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The human microbiome and bile acid metabolism: dysbiosis, dysmetabolism, disease and intervention
Abstract
INTRODUCTION: Recent evidence indicates that the human gut microbiome plays a significant role in health and disease. Dysbiosis, defined as a pathological imbalance in a microbial community, is becoming increasingly appreciated as a 'central environmental factor' that is both associated with complex phenotypes and affected by host genetics, diet and antibiotic use. More recently, a link has been established between the dysmetabolism of bile acids (BAs) in the gut to dysbiosis. AREAS COVERED: BAs, which are transformed by the gut microbiota, have been shown to regulate intestinal homeostasis and are recognized as signaling molecules in a wide range of metabolic processes. This review will examine the connection between BA metabolism as it relates to the gut microbiome and its implication in health and disease. EXPERT OPINION: A disrupted gut microbiome, including a reduction of bile salt hydrolase (BSH)-active bacteria, can significantly impair the metabolism of BAs and may result in an inability to maintain glucose homeostasis as well as normal cholesterol breakdown and excretion. To better understand the link between dysbiosis, BA dysmetabolism and chronic degenerative disease, large-scale metagenomic sequencing studies, metatranscriptomics, metaproteomics and metabolomics should continue to catalog functional diversity in the gastrointestinal tract of both healthy and diseased populations. Further, BSH-active probiotics should continue to be explored as treatment options to help restore metabolic levels.
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“Chenodeoxycholic acid (CDCA) is the major activator of FXR, followed by deoxycholic acid (DCA), colic acid (LCA), and cholic acid (CA) (Jones et al., 2014).”
From Bacteroides dorei BDX-01 alleviates DSS-induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway (2023) · cites this paper as Jones et al., 2014
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Bile acid signaling in metabolic disease and drug therapy
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“Dysbiosis is the major environmental factor that affects bile acid metabolism and contributes to diseases not only in the gastrointestinal system but also in chronic diseases, such as NAFLD, diabetes, and obesity (Jones et al., 2014).”
BackgroundIntestinal transport and metabolism of bile acids
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“Cholic acids, commonly described as bile acids, are important players of the lipid metabolism in the gut and help maintain a healthy gut microbial community, thus representing a viable therapeutic intervention against pathogens (29).”
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“Although BAs and SCFAs may control incretin release (Brighton et al., 2015; Canfora et al., 2015) and affect energy metabolism in rodents (Gao et al., 2009), no effects on postprandial energy and substrate metabolism and fasting and postprandial glucagon-like peptide 1 (GLP-1) concentrations were found in the present…”
BackgroundResultInfluential
Metadata
- Authors
- Jones, M. L., Martoni, C. J., Ganopolsky, J. G., Labbé, A., & Prakash, S.
- Affiliations
- Micropharma (Canada) (CA)
- Venue
- Expert Opinion on Biological Therapy
- Publisher
- Informa UK Limited
- Published
- 2014-01-30
- Volume
- 14
- Issue
- 4
- Pages
- 467-482
- ISSN
- 1471-2598 (ISSN-L)
- 1744-7682
- OpenAlex
- W2014099400
- Cited by
- 150
- References
- 128
- Citations by year
- 2026: 13 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 17 · 2021: 20 · 2020: 10 · 2019: 12 · 2018: 12 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 7
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Biological Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, bile acid metabolism, dysbiosis, bile salt hydrolase, probiotics, glucose homeostasis, cholesterol metabolism, intestinal homeostasis, chronic degenerative diseases, metagenomics, metaproteomics, metabolomics
- MeSH terms
- Animals, Bile Acids and Salts, Diabetes Mellitus, Type 2, Female, Gastrointestinal Diseases, Health Status, Humans, Male, Metabolic Diseases, Obesity, Osteoporosis, Probiotics, Atherosclerosis, Microbiota, Dysbiosis
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