Andrew, T., Gardner, J., Kimura, M., Oelsner, E., Cherkas, L., Aviv, A., & Spector, T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66630-5 · Cited by 1,363
Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
Fitzpatrick, A. L., Kronmal, R. A., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Walston, J., Kimura, M., & Aviv, A. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj346 · Cited by 773
Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study
Brouilette, S., Moore, J. S., McMahon, A. D., Thompson, J. R., Ford, I., Shepherd, J., Packard, C. J., & Samani, N. J. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60071-3 · Cited by 747
Genetic determination of telomere size in humans: a twin study of three age groups.
Slagboom, P. E., Droog, S., & Boomsma, D. I. (1994) · PubMed Central · Cited by 734

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Authors: Kananen, L., Surakka, I., Pirkola, S., Suvisaari, J., Lönnqvist, J., Peltonen, L., Ripatti, S., & Hovatta, I.
Affiliations: University of Helsinki (FI)
Helsinki University Hospital (FI)
Finnish Institute for Health and Welfare (FI)
Broad Institute (US)
Corresponding author: Hovatta, Iiris
ORCID: Kananen, Laura
Surakka, Ida
Pirkola, Sami
Suvisaari, Jaana
Lönnqvist, Jouko
Peltonen, Leena
Ripatti, Samuli
Hovatta, Iiris
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2010-05-25
Volume: 5
Issue: 5
Pages: e10826
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0010826
PMC: PMC2876034
OpenAlex: W1986488389
Cited by: 270
References: 71
Citations by year: 2026: 2 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 13 · 2020: 7 · 2019: 16 · 2018: 15 · 2017: 28 · 2016: 25 · 2015: 32 · 2014: 25 · 2013: 27 · 2012: 33
FWCI: 18.42
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
Työväentutkimus Vuosikirja (submittedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders: Academy of Finland
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: telomere length, childhood adversity, anxiety disorders, children with chronic illness, psychological distress, stress, aging, Health 2000 Survey
MeSH terms: Adult, Aging, Anxiety Disorders, Child, Child Abuse, Humans, Life Change Events, Socioeconomic Factors, Stress, Psychological, Case-Control Studies, Telomere

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Childhood Adversities Are Associated with Shorter Telomere Length at Adult Age both in Individuals with an Anxiety Disorder and Controls

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