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Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics
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Serial electron microscopy and 3-D reconstructions of dendritic spines from hippocampal area CA 1 dendrites were obtained to evaluate 2 questions about relationships between spine geometry and synaptic efficacy. First, under what biophysical conditions are the spine necks likely to reduce the magnitude of charge transferred from the synapses on the spine heads to the recipient dendrite? Simulation software provided by Charles Wilson (1984) was used to determine that if synaptic conductance is 1 nS or less, only 1% of the hippocampal spine necks are sufficiently thin and long to reduce charge transfer by more than 10%. If synaptic conductance approaches 5 nS, however, 33% of the hippocampal spine necks are sufficiently thin and long to reduce charge transfer by more than 10%. Second, is spine geometry associated with other anatomical indicators of synaptic efficacy, including the area of the postsynaptic density and the number of vesicles in the presynaptic axon? Reconstructed spines were graphically edited into head and neck compartments, and their dimensions were measured, the areas of the postsynaptic densities (PSD) were measured, and all of the vesicles in the presynaptic axonal varicosities were counted. The dimensions of the spine head were well correlated with the area of PSD and the number of vesicles in the presynaptic axonal varicosity. Spine neck diameter and length were not correlated with PSD area, head volume, or the number of vesicles. These results suggest that the dimensions of the spine head, but not the spine neck, reflect differences in synaptic efficacy. We suggest that the constricted necks of hippocampal dendritic spines might reduce diffusion of activated molecules to neighboring synapses, thereby attributing specificity to activated or potentiated synapses.
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“This is probably one of the reasons why many ultrastructural studies that utilized high concentrations of potassium ferrocyanide/ferricyanide (1.5–3.0%) provided no data on SS (e.g., Harris and Stevens, 1989; Hayworth et al., 2014; Yakoubi et al., 2019a; Yin et al., 2020; Gour et al., 2021; Phelps et al., 2021; Peddie et al., 2022; Turner et al., 2022).”
From Unambiguous identification of asymmetric and symmetric synapses using volume electron microscopy (2024) · cites this paper as Harris and Stevens, 1989
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“Given that each spine receives only one synaptic input13, our data indicate the highest possible degree of freedom is available in synaptic connections in the dendrites, which has been assumed in the learning models of most neural network theories17.”
From Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons (2001) · cites this paper as [13]
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“This observation suggests that the expression of AMPA receptors is controlled independently at a level of the individual spine, consistent with the classical notion that a single spine may behave as an independent chemical compartment to regulate synaptic transmission13, 14.”
From Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons (2001) · cites this paper as [13]
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“Regions of glutamate sensitivity tended to be asymmetrically localized to one portion of a spine (Figs. 3h and 4c–j), consistent with the predominant localization of AMPA receptors within PSDs with a diameter of 0.1 to 0.5μm13, 19, 20.”
From Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons (2001) · cites this paper as [13]
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“Syn1a-CFP puncta area calculated as a measure of bouton area, which correlated with pHuse area, as expected42.”
From A trans-synaptic nanocolumn aligns neurotransmitter release to receptors (2016) · cites this paper as [42]
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“In turn, the size of the postsynaptic density is correlated with the number of presynaptic vesicles, the number of postsynaptic receptors and the ready-releasable pool of transmitter (Harris and Stevens, 1989; Nusser et al., 1998; Schikorski and Stevens, 1999, 2001; Arellano et al., 2007a).”
From The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease (2013) · cites this paper as Harris and Stevens, 1989
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“Additionally, the volume of the dendritic spine head is related to the size of the postsynaptic density (Harris and Stevens, 1989; Schikorski and Stevens, 1997; Arellano et al., 2007b), the number of presynaptic vesicles, and the number of vesicles adjacent to the presynaptic cleft (Harris and Stevens, 1989).”
From The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease (2013) · cites this paper as Harris and Stevens, 1989
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“Furthermore, the volume of the head is directly proportional to the strength of synaptic currents (Harris and Stevens, 1989; Schikorski and Stevens, 1997; Arellano et al., 2007a).”
From The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease (2013) · cites this paper as Harris and Stevens, 1989
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“The relationship between spine geometry and expression of functional AMPA receptors demonstrated here provides substantial support to the hypothesis that neuronal fine structures have functional correlates in the brain13, 18, 21.”
From Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons (2001) · cites this paper as [13]
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“These data are consistent with the correlation between AMPA receptor immunoreactivity and the size of PSD19, 20, because the size of PSD is nearly proportional to the spine-head volume13.”
From Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons (2001) · cites this paper as [13]
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“whereas the spine head volume is correlated with the area of the postsynaptic density.”
From The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease (2013) · cites this paper as Harris and Stevens, 1989
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Citations
Cites
The Synaptic Organization of the Brain
(2004) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195159561.001.1 · Cited by 3,574
The Synaptic Organization of the Brain
Freemon, F. R. (1980) · JAMA · doi:10.1001/jama.1980.03300440052037 · Cited by 709
Chang, F., & Greenough, W. T. (1984) · Brain Research · doi:10.1016/0006-8993(84)91008-4 · Cited by 523
Lee, K. S., Schottler, F., Oliver, M. E., & LYNCH, G. S. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.44.2.247 · Cited by 473
Harris, K., & Stevens, J. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-12-04455.1988 · Cited by 318
Self-citationDesmond, N. L., & Levy, W. B. (1983) · Brain Research · doi:10.1016/0006-8993(83)91329-x · Cited by 276
Three-Dimensional analysis of dendritic spines
Špaček, J., & Hartmann, M. (1983) · Anatomy and Embryology · doi:10.1007/bf00298517 · Cited by 269
The anatomy of a memory: convergence of results across a diversity of tests
Greenough, W. T., & Bailey, C. H. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90139-7 · Cited by 266
Crick, F. (1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90020-0 · Cited by 254
Van Harreveld, A., & Fifkova, E. (1975) · Experimental Neurology · doi:10.1016/0014-4886(75)90055-2 · Cited by 239
Research works printed but not linked: 6
- Harris, K. M., F. E. Jensen, and B. Tsao (1988) Ultrastructure, de- velopment, and plasticity of synapses in area CA1 of the rat hippo- campus: Extending our vision with serial electron microscopy and three dimensional analyses. Neurol. Neurobiol. (in press).
- Andersen, P., T. Blackstad, G. Hulleberg, J. Line Vaaland, and M. Andersen, P., T. Blackstad, G. Hulleberg, M. Trommald, and J. L. Vaaland (1988b) Dimensions ofdendritic spines ofrat dentate gran- Trommald (1988a) Changes in spine morphology associated with ule cells during long-term potentiation (LTP). Proc. Physiol. Sot. P.C. 50. long-term potentiation in rat dentate granule cells. Proc. Physiol. Sot. s.
- Diamond, J., E. G. Gray, and G. M. Yasargil (1970) The function of dendritic spines: An hypothesis. In Excitatory Synaptic Mechanisms, P. Andersen and J. Jensen, eds., pp. 2 13-222, Universitets Forlaget, Oslo.
- Meek, G. A. (1976) Practical Electron Microscopyfor Biologists, Wiley, New York.
- Rall, W. (1970) Cable properties of dendrites and effects of synaptic location. In Excitatory Synaptic Mechanisms, P. Andersen and J. K. S. Jensen, eds., pp. 175-l 87, Universitets Forlaget, Oslo.
- Rall, W. (1978) Dendritic spines and synaptic potency. In Studies in NeurophysioloRy, A. K. McIntyre and K. Porter, eds., pp. 203-209, Cambridge U.-P., Cambridge.
