T-Cells in Alzheimer's Disease

Town, Terrence; Tan, Jun; Flavell, Richard A.; Mullan, Mike

doi:10.1385/nmm:7:3:255

Cited by 183Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 65 of the 66 references it cites were found in a registry or an index.

T-Cells in Alzheimer's Disease

Town, Terrence, Tan, Jun, Flavell, Richard A., Mullan, Mike·2005·NeuroMolecular Medicine

DOI 10.1385/nmm:7:3:255

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Abstract

Alzheimer's disease (AD) is the most common dementing illness and is pathologically characterized by deposition of the 40-42 amino acid peptide, amyloid-beta (Abeta), as senile plaques. It is well documented that brain inflammatory mechanisms mediated by reactive glia are activated in response to Abeta plaques. A number of reports further suggest that T-cells are activated in AD patients, and that these cells exist both in the periphery and as infiltrates in the brain. We explore the potential role of T-cells in the AD process, a controversial area, by reviewing reports that show disturbed activation profiles and/or altered numbers of various subsets of T-cells in the circulation as well as in the AD brain parenchyma and in cerebral amyloid angiopathy. We also discuss the recent Abeta immunotherapy approach vis-à-vis the activated, autoaggressive T-cell infiltrates that contributed to aseptic meningoencephalitis in a small percentage of patients, and present possible alternative approaches that may be both efficacious and safe. Finally, we explore the use of mouse models of AD as a system within which to definitively test the possible contribution of T-cells to AD pathogenesis.

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Systemic immune response, including T-cell immune response, may be involved in the inflammation process of AD.
“increased studies suggest that systemic immune response, including T-cell immune response, may be involved in the inflammation process of AD [152, 153].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [153]
Neuroinflammation is a key factor in the development and progression of Alzheimer's disease.
“Neuroinflammation is a key factor in the development and progression of AD [144, 145].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [144]

