The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy

MicroRNAs: Target Recognition and Regulatory Functions

Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948

Most mammalian mRNAs are conserved targets of microRNAs

Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462

Circulating microRNAs as stable blood-based markers for cancer detection

Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323

Oncomirs—MicroRNAs with a role in cancer

Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884

Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy

Jain, R. K. (2005) · Science · doi:10.1126/science.1104819 · Cited by 5,527 · cited 1×

The nuclear RNase III Drosha initiates microRNA processing

Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O., Kim, S., et al. (2003) · Nature · doi:10.1038/nature01957 · Cited by 5,114

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111

Identification of Novel Genes Coding for Small Expressed RNAs

Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956

A Perspective on Cancer Cell Metastasis

Chaffer, C. L., & Weinberg, R. A. (2011) · Science · doi:10.1126/science.1203543 · Cited by 4,807

The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited

Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686 · cited 1×

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., et al. (2008) · Cell Research · doi:10.1038/cr.2008.282 · Cited by 4,560

MicroRNA genes are transcribed by RNA polymerase II

Lee, Y., Kim, M., Han, J., Yeom, K., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,373

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew-Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,863

The impact of microRNAs on protein output

Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592

Widespread changes in protein synthesis induced by microRNAs

Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429 · cited 1×

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

Lau, N. C., Lim, L. P., Weinstein, E. G., & Bartel, D. P. (2001) · Science · doi:10.1126/science.1065062 · Cited by 3,345

An Extensive Class of Small RNAs in Caenorhabditis elegans

Lee, R. C., & Ambros, V. (2001) · Science · doi:10.1126/science.1065329 · Cited by 2,922

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

Hutvágner, G., McLachlan, J., Pasquinelli, A. E., Bálint, E., Tuschl, T., & Zamore, P. D. (2001) · Science · doi:10.1126/science.1062961 · Cited by 2,781

Principles of MicroRNA–Target Recognition

Brennecke, J., Stark, A., Russell, R. B., & Cohen, S. M. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030085 · Cited by 2,378

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

Park, S.-M., Gaur, A. B., Lengyel, E., & Peter, M. E. (2008) · Genes & Development · doi:10.1101/gad.1640608 · Cited by 2,272

The Drosha-DGCR8 complex in primary microRNA processing

Han, J., Lee, Y., Yeom, K.-H., Kim, Y.-K., Jin, H., & Kim, V. N. (2004) · Genes & Development · doi:10.1101/gad.1262504 · Cited by 2,220

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

Grishok, A., Pasquinelli, A. E., Conte, D., Li, N., Parrish, S., Ha, I., Baillie, D. L., Fire, A., Ruvkun, G., & Mello, C. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00431-7 · Cited by 1,908

Apoptosis in cancer

Lowe, S. W., & Lin, A. W. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.485 · Cited by 1,876

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

CAI, X., HAGEDORN, C. H., & CULLEN, B. R. (2004) · RNA · doi:10.1261/rna.7135204 · Cited by 1,872

MicroRNAs in Cancer

Garzon, R., Calin, G. A., & Croce, C. M. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.59.053006.104707 · Cited by 1,770

Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma

Lawrie, C. H., Gal, S., Dunlop, H. M., Pushkaran, B., Liggins, A. P., Pulford, K., Banham, A. H., Pezzella, F., Boultwood, J., Wainscoat, J. S., et al. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07077.x · Cited by 1,735

A reciprocal repression between ZEB1 and members of the miR‐200 family promotes EMT and invasion in cancer cells

Burk, U., Schubert, J., Wellner, U., Schmalhofer, O., Vincan, E., Spaderna, S., & Brabletz, T. (2008) · EMBO reports · doi:10.1038/embor.2008.74 · Cited by 1,722

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

Carmeliet, P., & Jain, R. K. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3455 · Cited by 1,675

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2

Korpal, M., Lee, E. S., Hu, G., & Kang, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800074200 · Cited by 1,645

Reduced accumulation of specific microRNAs in colorectal neoplasia.

Michael, M., Connor, S. M. O., Pellekaan, N. V. H., Young, G. P., & James, R. J. (2003) · PubMed · Cited by 1,581

The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion

Comijn, J., Berx, G., Vermassen, P., Verschueren, K., van Grunsven, L., Bruyneel, E., Mareel, M., Huylebroeck, D., & van Roy, F. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00260-x · Cited by 1,394

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

Shimono, Y., Zabala, M., Cho, R. W., Lobo, N., Dalerba, P., Qian, D., Diehn, M., Liu, H., Panula, S. P., Chiao, E., et al. (2009) · Cell · doi:10.1016/j.cell.2009.07.011 · Cited by 1,213

Repression of protein synthesis by miRNAs: how many mechanisms?