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Items 401–500 of 999
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Maus, L., Lee, C., Altas, B., Sertel, S. M., Weyand, K., Rizzoli, S. O., Rhee, J., Brose, N., Imig, C., & Cooper, B. H. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.083 · Cited by 68
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Dubinsky, J. M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.05.020 · Cited by 67
Hara, Y., Punsoni, M., Yuk, F., Park, C. S., Janssen, W. G. M., Rapp, P. R., & Morrison, J. H. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0605-12.2012 · Cited by 66
Chen, Y., Chen, C.-Y., Hu, H., & Hsueh, Y. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-05-0365 · Cited by 66
Tiwari, S. S., Mizuno, K., Ghosh, A., Aziz, W., Troakes, C., Daoud, J., Golash, V., Noble, W., Hortobágyi, T., & Giese, K. P. (2016) · Brain · doi:10.1093/brain/aww205 · Cited by 65
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Bostrom, C. A., Majaess, N. M., Morch, K., White, E. R., Eadie, B. D., & Christie, B. R. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht237 · Cited by 67
Bourne, J. N., Chirillo, M. A., & Harris, K. M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23384 · Cited by 68
Self-citationBinary and analog variation of synapses between cortical pyramidal neurons
Dorkenwald, S., Turner, N. L., Macrina, T., Lee, K., Lu, R., Wu, J., Bodor, A. L., Bleckert, A. A., Brittain, D., Kemnitz, N., et al. (2019) · doi:10.1101/2019.12.29.890319 · Cited by 130
“6a), in accord with previous studies (Harris and Stevens, 1989; Arellano et al., 2007; Bartol et al., 2015).”
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Srinivas, K. V., Buss, E. W., Sun, Q., Santoro, B., Takahashi, H., Nicholson, D. A., & Siegelbaum, S. A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2219-16.2017 · Cited by 69
Androuin, A., Potier, B., Nägerl, U. V., Cattaert, D., Danglot, L., Thierry, M., Youssef, I., Triller, A., Duyckaerts, C. J., Hachimi, K. H. E., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1847-6 · Cited by 66
Long-term potentiation expands information content of hippocampal dentate gyrus synapses
Bromer, C., Bartol, T. M., Bowden, J. B., Hubbard, D. D., Hanka, D. C., Gonzalez, P. V., Kuwajima, M., Mendenhall, J. M., Parker, P. H., Abraham, W. C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716189115 · Cited by 60
Self-citationMiner, D. C., & Triesch, J. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004759 · Cited by 63
Anderson, R. M., Glanz, R. M., Johnson, S. B., Miller, M. M., Romig‐Martin, S. A., & Radley, J. J. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24027 · Cited by 64
Kullmann, D. M., Min, M., Asztély, F., & Rusakov, D. A. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0392 · Cited by 61
The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory
Costa, J. F., Dines, M., & Lamprecht, R. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00012 · Cited by 58
Terzic, B., Davatolhagh, M. F., Ho, Y., Tang, S., Liu, Y.-T., Xia, Z., Cui, Y., Fuccillo, M. V., & Zhou, Z. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143655 · Cited by 63
Nicholson, D. A., & Geinisman, Y. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21896 · Cited by 57
Signaling mechanisms mediating the regulation of synaptic plasticity and memory by estradiol.
Arevalo, M., Azcoitia, Í., González-Burgos, I., & Garcia-Segura, L. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.04.016 · Cited by 60
Structure and molecular organization of dendritic spines.
Tashiro, A., & Yuste, R. (2003) · PubMed · doi:10.14670/hh-18.617 · Cited by 60
Bello-Medina, P. C., Flores, G., Quirarte, G. L., McGaugh, J. L., & Prado-Alcalá, R. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613680113 · Cited by 61
Jones, D. G., & Harris, R. J. (1995) · Reviews in the Neurosciences · doi:10.1515/revneuro.1995.6.3.177 · Cited by 61
Schmidt, E. R. E., Kupferman, J. V., Stackmann, M., & Polleux, F. (2019) · Scientific Reports · doi:10.1038/s41598-019-54887-4 · Cited by 55
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Padmanabhan, P., Kneynsberg, A., & Götz, J. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00531-y · Cited by 59
Smolen, P. D., Baxter, D. A., & Byrne, J. H. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002620 · Cited by 62
Coss, R. G. (1991) · Ecological Psychology · doi:10.1207/s15326969eco0304_1 · Cited by 60
Spolidoro, M., Putignano, E., Munafò, C., Maffei, L., & Pizzorusso, T. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr158 · Cited by 58
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Oliveira, R. F., Kim, M., & Blackwell, K. T. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002383 · Cited by 60
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Allen, A. R., Raber, J., Chakraborti, A., Sharma, S., & Fike, J. R. (2015) · Radiation Research · doi:10.1667/rr14103.1 · Cited by 58
Efficient temporal processing with biologically realistic dynamic synapses
Natschlger, T., Maass, W., & Zador, A. M. (2001) · Network Computation in Neural Systems · doi:10.1088/0954-898x/12/1/305 · Cited by 67
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McEwen, B. S., Coirini, H., & Schumacher, M. (2007) · Novartis Foundation symposium · doi:10.1002/9780470513989.ch2 · Cited by 58
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Kononenko, N. L., & Witter, M. P. (2011) · Hippocampus · doi:10.1002/hipo.20949 · Cited by 56
Pardo, M., Cheng, Y., Sitbon, Y. H., Lowell, J. A., Grieco, S. F., Worthen, R. J., Desse, S. I., & Barreda-Diaz, A. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.10.012 · Cited by 61
Andersen, P., & Soleng, A. F. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00042-8 · Cited by 57
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Wright, S. J., & Wright, D. J. (2002) · Methods in cell biology · doi:10.1016/s0091-679x(02)70002-2 · Cited by 56
Neurogranin controls the spatiotemporal pattern of postsynaptic Ca2+/CaM signaling.