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,506
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431
Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report
Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., & Weller, R. O. (2003) · Nature Medicine · doi:10.1038/nm840 · Cited by 1,397
Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
Moalem‐Taylor, G., Leibowitz‐Amit, R., Yoles, E., Mor, F., Cohen, I. R., & Schwartz, M. (1999) · Nature Medicine · doi:10.1038/4734 · Cited by 882
T-cell subsets (Th1 versus Th2)
Romagnani, S. (2000) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)62426-x · Cited by 846
T CELL MEMORY
Dutton, R. W., Bradley, L. M., & Swain, S. L. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.201 · Cited by 832
Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease
Rogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743
TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice
Wyss-Coray, T., Lin, C., Yan, F., Yu, G.-Q., Rohde, M., McConlogue, L., Masliah, E., & Mucke, L. (2001) · Nature Medicine · doi:10.1038/87945 · Cited by 587
Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV
Ellis, R. J., Olichney, J. M., Thal, L. J., Mirra, S. S., Morris, J. C., Beekly, D., & Heyman, A. (1996) · Neurology · doi:10.1212/wnl.46.6.1592 · Cited by 561
Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy
Pfeifer, M., Boncristiano, S., Bondolfi, L., Stalder, A., Deller, T., Staufenbiel, M., Mathews, P. M., & Jucker, M. (2002) · Science · doi:10.1126/science.1078259 · Cited by 511
Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases
Togo, T., Akiyama, H., Iseki, E., Kondo, H., Ikeda, K., Kato, M., Oda, T., Tsuchiya, K., & Kosaka, K. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00496-9 · Cited by 481
Basic principles of immunological surveillance of the normal central nervous system
Hickey, W. F. (2001) · Glia · doi:10.1002/glia.1101 · Cited by 476
Inflammation and Alzheimer's disease pathogenesis
Rogers, J., Webster, S. D., Lue, L., Brachova, L., CIVIN, W. H., Emmerling, M. R., Shivers, B. D., Walker, D. G., & McGeer, P. L. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00115-7 · Cited by 438
Clinical manifestations of cerebral amyloid angiopathy–related inflammation
Eng, J. A., Frosch, M. P., Choi, K., Rebeck, G. W., & Greenberg, S. M. (2004) · Annals of Neurology · doi:10.1002/ana.10810 · Cited by 417
Human TH1 and TH2 Subsets: Regulation of Differentiation and Role in Protection and Immunopathology
Romagnani, S. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000236199 · Cited by 383
A -related angiitis: primary angiitis of the central nervous system associated with cerebral amyloid angiopathy
Scolding, N. J. (2005) · Brain · doi:10.1093/brain/awh379 · Cited by 372
Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease
Monsonego, A., Zota, V., Karni, A., Krieger, J. I., Bar-Or, A., Bitan, G., Budson, A. E., Sperling, R., Selkoe, D. J., & Weiner, H. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318104 · Cited by 367
Microglial Activation Resulting from CD40-CD40L Interaction After β-Amyloid Stimulation
Tan, J., Town, T., Paris, D., Mori, T., Suo, Z., Crawford, F., Mattson, M. P., Flavell, R. A., & MULLAN, M. J. (1999) · Science · doi:10.1126/science.286.5448.2352 · Cited by 353
Self-citation
Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.
Weiner, H. L., Lemere, C. A., Maron, R., Spooner, E. T., Grenfell, T. J., Mori, C., Issazadeh‐Navikas, S., Hancock, W. W., & Selkoe, D. J. (2000) · PubMed · Cited by 310
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid
Cribbs, D. H. (2003) · International Immunology · doi:10.1093/intimm/dxg049 · Cited by 283
Antigen-independent changes in naive CD4 T cells with aging.
Linton, P. J., Haynes, L., Klinman, N. R., & Swain, S. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.5.1891 · Cited by 248
Inflammation of the brain in Alzheimer's disease: implications for therapy
McGeer, P. L., & McGeer, E. G. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.4.409 · Cited by 217
Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice
Tan, J., Town, T., Crawford, F., Mori, T., DelleDonne, A., Crescentini, R., Obregon, D., Flavell, R. A., & Mullan, M. J. (2002) · Nature Neuroscience · doi:10.1038/nn968 · Cited by 217
Self-citation
Th1 and Th2 cells
Dong, C., & Flavell, R. A. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200101000-00009 · Cited by 216
Self-citation
Brain Inflammation in Alzheimer Disease and the Therapeutic Implications
McGeer, E. G., & McGeer, P. L. (1999) · Current Pharmaceutical Design · doi:10.2174/1381612805666230111212056 · Cited by 198
Pathological CNS Autoimmune Disease Triggered by Traumatic Spinal Cord Injury: Implications for Autoimmune Vaccine Therapy
Jones, T. B., Basso, D. M., Sodhi, A., Pan, J. Z., Hart, R. P., MacCallum, R. C., Lee, S., Whitacre, C. C., & Popovich, P. G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02690.2002 · Cited by 188
Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals
Lombardi, V., Garcı́a, M., Rey, L., & Cacabelos, R. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00046-6 · Cited by 182
Immune hyporesponsiveness to amyloid β-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease
Monsonego, A., Maron, R., Zota, V. E., Selkoe, D. J., & Weiner, H. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191118298 · Cited by 162
The Role of Helper T Cell Subsets in Autoimmune Diseases
Lafaille, J. J. (1998) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(98)00009-4 · Cited by 161
Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia
Becker, K. J., McCarron, R. M., Ruetzler, C. A., Laban, O., Sternberg, E. M., Flanders, K. C., & Hallenbeck, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10873 · Cited by 153
Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition
Das, P., Murphy, M. P., Younkin, L. H., Younkin, S. G., & Golde, T. E. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00245-7 · Cited by 150
Autoantibodies to amyloid-? and Alzheimer's disease
Hyman, B. T., Smith, C. R., Buldyrev, I., Whelan, C. M., Brown, H., Tang, M., & Mayeux, R. P. (2001) · Annals of Neurology · doi:10.1002/ana.1061 · Cited by 144
Immune Reactions Associated With Cerebral Amyloid Angiopathy
Yamada, M., Itoh, Y., Shintaku, M., Kawamura, J., Jensson, Ó., Thorsteinsson, L., Suematsu, N., Matsushita, M., & Otomo, E. (1996) · Stroke · doi:10.1161/01.str.27.7.1155 · Cited by 125
CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid β‐peptide
Townsend, K. P., Town, T., Mori, T., Lue, L., Shytle, D., Sanberg, P. R., Morgan, D., Fernandez, F., Flavell, R. A., & Tan, J. (2005) · European Journal of Immunology · doi:10.1002/eji.200425585 · Cited by 121
Self-citation
Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice
Furlan, R. (2003) · Brain · doi:10.1093/brain/awg031 · Cited by 116
Autoimmunity in Alzheimer’s disease: increased levels of circulating IgGs binding Aβ and RAGE peptides
Mruthinti, S., Buccafusco, J. J., Hill, W., Waller, J. L., Jackson, T. W., ZAMRINI, E. Y., & Schade, R. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.001 · Cited by 112
