Effect of Engagement With Digital Interventions on Mental Health Outcomes: A Systematic Review and Meta-Analysis
Open accessAbstract
Digital mental health interventions (DMHIs) present a promising way to address gaps in mental health service provision. However, the relationship between user engagement and outcomes in the context of these interventions has not been established. This study addressed the current state of evidence on the relationship between engagement with DMHIs and mental health outcomes. MEDLINE, PsycINFO, and EmBASE databases were searched from inception to August 1, 2021. Original or secondary analyses of randomized controlled trials (RCTs) were included if they examined the relationship between DMHI engagement and post-intervention outcome(s). Thirty-five studies were eligible for inclusion in the narrative review and 25 studies had sufficient data for meta-analysis. Random-effects meta-analyses indicated that greater engagement was significantly associated with post-intervention mental health improvements, regardless of whether this relationship was explored using correlational [ r = 0.24, 95% CI (0.17, 0.32), Z = 6.29, p < 0.001] or between-groups designs [Hedges' g = 0.40, 95% CI (0.097, 0.705), p = 0.010]. This association was also consistent regardless of intervention type (unguided/guided), diagnostic status, or mental health condition targeted. This is the first review providing empirical evidence that engagement with DMHIs is associated with therapeutic gains. Implications and future directions are discussed. Systematic Review Registration: PROSPERO, identifier: CRD 42020184706.
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Written from the paper’s full text.
TL;DR
This systematic review and meta-analysis found that greater engagement with digital mental health interventions was modestly but significantly associated with post-intervention mental health improvements. It is reported as the first meta-analytic evidence quantifying this engagement–outcome relationship across randomized controlled trial analyses.
Key findings
- In the main correlational meta-analysis, greater engagement was associated with better post-intervention mental health outcomes: 20 studies, N = 1,808, r = 0.25, 95% CI (0.17, 0.32), Z = 6.29, p < 0.001; the abstract reports r = 0.24 for this association.
- In between-groups designs, higher content access was associated with moderate improvements: 5 studies, Hedges’ g = 0.40, SE = 0.16, 95% CI (0.097, 0.705), Z = 2.59, p = 0.010.
- Subgroup meta-analyses found significant positive associations for unguided interventions (r = 0.23), guided interventions (r = 0.30), self-report symptom screening (r = 0.24), diagnosed samples (r = 0.28), anxiety outcomes (r = 0.33), and depressive outcomes (r = 0.33).
- Narrative synthesis of 35 studies was mixed: 14 studies (40%) reported a significant positive association, 5 (17.1%) reported mixed findings, and 16 (45.7%) found no significant association.
Methods
- Systematic search of MEDLINE, PsycINFO, and EmBASE from inception to August 1, 2021; eligible studies were original or secondary analyses of RCTs of digital mental health interventions that quantitatively examined engagement and post-intervention mental health outcomes.
- Thirty-five studies were included in the narrative review; 25 had sufficient data for meta-analysis. Engagement was defined as objective intervention use, with number of modules/activities/sessions completed used as the primary engagement measure.
- Random-effects meta-analyses were conducted separately for correlational and between-groups designs, with planned subgroup analyses by guided/unguided intervention, diagnostic status, and anxiety/depression target; heterogeneity was assessed with I², publication bias with funnel plots and Egger’s test, and risk of bias with Cochrane RoB 2.
Limitations
- The authors state that included studies differed in target population, digital intervention, and mental health condition, preventing specific analyses of a particular engagement measure on a particular outcome.
- The authors state that studies used different statistical approaches, so repeated-measures and between-subject designs had to be analyzed separately; Pearson’s r also had to be estimated for some correlational studies.
- The authors note that bivariate correlations do not account for other variables that may influence the engagement–outcome association; the text also makes evident risk-of-bias concerns, including selective reporting in 28 studies (80.0%), outcome measurement bias in 19 studies (54.3%), and lack of participant blinding in 16 studies (45.7%).
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Integrity signals
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Cites
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Claims the paper makes
0 of 27 cited sources checked · 0 supported · 0 flagged
- Findingown data
Among 14 studies of guided digital interventions, 6 reported a positive association between engagement and mental health outcomes.
“Fourteen studies examined DMHIs that were guided (20, 50–62). Among these studies, six reported a positive association between engagement and mental health outcomes”
Quote in the paperNot a substantial claim - Findingown data
Of 35 included studies, 16 (45.7%) did not find any significant association between engagement and post-intervention mental health outcomes.
“Sixteen studies (45.7%) did not find any significant association between engagement and post-intervention mental health outcomes”
Quote in the paperNot a substantial claim - Findingown data
In 23 studies where participants were not formally diagnosed but screened for symptoms, 11 did not find a significant association between engagement and the primary mental health outcome.
“while the other 11 did not find a significant association”
Quote in the paperNot a substantial claim - Findingown data
The association between greater engagement and post-intervention mental health improvements was consistent regardless of intervention type (unguided/guided), diagnostic status, or mental health condition targeted.
“This association was also consistent regardless of intervention type (unguided/guided), diagnostic status, or mental health condition targeted.”
Quote in the paperSubstantial claim- Rests on an assumption: The included studies' engagement measures and mental health outcomes are sufficiently comparable to pool in meta-analysis.
- Findingown data
In 23 studies where participants were not formally diagnosed but screened for symptoms, 12 reported a positive association between engagement and the primary mental health outcome.
“In the remaining 23 studies, participants were not formally diagnosed with a mental health condition but were screened for symptoms indicative of mental disorders. Of these studies, 12 reported a positive association between engagement and the primary mental health outcome”
Quote in the paperNot a substantial claim
- Findingown data
Greater engagement with digital mental health interventions was significantly associated with post-intervention mental health improvements in correlational-design studies (r = 0.24, 95% CI 0.17-0.32, Z = 6.29, p < 0.001).
“Random-effects meta-analyses indicated that greater engagement was significantly associated with post-intervention mental health improvements, regardless of whether this relationship was explored using correlational [r = 0.24, 95% CI (0.17, 0.32), Z = 6.29, p < 0.001] or between-groups designs [Hedges' g = 0.40, 95% CI (0.097, 0.705), p = 0.010].”
Quote in the paperSubstantial claim- Rests on an assumption: The included studies' engagement measures and mental health outcomes are sufficiently comparable to pool in meta-analysis.
- Rests on an assumption: The association between engagement and mental health outcomes can be interpreted as therapeutic gains from engagement, rather than reverse causation or confounding.
- Findingown data
Greater engagement with digital mental health interventions was significantly associated with post-intervention mental health improvements in between-groups-design studies (Hedges' g = 0.40, 95% CI 0.097-0.705, p = 0.010).
“Random-effects meta-analyses indicated that greater engagement was significantly associated with post-intervention mental health improvements, regardless of whether this relationship was explored using correlational [r = 0.24, 95% CI (0.17, 0.32), Z = 6.29, p < 0.001] or between-groups designs [Hedges' g = 0.40, 95% CI (0.097, 0.705), p = 0.010].”
Quote in the paperSubstantial claim- Rests on an assumption: The included studies' engagement measures and mental health outcomes are sufficiently comparable to pool in meta-analysis.