Kubota, Y., Putkey, J., & Waxham, M. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.106849 · Cited by 52
Nava, N., Treccani, G., Al‐Absi, A., Müller, H. K., Elfving, B., Popoli, M., Wegener, G., & Nyengaard, J. R. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv254 · Cited by 54
Lazarczyk, M. J., Kemmler, J. E., Eyford, B. A., Short, J. A., Varghese, M., Sowa, A., Dickstein, D. R., Yuk, F. J., Puri, R., Biron, K. E., et al. (2016) · Scientific Reports · doi:10.1038/srep26199 · Cited by 55
PTEN knockdown alters dendritic spine/protrusion morphology, not density
Haws, M. E., Jaramillo, T. C., Espinosa, F., Widman, A. J., Stuber, G. D., Sparta, D. R., Tye, K. M., Russo, S. J., Parada, L. F., Stavarache, M. A., et al. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23488 · Cited by 56
How multiple-synapse boutons could preserve input specificity during an interneuronal spread of LTP
Harris, K. M. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93930-v · Cited by 54
Self-citationDendritic integration in pyramidal neurons during network activity and disease
Palmer, L. M. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.09.010 · Cited by 56
Shinohara, Y. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.010.2009 · Cited by 53
Massie, A., Cnops, L., Smolders, I. J., McCullumsmith, R. E., Kooijman, R., Kwak, S., Arckens, L., & Michotte, Y. M. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21823 · Cited by 53
Brunkhorst, R., Kanaan, N., Koch, A. H., Ferreirós, N., Mirceska, A., Zeiner, P. S., Mittelbronn, M. G. A., Derouiche, A., Steinmetz, H., Foerch, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070124 · Cited by 53
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Miermans, C. A., Kusters, R., Hoogenraad, C. C., & Storm, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170113 · Cited by 60
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Germuska, M. A., Saha, S. G., Fiala, J. C., & Barbas, H. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj030 · Cited by 52
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Oliveira, A. F., & Yasuda, R. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3096-13.2014 · Cited by 52
Kerrisk, M. E., Greer, C. A., & Koleske, A. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0528-13.2013 · Cited by 53
Radley, J. J., Anderson, R. M., Cosme, C. V., Glanz, R. M., Miller, M. C., Romig‐Martin, S. A., & LaLumiere, R. T. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4961-14.2015 · Cited by 56
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Hiratani, N., & Fukai, T. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803274115 · Cited by 58
Takasaki, K., & Sabatini, B. L. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00029 · Cited by 51
Bączyńska, E., Pels, K. K., Basu, S., Włodarczyk, J., & Ruszczycki, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084053 · Cited by 49
Heck, N., Bétuing, S., Vanhoutte, P., & Caboche, J. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0340-y · Cited by 58
Sauerbeck, A. D., Gangolli, M., Reitz, S. J., Salyards, M. H., Kim, S., Hemingway, C., Gratuze, M., Makkapati, T., Kerschensteiner, M., Holtzman, D. M., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.04.012 · Cited by 53
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Buss, E. W., Corbett, N. J., Roberts, J. G., Ybarra, N., Musial, T. F., Simkin, D., Molina-Campos, E., Oh, K.-J., Nielsen, L. L., Ayala, G. D., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921481118 · Cited by 52
Sun, Y., Smirnov, M., Kamasawa, N., & Yasuda, R. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.1964-20.2021 · Cited by 51
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Shoop, R. D., Esquenazi, E., Yamada, N., Ellisman, M. H., & Berg, D. K. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00748.2002 · Cited by 52