Autoantibodies to Amyloid β-Peptide (Aβ) are Increased in Alzheimer's Disease Patients and Aβ Antibodies Can Enhance Aβ Neurotoxicity: Implications for Disease Pathogenesis and Vaccine Development
Nath, A., Hall, E., Tuzova, M., Dobbs, M., Jones, M., Anderson, C., Woodward, J. G., Guo, Z., Fu, W., Kryscio, R. J., et al. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:3:1:29 · Cited by 107
A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and β-amyloid plaques in a mouse model of Alzheimer's disease
Zhang, J., Wu, X., Qin, C., Jin, Q., Ma, S., Zhang, H., Kong, Q., Chen, D., Ba, D., & He, W. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.07.005 · Cited by 104
Nasal Aβ Treatment Induces Anti‐Aβ Antibody Production and Decreases Cerebral Amyloid Burden in PD‐APP Mice
Lemere, C. A., Maron, R., SPOONER, E. T., Grenfell, T. J., Mori, C., Desai, R. V., Hancock, W. W., Weiner, H. L., & Selkoe, D. J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06943.x · Cited by 101
Quantitative Analysis of the T Cell Repertoire that Escapes Negative Selection
Peterson, D. A., DiPaolo, R. J., Kanagawa, O., & Unanue, E. R. (1999) · Immunity · doi:10.1016/s1074-7613(00)80120-x · Cited by 100
Local and systemic GM-CSF increase in Alzheimer's disease and vascular dementia
Tarkowski, E., Wallin, A., Regland, B., Blennow, K., & Tarkowski, A. (2001) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2001.103003166.x · Cited by 91
Microglia-Mediated Nitric Oxide Cytotoxicity of T Cells Following Amyloid β-Peptide Presentation to Th1 Cells
Monsonego, A., Imitola, J., Zota, V., Oida, T., & Weiner, H. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2216 · Cited by 91
Nasal Vaccination with β -Amyloid Peptide for the Treatment of Alzheimer's Disease
Lemere, C. A., Maron, R., Selkoe, D. J., & Weiner, H. L. (2001) · DNA and Cell Biology · doi:10.1089/10445490152717569 · Cited by 82
Giant cell arteritis in association with cerebral amyloid angiopathy: Immunohistochemical and molecular studies
Anders, K. H., Wang, Z. Z., Kornfeld, M., Gray, F., Soontornniyomkij, V., Reed, L. A., Hart, M. N., Menchine, M. D., Secor, D. L., & Vinters, H. V. (1997) · Human Pathology · doi:10.1016/s0046-8177(97)90196-9 · Cited by 81
Gene Vaccination to Bias the Immune Response to Amyloid-β Peptide as Therapy for Alzheimer Disease
Qu, B. (2004) · Archives of Neurology · doi:10.1001/archneur.61.12.1859 · Cited by 80
Innate Immunity, Local Inflammation, and Degenerative Disease
McGeer, P. L., & McGeer, E. G. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.29.re3 · Cited by 75
Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's β-amyloid1–42
Town, T., Vendrame, M., Patel, A., Poetter, D., DelleDonne, A., Mori, T., Smeed, R., Crawford, F., Klein, T., Tan, J., et al. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00307-7 · Cited by 72
Self-citation
Defining antigen‐dependent stages of T cell migration from the blood to the central nervous system parenchyma
Archambault, A. S., Sim, J. E., Gimenez, M. A. T., & Russell, J. H. (2005) · European Journal of Immunology · doi:10.1002/eji.200425864 · Cited by 70
Autoimmune Responses to Amyloid Structures of Aβ(25–35) Peptide and Human Lysozyme in the Serum of Patients with Progressive Alzheimer’s Disease
Алексеевна, Г. М., Davudova, T. B., Mališauskas, M., Zamotin, V., Sewell, R. D. E., Voskresenskaya, N. I., Kostanyan, I. A., Sherstnev, V. V., & Morozova‐Roche, L. A. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000079197 · Cited by 65
Characterization of murine immunoglobulin G antibodies against human amyloid-β1–42
Town, T., Tan, J., Sansone, N., Obregon, D. F., Klein, T., & MULLAN, M. J. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01951-6 · Cited by 64
Self-citation
IL-2 and IL-6 secretion in dementia: correlation with type and severity of disease
Huberman, M., Sredni, B., Stern, L., Kott, E., & Shalit, F. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00016-u · Cited by 62
CD40 signaling and Alzheimer's disease pathogenesis
Town, T., Tan, J., & MULLAN, M. J. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00044-4 · Cited by 61
Self-citation
CD40–CD40L interaction in Alzheimer's disease
Tan, J. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00180-7 · Cited by 57
Self-citation
Elevated interleukin-6 secretion levels by mononuclear cells of Alzheimer's patients
Shalit, F., Sredni, B., Stern, L., Kott, E., & Huberman, M. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90003-5 · Cited by 54
CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease
Tan, J., Town, T., Abdullah, L. I., Wu, Y., Placzek, A. N., Small, B. J., Kroeger, J. L., Crawford, F., Richards, D., & MULLAN, M. J. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00309-0 · Cited by 49
Self-citation
Immune response to Aβ-peptides in peripheral blood from patients with Alzheimer's disease and control subjects
Baril, L., Nicolàs, L. S. D. S., Croisile, B., Crozier, P., Hessler, C., Sassolas, A., McCormick, J. B., & Trannoy, E. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.071 · Cited by 40
Induction of CD40 on human endothelial cells by Alzheimer’s β-amyloid peptides
Tan, J., Town, T., Suo, Z., Wu, Y., Song, S., Kundtz, A., Kroeger, J. L., Humphrey, J., Crawford, F., & MULLAN, M. J. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00122-7 · Cited by 40
Self-citation
Role of Th1 and Th2 cells in autoimmune demyelinating disease
Nagelkerken, L. M. (1998) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1998000100007 · Cited by 40
Induction of a Th2 immune response by co-administration of recombinant adenovirus vectors encoding amyloid β-protein and GM-CSF
Kim, H., Cao, Y., Kong, F.-K., Kampen, K. R. V., Lewis, T. L., Ma, Z., Tang, D.-C. C., & Fukuchi, K.-I. (2005) · Vaccine · doi:10.1016/j.vaccine.2004.12.015 · Cited by 39
Association between APOE epsilon4 allele and increased expression of CD95 on T cells from patients with Alzheimer's disease
Lombardi, V., Fernández‐Novoa, L., Etcheverrı́a, I., Seoane, S., & Cacabelos, R. (2004) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2004.26.7.863735 · Cited by 20
Serum auto-antibodies in Alzheimer's disease
López, O. L., Rabin, B. S., & Huff, F. J. (1991) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1991.tb04985.x · Cited by 17
A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and β-amyloid plaques in a mouse model of Alzheimer＇s disease
Jianmin, Zhang, X., Xiaobing, Wu, chuan, C., Qin, Q., Jin, Qi, Shibin, -, M., et al. (2006) · 中国生物学文摘 · Cited by 16
T-Cell Interferon Gamma Binding in Patients With Dementia of the Alzheimer Type
Bongioanni, P., Boccardi, B., Borgna, M., Castagna, M., & Mondino, C. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550160085021 · Cited by 13
Content of Autoantibodies to Bradykinin and β-Amyloid1-42 as a Criterion for Biochemical Differences between Alzheimer's Dementias
Myagkova, M. А., Si, G., Lermontova, N. N., Kalyn, Y. B., Селезнева, Н. Д., Zharikov, G. A., Колыхалов, И. В., Абраменко, Т. В., Serkova, T. P., & Бачурин, С. О. (2003) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1026036829237 · Cited by 11