Pillai, R. S., Bhattacharyya, S. N., & Filipowicz, W. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.12.007 · Cited by 1,108

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

Bracken, C. P., Gregory, P. A., Kolesnikoff, N., Bert, A. G., Wang, J., Shannon, M. F., & Goodall, G. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1942 · Cited by 1,060

Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

Wyckoff, J. B., Wang, Y., Lin, E. Y., Li, J.-F., Goswami, S., Stanley, E. R., Segall, J. E., Pollard, J. W., & Condeelis, J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1823 · Cited by 1,053

Involvement of Human Micro-RNA in Growth and Response to Chemotherapy in Human Cholangiocarcinoma Cell Lines

Meng, F., Henson, R., Lang, M., Wehbe, H., Maheshwari, S., Mendell, J. T., Jiang, J., Schmittgen, T. D., & Patel, T. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.02.057 · Cited by 984

Detection and Characterization of Placental MicroRNAs in Maternal Plasma

Chim, S. S. C., Shing, T. K. F., Hung, E. C. W., Leung, T.-Y., Lau, T.-K., Chiu, R. W. K., & Dennis Lo, Y. M. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.097972 · Cited by 850

Salivary microRNA: Discovery, Characterization, and Clinical Utility for Oral Cancer Detection

Park, N. J., Zhou, H., Elashoff, D., Henson, B. S., Kastratovic, D. A., Abemayor, E., & Wong, D. T. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0736 · Cited by 843

DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells

Eger, A., Aigner, K., Sonderegger, S., Dampier, B., Oehler, S., Schreiber, M., Berx, G., Cano, A., Beug, H., & Foisner, R. (2005) · Oncogene · doi:10.1038/sj.onc.1208429 · Cited by 808

Clustering and conservation patterns of human microRNAs

Altuvia, Y. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki567 · Cited by 802

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

Chang, C.-J., Chao, C.-H., Xia, W., Yang, J.-Y., Xiong, Y., Li, C.-W., Yu, W.-H., Rehman, S. K., Hsu, J. L., Lee, H.-H., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2173 · Cited by 745

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

Korpal, M., Ell, B. J., Buffa, F. M., Ibrahim, T., Blanco, M. A., Celià-Terrassa, T., Mercatali, L., Khan, Z., Goodarzi, H., Hua, Y., et al. (2011) · Nature Medicine · doi:10.1038/nm.2401 · Cited by 636

Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin

Kovalchuk, O., Filkowski, J., Meservy, J., Ilnytskyy, Y., Tryndyak, V. P., Chekhun, V. F., & Pogribny, I. P. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0021 · Cited by 635

MicroRNAs, SNPs and Cancer

Vitale, A. V., Tan, H., & Jin, P. (2011) · Journal of Nucleic Acids Investigation · doi:10.4081/jnai.2011.2236 · Cited by 623

The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity

Aigner, K., Dampier, B., Descovich, L., Mikula, M., Sultan, A., Schreiber, M., Mikulits, W., Brabletz, T., Strand, D., Obrist, P., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210508 · Cited by 617

Circulating miRNAs are correlated with tumor progression in prostate cancer

Brase, J. C., Johannes, M., Schlomm, T., Fälth, M., Haese, A., Steuber, T., Beissbarth, T., Kuner, R., & Sültmann, H. (2011) · International Journal of Cancer · doi:10.1002/ijc.25376 · Cited by 587

Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression

Zhao, C. Q., Young, M. R., Diwan, B. A., Coogan, T. P., & Waalkes, M. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10907 · Cited by 559

The Role of ABC Transporters in Drug Resistance, Metabolism and Toxicity

Glavinas, H., Krajcsi, P., Cserepes, J., & Sarkadi, B. (2004) · Current Drug Delivery · doi:10.2174/1567201043480036 · Cited by 558

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

Kim, T., Veronese, A., Pichiorri, F., Lee, T. J., Jeon, Y.-J., Volinia, S., Pineau, P., Marchio, A., Palatini, J., Suh, S.-S., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110235 · Cited by 514

Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression

Gibbons, D. L., Lin, W., Creighton, C. J., Rizvi, Z. H., Gregory, P. A., Goodall, G. J., Thilaganathan, N., Du, L., Zhang, Y., Pertsemlidis, A., et al. (2009) · Genes & Development · doi:10.1101/gad.1820209 · Cited by 512