- Rests on an assumption: The association between engagement and mental health outcomes can be interpreted as therapeutic gains from engagement, rather than reverse causation or confounding.
- Findingown data
In 12 studies where participants' mental health status was confirmed with formal diagnostic instruments, 6 did not find a significant association between engagement and the primary mental health outcome.
“Of these studies, six reported a positive association between engagement and the primary mental health outcome (34, 39, 51, 54, 55, 66) while the other six did not find a significant association”
Quote in the paperNot a substantial claim - Findingown data
In 12 studies where participants' mental health status was confirmed with formal diagnostic instruments, 6 reported a positive association between engagement and the primary mental health outcome.
“Of these studies, six reported a positive association between engagement and the primary mental health outcome (34, 39, 51, 54, 55, 66) while the other six did not find a significant association”
Quote in the paperNot a substantial claim - Findingown data
Among 10 studies investigating anxiety-related symptoms, 5 did not find any significant association between engagement and post-intervention symptoms.
“while five did not find any significant association”
Quote in the paperNot a substantial claim - Findingown data
Of 35 included studies, 14 (40%) reported evidence that greater engagement with digital mental health interventions was associated with statistically significant improvements in mental health symptoms at post-intervention.
“Of the 35 studies, 14 (40%) reported evidence that greater engagement with DMHIs was associated with statistically significant improvements in mental health symptoms at post-intervention”
Quote in the paperSubstantial claim - Findingown data
Among 17 studies of unguided digital interventions, 9 reported a positive association between engagement and mental health outcomes.
“Seventeen studies evaluated digital interventions that were unguided (33–49). Of these, nine reported a positive association between engagement and mental health outcomes”
Quote in the paperNot a substantial claim - Findingown data
Of 35 included studies, 5 (17.1%) reported mixed findings, where improvements in the primary mental health outcome were associated with some, but not all, measures of engagement.
“Five studies (17.1%) reported mixed findings, where improvements in the primary mental health outcome were associated with some, but not all, measures of engagement”
Quote in the paperNot a substantial claim - Findingown data
Among 14 studies of guided digital interventions, 8 did not find a significant association between engagement and mental health outcomes.
“while eight did not find a significant association (20, 53, 56, 58–62).”
Quote in the paperNot a substantial claim - Findingown data
Among 10 studies investigating anxiety-related symptoms, 5 reported a positive association between engagement and post-intervention symptoms.
“Ten studies (20, 34, 38, 51, 53–55, 58, 61, 66) investigated the relationship between engagement and anxiety-related symptoms. Of these, five reported a positive association between engagement and post-intervention symptoms”
Quote in the paperNot a substantial claim - Findingown data
Among 17 studies of unguided digital interventions, 8 did not find a significant association between engagement and mental health outcomes.
“while eight did not find a significant association”
Quote in the paperNot a substantial claim - Findingown data
Removal of Mira et al. (65) had the largest effect influence on the main correlation model, reducing the overall r from 0.25 to 0.21.
“Removal of Mira et al. (65) had the largest effect influence on the model, reducing the overall r from 0.25 to 0.21.”
Quote in the paperNot a substantial claim - Findingown data
Removal of Mira et al. (65) had the largest effect influence on the self-report symptom measure model, reducing the overall r from 0.27 to 0.17.
“Removal of Mira et al. (65) had the largest effect influence on the model, reducing the overall r from 0.27 to 0.17.”
Quote in the paperNot a substantial claim - Findingown data
There was a high level of heterogeneity in the distribution of individual study effect sizes for the depressive symptoms meta-analysis (I2 = 82.2%).
“There was a high level of heterogeneity in the distribution of individual study effect sizes (I2 = 82.2%).”
Quote in the paperNot a substantial claim - Findingown data
Meta-analysis of six studies evaluating guided interventions (N = 423) showed a significant, moderate positive association between engagement and post-intervention mental health outcomes (r = 0.30, 95% CI 0.20-0.38, Z = 6.13, p < 0.001).
“The overall mean pooled correlation for the meta-analysis of six studies evaluating guided interventions (N = 423; Supplementary Figure 4B) showed a significant, moderate positive association between engagement and post-intervention mental health outcomes (r = 0.30, 95% CI [0.20, 0.38], Z = 6.13, p < 0.001).”
Quote in the paperSubstantial claim - Findingown data
Meta-analysis of self-report symptom measures (11 studies, N = 1,056) showed a significant positive association between engagement and post-intervention mental health outcomes (r = 0.24, 95% CI 0.17-0.32, Z = 6.29, p < 0.001).
“The overall mean pooled correlation for the meta-analysis of self-report symptom measures (N = 1,056; Supplementary Figure 4C) showed a significant positive association between engagement and post-intervention mental health outcomes (r = 0.24, 95% CI [0.17, 0.32], Z = 6.29, p < 0.001).”
Quote in the paperSubstantial claim - Findingown data
There was minimal heterogeneity in the distribution of individual study effect sizes for the unguided intervention meta-analysis (I2 = 0.0%).
“There was minimal heterogeneity in the distribution of individual study effect sizes (I2 = 0.0%).”
Quote in the paperNot a substantial claim - Findingown data
Removal of Spence et al. (61) had the largest effect influence on the guided intervention model, reducing the overall r from 0.30 to 0.26.
“Removal of Spence et al. (61) had the largest effect influence on the model, reducing the overall r from 0.30 to 0.26.”
Quote in the paperNot a substantial claim - Findingown data
There was no heterogeneity in the distribution of individual study effect sizes for the guided intervention meta-analysis (I2 = 0.0%).
“There was no heterogeneity in the distribution of individual study effect sizes (I2 = 0.0%).”
Quote in the paperNot a substantial claim - Findingown data
Meta-analysis of five studies with anxiety-related symptoms as the primary outcome (N = 411) showed a significant positive association between engagement and post-intervention mental health outcomes (r = 0.33, 95% CI 0.24-0.41, Z = 6.76, p < 0.001).
“The overall mean pooled correlation for the meta-analysis of 5 studies with anxiety-related symptoms as the primary outcome (N = 411; Supplementary Figure 4E) showed a significant positive association between engagement and post-intervention mental health outcomes (r = 0.33, 95% CI [0.24, 0.41], Z = 6.76, p < 0.001).”
Quote in the paperSubstantial claim - Findingown data
There was a moderate level of heterogeneity in the distribution of individual study effect sizes for the between-group meta-analysis (I2 = 65.8%).
“There was a moderate level of heterogeneity in the distribution of individual study effect sizes (I2 = 65.8%).”
Quote in the paperNot a substantial claim - Findingown data
Removal of Mira et al. (65) had the largest effect on the depressive symptoms model, reducing the overall r from 0.33 to 0.17.
“Removal of Mira et al. (65) had the largest effect on the model, reducing the overall r from 0.33 to 0.17.”
Quote in the paperNot a substantial claim - Findingown data
Meta-analysis of the mean pooled correlation between number of modules completed and change in any mental health outcome (20 studies, N = 1,808) showed a small, significant positive association (r = 0.25, 95% CI 0.17-0.32, Z = 6.29, p < 0.001).