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Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750
The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases
Weiss, N., Miller, F., Cazaubon, S., & Couraud, P.-O. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.022 · Cited by 731
The impact of microglial activation on blood-brain barrier in brain diseases
da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572
Inflammation in neurodegenerative diseases—An update
Amor, S., Peferoen, L. A. N., Vogel, D. Y. S., Breur, M., van der Valk, P., Baker, D., & van Noort, J. M. (2014) · Immunology · doi:10.1111/imm.12233 · Cited by 550
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1362-5 · Cited by 521
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Cameron, B., & Landreth, G. E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.006 · Cited by 452
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vom Berg, J., Prokop, S., Miller, K. R., Obst, J., Kälin, R. E., Lopategui-Cabezas, I., Wegner, A., Mair, F., Schipke, C. G., Peters, O., et al. (2012) · Nature Medicine · doi:10.1038/nm.2965 · Cited by 416
Blood–Brain Barrier Pathology in Alzheimer's and Parkinson's Disease: Implications for Drug Therapy
Desai, B. S., Monahan, A. J., Carvey, P. M., & Hendey, B. (2007) · Cell Transplantation · doi:10.3727/000000007783464731 · Cited by 339
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Browne, T. C., McQuillan, K., McManus, R. M., O’Reilly, J.-A., Mills, K. H. G., & Lynch, M. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200947 · Cited by 329
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Self-citation
Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer’s disease
Saresella, M., Calabrese, E., Marventano, I., Piancone, F., Gatti, A. V., Alberoni, M., Nemni, R., & Clerici, M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.004 · Cited by 194
Transcriptomic profiling of microglia and astrocytes throughout aging
Pan, J., Ma, N., Yu, B., Zhang, W., & Wan, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01774-9 · Cited by 188
Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease
Dionisio-Santos, D. A., Olschowka, J. A., & O’Banion, M. K. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1453-0 · Cited by 184
Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease
Landel, V., Baranger, K., Virard, I., Loriod, B., Khrestchatisky, M., Rivera, S., Benech, P., & Féron, F. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-33 · Cited by 176
Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte–endothelial interactions
Rossi, B., Angiari, S., Zenaro, E., Budui, S. L., & Constantin, G. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0710432 · Cited by 172
PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia
Rustenhoven, J., Smith, A. M., Smyth, L. C., Jansson, D., Scotter, E. L., Swanson, M. E. V., Aalderink, M., Coppieters, N., Narayan, P., Handley, R., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0277-1 · Cited by 155
Immune profiling of Alzheimer patients
Pellicanò, M., Larbi, A., Goldeck, D., Colonna‐Romano, G., Buffa, S., Bulati, M., Rubino, G., Iemolo, F., Candore, G., Caruso, C., et al. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.11.005 · Cited by 150
Mitochondrial Dysfunction and Immune Activation are Detectable in Early Alzheimer's Disease Blood
Lunnon, K., Ibrahim, Z. M., Proitsi, P., Lourdusamy, A., Newhouse, S., Sattlecker, M., Furney, S. J., Saleem, M., Soininen, H. S., Kłoszewska, I., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111592 · Cited by 145
Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration
Henstridge, C. M., Tzioras, M., & Paolicelli, R. C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00063 · Cited by 155
IL-4-Induced Selective Clearance of Oligomeric β-Amyloid Peptide1–42 by Rat Primary Type 2 Microglia
Shimizu, E., Kawahara, K., Kajizono, M., Sawada, M., & Nakayama, H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6503 · Cited by 143
Systemic immune aberrations in Alzheimer's disease patients
Bonotis, K. S., Krikki, E., Holeva, V., Aggouridaki, C., Costa, V., & Balogiannis, S. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.10.020 · Cited by 134
Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice
McManus, R. M., Higgins, S. C., Mills, K. H. G., & Lynch, M. A. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.025 · Cited by 134
Th17 and Cognitive Impairment: Possible Mechanisms of Action
Cipollini, V., Anrather, J., Orzi, F., & Iadecola, C. (2019) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2019.00095 · Cited by 133
Blood-brain barrier integrity in the pathogenesis of Alzheimer’s disease
Huang, Z., Wong, L., Su, Y., Huang, X., Wang, N., Chen, H., & Yi, C. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100857 · Cited by 135
Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept
Maezawa, I., Nguyen, H. M., Di Lucente, J., Jenkins, D. P., Singh, V., Hilt, S., Kim, K., Rangaraju, S., Levey, A. I., Wulff, H., et al. (2018) · Brain · doi:10.1093/brain/awx346 · Cited by 125
CNS: Not an immunoprivilaged site anymore but a virtual secondary lymphoid organ
Negi, N., & Das, B. K. (2018) · International Reviews of Immunology · doi:10.1080/08830185.2017.1357719 · Cited by 123
Insights into T‐cell dysfunction in Alzheimer's disease