Harris, K. M., Špaček, J., Bell, M. E., Parker, P. H., Lindsey, L. F., Baden, A. D., Vogelstein, J. T., & Burns, R. C. (2015) · Scientific Data · doi:10.1038/sdata.2015.46 · Cited by 51
Self-citationLayer‐specific alterations to CA1 dendritic spines in a mouse model of Alzheimer's disease
Merino‐Serrais, P., Knafo, S., Alonso‐Nanclares, L., Fernaud-Espinosa, I., & DeFelipe, J. (2010) · Hippocampus · doi:10.1002/hipo.20861 · Cited by 51
Moderate AMPA receptor clustering on the nanoscale can efficiently potentiate synaptic current
Savtchenko, L. P., & Rusakov, D. A. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0167 · Cited by 51
Hosseiny, S., Piétri, M., Petit-Paitel, A., Zarif, H., Heurteaux, C., Chabry, J., & Guyon, A. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0865-y · Cited by 50
CREB regulates spine density of lateral amygdala neurons: implications for memory allocation
Sargin, D., Mercaldo, V., Yiu, A. P., Higgs, G. V., Han, J., Frankland, P. W., & Josselyn, S. A. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00209 · Cited by 50
Shi, S., Cheng, T., Jan, L. Y., & Jan, Y. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405371101 · Cited by 50
Lin, H., Huganir, R. L., & Liao, D. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.086 · Cited by 53
Cohen, R. S., & Pfaff, D. W. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90045-g · Cited by 50
Kim, M., Park, A. J., Havekes, R., Chay, A., Guercio, L. A., Oliveira, R. F., Abel, T. G., & Blackwell, K. T. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002084 · Cited by 55
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Cameron, H. A., Kaliszewski, C. K., & Greer, C. A. (1991) · Synapse · doi:10.1002/syn.890080205 · Cited by 49
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Briones, T. L., Therrien, B. A., & Metzger, B. L. (2000) · Biological Research For Nursing · doi:10.1177/109980040000100406 · Cited by 49
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Takahashi, N., Sawada, W., Noguchi, J., Watanabe, S., Ucar, H., Hayashi-Takagi, A., Yagishita, S., Ohno, M., Tokumaru, H., & Kasai, H. (2015) · Nature Communications · doi:10.1038/ncomms9531 · Cited by 46
Travaglia, A., Bisaz, R., Cruz, E., & Alberini, C. M. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.005 · Cited by 50
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Metadata
- Authors
- Harris, K., & Stevens, J.
- Affiliations
- Boston Children's Hospital (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1989-08-01
- Volume
- 9
- Issue
- 8
- Pages
- 2982-2997
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6569708
- OpenAlex
- W2117664079
- Cited by
- 1,073
- References
- 38
- Citations by year
- 2026: 17 · 2025: 26 · 2024: 35 · 2023: 33 · 2022: 31 · 2021: 50 · 2020: 39 · 2019: 43 · 2018: 47 · 2017: 33 · 2016: 40 · 2015: 48 · 2014: 44 · 2013: 50 · 2012: 42
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alfred P. Sloan Foundation
- National Institutes of Health (NS21184)
- Medical Research Council
- National Institute of Neurological Disorders and Stroke (NS21184, NS 20820)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD018655, P30HD-18655)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dendritic spines, CA1 pyramidal neurons, hippocampus, synaptic efficacy, postsynaptic density, synaptic vesicles, charge transfer, synaptic conductance, dendritic spine morphology, synaptic specificity
- MeSH terms
- Animals, Axons, Biophysics, Dendrites, Electric Conductivity, Endoplasmic Reticulum, Hippocampus, Image Processing, Computer-Assisted, Male, Microscopy, Electron, Models, Neurological, Neurons, Purkinje Cells, Rats, Inbred Strains, Synapses, Rats, Biophysical Phenomena
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