“Meta-analysis of the mean pooled correlation between number of modules completed and change in any mental health outcome (20 studies, N = 1,808 participants; Figure 2) showed a small, significant positive association [r = 0.25, 95% CI (0.17, 0.32), Z = 6.29, p < 0.001].”
Quote in the paperSubstantial claim - Findingown data
Removal of Spence et al. (61) had the largest effect on the anxiety-related symptoms model, reducing the overall r from 0.33 to 0.20.
“Removal of Spence et al. (61) had the largest effect on the model, reducing the overall r from 0.33 to 0.20.”
Quote in the paperNot a substantial claim - Findingown data
Heterogeneity in the distribution of individual study effect sizes for the psychiatric diagnosis meta-analysis was minimal (I2 = 11.6%).
“Heterogeneity in the distribution of individual study effect sizes was minimal (I2 = 11.6%).”
Quote in the paperNot a substantial claim - Findingown data
Removal of Spence et al. (61) had the largest effect influence on the psychiatric diagnosis model, reducing the overall r from 0.28 to 0.26.
“Removal of Spence et al. (61) had the largest effect influence on the model, reducing the overall r from 0.28 to 0.26.”
Quote in the paperNot a substantial claim - Findingown data
Meta-analysis of six studies with participants who fulfilled criteria for a psychiatric diagnosis (N = 530) showed a significant positive association between engagement and post-intervention mental health outcomes (r = 0.28, 95% CI 0.19-0.36, Z = 6.03, p < 0.001).
“The overall mean pooled correlation for the meta-analysis of 6 studies with participants who fulfilled criteria for a psychiatric diagnosis (N = 530; Supplementary Figure 4D) showed a significant positive association between engagement and post-intervention mental health outcomes (r = 0.28, 95% CI [0.19, 0.36], Z = 6.03, p < 0.001).”
Quote in the paperSubstantial claim - Findingown data
35 unique studies were identified that met inclusion criteria.
“Following removal of duplicates and non-eligible studies, 35 unique studies were identified that met inclusion criteria (Figure 1).”
Quote in the paperSubstantial claim - Findingown data
Ten studies could not be included in the meta-analysis because study authors were unable to provide the required data (n = 7) or were uncontactable (n = 3).
“Ten studies could not be included in the meta-analysis because study authors were either unable to provide the data required for effect size calculation (n = 7) or were uncontactable (n = 3).”
Quote in the paperNot a substantial claim - Findingown data
Meta-analysis of nine studies evaluating unguided interventions (N = 674) showed a small, significant positive association between engagement and post-intervention mental health outcomes (r = 0.23, 95% CI 0.16-0.31, Z = 6.07, p < 0.001).
“The overall mean pooled correlation for the meta-analysis of nine studies evaluating unguided interventions (N = 674; Supplementary Figure 4A) showed a small, significant positive association between engagement and post-intervention mental health outcomes (r = 0.23, 95% CI [0.16, 0.31], Z = 6.07, p < 0.001).”
Quote in the paperSubstantial claim - Findingown data
There was a moderate level of heterogeneity in the distribution of individual study effect sizes for the self-report symptom measure meta-analysis (I2 = 70.2%).
“There was a moderate level of heterogeneity in the distribution of individual study effect sizes (I2 = 70.2%).”
Quote in the paperNot a substantial claim - Findingown data
Removal of Forand et al. (40) had the largest effect influence on the unguided intervention model, increasing the overall r from 0.23 to 0.25.
“Removal of Forand et al. (40) had the largest effect influence on the model, increasing the overall r from 0.23 to 0.25.”
Quote in the paperNot a substantial claim - Findingown data
Meta-analysis of six studies with depressive symptoms as the primary outcome (N = 735) showed a significant positive association between engagement and post-intervention mental health outcomes (r = 0.33, 95% CI 0.13-0.50, Z = 3.12, p = 0.002).
“The overall mean pooled correlation for the meta-analysis of 6 studies with depressive symptoms as the primary outcome (N = 735; Supplementary Figure 4F) showed a significant positive association between engagement and post-intervention mental health outcomes (r = 0.33, 95% CI [0.13, 0.50], Z = 3.12, p = 0.002).”
Quote in the paperSubstantial claim - Findingown data
There was a moderate level of heterogeneity in the distribution of individual study effect sizes for the main correlation meta-analysis (I2 = 60.7%).
“There was a moderate level of heterogeneity in the distribution of individual study effect sizes (I2 = 60.7%).”
Quote in the paperNot a substantial claim - Findingown data
Meta-analysis of the effect of engagement on any mental health outcome among studies using between-group comparisons (5 studies) showed that users reporting higher levels of content access had significant, moderate improvements in post-intervention mental health outcomes relative to users with lower levels of engagement (Hedges' g = 0.40, SE = 0.16, 95% CI 0.097-0.705, Z = 2.59, p = 0.010).
“Meta-analysis of the effect of engagement on any mental health outcome among studies that used between-group comparisons (n = 5 studies; Figure 3) showed that users reporting higher levels of content access had significant, moderate improvements in post-intervention mental health outcomes relative to users with lower levels of engagement [Hedges' g = 0.40, SE =0.16, 95% CI (0.097, 0.705), Z = 2.59”
Quote in the paperSubstantial claim - Premisecitation
Two separate meta-analyses were needed because effect sizes of studies using between-group vs. correlational designs cannot be combined.
“Two analyses were needed because effect sizes of studies using between-group vs. correlational designs cannot be combined (26).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [26] Wilson, 2001
Not checked in the free run.
- Study design and conductown data
Participants in 16 studies (45.7%) were not blinded to their assigned intervention.
“Participants in 16 studies (45.7%) were not blinded to their assigned intervention.”
Quote in the paperNot a substantial claim - Interpretationown data
This review is the first to provide empirical evidence that engagement with digital mental health interventions is associated with therapeutic gains.
“This is the first review providing empirical evidence that engagement with DMHIs is associated with therapeutic gains.”
Quote in the paperSubstantial claim- Rests on an assumption: The association between engagement and mental health outcomes can be interpreted as therapeutic gains from engagement, rather than reverse causation or confounding.
- Study design and conductown data
Most studies had sound random sequence generation and allocation concealment processes.
“Most studies had sound random sequence generation and allocation concealment processes”
Quote in the paperNot a substantial claim - Study design and conductown data
Most studies employed analytical techniques to minimize bias in missing post-intervention outcome data.
“employed analytical techniques to minimize bias in missing post-intervention outcome data”
Quote in the paperNot a substantial claim - Study design and conductown data
Most included studies had some level of potential bias on the Cochrane Risk of Bias 2.0 tool.
“Assessment of the methodological quality of studies on the Cochrane Risk of Bias 2.0 tool found most studies to have some level of potential bias”
Quote in the paperNot a substantial claim - Study design and conductown data
It was not possible in this study to quantitatively explore the engagement-outcome relationship using engagement indicators other than module completion because too few included studies reported such data.
“In our study, it was not possible to quantitatively explore this relationship using these latter engagement indicators as too few of the included studies reported on such data.”
Quote in the paperSubstantial claim - Study design and conductown data
Leave-one-out analysis for the depressive symptoms meta-analysis revealed that no single study rendered the random-effects model non-significant.