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

Eichhorn, S. W., Guo, H., McGeary, S. E., Rodriguez-Mias, R. A., Shin, C., Baek, D., Hsu, S.-H., Ghoshal, K., Villén, J., & Bartel, D. P. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.028 · Cited by 503

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

Mateescu, B., Batista, L., Cardon, M., Gruosso, T., de Feraudy, Y., Mariani, O., Nicolas, A., Meyniel, J.-P., Cottu, P., Sastre-Garau, X., et al. (2011) · Nature Medicine · doi:10.1038/nm.2512 · Cited by 502

miR-200–containing extracellular vesicles promote breast cancer cell metastasis

Le, M. T. N., Hamar, P., Guo, C., Basar, E., Perdigão-Henriques, R., Balaj, L., & Lieberman, J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75695 · Cited by 449

Circulating Plasma MiR-141 Is a Novel Biomarker for Metastatic Colon Cancer and Predicts Poor Prognosis

Cheng, H., Zhang, L., Cogdell, D. E., Zheng, H., Schetter, A. J., Nykter, M., Harris, C. C., Chen, K., Hamilton, S. R., & Zhang, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017745 · Cited by 430

miR-200 Expression Regulates Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Reverses Resistance to Epidermal Growth Factor Receptor Therapy

Adam, L., Zhong, M., Choi, W., Qi, W., Nicoloso, M., Arora, A., Calin, G., Wang, H., Siefker-Radtke, A., McConkey, D., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2245 · Cited by 412

Tumour angiogenesis regulation by the miR-200 family

Pecot, C. V., Rupaimoole, R., Yang, D., Akbani, R., Ivan, C., Lu, C., Wu, S., Han, H.-D., Shah, M. Y., Rodriguez-Aguayo, C., et al. (2013) · Nature Communications · doi:10.1038/ncomms3427 · Cited by 402

Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

Iliopoulos, D., Lindahl-Allen, M., Polytarchou, C., Hirsch, H. A., Tsichlis, P. N., & Struhl, K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.013 · Cited by 399

The ZEB1/miR‐200 feedback loop controls Notch signalling in cancer cells

Brabletz, S., Bajdak, K., Meidhof, S., Burk, U., Niedermann, G., Firat, E., Wellner, U., Dimmler, A., Faller, G., Schubert, J., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.349 · Cited by 369

Clinical Applications for microRNAs in Cancer

Nana-Sinkam, S. P., & Croce, C. M. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.192 · Cited by 352

MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types

Hummel, R., Hussey, D. J., & Haier, J. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2009.10.027 · Cited by 344

Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin

Pogribny, I. P., Filkowski, J. N., Tryndyak, V. P., Golubov, A., Shpyleva, S. I., & Kovalchuk, O. (2010) · International Journal of Cancer · doi:10.1002/ijc.25191 · Cited by 334

MicroRNA-200b Regulates Vascular Endothelial Growth Factor–Mediated Alterations in Diabetic Retinopathy

McArthur, K., Feng, B., Wu, Y., Chen, S., & Chakrabarti, S. (2011) · Diabetes · doi:10.2337/db10-1557 · Cited by 329

miR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases

Dykxhoorn, D. M., Wu, Y., Xie, H., Yu, F., Lal, A., Petrocca, F., Martinvalet, D., Song, E., Lim, B., & Lieberman, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007181 · Cited by 324

MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents

Cochrane, D. R., Spoelstra, N. S., Howe, E. N., Nordeen, S. K., & Richer, J. K. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-1046 · Cited by 320

miR-200a Regulates Nrf2 Activation by Targeting Keap1 mRNA in Breast Cancer Cells

Eades, G., Yang, M., Yao, Y., Zhang, Y., & Zhou, Q. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.275495 · Cited by 305

EMT and Stem Cell–Like Properties Associated with miR-205 and miR-200 Epigenetic Silencing Are Early Manifestations during Carcinogen-Induced Transformation of Human Lung Epithelial Cells

Tellez, C. S., Juri, D. E., Do, K., Bernauer, A. M., Thomas, C. L., Damiani, L. A., Tessema, M., Leng, S., & Belinsky, S. A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3035 · Cited by 277

A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer

Hu, X., Macdonald, D. M., Huettner, P. C., Feng, Z., El Naqa, I. M., Schwarz, J. K., Mutch, D. G., Grigsby, P. W., Powell, S. N., & Wang, X. (2009) · Gynecologic Oncology · doi:10.1016/j.ygyno.2009.05.022 · Cited by 275

Downregulated MicroRNA-200a in Meningiomas Promotes Tumor Growth by Reducing E-Cadherin and Activating the Wnt/β-Catenin Signaling Pathway