Dai, L., & Shen, Y. (2021) · Aging Cell · doi:10.1111/acel.13511 · Cited by 121
Amyloid β Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier
Li, M., Shang, D., Zhao, W., Li, T. X., Li, B., Fang, W., Zhu, L., Man, S., & Chen, Y. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803013 · Cited by 121
Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice
Kawahara, K., Suenobu, M., Yoshida, A., Koga, K., Hyodo, A., Ohtsuka, H., Kuniyasu, A., Tamamaki, N., Sugimoto, Y., & Nakayama, H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.049 · Cited by 113
Peripherally Administered Human Umbilical Cord Blood Cells Reduce Parenchymal and Vascular β -Amyloid Deposits in Alzheimer Mice
Nikolic, W. V., Hou, H., Town, T., Zhu, Y., Giunta, B. N., Sanberg, C. D., Zeng, J., Luo, D., Ehrhart, J. C., Mori, T., et al. (2008) · Stem Cells and Development · doi:10.1089/scd.2008.0018 · Cited by 114
Self-citation
The role of neutrophil granule proteins in neuroinflammation and Alzheimer’s disease
Stock, A. J., Kasus‐Jacobi, A., & Pereira, H. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1284-4 · Cited by 117
Systemic and CNS Inflammation Crosstalk: Implications for Alzheimer’s Disease
Paouri, E., & Georgopoulos, S. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190321154618 · Cited by 109
Th17 cells and inflammation in neurological disorders: Possible mechanisms of action
Shi, Y., Wei, B., Li, L., Wang, B., & Sun, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.932152 · Cited by 108
Macrophages in Alzheimer’s disease: the blood-borne identity
Gate, D., Rezai-Zadeh, K., Jodry, D., Rentsendorj, A., & Town, T. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0422-7 · Cited by 107
Self-citation
The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?
Doty, K. R., Guillot-Sestier, M.-V., & Town, T. (2015) · Brain Research · doi:10.1016/j.brainres.2014.09.008 · Cited by 104
Self-citation
CD8 + T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability
Melzer, N., Meuth, S. G., & Wiendl, H. (2009) · The FASEB Journal · doi:10.1096/fj.09-136200 · Cited by 105
Increased Serum Levels of Interleukin-18, -23 and -17 in Chinese Patients with Alzheimer's Disease
Chen, J., Jiang, G., Li, Q., Zhou, Z., & Cheng, Q. H. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000360606 · Cited by 100
Alterations in the Peripheral Immune System in Dementia
Busse, M., Michler, E., von Hoff, F., Dobrowolny, H., Hartig, R., Frodl, T., & Busse, S. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-161304 · Cited by 94
Is Alzheimer’s disease an inflammasomopathy?
Pereira, C., Santos, A. E., Moreira, P. I., Pereira, A. C., Sousa, F. J., Cardoso, S. M., & Cruz, M. T. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100966 · Cited by 95
Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-α-dependent
Liu, Y.-J., Guo, D.-W., Tian, L., Shang, D.-S., Zhao, W.-D., Li, B., Fang, W.-G., Zhu, L., & Chen, Y.-H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.024 · Cited by 92
miR-155 is involved in Alzheimer’s disease by regulating T lymphocyte function
Song, J., & Lee, J. E. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00061 · Cited by 91
Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study
Hwang, J.-M., Kim, J.-H., Park, J.-S., Chang, M. C., & Park, D. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04541-z · Cited by 89
Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells
Späni, C., Suter, T., Derungs, R., Ferretti, M. T., Welt, T., Wirth, F., Gericke, C., Nitsch, R. M., & Kulic, L. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0251-x · Cited by 88
Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer’s disease
Ye, M., Chung, H., Lee, C., Yoon, M. S., Yu, A., Kim, J. S., Hwang, D., Shim, I., & Bae, H. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0476-z · Cited by 96
Could Alzheimer’s Disease Originate in the Periphery and If So How So?
Morris, G., Berk, M., Maes, M. H. J., & Puri, B. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1092-y · Cited by 84
Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders
Anderson, K. M., Olson, K. E., Estes, K. A., Flanagan, K., Gendelman, H. E., & Mosley, R. L. (2014) · Translational Neurodegeneration · doi:10.1186/2047-9158-3-25 · Cited by 82
Blockade of α4 integrins reduces leukocyte–endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer’s disease
Pietronigro, E. C., Zenaro, E., Bianca, V. D., Dusi, S., Terrabuio, E., Iannoto, G., Slanzi, A., Ghasemi, S., Nagarajan, R., Piacentino, G., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-48538-x · Cited by 82
The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases
Sommer, A., Winner, B., & Prots, I. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0222-8 · Cited by 84
Migration of blood cells to β-amyloid plaques in Alzheimer's disease
Hohsfield, L. A., & Humpel, C. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.03.002 · Cited by 79
Chronic Intranasal Treatment with an Anti-Aβ30-42 scFv Antibody Ameliorates Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease
Cattepoel, S., Hanenberg, M., Kulic, L., & Nitsch, R. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018296 · Cited by 74
Double Negative (IgG + IgD − CD27 − ) B Cells are Increased in a Cohort of Moderate-Severe Alzheimer's Disease Patients and Show a Pro-Inflammatory Trafficking Receptor Phenotype