“The overall mean pooled correlation for the meta-analysis of 6 studies with depressive symptoms as the primary outcome (N = 735; Supplementary Figure 4F) showed a significant positive association between engagement and post-intervention mental health outcomes (r = 0.33, 95% CI [0.13, 0.50], Z = 3.12, p = 0.002). Leave-one-out analysis revealed that no single study rendered the random-effects”
Quote in the paperNot a substantial claim - Premisecitation
Research on the impact of engagement on mental health outcomes has been hindered by the lack of consensus over a suitable engagement measure.
“Given that research on the impact of engagement on mental health outcomes has been hindered by the lack of consensus over a suitable engagement measure (72, 73), we recommend that future studies consider including module completion as the primary engagement measure to facilitate future corroboration of the present findings.”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [72] Perski, 2016, Conceptualising engagement with digital behaviour change interventions: a systematic review using principles from critical interpretive synthesis, Transl Behav Med. source
Not checked in the free run.
- cites [73] Short, 2018, Measuring engagement in eHealth and mHealth behavior change interventions: viewpoint of methodologies, J Med Internet Res. source
Not checked in the free run.
- Study design and conductown data
Examination of the funnel plot revealed no publication bias for the self-report symptom measure meta-analysis, as indicated by the one-tailed p-value (p = 0.08).
“Examination of the funnel plot (Supplementary Figure 5B, p. 6) revealed that there was no publication bias for this analysis, as indicated by the one-tailed p-value (p = 0.08).”
Quote in the paperNot a substantial claim - Study design and conductown data
Leave-one-out analysis for the psychiatric diagnosis meta-analysis revealed that no single study rendered the random-effects model non-significant.
“The overall mean pooled correlation for the meta-analysis of 6 studies with participants who fulfilled criteria for a psychiatric diagnosis (N = 530; Supplementary Figure 4D) showed a significant positive association between engagement and post-intervention mental health outcomes (r = 0.28, 95% CI [0.19, 0.36], Z = 6.03, p < 0.001). Leave-one-out analysis revealed that no single study rendered the”
Quote in the paperNot a substantial claim - Interpretationcitation
The study findings support the view that users' level of engagement with intervention content is likely a key mechanism for predicting the amount of treatment benefit obtained.
“Firstly, they support the view that users' level of engagement with intervention content is likely a key mechanism for predicting the amount of treatment benefit obtained (18), justifying the development of strategies aimed at increasing engagement with digital interventions.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [18] Donkin, 2011, Systematic review of the impact of adherence on the effectiveness of e-therapies, J Med Internet Res. source
Not checked in the free run.
- Premisecitation
Extrapolating research findings from face-to-face therapies to their digital equivalents may not be appropriately comparable because differences in how content is delivered are likely to affect both engagement and associated treatment responses.
“However, extrapolating research findings from face-to-face therapies to their digital equivalents may not be appropriately comparable because differences in how content is delivered (e.g., via developing human relationships) is likely to affect both engagement and associated treatment responses (20).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [20] Stjerneklar, 2019, Guided internet-based cognitive behavioral therapy for adolescent anxiety: predictors of treatment response, Internet Intervent. source
Not checked in the free run.
- Premisecitation
Digital mental health interventions can have significant small-to-moderate effects on alleviating or preventing symptoms of mental health disorders.
“While there is a growing body of evidence supporting that DMHIs can have significant small-to-moderate effects on alleviating or preventing symptoms of mental health disorders (6–10)”
Quote in the paperSubstantial claim0 of 5 sources checked- cites [6] Andrews, 2018, Computer therapy for the anxiety and depression disorders is effective, acceptable and practical health care: an updated meta-analysis, J Anxiety Disord. source
Not checked in the free run.
- cites [7] Deady, 2017, eHealth interventions for the prevention of depression and anxiety in the general population: a systematic review and meta-analysis, BMC Psychiatry. source
Not checked in the free run.
- cites [8] Mason, 2015, Text messaging interventions for adolescent and young adult substance use: a meta-analysis, Prev Sci. source
Not checked in the free run.
- cites [9] Stefanopoulou, 2020, Are digital interventions effective in reducing suicidal ideation and self-harm? A systematic review, J Mental Health. source
Not checked in the free run.
- cites [10] Torok, 2020, Suicide prevention using self-guided digital interventions: a systematic review and meta-analysis of randomised controlled trials, Lancet Digit Health. source
Not checked in the free run.
- Study design and conductown data
Examination of the funnel plot revealed no publication bias for the main correlation meta-analysis, as indicated by the one-tailed p-value (p = 0.11).
“Examination of the funnel plot (Supplementary Figure 5A, p. 6) revealed that there was no publication bias for this analysis, as indicated by the one-tailed p-value (p = 0.11).”
Quote in the paperNot a substantial claim - Premisecitation
External strategies such as automated reminders, therapist-led coaching, and moderated peer-support groups can be effective toward promoting engagement with digital interventions for mental health.
“There is already some promising research being done in this space, with several studies finding that external strategies such as automated reminders (13, 67), therapist-led coaching (68, 69), and moderated peer-support groups (70) can be effective toward promoting engagement with digital interventions for mental health.”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [13] Bidargaddi, 2018, To prompt or not to prompt? A microrandomized trial of time-varying push notifications to increase proximal engagement with a mobile health app, JMIR mHealth uHealth. source
Not checked in the free run.
- cites [67] Bidargaddi, 2018, Predicting which type of push notification content motivates users to engage in a self-monitoring app, Prev Med Rep. source
Not checked in the free run.
- cites [68] Beintner, 2019, Impact of telephone prompts on the adherence to an Internet-based aftercare program for women with bulimia nervosa: a secondary analysis of data from a randomized controlled trial, Internet Interv. source
Not checked in the free run.
- Study design and conductown data
Leave-one-out analysis for the between-group meta-analysis revealed that no single study rendered the random-effects model non-significant.
“Meta-analysis of the effect of engagement on any mental health outcome among studies that used between-group comparisons (n = 5 studies; Figure 3) showed that users reporting higher levels of content access had significant, moderate improvements in post-intervention mental health outcomes relative to users with lower levels of engagement [Hedges' g = 0.40, SE =0.16, 95% CI (0.097, 0.705), Z = 2.59”
Quote in the paperNot a substantial claim - Study design and conductown data
Leave-one-out analysis for the self-report symptom measure meta-analysis revealed that no single study rendered the random-effects model non-significant.
“The overall mean pooled correlation for the meta-analysis of self-report symptom measures (N = 1,056; Supplementary Figure 4C) showed a significant positive association between engagement and post-intervention mental health outcomes (r = 0.24, 95% CI [0.17, 0.32], Z = 6.29, p < 0.001). Leave-one-out analysis revealed that no single study rendered the random-effects model non”
Quote in the paperNot a substantial claim - Study design and conductown data
Leave-one-out analysis for the main correlation meta-analysis revealed that no single study rendered the random-effects model non-significant.