Saydam, O., Shen, Y., Würdinger, T., Senol, O., Boke, E., James, M. F., Tannous, B. A., Stemmer-Rachamimov, A. O., Yi, M., Stephens, R. M., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00332-09 · Cited by 255

Targets of miR-200c mediate suppression of cell motility and anoikis resistance

Howe, E. N., Cochrane, D. R., & Richer, J. K. (2011) · Breast Cancer Research · doi:10.1186/bcr2867 · Cited by 249

Circulating miRNAs as Surrogate Markers for Circulating Tumor Cells and Prognostic Markers in Metastatic Breast Cancer

Madhavan, D., Zucknick, M., Wallwiener, M., Cuk, K., Modugno, C., Scharpff, M., Schott, S., Heil, J., Turchinovich, A., Yang, R., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1407 · Cited by 249

miR-24 Regulates Apoptosis by Targeting the Open Reading Frame (ORF) Region of FAF1 in Cancer Cells

Qin, W., Shi, Y., Zhao, B., Yao, C., Jin, L., Ma, J., & Jin, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009429 · Cited by 247

Overexpression of miR-200c Induces Chemoresistance in Esophageal Cancers Mediated Through Activation of the Akt Signaling Pathway

Hamano, R., Miyata, H., Yamasaki, M., Kurokawa, Y., Hara, J., Moon, J. H., Nakajima, K., Takiguchi, S., Fujiwara, Y., Mori, M., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2532 · Cited by 243

miR-200b Targets Ets-1 and Is Down-regulated by Hypoxia to Induce Angiogenic Response of Endothelial Cells

Chan, Y. C., Khanna, S., Roy, S., & Sen, C. K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158790 · Cited by 237

MicroRNA-200c Represses Migration and Invasion of Breast Cancer Cells by Targeting Actin-Regulatory Proteins FHOD1 and PPM1F

Jurmeister, S., Baumann, M., Balwierz, A., Keklikoglou, I., Ward, A., Uhlmann, S., Zhang, J. D., Wiemann, S., & Sahin, Ö. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06212-11 · Cited by 229

Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling

Sonoshita, M., Aoki, M., Fuwa, H., Aoki, K., Hosogi, H., Sakai, Y., Hashida, H., Takabayashi, A., Sasaki, M., Robine, S., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.11.008 · Cited by 209

Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors

Xu, Y., Brenn, T., Brown, E. R. S., Doherty, V, & Melton, D. W. (2012) · British Journal of Cancer · doi:10.1038/bjc.2011.568 · Cited by 202

miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP

Zhu, W., Xu, H., Zhu, D., Zhi, H., Wang, T., Wang, J., Jiang, B., Shu, Y., & Liu, P. (2012) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-011-1752-3 · Cited by 199

miR-200bc/429 cluster targets PLCγ1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer

Uhlmann, S., Zhang, J. D., Schwäger, A., Mannsperger, H., Riazalhosseini, Y., Burmester, S., Ward, A., Korf, U., Wiemann, S., & Sahin, Ö. (2010) · Oncogene · doi:10.1038/onc.2010.201 · Cited by 199

Therapeutic Delivery of miR-200c Enhances Radiosensitivity in Lung Cancer

Cortez, M. A., Valdecanas, D., Zhang, X., Zhan, Y., Bhardwaj, V., Calin, G. A., Komaki, R., Giri, D. K., Quini, C. C., Wolfe, T., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.79 · Cited by 196

miR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion

Xia, H., Ng, S. S., Jiang, S., Cheung, W. K. C., Sze, J., Bian, X.-W., Kung, H.-F., & Lin, M. C. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.093 · Cited by 193

Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem cell-like state

Lim, Y., Wright, J. A., Attema, J. L., Gregory, P. A., Bert, A. G., Smith, E., Thomas, D., Drew, P. A., Khew-Goodall, Y., & Goodall, G. J. (2013) · Journal of Cell Science · doi:10.1242/jcs.122275 · Cited by 191

Diverse Endonucleolytic Cleavage Sites in the Mammalian Transcriptome Depend upon MicroRNAs, Drosha, and Additional Nucleases

Karginov, F. V., Cheloufi, S., Chong, M. M. W., Stark, A., Smith, A. D., & Hannon, G. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.001 · Cited by 186

Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells

Neves, R., Scheel, C., Weinhold, S., Honisch, E., Iwaniuk, K. M., Trompeter, H.-I., Niederacher, D., Wernet, P., Santourlidis, S., & Uhrberg, M. (2010) · BMC Research Notes · doi:10.1186/1756-0500-3-219 · Cited by 178

