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Design Challenges in Polymeric Scaffolds for Tissue Engineering
Open accessAbstract
Numerous surgical procedures are daily performed worldwide to replace and repair damaged tissue. Tissue engineering is the field devoted to the regeneration of damaged tissue through the incorporation of cells in biocompatible and biodegradable porous constructs, known as scaffolds. The scaffolds act as host biomaterials of the incubating cells, guiding their attachment, growth, differentiation, proliferation, phenotype, and migration for the development of new tissue. Furthermore, cellular behavior and fate are bound to the biodegradation of the scaffold during tissue generation. This article provides a critical appraisal of how key biomaterial scaffold parameters, such as structure architecture, biochemistry, mechanical behavior, and biodegradability, impart the needed morphological, structural, and biochemical cues for eliciting cell behavior in various tissue engineering applications. Particular emphasis is given on specific scaffold attributes pertaining to skin and brain tissue generation, where further progress is needed (skin) or the research is at a relatively primitive stage (brain), and the enumeration of some of the most important challenges regarding scaffold constructs for tissue engineering.
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“This can be related to the fact that fabricated materials were mainly developed as biologically inert, so they would not have provoked any reaction from the recipient’s side [199].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [199]
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“Although many scaffolds have been successfully applied in vivo or utilized in clinical medicine to restore damaged tissues, adverse effects such as extensive inflammatory response leading to transplant rejection were often observed.”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [199]
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“Furthermore, the synthetic material’s prolonged presence causes an inflammatory response mediated by phagocytes and foreign body giant cells.”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [199]
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“By-effects of this phenomenon include fibrous encapsulation of the implanted scaffold [199].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [199]
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“The implantation site, as well as the procedure of scaffold implantation itself, affect the recruitment and composition of adjacent cell populations.”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [199]
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- 2020, Tissue Engineering Market Size, Share & Trends Analysis Report by Application (Cord Blood & Cell Banking, Cancer, GI & Gynecology, Dental, Orthopedics, Musculoskeletal, & Spine), by Region, and Segment Forecasts, 2020-2027
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Metadata
- Authors
- Echeverria Molina, M. I., Malollari, K. G., & Komvopoulos, K.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Komvopoulos, Kyriakos
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2021-06-14
- Volume
- 9
- Pages
- 617141-617141
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC8236583
- OpenAlex
- W3171498185
- Cited by
- 397
- References
- 318
- Citations by year
- 2026: 103 · 2025: 124 · 2024: 89 · 2023: 49 · 2022: 30 · 2021: 2
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Keywords
- polymer scaffolds, tissue engineering, biodegradable biomaterials, scaffold design, biodegradation, cell behavior, scaffold architecture, mechanical properties, skin regeneration, brain tissue regeneration
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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