“Meta-analysis of the mean pooled correlation between number of modules completed and change in any mental health outcome (20 studies, N = 1,808 participants; Figure 2) showed a small, significant positive association [r = 0.25, 95% CI (0.17, 0.32), Z = 6.29, p < 0.001]. Leave-one-out analysis revealed that no single study rendered the random-effects model non-significant.”
Quote in the paperNot a substantial claim - Study design and conductown data
Leave-one-out analysis for the anxiety-related symptoms meta-analysis revealed that no single study rendered the random-effects model non-significant.
“The overall mean pooled correlation for the meta-analysis of 5 studies with anxiety-related symptoms as the primary outcome (N = 411; Supplementary Figure 4E) showed a significant positive association between engagement and post-intervention mental health outcomes (r = 0.33, 95% CI [0.24, 0.41], Z = 6.76, p < 0.001). Leave-one-out analysis revealed that no single study rendered the random-effects”
Quote in the paperNot a substantial claim - Premisecitation
Reminders, coaching, and tailored feedback delivered via telephone or email have modest to moderate effects toward increasing engagement with digital interventions targeting physical and mental health outcomes, compared to no strategy.
“Reminders, coaching, and tailored feedback delivered via telephone or email have been found to have modest to moderate effects toward increasing engagement with digital interventions targeting physical and mental health outcomes, compared to if no strategy was used (16).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [16] Alkhaldi, 2016, The effectiveness of prompts to promote engagement with digital interventions: a systematic review, J Med Internet Res. source
Not checked in the free run.
- Study design and conductown data
Leave-one-out analysis for the unguided intervention meta-analysis revealed that no single study rendered the random-effects model non-significant.
“The overall mean pooled correlation for the meta-analysis of nine studies evaluating unguided interventions (N = 674; Supplementary Figure 4A) showed a small, significant positive association between engagement and post-intervention mental health outcomes (r = 0.23, 95% CI [0.16, 0.31], Z = 6.07, p < 0.001). Leave-one-out analysis revealed that no single study rendered the random-effects model non”
Quote in the paperNot a substantial claim - Study design and conductown data
Leave-one-out analysis for the guided intervention meta-analysis revealed that no single study rendered the random-effects model non-significant.
“The overall mean pooled correlation for the meta-analysis of six studies evaluating guided interventions (N = 423; Supplementary Figure 4B) showed a significant, moderate positive association between engagement and post-intervention mental health outcomes (r = 0.30, 95% CI [0.20, 0.38], Z = 6.13, p < 0.001). Leave-one-out analysis revealed that no single study rendered the random-effects model non”
Quote in the paperNot a substantial claim - Premisereasoning
No meta-analyses have yet empirically examined the pooled strength of the association between DMHI engagement and its impacts on mental health outcomes.
“Accordingly, no meta-analyses have yet empirically examined the pooled strength of the association between DMHI engagement and its impacts on mental health outcomes.”
Quote in the paperSubstantial claim- Rests on an assumption: The relationship between user engagement and outcomes in digital mental health interventions has not been established.
- Study design and conductreasoning
Bivariate correlations between engagement and outcomes do not account for the possibility that other variables may influence the association.
“Finally, bivariate correlations between engagement and outcomes do not account for the possibility that other variables may influence this association.”
Quote in the paperSubstantial claim
- May combine two claims. 20
- Classified as probably not a substantial claim. 10
- The quote only partly states this claim. 1
May combine two claims.
Findingown dataAmong 4 studies including both unguided and guided versions, 3 reported a positive association between engagement and mental health outcomes.
“The remaining four studies included participants who used both unguided and guided versions of the same digital intervention (63–66). Of these studies, three reported a positive association between engagement and mental health outcomes”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataAmong 4 studies including both unguided and guided versions, 1 did not find a significant association between engagement and mental health outcomes.
“while one did not find a significant association”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataIn the nine included studies examining psychological distress or psychological recovery, three reported a positive association between engagement and post-intervention symptoms, while six found no significant association.
“Nine studies (35, 36, 42, 44, 46, 50, 52, 59, 64) investigated the relationship between engagement and psychological distress or psychological recovery. Of these, three reported a positive association between engagement and post-intervention symptoms (36, 50, 52) while six did not find any significant association (35, 42, 44, 46, 59, 64).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataOmission of Oromendia et al. (66) had the largest effect reduction in the between-group meta-analysis, increasing the Hedges' g value from 0.40 to 0.25.
“Omission of Oromendia et al. (66) had the largest effect reduction, increasing the Hedges' g value from 0.40 to 0.25.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataIn the nine included studies examining depression-related symptoms, six reported a positive association between engagement and post-intervention symptoms, while three found no significant association.
“Nine studies (33, 38, 40, 48, 49, 57, 58, 63, 65) investigated the relationship between engagement and depression-related symptoms. Of these, six reported a positive association between engagement and post-intervention symptoms (33, 40, 49, 57, 63, 65) while three did not find any significant association (38, 48, 58).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataOf the 25 studies included in the meta-analysis, 20 employed correlational designs to investigate the association between engagement and mental health outcomes, and 5 used between-group mixed model comparisons to identify differences in post-intervention outcomes between users with higher vs. lower levels of engagement.
“Of the 25 studies included in the meta-analysis, 20 studies (20, 33–35, 37, 40, 41, 43, 47, 48, 51, 54–57, 59, 61, 63–65) employed correlational designs to investigate the association between engagement and mental health outcomes. The other five studies (36, 38, 50, 52, 66) used between-group mixed model comparisons to identify any differences in post-intervention outcomes between users who”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown data25 of the 35 included studies were included in the meta-analysis.
“All studies were included in the narrative synthesis, and 25 of the 35 were included in the meta-analysis.”
Quote in the paperNot a substantial claimThe quote only partly states this claim.
Findingown dataThere was no heterogeneity in the distribution of individual study effect sizes for the anxiety-related symptoms meta-analysis (I2 = 0.0%).
“There was no heterogeneity in the distribution of individual study effect sizes (I2 = 0.0%).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThe search strategy achieved 100% sensitivity against the initial test set in MEDLINE.
“This search strategy was tested in MEDLINE, where it achieved 100% sensitivity against the initial test set”
Quote in the paperNot a substantial claim- Rests on an assumption: The search strategy adapted from MEDLINE to other databases retains adequate sensitivity.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataInter-rater consensus was acceptable for full-text screening (κ = 0.80, p < 0.001).
“Inter-rater consensus was acceptable for both title/abstract (κ = 0.86, p < 0.001) and full-text screening (κ = 0.80, p < 0.001).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductcitationThis study is registered with PROSPERO (CRD 42020184706) and adheres to PRISMA reporting guidelines.
“This study is registered with PROSPERO (CRD 42020184706) and adheres to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines (23).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [23] Liberati, 2009, The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration, J Clin Epidemiol. source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataRisk of bias ratings were independently conducted by two pairs of coders, with an overall agreement rate of 93.3%.
“Ratings were independently conducted by two pairs of coders (40% by DZQG and LM, and 60% by DZQG and JH). Discrepancies were resolved through mutual discussion. An overall agreement rate of 93.3% was reached.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductown dataSelective reporting was the largest source of bias, with 28 studies (80.0%) not reporting sufficient information to rule out bias in this domain.