ZEB1 Enhances Transendothelial Migration and Represses the Epithelial Phenotype of Prostate Cancer Cells

Drake, J. M., Strohbehn, G., Bair, T. B., Moreland, J. G., & Henry, M. D. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-10-1076 · Cited by 177

miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1

Roybal, J. D., Zang, Y., Ahn, Y.-H., Yang, Y., Gibbons, D. L., Baird, B. N., Alvarez, C., Thilaganathan, N., Liu, D. D., Saintigny, P., et al. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0497 · Cited by 174

mir-200c Regulates Induction of Apoptosis through CD95 by Targeting FAP-1

Schickel, R., Park, S.-M., Murmann, A. E., & Peter, M. E. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.018 · Cited by 167

miR-200c Inhibits Melanoma Progression and Drug Resistance through Down-Regulation of Bmi-1

Liu, S., Tetzlaff, M. T., Cui, R., & Xu, X. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.07.009 · Cited by 165

Loss of miR-200c: A Marker of Aggressiveness and Chemoresistance in Female Reproductive Cancers

Cochrane, D. R., Howe, E. N., Spoelstra, N. S., & Richer, J. K. (2010) · Journal of Oncology · doi:10.1155/2010/821717 · Cited by 162

miR-200b and miR-200c as Prognostic Factors and Mediators of Gastric Cancer Cell Progression

Tang, H., Deng, M., Tang, Y., Xie, X., Guo, J., Kong, Y., Ye, F., Su, Q., & Xie, X. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1326 · Cited by 160

MicroRNA-200a Promotes Anoikis Resistance and Metastasis by Targeting YAP1 in Human Breast Cancer

Yu, S.-J., Hu, J.-Y., Kuang, X.-Y., Luo, J.-M., Hou, Y.-F., Di, G.-H., Wu, J., Shen, Z.-Z., Song, H.-Y., & Shao, Z.-M. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1959 · Cited by 159

Diagnostic and prognostic significance of miRNA signatures in tissues and plasma of endometrioid endometrial carcinoma patients

Torres, A., Torres, K., Pesci, A., Ceccaroni, M., Paszkowski, T., Cassandrini, P. A., Zamboni, G., & Maciejewski, R. (2012) · International Journal of Cancer · doi:10.1002/ijc.27840 · Cited by 158

Resistance May Not Be Futile: microRNA Biomarkers for Chemoresistance and Potential Therapeutics

Allen, K. E., & Weiss, G. J. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0397 · Cited by 158

Downregulation of Endothelial MicroRNA-200b Supports Cutaneous Wound Angiogenesis By Desilencing GATA Binding Protein 2 and Vascular Endothelial Growth Factor Receptor 2

Chan, Y. C., Roy, S., Khanna, S., & Sen, C. K. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.112.248583 · Cited by 154

MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor

Williams, K., Renthal, N. E., Condon, J. C., Gerard, R. D., & Mendelson, C. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200650109 · Cited by 153

Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer

Valladares‐Ayerbes, M., Reboredo, M., Villaamil, V. M., Iglesias-Díaz, P., Lorenzo-Patiño, M. J., Haz‐Conde, M., Santamarina, I., Blanco, M., Fernandez-Tajes, J. J., Quindós, M., et al. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-186 · Cited by 153

miR-429 inhibits cells growth and invasion and regulates EMT-related marker genes by targeting Onecut2 in colorectal carcinoma

Sun, Y., Shen, S., Liu, X., Tang, H., Wang, Z., Yu, Z., Li, X., & Wu, M. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1950-x · Cited by 152

Reversal and Prevention of Arsenic-Induced Human Bronchial Epithelial Cell Malignant Transformation by microRNA-200b

Wang, Z., Zhao, Y. M., Smith, E., Goodall, G. J., Drew, P. A., Brabletz, T., & Yang, C. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr029 · Cited by 139

Genome‐wide identification of miR‐200 targets reveals a regulatory network controlling cell invasion

Bracken, C. P., Li, X., Wright, J. A., Lawrence, D., Pillman, K. A., Salmanidis, M., Anderson, M. A., Dredge, B. K., Gregory, P. A., Tsykin, A., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201488641 · Cited by 139

Targets of the Tumor Suppressor miR-200 in Regulation of the Epithelial–Mesenchymal Transition in Cancer

Schliekelman, M. J., Gibbons, D. L., Faça, V. M., Creighton, C. J., Rizvi, Z. H., Zhang, Q. H., Wong, C., Wang, H., Ungewiss, C., Ahn, Y., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0964 · Cited by 138