Bulati, M., Buffa, S., Martorana, A., Gervasi, F., Camarda, C., Azzarello, D. M., Monastero, R., Caruso, C., & Colonna-Romano, G. (2015) · Journal of Alzheimer’s Disease · doi:10.3233/jad-142412 · Cited by 72
Anti-Selectin Therapy for the Treatment of Inflammatory Diseases
Rossi, B., & Constantin, G. (2008) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152808785107633 · Cited by 66
Elevated Osteopontin Levels in Mild Cognitive Impairment and Alzheimer's Disease
Sun, Y., Yin, X.-S., Guo, H., Han, R.-K., He, R.-D., & Chi, L. (2013) · Mediators of Inflammation · doi:10.1155/2013/615745 · Cited by 63
How to Get from Here to There: Macrophage Recruitment in Alzheimers Disease
Rezai-Zadeh, K. P., Gate, D., Gowing, G., & Town, T. (2011) · Current Alzheimer Research · doi:10.2174/156720511795256017 · Cited by 64
Self-citation
Transcutaneous β-amyloid immunization reduces cerebral β-amyloid deposits without T cell infiltration and microhemorrhage
Nikolic, W. V., Bai, Y., Obregon, D. F., Hou, H., Mori, T., Zeng, J., Ehrhart, J. C., Shytle, R. D., Giunta, B. N., Morgan, D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609377104 · Cited by 63
Self-citation
The impact of neuroimmune changes on development of amyloid pathology; relevance to A lzheimer's disease
Lynch, M. A. (2013) · Immunology · doi:10.1111/imm.12156 · Cited by 64
Women’s Pregnancy Life History and Alzheimer’s Risk: Can Immunoregulation Explain the Link?
Fox, M. M., Berzuini, C., Knapp, L. A., & Glynn, L. M. (2018) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317518786447 · Cited by 59
The emerging role of neutrophils in neurodegeneration
Rossi, B., Constantin, G., & Zenaro, E. (2019) · Immunobiology · doi:10.1016/j.imbio.2019.10.014 · Cited by 60
Enhanced Chemokine Receptor Expression on Leukocytes of Patients with Alzheimer's Disease
Goldeck, D., Larbi, A., Pellicanò, M., Alam, I., Zerr, I., Schmidt, C., Fülöp, T., & Pawelec, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066664 · Cited by 60
Microglial TNF-α-Dependent Elevation of MHC Class I Expression on Brain Endothelium Induced by Amyloid-Beta Promotes T Cell Transendothelial Migration
Yang, Y.-M., Shang, D.-S., Zhao, W.-D., Fang, W.-G., & Chen, Y.-H. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1138-5 · Cited by 57
A potential role for the PD1/PD-L1 pathway in the neuroinflammation of Alzheimer's disease
Saresella, M., Calabrese, E., Marventano, I., Piancone, F., Gatti, A. V., Farina, E., Alberoni, M., & Clerici, M. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.004 · Cited by 57
Increased T-cell Reactivity and Elevated Levels of CD8+ Memory T-cells in Alzheimer’s Disease-patients and T-cell Hyporeactivity in an Alzheimer’s Disease-mouse Model: Implications for Immunotherapy
Schindowski, K., Eckert, A., Peters, J., Gorriz, C., Schramm, U., Weinandi, T., Maurer, K., Frölich, L., & Müller, W. E. (2007) · NeuroMolecular Medicine · doi:10.1007/s12017-007-8015-9 · Cited by 54
Imaging of Leukocyte Trafficking in Alzheimer’s Disease
Pietronigro, E. C., Zenaro, E., & Constantin, G. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00033 · Cited by 52
Blood-Based Biomarkers of Neuroinflammation in Alzheimer’s Disease: A Central Role for Periphery?
Angiulli, F., Conti, E., Zoia, C., Re, F. D., Appollonio, I. M., Ferrarese, C., & Tremolizzo, L. (2021) · Diagnostics · doi:10.3390/diagnostics11091525 · Cited by 55
Hygiene and the world distribution of Alzheimer’s disease
Fox, M. M., Knapp, L. A., Andrews, P. W., & Fincher, C. L. (2013) · Evolution Medicine and Public Health · doi:10.1093/emph/eot015 · Cited by 50
Dual Effects of Human Placenta-Derived Neural Cells on Neuroprotection and the Inhibition of Neuroinflammation in a Rodent Model of Parkinson’s Disease
Kim, H. W., Lee, H., Kang, J. M., Bae, S., Kim, C., Lee, S., Schwarz, J., Kim, G. J., Kim, J.-S., Cha, D. H., et al. (2018) · Cell Transplantation · doi:10.1177/0963689718766324 · Cited by 50
T Cells—Protective or Pathogenic in Alzheimer’s Disease?
McManus, R. M., Mills, K. H. G., & Lynch, M. A. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9612-2 · Cited by 54
Microglial MHC-I induction with aging and Alzheimer’s is conserved in mouse models and humans
Kellogg, C. M., Pham, K. D., Machalinski, A. H., Porter, H. L., Blankenship, H. E., Tooley, K. B., Stout, M. B., Rice, H. C., Sharpe, A. L., Beckstead, M. J., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00859-6 · Cited by 51
PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease
Morel, M., Couturier, J., Lafay‐Chebassier, C., Paccalin, M., & Page, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00849.x · Cited by 47
Multiple Low-Dose Infusions of Human Umbilical Cord Blood Cells Improve Cognitive Impairments and Reduce Amyloid-β-Associated Neuropathology in Alzheimer Mice
Darlington, D., Deng, J., Giunta, B. N., Hou, H., Sanberg, C. D., Kuzmin‐Nichols, N., Zhou, H., Mori, T., Ehrhart, J. C., Sanberg, P. R., et al. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0345 · Cited by 46
Self-citation
MHC-I promotes apoptosis of GABAergic interneurons in the spinal dorsal horn and contributes to cancer induced bone pain
Fu, Q., Shi, D., Zhou, Y., Zheng, H., Xiang, H., Tian, X., Gao, F., Manyande, A., Cao, F., Tian, Y., et al. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.09.002 · Cited by 46
Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways
Wang, L., Xiaokaiti, Y., Wang, G., Xu, X., Chen, L., Huang, X., Liu, L., Pan, J., Hu, S., Chen, Z., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08070-2 · Cited by 46
Alzheimer’s Disease: From Immune Homeostasis to Neuroinflammatory Condition
Cariddi, L. P., Mauri, M. F., Cosentino, M., Versino, M., & Marino, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113008 · Cited by 45
T cell infiltration mediates neurodegeneration and cognitive decline in Alzheimer's disease
Zeng, J., Liao, Z., Yang, H., Wang, Q., Wu, Z., Hua, F., & Zhou, Z. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106461 · Cited by 52
Evidence from Human and Animal Studies: Pathological Roles of CD8+ T Cells in Autoimmune Peripheral Neuropathies
Yang, M., Peyret, C., Shi, X., Siron, N., Jang, J. H., Wu, S., Fournier, S., & Zhang, J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00532 · Cited by 45
DNA prime–protein boost increased the titer, avidity and persistence of anti-Aβ antibodies in wild-type mice
Davtyan, H., Mkrtichyan, M., Movsesyan, N., Petrushina, I., Mamikonyan, G., Cribbs, D. H., Agadjanyan, M. G., & Ghochikyan, A. (2009) · Gene Therapy · doi:10.1038/gt.2009.140 · Cited by 43
Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System
Foster, V. S., Rash, L. D., King, G. F., & Rank, M. M. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.738043 · Cited by 44
Alternative Aβ Immunotherapy Approaches for Alzheimers Disease
Town, T. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709787847306 · Cited by 42
Self-citation
Decreased Netrin-1 and Correlated Th17/Tregs Balance Disorder in Aβ1–42 Induced Alzheimer’s Disease Model Rats
Sun, L., Ju, T., Wang, T., Zhang, L., Ding, F., Zhang, Y., An, R., Sun, Y., Li, Y., Lu, Y., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00124 · Cited by 45
Aβ1–42 stimulated T cells express P-PKC-δ and P-PKC-ζ in Alzheimer disease
Miscia, S., Ciccocioppo, F., Lanuti, P., Velluto, L., Bascelli, A., Pierdomenico, L., Genovesi, D., Di Siena, A., Santavenere, E., Gambi, F., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.011 · Cited by 40
The intricate role of CCL5/CCR5 axis in Alzheimer disease
Ma, W., Liu, A., Wu, X., Gao, L., Chen, J., Wu, H., Liu, M., Fan, Y., Li, P., Yang, J., et al. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad071 · Cited by 41
Shared Molecular and Functional Frameworks among Five Complex Human Disorders: A Comparative Study on Interactomes Linked to Susceptibility Genes
Menon, R., & Farina, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018660 · Cited by 39
Association of IL-12A and IL-12B polymorphisms with Alzheimer's disease susceptibility in a Han Chinese population
Zhu, X., Tan, L., Jiang, T., Tan, M., Zhang, W., & Yu, J. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.06.026 · Cited by 39
Enhanced soluble CD40 ligand and Alzheimer's disease: Evidence of a possible pathogenetic role
Desideri, G., Cipollone, F., Necozione, S., Marini, C., Lechiara, M. C., Taglieri, G., Zuliani, G., Fellin, R., Mezzetti, A., di Orio, F., et al. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.10.019 · Cited by 38
Dementia-associated changes of immune cell composition within the cerebrospinal fluid
Busse, S., Hoffmann, J., Michler, E., Hartig, R., Frodl, T., & Busse, M. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100218 · Cited by 39
Can peripheral leukocytes be used as Alzheimer’s disease biomarkers?
Rezai-Zadeh, K. P., Gate, D., Szekely, C. A., & Town, T. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.118 · Cited by 36
Self-citation
Peripheral and Central Glutamate Dyshomeostasis in Neurodegenerative Disorders
Onaolapo, A. Y., & Onaolapo, O. J. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666201015161919 · Cited by 37
Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair
Bryson, K. J., & Lynch, M. A. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.10.003 · Cited by 33
In VivoMRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation
Tang, T., Valenzuela, A. E., Petit, F., Chow, S. S. L., Leung, K. H., Gorin, F. A., Louie, A. Y., & Dhénain, M. (2018) · Contrast Media & Molecular Imaging · doi:10.1155/2018/3476476 · Cited by 35
T-Lymphocyte Deficiency Exacerbates Behavioral Deficits in the 6-OHDA Unilateral Lesion Rat Model for Parkinson’s Disease
Wheeler, C. J. (2014) · Journal of Neurology & Neurophysiology · doi:10.4172/2155-9562.1000209 · Cited by 32
Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer’s disease
Bahado-Singh, R. O., Vishweswaraiah, S., Aydas, B., Yılmaz, A., Metpally, R. P. R., Carey, D. J., Crist, R. C., Berrettini, W. H., Wilson, G. D., Imam, K., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248375 · Cited by 31
Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer’s disease
Liang, N., Nho, K. T., Newman, J. W. I., Arnold, M., Huynh, K., Meikle, P. J., Borkowski, K., Kaddurah‐Daouk, R., Kueider‐Paisley, A., Doraiswamy, P. M., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-67177-5 · Cited by 37
Neuroinflammation and β Amyloid Deposition in Alzheimer's Disease: In vivo Quantification with Molecular Imaging
Hommet, C., Mondon, K., Camus, V., Ribeiro, M. J., Beaufils, É., Arlicot, N., Corcia, P., Paccalin, M., Minier, F., Gosselin, T., et al. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000354363 · Cited by 36