“Selective reporting was identified to be the largest source of bias, with 28 studies (80.0%) not reporting sufficient information—such as a prospectively published trial protocol—to rule out bias in this domain.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataInter-rater consensus was acceptable for title/abstract screening (κ = 0.86, p < 0.001).
“Inter-rater consensus was acceptable for both title/abstract (κ = 0.86, p < 0.001) and full-text screening (κ = 0.80, p < 0.001).”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationOnly one prior systematic review has explored the effect of engagement on the effectiveness of digital interventions, and it was limited to a narrative synthesis due to heterogeneity in how engagement is operationalized.
“To date, only one prior systematic review (18) has explored the effect of engagement on the effectiveness of digital interventions. This review was limited to a narrative synthesis, citing heterogeneity in how engagement is operationalized”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [18] Donkin, 2011, Systematic review of the impact of adherence on the effectiveness of e-therapies, J Med Internet Res. source
Not checked in the free run.
May combine two claims.
Study design and conductown dataRisk of outcome measurement bias was the second most common source of potential bias, with 19 studies (54.3%) reporting that outcome assessors were aware of the intervention received.
“Risk of outcome measurement bias was the second most common source of potential bias, with 19 studies (54.3%) reporting that outcome assessors—usually study participants themselves—were aware of the intervention received by study participants.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitationRisk of bias was assessed using Version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2).
“Risk of bias was assessed using Version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2) (32).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [32] Sterne, 2019, RoB 2: a revised tool for assessing risk of bias in randomised trials, BMJ. source
Not checked in the free run.
May combine two claims.
Interpretationown dataGreater engagement with digital interventions is modestly but significantly associated with improvements in mental health (effect size range: r = 0.23 to Hedges' g = −0.40) regardless of the level of guidance provided, mental health symptom severity of users, or type of mental health condition(s) targeted by the intervention.
“That is, the results unequivocally support that greater engagement with digital interventions is modestly but significantly associated with improvements in mental health (effect size range: r = 0.23 to Hedges' g = −0.40) regardless of the level of guidance provided, mental health symptom severity of users, or type of mental health condition(s) targeted by the intervention.”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductcitationPearson's r had to be estimated for some studies employing correlational designs; this was preferred to omitting studies without this data to maximize objectivity and minimize selection bias.
“Third, Pearson's r had to be estimated for some of the studies which employed correlational designs. While estimating r from other indices may not be ideal, it is preferred to omitting studies without this data so as to maximize objectivity and minimize selection bias (26, 29).”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [26] Wilson, 2001
Not checked in the free run.
- cites [29] Borenstein, 2009, Effect sizes for continuous data
Not checked in the free run.
Probably not a substantial claim: may not pass S2 (checkable).
InterpretationreasoningControlling for factors linked with engagement may be necessary for verifying the robustness of its relationship with outcomes.
“Controlling for factors linked with engagement may be necessary for verifying the robustness of its relationship with outcomes.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductcitationEffect sizes from repeated measures and between-subject designs are not comparable, so data from both types of studies had to be analyzed separately.
“As effect sizes from repeated measures and between-subject designs are not comparable (26), data provided by both types of studies had to be analyzed separately.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [26] Wilson, 2001
Not checked in the free run.
May combine two claims.
Interpretationown dataThe meta-analyses (main and subgroup) consistently supported the a priori hypothesis of a positive engagement-outcome relationship, while the narrative synthesis showed mixed support.
“While the narrative synthesis showed mixed support for a positive engagement—outcome relationship, the meta-analyses (main and subgroup) consistently supported our main a priori hypothesis.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationOver 70% of users fail to complete all treatment modules, and more than 50% disengage before completing half of all treatment modules.
“A review of empirical studies has found collectively low rates of DMHI completion, with over 70% of users failing to complete all treatment modules, and more than 50% disengaging before completing half of all treatment modules (15).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [15] Karyotaki, 2015, Predictors of treatment dropout in self-guided web-based interventions for depression: an “individual patient data” meta-analysis, Psychol Med. source
Not checked in the free run.
Classified as probably not a substantial claim.
PremisecitationApps which incorporated more elements aimed at promoting user engagement had larger effect sizes in a review of efficacy studies of smartphone apps for depression and anxiety.
“a review of efficacy studies of smartphone apps for depression and anxiety found that apps which incorporated more elements aimed at promoting user engagement had larger effect sizes (17).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [17] Wu, 2021, Smartphone apps for depression and anxiety: a systematic review and meta-analysis of techniques to increase engagement, NPJ Digit Med. source
Not checked in the free run.
May combine two claims.
PremisecitationLow engagement is a barrier to both optimal efficacy and adoption of digital mental health interventions into health settings and other translational pathways.
“Low engagement—defined as suboptimal levels of user access and/or adherence to an intervention (12)—is touted as one of the main reasons why the potential benefits of these interventions remain unrealized in the real world (13, 14).”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [12] Torous, 2018, Clinical review of user engagement with mental health smartphone apps: evidence, theory and improvements, Evid Based Mental Health. source
Not checked in the free run.
- cites [13] Bidargaddi, 2018, To prompt or not to prompt? A microrandomized trial of time-varying push notifications to increase proximal engagement with a mobile health app, JMIR mHealth uHealth. source
Not checked in the free run.
- cites [14] Yardley, 2016, Understanding and promoting effective engagement with digital behavior change interventions, Am J Prev Med. source
Not checked in the free run.
May combine two claims.
Study design and conductreasoningThe included studies differed in target population, DMHIs employed, and types of mental health conditions examined, so specific analyses of the effect of a specific measure of engagement on a particular mental health outcome could not be conducted.
“First, the included studies differed in many ways, such as by target population, DMHIs employed, and the types of mental health conditions examined. Thus, specific analyses of the effect of a specific measure of engagement on a particular mental health outcome could not be conducted.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationIn one included study, sessions completed and time spent were correlated with reduced depression scores at post-intervention, but these associations were non-significant after email support was accounted for.
“For example, one of the included studies reported that sessions completed and time spent were correlated with reduced depression scores at post-intervention; however, these associations were non-significant after email support was accounted for (63).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [63] Fuhr, 2018, The association between adherence and outcome in an Internet intervention for depression, J Affect Disord. source
Not checked in the free run.
Probably not a substantial claim: may not pass S2 (checkable).
Interpretationown dataThe present findings suggest that module completion may be one of the more acceptable measures of engagement to evaluate.
“Secondly, our findings suggest that module completion may be one of the more acceptable measures of engagement to evaluate.”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationcitationThe present findings validate the qualitative findings of Donkin et al. (18) that improvements in mental health-related outcomes appeared to be associated with the number of modules accessed, but not with other engagement indicators (e.g., time spent, logins, and online interactions).
“Our findings validate the qualitative findings reported in the systematic review by Donkin and colleagues (18), who reported that improvements in mental health-related outcomes appeared to be associated with the number of modules accessed, but not with other engagement indicators (e.g., time spent, logins, and online interactions).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Donkin and colleagues (18)
Not checked in the free run.
The paper relies on this without support.
The included studies' engagement measures and mental health outcomes are sufficiently comparable to pool in meta-analysis.