Inorganic Arsenite-Induced Malignant Transformation of Human Prostate Epithelial Cells

Achanzar, W. E., Brambila, E., Diwan, B. A., Webber, M. M., & Waalkes, M. P. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.24.1888 · Cited by 137

MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways

Li, X., Roslan, S., Johnstone, C. N., Wright, J. A., Bracken, C. P., Anderson, M. A., Bert, A. G., Selth, L. A., Anderson, R. L., Goodall, G. J., et al. (2013) · Oncogene · doi:10.1038/onc.2013.370 · Cited by 127

Restoration of miR-200c to Ovarian Cancer Reduces Tumor Burden and Increases Sensitivity to Paclitaxel

Cittelly, D. M., Dimitrova, I. K., Howe, E. N., Cochrane, D. R., Jean, A., Spoelstra, N. S., Post, M. D., Lu, X. J. D., Broaddus, R. R., Spillman, M. A., et al. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0463 · Cited by 126

miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25

Li, J., Tan, Q., Yan, M., Liu, L., Lin, H., Zhao, F., Bao, G., Kong, H., Ge, C., Zhang, F., et al. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-166 · Cited by 126

The rejuvenated scenario of epithelial–mesenchymal transition (EMT) and cancer metastasis

Meng, F., & Wu, G. (2012) · Cancer and Metastasis Reviews · doi:10.1007/s10555-012-9379-3 · Cited by 124

Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22

Tang, H., Kong, Y., Guo, J., Tang, Y., Xie, X., Yang, L., Su, Q., & Xie, X. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.06.027 · Cited by 123

Regulation of Vascular Endothelial Growth Factor Signaling by miR-200b

Choi, Y.-C., Yoon, S., Jeong, Y., Yoon, J., & Baek, K. (2011) · Molecules and Cells · doi:10.1007/s10059-011-1042-2 · Cited by 122

miR-200b Inhibits Prostate Cancer EMT, Growth and Metastasis

Williams, L. V., Veliceasa, D., Vinokour, E. I., & Volpert, O. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083991 · Cited by 121

miR-200c Sensitizes Breast Cancer Cells to Doxorubicin Treatment by Decreasing TrkB and Bmi1 Expression

Kopp, F. B., Oak, P., Wagner, E., & Roidl, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050469 · Cited by 121

miR-200c Inhibits invasion, migration and proliferation of bladder cancer cells through down-regulation of BMI-1 and E2F3

Liu, L., Qiu, M., Tan, G., Liang, Z., Qin, Y., Chen, L., Chen, H., & Liu, J. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0305-z · Cited by 121

The miR200 Family of MicroRNAs Regulates WAVE3-dependent Cancer Cell Invasion

Sossey‐Alaoui, K., Białkowska, K., & Plow, E. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.034553 · Cited by 116

MicroRNA-200b targets protein kinase Cα and suppresses triple-negative breast cancer metastasis

Humphries, B. A., Wang, Z., Oom, A. L., Fisher, T., Tan, D., Cui, Y., Jiang, Y., & Yang, C. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu133 · Cited by 113

Direct targeting of SUZ12/ROCK2 by miR-200b/c inhibits cholangiocarcinoma tumourigenesis and metastasis

Peng, F., Jiang, J., Yu, Y., Tian, R., Guo, X., Li, X., Shen, M., Xu, M., Zhu, F., Shi, C., et al. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.655 · Cited by 107

MicroRNA-200 Family Modulation in Distinct Breast Cancer Phenotypes

Castilla, M. Á., Díaz‐Martín, J., Sarrió, D., Romero‐Pérez, L., López‐García, M. Á., Vieites, B., Biscuola, M., Ramiro-Fuentes, S., Isacke, C. M., & Palacios, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047709 · Cited by 104

MiR-200c and HuR in ovarian cancer

Prislei, S., Martinelli, E., Mariani, M., Raspaglio, G., Sieber, S. C., Ferrandina, G., Shahabi, S., Scambia, G., & Ferlini, C. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-72 · Cited by 102

Reduced Expression of miR-200 Family Members Contributes to Antiestrogen Resistance in LY2 Human Breast Cancer Cells

Manavalan, T. T., Teng, Y., Litchfield, L. M., Muluhngwi, P., Al-Rayyan, N., & Klinge, C. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062334 · Cited by 100

A Unilateral Negative Feedback Loop Between miR-200 microRNAs and Sox2/E2F3 Controls Neural Progenitor Cell-Cycle Exit and Differentiation

