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Cited by 58Memory and Neural MechanismsSpatial Cognition and NavigationMemory Processes and Influences

Memory for familiar environments learned in the remote past: fMRI studies of healthy people and an amnesic person with extensive bilateral hippocampal lesions

Rosenbaum, R. Shayna, Winocur, Gordon, Grady, Cheryl L., Ziegler, Marilyne, Moscovitch, Morris·2007·Hippocampus
DOI 10.1002/hipo.20354
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Abstract

Preserved remote spatial memory in amnesic people with bilateral hippocampal damage, including the well‐studied case K.C., challenges spatial theories, which assume that the hippocampus is needed to support all allocentric spatial representations, old or new. It remains possible, however, that residual hippocampal tissue is functional and contributes to successful performance. Here, we examine brain activity with fMRI during the retrieval of spatial information in K.C. and in healthy controls using landmark and route stimuli from a premorbidly familiar neighborhood that K.C. can navigate normally. In all participants, activity was found in the parahippocampal cortex, but not in the hippocampus itself, during all navigational tasks on which K.C. performs well, even though part of his hippocampus remains viable. The opposite pattern was observed on a house recognition task, which is inconsequential to navigation, and on which K.C. performed poorly. On that task, K.C. recruited the right hippocampus presumably because even “familiar” houses were treated as novel by him, whereas controls recruited occipitotemporal cortex, including parahippocampal cortex. The distinction between recent and remote memory, therefore, may apply as much to spatial theories of hippocampal function as it does to theories emphasizing the role of the hippocampus in other types of explicit memory. © 2007 Wiley‐Liss, Inc.

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  • L.G.'s knowledge of the routes and of the locations of landmarks along them were intact; he needed only to be reminded of the goal for the representation to be expressed appropriately during navigation.

    “L.G.'s knowledge of the routes and of the locations of landmarks along them were intact; he needed only to be reminded of the goal for the representation to be expressed appropriately during navigation.”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [199]

  • The difficulty that an individual with vmPFC damage (L.G.) had in navigating in a familiar environment was found to relate to L.G.'s inability to maintain a goal in mind, rather than to a loss of schema representations per se.

    “In one such study, the difficulty that an individual with vmPFC damage, who was known as L.G., had in navigating in a familiar environment was found to relate to L.G.'s inability to maintain a goal in mind, rather than to a loss of schema representations per se 199 .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [199]

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Authors
Rosenbaum, R. S., Winocur, G., Grady, C. L., Ziegler, M., & Moscovitch, M.
Affiliations
  • York University (CA)
  • University of Toronto (CA)
Corresponding author
Rosenbaum, R. Shayna
ORCID
Venue
Hippocampus
Publisher
Wiley
Published
2007-09-12
Volume
17
Issue
12
Pages
1241-1251
ISSN
  • 1050-9631 (ISSN-L)
  • 1098-1063
DOI
10.1002/hipo.20354
OpenAlex
W2117996827
Cited by
58
References
63
Citations by year
2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 6 · 2014: 4 · 2013: 3 · 2012: 7
FWCI
2.50
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Hippocampus (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
hippocampal lesions, parahippocampal cortex, spatial navigation, allocentric spatial representation, hippocampal function, hippocampal sparing, occipitotemporal cortex
MeSH terms
Adult, Anomia, Brain Mapping, Environment, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen, Recognition, Psychology

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