“Studies which utilized similar measures of engagement and which employed similar analytical techniques to test the association between engagement and outcome(s) were pooled together for meta-analysis.”
The paper relies on this without support.
The association between engagement and mental health outcomes can be interpreted as therapeutic gains from engagement, rather than reverse causation or confounding.
“This is the first review providing empirical evidence that engagement with DMHIs is associated with therapeutic gains.”
The paper relies on this without support.
The search strategy adapted from MEDLINE to other databases retains adequate sensitivity.
“This search strategy was tested in MEDLINE, where it achieved 100% sensitivity against the initial test set, and was subsequently adapted for use in the other databases.”
The paper relies on this without support.
The increasing number of individual studies examining the engagement–mental health outcome association now enables a review and quantification of the literature.
“The increasing number of individual studies examining the engagement—mental health outcome association published in recent years, now enables a review and quantification of the literature.”
The paper relies on this without support.
The relationship between user engagement and outcomes in digital mental health interventions has not been established.
“However, the relationship between user engagement and outcomes in the context of these interventions has not been established.”
The paper relies on this without support.
This is the first systematic review and meta-analysis to quantitatively examine whether the level of user engagement with a digital intervention is associated with change in mental health outcomes after the intervention period.
“To our knowledge, this is the first systematic review and meta-analysis to quantitatively examine whether the level of user engagement with a digital intervention was associated with change in mental health outcomes after the intervention period.”
The paper relies on this without support.
Robust empirical evidence to support or validate the hypothesis that engagement with digital interventions is positively associated with improvements in mental health is scant.
“Although it is widely accepted that the extent of engagement with digital interventions will be positively associated with improvements in mental health, robust empirical evidence to support or validate this hypothesis is scant.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This finding is consistent with previous research highlighting the role of continuous engagement in the effectiveness of digital health interventions.
“This finding is consistent with previous research that has highlighted the role of continuous engagement in the effectiveness of digital health interventions25–27.”
From Impact of digital health interventions on glycemic control and weight management. (2025) · cites this paper as [25]
The Discussion reports that greater engagement with digital mental health interventions is associated with greater improvement in mental health symptoms. It does not establish that engagement must be continuous, and its findings concern mental health interventions rather than digital health interventions generally. (LLM, conf=0.79)
Experimental — accuracy not yet measuredPoor engagement with digital health interventions is well documented, with an average of 70% of users not completing all treatment modules.
“issues of poor engagement with digital health interventions are well documented, with an average of 70% of users not completing all treatment modules [28]”
From The Effectiveness of a Smartphone Intervention Targeting Suicidal Ideation in Young Adults: Randomized Controlled Trial Examining the Influence of Loneliness (2023) · cites this paper as [28]
The Introduction reports low completion of digital mental health interventions, with over 70% of users failing to complete all treatment modules. The citing sentence broadens this figure to digital health interventions generally and describes it as an average of 70%, neither of which the passage establishes. (LLM, conf=0.84)
Experimental — accuracy not yet measuredGreater engagement can be associated with post-intervention improvement in mental health.
“Greater engagement can be associated with post-intervention improvement in mental health [10].”
From Young People’s Barriers and Facilitators of Engagement with Web-Based Mental Health Interventions for Anxiety and Depression: A Qualitative Study (2024) · cites this paper as [10]
The level of engagement with digital health interventions is a significant positive moderator of clinical benefit.
“there is also evidence that the level of engagement with digital health interventions is a significant positive moderator of clinical benefit [28,29].”
Pooled findings from prior research estimate that treatment dropout is 74% for unsupervised digital therapeutics, and low engagement has been shown to reduce efficacy.
“Pooled findings from prior research estimate that treatment dropout is 74% for unsupervised digital therapeutics [37], which is problematic as low engagement has been shown to reduce the efficacy [38].”
From The effect of a therapeutic smartphone application on suicidal ideation in young adults: Findings from a randomized controlled trial in Australia. (2022) · cites this paper as [38]
User engagement is associated with better treatment outcomes and more cost-effective treatment.
“especially given that user engagement is associated with better treatment outcomes [15,53] and more cost-effective treatment [54,55].”
Statistics recomputed
Every reported test result, recomputed from its test statistic and degrees of freedom. A result shows as not adding up only once an independent check has confirmed it.
- Consistentz = 6.29reported p < .001 · recomputed p < .001
“Z = 6.29, p < .001”
- Consistentz = 2.59reported p = .01 · recomputed p = .010
“Z = 2.59, p = .010”
- Consistentz = 6.07reported p < .001 · recomputed p < .001
“Z = 6.07, p < .001”
- Consistentz = 6.13reported p < .001 · recomputed p < .001
“Z = 6.13, p < .001”
- Consistentz = 6.03reported p < .001 · recomputed p < .001
“Z = 6.03, p < .001”
- Consistentz = 6.76reported p < .001 · recomputed p < .001
“Z = 6.76, p < .001”
- Consistentz = 3.12reported p = .002 · recomputed p = .002
“Z = 3.12, p = .002”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Mixed-findings percentage does not match the study count
MinorFive of 35 studies is 14.3%, not 17.1%.
Reported 17.1 · recomputed 14.285714
“Five studies (17.1%) reported mixed findings”
Reported maximum mean age excludes a listed study
MinorThe stated maximum mean age is 58.4 years, but Table 1 lists a study with a mean age of 63.6 years.
“Mean participant ages ranged from 11.0 (SD 2.57) to 58.4 (SD 9.0) years.”
“AdultsMage = 63.6 (13.9)60% female”
A decrease in Hedges' g is called an increase
MinorThe leave-one-out description calls the change from 0.40 to 0.25 an increase, although it also describes the omission as producing a reduction.
“increasing the Hedges' g value from 0.40 to 0.25.”
“Omission of Oromendia et al. (66) had the largest effect reduction”
Discussion reverses the sign of the pooled Hedges' g
MinorThe discussion reports the conclusion-bearing between-groups effect as −0.40, whereas the main analysis reports +0.40.
“effect size range: r = 0.23 to Hedges' g = −0.40”
“Hedges' g = 0.40, SE =0.16, 95% CI (0.097, 0.705), Z = 2.59, p = 0.010”
Study 50 is classified as not formally diagnosed
MinorThe diagnostic-status narrative places study 50 among studies whose participants were not formally diagnosed, whereas Table 1 says its participants fulfilled diagnostic criteria.
“In the remaining 23 studies, participants were not formally diagnosed with a mental health condition but were screened for symptoms indicative of mental disorders. Of these studies, 12 reported a positive association between engagement and the primary mental health outcome (33, 36, 40, 41, 43, 47, 49, 50, 52, 57, 63, 65)”
“Fulfill diagnostic criteria for schizophrenia-related, bipolar, or depressive disorder.”
Self-report subgroup has conflicting starting correlations
MinorThe subgroup's pooled correlation is stated as 0.24, but its leave-one-out description says removal reduced the overall correlation from 0.27.
“r = 0.24, 95% CI [0.17, 0.32], Z = 6.29, p < 0.001”
“Removal of Mira et al. (65) had the largest effect influence on the model, reducing the overall r from 0.27 to 0.17.”