Peng, C., Li, N., Ng, Y.-K., Zhang, J., Meier, F., Theis, F. J., Merkenschlager, M., Chen, W., Wurst, W., & Prakash, N. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2124-12.2012 · Cited by 100

MicroRNAs Regulate Renal Tubule Maturation through Modulation of Pkd1

Patel, V., Hajarnis, S. S., Williams, D., Hunter, R. W., Huynh, D., & Igarashi, P. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012030321 · Cited by 99

MiR-200c Increases the Radiosensitivity of Non-Small-Cell Lung Cancer Cell Line A549 by Targeting VEGF-VEGFR2 Pathway

Shi, L., Zhang, S., Wu, H., Zhang, L., Dai, X., Hu, J., Xue, J. F., Liu, T., Liang, Y., & Wu, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078344 · Cited by 98

Regulation of Colorectal Carcinoma Stemness, Growth, and Metastasis by an miR-200c -Sox2–Negative Feedback Loop Mechanism

Lu, Y., Li, Y., Xue, X., Zhou, M., Liu, Y., Zhang, C., Li, J., Zheng, L., Hong, M., & Li, X. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2348 · Cited by 96

Global analysis of the mammalian RNA degradome reveals widespread miRNA-dependent and miRNA-independent endonucleolytic cleavage

Bracken, C. P., Szubert, J. M., Mercer, T. R., Dinger, M. E., Thomson, D. W., Mattick, J. S., Michael, M., & Goodall, G. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr110 · Cited by 91

miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5

Chuang, T., Panda, H., Luo, X., & Chegini, N. (2012) · Endocrine Related Cancer · doi:10.1530/erc-12-0007 · Cited by 89

Endometrial miR-200c is Altered During Transformation into Cancerous States and Targets the Expression of ZEBs, VEGFA, FLT1, IKKβ, KLF9, and FBLN5

Panda, H., Pelakh, L., Chuang, T., Luo, X., Bükülmez, O., & Chegini, N. (2012) · Reproductive Sciences · doi:10.1177/1933719112438448 · Cited by 88

miR-200c Targets a NF-κB Up-Regulated TrkB/NTF3 Autocrine Signaling Loop to Enhance Anoikis Sensitivity in Triple Negative Breast Cancer

Howe, E. N., Cochrane, D. R., Cittelly, D. M., & Richer, J. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049987 · Cited by 87

Prolyl Isomerase Pin1 Acts Downstream of miR200c to Promote Cancer Stem–like Cell Traits in Breast Cancer

Luo, M.-L., Gong, C., Chen, C.-H., Lee, D. Y., Hu, H., Huang, P., Yao, Y., Guo, W., Reinhardt, F., Wulf, G. M., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2785 · Cited by 86

miR-200b as a prognostic factor in breast cancer targets multiple members of RAB family

Feng, Y., Tang, H., Liu, Q., Xie, X., Wu, M., Liu, X., Chen, B., & Xie, X. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-17 · Cited by 78

Downregulation of miR-200a Induces EMT Phenotypes and CSC-like Signatures through Targeting the β-catenin Pathway in Hepatic Oval Cells

Liu, J., Ruan, B., You, N., Huang, Q., Liu, W., Dang, Z., Xu, W., Zhou, T., Ji, R., Cao, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079409 · Cited by 74

miR-200c Regulates IL8 Expression by Targeting IKBKB: A Potential Mediator of Inflammation in Leiomyoma Pathogenesis

Chuang, T., & Khorram, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095370 · Cited by 72

MicroRNA-200b Suppresses Arsenic-transformed Cell Migration by Targeting Protein Kinase Cα and Wnt5b-Protein Kinase Cα Positive Feedback Loop and Inhibiting Rac1 Activation

Wang, Z., Humphries, B. A., Xiao, H., Jiang, Y., & Yang, C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.554246 · Cited by 70

Understanding principles of miRNA target recognition and function through integrated biological and bioinformatics approaches

Carroll, A. P., Goodall, G. J., & Liu, B. (2014) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1217 · Cited by 70

Akt Activation Is Responsible for Enhanced Migratory and Invasive Behavior of Arsenic-Transformed Human Bronchial Epithelial Cells

Wang, Z., Yang, J., Fisher, T., Xiao, H., Jiang, Y., & Yang, C. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1104061 · Cited by 69

MicroRNA signature in massive macronodular adrenocortical disease and implications for adrenocortical tumourigenesis

Bimpaki, E. I., Iliopoulos, D., Moraitis, A. G., & Stratakis, C. A. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03725.x · Cited by 64