T Cells—Protective or Pathogenic in Alzheimer’s Disease?
McManus, R. M., Mills, K. H. G., & Lynch, M. A. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9612-2 · Cited by 54
The role of T cells in the pathogenesis and prevention of the inflammatory and neurodegenerative changes associated with Alzheimer's disease
McQuillan, K. (2009) · Arrow@dit (Dublin Institute of Technology)
Role of infection and T cells in disease pathogenesis in a model of Alzheimer's disease
McManus, R. M. (2015) · Arrow@dit (Dublin Institute of Technology)
Neuroinflammation and neuroimmunology in Alzheimer's disease: The role of T‐lymphocytes in Alzheimer's disease
Chihara, N., Tsuji, A., & Matsumoto, R. (2023) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12747 · Cited by 4
Insights into T‐cell dysfunction in Alzheimer's disease
Dai, L., & Shen, Y. (2021) · Aging Cell · doi:10.1111/acel.13511 · Cited by 121

Authors: Town, T., Tan, J., Flavell, R. A., & Mullan, M.
Affiliations: Yale University (US)
University of South Florida (US)
Howard Hughes Medical Institute (US)
Roskamp Institute (US)
Corresponding author: Mullan, Mike
ORCID: Tan, Jun
Flavell, Richard A.
Venue: NeuroMolecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2005
Volume: 7
Issue: 3
Pages: 255-264
ISSN: 1535-1084 (ISSN-L)
DOI: 10.1385/nmm:7:3:255
OpenAlex: W1992860518
Cited by: 183
References: 66
Citations by year: 2026: 2 · 2025: 2 · 2024: 7 · 2023: 9 · 2022: 12 · 2021: 11 · 2020: 13 · 2019: 11 · 2018: 11 · 2017: 12 · 2016: 7 · 2015: 10 · 2014: 13 · 2013: 15 · 2012: 8
FWCI: 3.20
Type: journal article
Language: en
Open access: closed
Locations: NeuroMolecular Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, T cells, amyloid-beta, amyloid plaques, cerebral amyloid angiopathy, neuroinflammation, reactive glia, T cell activation, aseptic meningoencephalitis, amyloid-beta immunotherapy, mouse models of Alzheimer's disease
MeSH terms: Alzheimer Disease, Humans, Immunity, Innate, Immunotherapy, Lymphocyte Activation, T-Lymphocytes, Cerebral Amyloid Angiopathy, Microglia, Plaque, Amyloid

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T-Cells in Alzheimer's Disease

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