Study 47 is described as mixed despite its sole listed positive measure
MinorStudy 47 is included among studies with positive results for some but not all engagement measures. Table 1 lists only one engagement measure for it, marked positive.
“Five studies (17.1%) reported mixed findings, where improvements in the primary mental health outcome were associated with some, but not all, measures of engagement (37, 43, 47, 49, 57).”
“Pain self-efficacy | Activities completed (+)”
Study 52 did not show an association across all engagement measures
MinorThe narrative includes study 52 among studies with significant improvements consistently across all measures, but Table 1 marks four of its five engagement measures as having no association.
“this was consistent across all engagement measures used if multiple measures were used in a single study (33, 34, 36, 39, 40, 50–52, 54, 55, 61, 63, 65, 66)”
“Exercises completed (+)Emails sent (ns)Mean time logged in (ns)Total time logged in (ns)No. of logins (ns)”
Outcome subgroup is introduced as a diagnostic-status subgroup
MinorThe specific-outcomes section says its second analysis combines six studies involving participants who met diagnostic criteria, but describes the resulting analysis as six studies with depressive symptoms as the primary outcome.
“Data for five of the 10 studies which investigated the relationship between engagement and anxiety-related symptoms, and for six of the 12 studies involving participants who met diagnostic criteria for a mental health condition were combined and examined in two separate meta-analyses.”
“The overall mean pooled correlation for the meta-analysis of 6 studies with depressive symptoms as the primary outcome”
Study 41 is counted as null despite a positive table result
MinorThe narrative places study 41 among those with no significant association, while Table 1 marks its engagement measure as positively associated with improvement.
“Sixteen studies (45.7%) did not find any significant association between engagement and post-intervention mental health outcomes (20, 35, 38, 41, 42, 44–46, 48, 53, 56, 58–60, 62, 64).”
“Activities completed (+)”
CBT study percentage does not match the study count
MinorTwenty-seven of 35 studies is 77.1%, not 80%.
Reported 80 · recomputed 77.142857
“Most of the interventions were either fully or partially based on cognitive-behavioral therapy (27 studies, 80%).”
Abstract and results give different pooled correlations
MinorThe abstract reports r = 0.24 for the correlational analysis, while the main results report r = 0.25 for that analysis.
“correlational [r = 0.24, 95% CI (0.17, 0.32), Z = 6.29, p < 0.001]”
“20 studies, N = 1,808 participants; Figure 2) showed a small, significant positive association [r = 0.25, 95% CI (0.17, 0.32), Z = 6.29, p < 0.001]”
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“…greater engagement with DMHIs was associated with statistically significant improvements in mental health symptoms at post-intervention, and this was consistent across all engagement measures used if multiple measures were used in a single study (33, 34, 36, 39, 40, 50–52, 54, 55, 61, 63, 65, 66).”
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“…greater engagement with DMHIs was associated with statistically significant improvements in mental health symptoms at post-intervention, and this was consistent across all engagement measures used if multiple measures were used in a single study (33, 34, 36, 39, 40, 50–52, 54, 55, 61, 63, 65, 66).”
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Editorial: Digital Interventions in Mental Health: Current Status and Future Directions
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“…greater engagement with DMHIs was associated with statistically significant improvements in mental health symptoms at post-intervention, and this was consistent across all engagement measures used if multiple measures were used in a single study (33, 34, 36, 39, 40, 50–52, 54, 55, 61, 63, 65, 66).”
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“Despite the lack of meta-analytic evidence, it has been widely assumed that the association between face-to-face treatment engagement and treatment success extends to these tools by virtue of the extensive replication of this relationship in the general intervention literature (19).”
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“dropout is 74% for unsupervised digital therapeutics [37], which is problematic as low engagement has been shown to reduce the efficacy [38].”
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Smartphone-based serious games for mental health: a scoping review
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An Integrative Engagement Model of Digital Psychotherapy: Exploratory Focus Group Findings
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Personalisation and Recommendation for Mental Health Apps: A Scoping Review
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Development of a digital intervention for psychedelic preparation (DIPP)
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Framework for Guiding the Development of High-Quality Conversational Agents in Healthcare
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Jagayat, J., Kumar, A., Shao, Y., Pannu, A., Patel, C. B., Shirazi, A., Omrani, M., & Alavi, N. (2023) · JMIR Mental Health · doi:10.2196/51704 · Cited by 15 · see citing works
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“Greater engagement can be associated with post-intervention improvement in mental health [10].”
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Provision of Digital Primary Health Care Services: Overview of Reviews
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Optimizing Workplace Digital Mental Health Interventions: Systematic Review and Meta-Analysis
Stratton, E., Morris, R. W., Milton, A. C., Deady, M., Choi, I., & Glozier, N. (2025) · Journal of Medical Internet Research · doi:10.2196/71253 · Cited by 15 · see citing works
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Self-citationExamining young adults daily perspectives on usage of anxiety apps: A user study
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Developing personas to inform the design of digital interventions for perinatal mental health
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The Missing Piece: A Population Health Perspective to Address the U.S. Mental Health Crisis
Sampson, L., Kubzansky, L. D., & Koenen, K. C. (2023) · Daedalus · doi:10.1162/daed_a_02030 · Cited by 12 · see citing works
Using Adaptive Bandit Experiments to Increase and Investigate Engagement in Mental Health
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“This clear link between engagement and clinical outcomes is often overlooked in digital mental health research [43,44].”
Choi, S. K., Bruehlman-Senecal, E., Green, A. C., Lavra, J., & Bauermeister, J. A. (2023) · Frontiers in Digital Health · doi:10.3389/fdgth.2023.1254929 · Cited by 10 · see citing works
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Blended care in psychosis – A systematic review
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Zainal, N. H., Benjet, C. L., Albor, Y., Núñez-Delgado, M. J., Cruz, R. Z., Contreras‐Ibáñez, C. C., Cudris–Torres, L., de la Peña, F. R., González, N., Guerrero-López, B., et al. (2025) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.70005 · Cited by 9 · see citing works
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User journey method: a case study for improving digital intervention use measurement
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Who engages in well-being interventions? An analysis of a global digital intervention study
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Universal digital mental health interventions for children and youth: a scoping review
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- Authors
- Gan, D. Z. Q., McGillivray, L., Han, J., Christensen, H., & Torok, M.
- Affiliations
- Black Dog Institute (AU)
- Corresponding author
- Gan, Daniel Z. Q.
- Venue
- Frontiers in Digital Health
- Publisher
- Frontiers Media SA
- Published
- 2021-11-04
- Volume
- 3
- Pages
- 764079-764079
- ISSN
- 2673-253X (ISSN-L)
- PMC
- PMC8599127
- OpenAlex
- W3213740945
- Semantic Scholar
- e547b3c221a962dd1b4e073942362ba3e9bc08fa
- Cited by
- 305
- References
- 74
- Citations by year
- 2026: 82 · 2025: 95 · 2024: 71 · 2023: 42 · 2022: 14 · 2021: 1
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Digital Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Australian Government
- National Health and Medical Research Council
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- digital mental health interventions, user engagement, mental health outcomes, mental health treatment gap, therapeutic gain
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