Specificity Protein 1 (Sp1) Maintains Basal Epithelial Expression of the miR-200 Family

Kolesnikoff, N., Attema, J. L., Roslan, S., Bert, A. G., Schwarz, Q., Gregory, P. A., & Goodall, G. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.529172 · Cited by 62

miR-200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin-2

Zhang, H., Zhang, K., Liao, L., Li, L., Du, Z., Wu, B., Wu, J., Xu, X., Zeng, F., Chen, B., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt320 · Cited by 61

Biochemical relapse following radical prostatectomy and miR‐200a levels in prostate cancer

Barron, N., Keenan, J., Gammell, P., Martínez, V. G., Freeman, A., Masters, J. R., & CLYNES, M. M. (2011) · The Prostate · doi:10.1002/pros.22469 · Cited by 56

miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation

Huang, H.-N., Chen, S.-Y., Hwang, S., Yu, C.-C., Su, M., Mai, W., Wang, H., Cheng, W., Schuyler, S. C., Ma, N. J.-L., et al. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.11.009 · Cited by 56

Regulation of the MicroRNA 200b (miRNA-200b) by Transcriptional Regulators PEA3 and ELK-1 Protein Affects Expression of Pin1 Protein to Control Anoikis

Zhang, X., Zhang, B., Gao, J., Wang, X., & Liu, Z. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.478016 · Cited by 55

miR-200b targets GATA-4 during cell growth and differentiation

Yao, C.-X., Wei, Q.-X., Zhang, Y., Wang, W.-P., Xue, L., Yang, F., Zhang, S., Xiong, C.-J., Li, W., Wei, Z., et al. (2013) · RNA Biology · doi:10.4161/rna.24370 · Cited by 51

Epithelial to mesenchymal transition in arsenic-transformed cells promotes angiogenesis through activating β-catenin–vascular endothelial growth factor pathway

Wang, Z., Humphries, B. A., Xiao, H., Jiang, Y., & Yang, C. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.04.018 · Cited by 42

SUZ12 Depletion Suppresses the Proliferation of Gastric Cancer Cells

Cui, Y., Chen, J., He, Z., & Xiao, Y. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350095 · Cited by 40

MicroRNA-200c Inhibits Apoptosis in Pituitary Adenoma Cells by Targeting the PTEN/Akt Signaling Pathway

Liao, C., Chen, W., Fan, X., Jiang, X., Qiu, L., Chen, C., Zhu, Y., & Wang, H. (2014) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504013x13832473329999 · Cited by 38

Autoregulatory feedback loop of EZH2/miR-200c/E2F3 as a driving force for prostate cancer development

Tao, T., Liu, D., Liu, C., Xu, B., Chen, S., Yin, Y., Ang, L., Huang, Y., Zhang, X., & Chen, M. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.07.001 · Cited by 30

MiR-200c Regulates Noxa Expression and Sensitivity to Proteasomal Inhibitors

Lerner, M., Haneklaus, M., Harada, M., & Grandér, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036490 · Cited by 30

Snail Promotes the Cell-Autonomous Generation of Flk1 + Endothelial Cells Through the Repression of the microRNA-200 Family

Gill, J. G., Langer, E. M., Lindsley, R. C., Cai, M., Murphy, T. L., & MURPHY, K. M. M. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0194 · Cited by 27

MiR-200a is involved in proliferation and apoptosis in the human endometrial adenocarcinoma cell line HEC-1B by targeting the tumor suppressor PTEN

Li, R., He, J., Chen, X.-M., Long, C., Yang, D.-H., Ding, Y., Qi, H., & Liu, X. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3045-5 · Cited by 16

Circular RNA: a new star of noncoding RNAs

Qu, S., Yang, X., Li, X., Wang, J., Gao, Y., Shang, R., Sun, W., Dou, K., & Li, H. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.06.003 · Cited by 1,808

Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells

Vafadar, A., Shabaninejad, Z., Movahedpour, A., Fallahi, F., Taghavipour, M., Ghasemi, Y., Akbari, M., Shafiee, A., Hajighadimi, S., Moradizarmehri, S., et al. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00397-0 · Cited by 296

Circular RNAs: a new frontier in the study of human diseases

Chen, Y., Li, C., Tan, C., & Liu, X. (2016) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2016-103758 · Cited by 293

The Endometriotic Tumor Microenvironment in Ovarian Cancer

Wendel, J. R. H., Wang, X., & Hawkins, S. M. (2018) · Cancers · doi:10.3390/cancers10080261 · Cited by 51